CA2263455A1 - Liposomes containing a cisplatin compound - Google Patents

Liposomes containing a cisplatin compound

Info

Publication number
CA2263455A1
CA2263455A1 CA002263455A CA2263455A CA2263455A1 CA 2263455 A1 CA2263455 A1 CA 2263455A1 CA 002263455 A CA002263455 A CA 002263455A CA 2263455 A CA2263455 A CA 2263455A CA 2263455 A1 CA2263455 A1 CA 2263455A1
Authority
CA
Canada
Prior art keywords
compound
liposomes
liposomes containing
cisplatin compound
entrapped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002263455A
Other languages
French (fr)
Other versions
CA2263455C (en
Inventor
Robert M. Abra
Karen Reis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Sequus Pharmaceuticals, Inc.
Robert M. Abra
Karen Reis
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequus Pharmaceuticals, Inc., Robert M. Abra, Karen Reis, Alza Corporation filed Critical Sequus Pharmaceuticals, Inc.
Publication of CA2263455A1 publication Critical patent/CA2263455A1/en
Application granted granted Critical
Publication of CA2263455C publication Critical patent/CA2263455C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A liposome composition containing an entrapped cisplatin compound is described.
The liposomes have a surface coating of hydrophilic polymer chains on inner and outer surfaces and an entrapped cisplatin compound. The compound is entrapped with substantially greater retention in the liposomes, when compared to liposomes lacking the polymer coating. A method of preparing the composition is also described.
CA002263455A 1996-08-23 1997-08-19 Liposomes containing a cisplatin compound Expired - Fee Related CA2263455C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2435096P 1996-08-23 1996-08-23
US60/024,350 1996-08-23
PCT/US1997/014541 WO1998007409A1 (en) 1996-08-23 1997-08-19 Liposomes containing a cisplatin compound

Publications (2)

Publication Number Publication Date
CA2263455A1 true CA2263455A1 (en) 1998-02-26
CA2263455C CA2263455C (en) 2002-10-29

Family

ID=21820133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002263455A Expired - Fee Related CA2263455C (en) 1996-08-23 1997-08-19 Liposomes containing a cisplatin compound

Country Status (13)

Country Link
US (2) US5945122A (en)
EP (1) EP0929293B1 (en)
JP (1) JP2001501173A (en)
AT (1) ATE252372T1 (en)
AU (1) AU714992B2 (en)
CA (1) CA2263455C (en)
DE (1) DE69725747T2 (en)
DK (1) DK0929293T3 (en)
ES (1) ES2208946T3 (en)
HK (1) HK1021320A1 (en)
PT (1) PT929293E (en)
TW (1) TW483759B (en)
WO (1) WO1998007409A1 (en)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE506164C2 (en) * 1995-10-09 1997-11-17 Medscand Medical Ab Instruments for the treatment of urinary incontinence in women
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
WO1998007409A1 (en) * 1996-08-23 1998-02-26 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
FR2759293B1 (en) * 1997-02-11 1999-04-30 Ethypharm Lab Prod Ethiques CISPLATIN-CONTAINING MICROGRANULES, MANUFACTURING METHOD, PHARMACEUTICAL PREPARATION AND USE IN POLYCHEMOTHERAPY OR IN ASSOCIATION WITH RADIOTHERAPY
DE19724796A1 (en) * 1997-06-06 1998-12-10 Max Delbrueck Centrum Antitumor therapy agents
CA2346879A1 (en) 1998-09-16 2000-04-27 Alza Corporation Liposome-entrapped topoisomerase inhibitors
US20050084524A1 (en) * 1998-09-30 2005-04-21 Alza Corporation Method for potentiating activity of a chemotherapeutic drug
AU769863B2 (en) * 1999-06-09 2004-02-05 Ethicon Inc. Method and apparatus for adjusting flexible areal polymer implants
US6932759B2 (en) 1999-06-09 2005-08-23 Gene W. Kammerer Surgical instrument and method for treating female urinary incontinence
US7226407B2 (en) 1999-06-09 2007-06-05 Ethicon, Inc. Surgical instrument and method for treating female urinary incontinence
US7121997B2 (en) * 1999-06-09 2006-10-17 Ethicon, Inc. Surgical instrument and method for treating female urinary incontinence
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
AU2136501A (en) * 1999-12-10 2001-06-18 Celator Technologies Inc. Lipid carrier compositions with protected surface reactive functions
DK1274399T3 (en) * 2000-01-28 2005-08-08 Alza Corp Liposomes containing an encapsulated compound in supersaturated solution
US7131943B2 (en) * 2000-03-09 2006-11-07 Ethicon, Inc. Surgical instrument and method for treating organ prolapse conditions
DE10019604C2 (en) * 2000-04-20 2002-06-27 Ethicon Gmbh implant
JP2001336528A (en) * 2000-05-25 2001-12-07 Ntn Corp Magnetic levitation device
US7025063B2 (en) * 2000-09-07 2006-04-11 Ams Research Corporation Coated sling material
DE60108405D1 (en) * 2000-10-03 2005-02-17 Debiopharm Sa PLGA / PLA-TYPE MICROBALLS CONTAINING A WATER-SOLUBLE COMPOUND AND METHOD OF MANUFACTURING THEREOF
DK1347743T3 (en) * 2000-12-07 2006-07-03 Univ Utrecht Holding Bv Preparation for the treatment of inflammatory disorders
US6802807B2 (en) 2001-01-23 2004-10-12 American Medical Systems, Inc. Surgical instrument and method
US6641525B2 (en) * 2001-01-23 2003-11-04 Ams Research Corporation Sling assembly with secure and convenient attachment
US6612977B2 (en) 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
DE10107165A1 (en) * 2001-02-15 2002-08-29 Max Planck Gesellschaft Thermolabile liposome with controlled release temperature
WO2002078672A2 (en) * 2001-03-30 2002-10-10 Alza Corporation Liposomal tumor necrosis factor compositions and methods
WO2003015521A1 (en) * 2001-08-20 2003-02-27 Transave, Inc. Treatment of cancers by inhalation of stable platinum-containing formulations
WO2003015707A2 (en) * 2001-08-20 2003-02-27 Transave, Inc. Method for treating lung cancers
MXPA04002707A (en) * 2001-09-24 2005-06-06 Tosk Inc Reduced toxicity cisplatin formulations and methods for using the same.
US7087065B2 (en) * 2001-10-04 2006-08-08 Ethicon, Inc. Mesh for pelvic floor repair
JP4555569B2 (en) * 2001-11-13 2010-10-06 セレーター ファーマシューティカルズ， インコーポレイテッド Lipid carrier composition having enhanced blood stability
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
AU2003215843C1 (en) 2002-03-01 2009-02-19 Ethicon, Inc. Method and apparatus for treating pelvic organ prolapses in female patients
US20040009126A1 (en) * 2002-03-05 2004-01-15 Transave, Inc. Inhalation system for prevention and treatment of intracellular infections
US20110142922A1 (en) * 2002-04-30 2011-06-16 Ferndale Ip, Inc. Stabilized composition and method for dermatological treatment
US20030215493A1 (en) * 2002-04-30 2003-11-20 Patel Pravin M. Composition and method for dermatological treatment
US20090060992A1 (en) * 2002-05-08 2009-03-05 University Of Central Florida Research Foundation, Inc., Preparation of magneto-vesicles with DOPE/DDAB layers
JP3415131B1 (en) * 2002-06-03 2003-06-09 メビオファーム株式会社 Liposome preparation
US20040022842A1 (en) * 2002-06-03 2004-02-05 Mebiopharm Co., Ltd. Liposome preparations containing oxaliplatin
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
MXPA05001312A (en) * 2002-08-02 2005-08-03 Transave Inc Platinum aggregates and process for producing the same.
EP1393720A1 (en) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
ES2686361T3 (en) * 2002-10-29 2018-10-17 Insmed Incorporated Liposomes comprising an aminoglycoside for the treatment of lung infections
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
EP1565165A2 (en) * 2002-11-26 2005-08-24 Gilead Sciences, Inc. Liposomal formulations
KR20050090987A (en) * 2002-12-19 2005-09-14 알자 코포레이션 Method of treating angiogenic tissue growth
ES2337563T3 (en) * 2002-12-31 2010-04-27 Zydus Bsv Pharma Private Limited UNPEGLATED LIPOSOMES OF LASTING CIRCULATION.
WO2004078121A2 (en) * 2003-02-28 2004-09-16 Alza Coporation Liposome composition for reduction of liposome-induced complement activation
US7968115B2 (en) 2004-03-05 2011-06-28 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of cancer
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
AU2004240640A1 (en) * 2003-05-19 2004-12-02 Baxter International Inc. Solid particles comprising an anticonvulsant or an immunosuppressive coated with one or more surface modifiers
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
EP1661556A4 (en) * 2003-08-20 2010-05-19 Ajinomoto Kk Medicinal preparation having improved dissolution properties
CN100471493C (en) * 2003-12-17 2009-03-25 梅比欧法姆股份有限公司 Liposome preparation containing Oxaliplatin
US8784881B2 (en) 2004-03-05 2014-07-22 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of diseases
US20080103213A1 (en) * 2004-03-05 2008-05-01 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of neurofibromatosis
US20070065522A1 (en) * 2004-03-18 2007-03-22 Transave, Inc. Administration of high potency platinum compound formulations by inhalation
CA2559722A1 (en) * 2004-03-18 2005-09-29 Transave, Inc. Administration of cisplatin by inhalation
US8047982B2 (en) * 2004-05-07 2011-11-01 Ethicon, Inc. Mesh tape with wing-like extensions for treating female urinary incontinence
JP2008500397A (en) * 2004-05-21 2008-01-10 トランセイブ， インク． Treatment of pulmonary and pre-pulmonary disease states
WO2006015031A2 (en) * 2004-07-28 2006-02-09 Ethicon, Inc. Minimally invasive medical implant and insertion device and method for using the same
JP2006056807A (en) * 2004-08-18 2006-03-02 Konica Minolta Medical & Graphic Inc Preparation for use in photodynamic therapy
JP4715133B2 (en) * 2004-08-26 2011-07-06 コニカミノルタエムジー株式会社 Anti-tumor liposome preparation and production method thereof
JP2006069929A (en) * 2004-08-31 2006-03-16 Konica Minolta Medical & Graphic Inc Preparation for treating mycosis and method for producing the same
CN101048138B (en) 2004-09-09 2010-12-08 耶路撒冷希伯来大学伊萨姆研发公司 Use of liposomal glucocorticoids for treating inflammatory states
US7527588B2 (en) * 2004-09-15 2009-05-05 Ethicon, Inc. System and method for surgical implant placement
EP1811963A4 (en) * 2004-11-08 2010-01-06 Transave Inc Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally
US7481314B2 (en) * 2005-02-02 2009-01-27 Ethicon, Inc. Packaging assembly for surgical mesh implants
JP2006248978A (en) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd New liposome preparation
US20060283742A1 (en) * 2005-06-16 2006-12-21 Canel Lightning Co. Ltd. Multi-lamp display packaging for lamps with collapsible lampshades
CN1913508B (en) * 2005-08-08 2010-05-05 华为技术有限公司 Signal modulation method based on orthogonal frequency division multiplex and its modulation device
JP2009509535A (en) * 2005-09-27 2009-03-12 アムニクス， インコーポレイテッド Proteinaceous drugs and their use
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US9107824B2 (en) * 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007056264A2 (en) * 2005-11-08 2007-05-18 Transave, Inc. Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
US20070190180A1 (en) * 2005-11-08 2007-08-16 Pilkiewicz Frank G Methods of treating cancer with high potency lipid-based platinum compound formulations administered intravenously
WO2007056236A2 (en) * 2005-11-08 2007-05-18 Transave, Inc. Methods of treating cancer with lipid-based platinum compound formulations administered intravenously
WO2007064658A2 (en) * 2005-11-30 2007-06-07 Transave, Inc. Safe and effective methods of administering therapeutic agents
CA2896083A1 (en) 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
CA2841386A1 (en) 2005-12-30 2007-07-12 Zensun (Shanghai) Science & Technology Limited Extended release of neuregulin for improved cardiac function
WO2007089043A1 (en) * 2006-02-03 2007-08-09 Takeda Pharmaceutical Company Limited Liposome preparation
JP5364381B2 (en) * 2006-12-08 2013-12-11 片山化学工業株式会社 Liposome encapsulating ammine platinum complex at high concentration and method for producing the same
WO2008079973A2 (en) * 2006-12-21 2008-07-03 Centocor, Inc. Egfr binding peptides and uses thereof
US8278415B2 (en) 2006-12-21 2012-10-02 Centocor, Inc. Dimeric high affinity EGFR constructs and uses thereof
US8834920B2 (en) 2006-12-21 2014-09-16 Alza Corporation Liposome composition for targeting egfr receptor
US20100196455A1 (en) * 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
JP2010536341A (en) * 2007-08-15 2010-12-02 アムニクス， インコーポレイテッド Compositions and methods for altering properties of biologically active polypeptides
WO2009097011A1 (en) 2007-08-17 2009-08-06 Celator Pharmaceuticals, Inc. Improved platinum drug formulations
JP2010540498A (en) 2007-09-28 2010-12-24 ウニヴェルズィテーツシュピタール バーゼル Immunoliposomes for the treatment of cancer
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
TWI468188B (en) * 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
EP3415151A1 (en) * 2008-05-23 2018-12-19 The University of British Columbia Modified drugs for use in liposomal nanoparticles
US20100035853A1 (en) * 2008-08-07 2010-02-11 Hyogo College Of Medicine Method for preventing or treating cisplatin-induced nephrotoxicity
US9322831B2 (en) * 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
US8449573B2 (en) 2008-12-05 2013-05-28 Boston Scientific Scimed, Inc. Insertion device and method for delivery of a mesh carrier
NZ593833A (en) 2009-02-03 2013-10-25 Amunix Operating Inc Extended recombinant polypeptides and compositions comprising same
US8957021B2 (en) 2009-02-03 2015-02-17 Amunix Operating Inc. Glucose-regulating polypeptides and methods of making and using same
EP2228059A1 (en) 2009-03-12 2010-09-15 Universitätsspital Basel Chemotherapeutic composition for the treatment of cancer
WO2010120336A1 (en) * 2009-04-15 2010-10-21 Poniard Pharmaceuticals, Inc. High bioavailability oral picoplatin anti-cancer therapy
US8968334B2 (en) 2009-04-17 2015-03-03 Boston Scientific Scimed, Inc. Apparatus for delivering and anchoring implantable medical devices
CN106916229A (en) 2009-06-08 2017-07-04 阿穆尼克斯运营公司 Growth hormone polypeptides and its preparation and application
WO2010143193A1 (en) 2009-06-11 2010-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
EP3222287A1 (en) 2009-08-24 2017-09-27 Amunix Operating Inc. Coagulation factor ix compositions and methods of making and using same
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
NZ599543A (en) 2009-10-30 2014-02-28 Ntf Therapeutics Inc Improved neurturin molecules
US9301750B2 (en) * 2009-11-03 2016-04-05 Boston Scientific Scimed, Inc. Device and method for delivery of mesh-based devices
US20130052259A1 (en) 2010-02-01 2013-02-28 Yechezkel Barenholz Liposomes comprising amphipathic drugs and method for their preparation
US9518114B2 (en) 2010-11-12 2016-12-13 Purdue Research Foundation Treating bladder tumor cells using fibronectin attachment protein as a target
EP2508176A1 (en) 2011-04-08 2012-10-10 Lipotarg Gmbh Novel combination treatment of cancer
PL2731591T3 (en) 2011-07-13 2021-05-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomes co-encapsulating a bisphosphonate and an amphipathic agent
US20150004219A1 (en) 2012-02-02 2015-01-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Stable liposomes for drug delivery
DK2822577T3 (en) 2012-02-15 2019-04-01 Bioverativ Therapeutics Inc RECOMBINANT FACTOR VIII PROTEINS
ES2771208T3 (en) 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Factor VIII compositions and methods of preparation and use thereof
CA2870860C (en) 2012-05-21 2021-07-27 Insmed Incorporated Systems for treating pulmonary infections
NZ630849A (en) 2012-06-08 2016-04-29 Alkermes Inc Ligands modified by circular permutation as agonists and antagonists
JP2015524410A (en) 2012-07-18 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Liposome composition of epoxy ketone-based proteasome inhibitor
MA37931A1 (en) * 2012-08-13 2016-07-29 Teni Boulikas Improved methods for treating cancer with reduced renal toxicity
ES2848025T3 (en) 2012-09-04 2021-08-05 Eleison Pharmaceuticals LLC Prevention of lung cancer recurrence with lipid-complexed cisplatin
US20150246137A1 (en) * 2012-09-27 2015-09-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
RU2675859C2 (en) 2012-11-29 2018-12-25 Инсмед Инкорпорейтед Stabilised vancomycin formulations
US9556214B2 (en) * 2012-12-19 2017-01-31 Placon Therapeutics, Inc. Compounds, compositions, and methods for the treatment of cancers
MX2015012200A (en) * 2013-03-13 2015-11-30 Mallinckrodt Llc Liposome oxaliplatin compositions for cancer therapy.
MX2015012199A (en) * 2013-03-13 2015-11-30 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy.
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
US9987375B2 (en) * 2013-09-23 2018-06-05 Amirhossein Sahebkar Method and composition for treatment of dyslipidemia and other diseases
WO2015148648A1 (en) 2014-03-25 2015-10-01 The Government Of The United States Of America As Represented By The Secretary Of The Army Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (mpla)-containing liposome composition and a saponin
ES2926985T3 (en) 2014-05-15 2022-10-31 Insmed Inc Methods for treating nontuberculous mycobacterial lung infections
AU2016233143B2 (en) 2015-03-17 2021-03-25 Alberto Gabizon Methods for the treatment of bladder cancer
KR20180029262A (en) 2015-08-03 2018-03-20 바이오버라티브 테라퓨틱스 인크. Factor IX fusion proteins and methods for their manufacture and use
KR20180077180A (en) 2015-11-06 2018-07-06 아쥬반스 테크놀로지스 인코포레이티드 Triterpene saponin analog
FR3051674B1 (en) * 2016-05-31 2019-11-08 Universite De Bourgogne LIPOPROTEINS FILLED WITH PLATINUM COMPLEXES FOR THE TREATMENT OF CANCER
CN109996809A (en) 2016-11-14 2019-07-09 诺华股份有限公司 Composition relevant to fusogenic protein MINION, method and therapeutical uses
SG11202001826YA (en) 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues
EP3706801A4 (en) * 2017-11-08 2022-04-06 L.E.A.F Holdings Group LLC Platinum complexes and uses thereof
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
CN114163481B (en) * 2021-12-06 2023-06-23 郑州大学 Platinum-containing drug nano vesicle and preparation method and application thereof
WO2023175454A1 (en) 2022-03-14 2023-09-21 Pfizer Inc. Methods for producing an adjuvant

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1162479A (en) * 1980-03-31 1984-02-21 Murray A. Kaplan Pharmaceutical formulations containing cisplatin
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
WO1991016040A1 (en) * 1990-04-18 1991-10-31 Takeda Chemical Industries, Ltd. Liposome composition
JP3220180B2 (en) * 1991-05-23 2001-10-22 三菱化学株式会社 Drug-containing protein-bound liposomes
EP0551169A1 (en) * 1992-01-10 1993-07-14 Takeda Chemical Industries, Ltd. Liposome composition and production thereof
WO1998007409A1 (en) * 1996-08-23 1998-02-26 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound

Also Published As

Publication number Publication date
CA2263455C (en) 2002-10-29
EP0929293B1 (en) 2003-10-22
HK1021320A1 (en) 2000-06-09
WO1998007409A1 (en) 1998-02-26
AU3985697A (en) 1998-03-06
ATE252372T1 (en) 2003-11-15
JP2001501173A (en) 2001-01-30
DE69725747T2 (en) 2004-07-29
EP0929293A1 (en) 1999-07-21
PT929293E (en) 2004-03-31
US5945122A (en) 1999-08-31
ES2208946T3 (en) 2004-06-16
DE69725747D1 (en) 2003-11-27
TW483759B (en) 2002-04-21
US6126966A (en) 2000-10-03
DK0929293T3 (en) 2004-02-02
AU714992B2 (en) 2000-01-13

Similar Documents

Publication Publication Date Title
CA2263455A1 (en) Liposomes containing a cisplatin compound
CA2267904A1 (en) Fusogenic liposome composition and method
AU8747991A (en) A solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surface, and a conjugate therefor
EP0801119A4 (en) Water base ink
EP0265906A3 (en) Wound dressing
IE46009L (en) Superficially porous macroparticles
AU4834393A (en) Method of forming air film on submerged surface of submerged part-carrying structure, and film structure on submerged surface
WO1999051202A3 (en) Quinolone containing liposomes and their use as antibacterial agents
CA2238272A1 (en) Wear member
CA2094252A1 (en) Rotating magnetron incorporating a removable cathode
CA2270992A1 (en) Coated confectionary products and methods of manufacturing same
EP1291941A3 (en) Active material for battery and method of preparing the same
EP0811669A4 (en) Antifouling agent and nonaqueous coating composition containing said agent
CA2086077A1 (en) Agricultural microcapsule and production thereof
AU5523399A (en) Cellulose microfibrils with modified surface, preparation method and use thereof
CA2269739A1 (en) Acrylic-melamine-functionalized oligomer coating composition
CA2278418A1 (en) Epoxy coated tampon applicator having a pierce-through fingergrip
CA2337509A1 (en) Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
CA2194042A1 (en) A dual type composition brake block specifically designed for use in predetermined type brake system
CA2072224A1 (en) Electrically conductive polymer composition, method of making same and device incorporating same
EP0812874A4 (en) Easy-to-break-through film
AU4683397A (en) Composite melanin pigment in the form of particles comprising a wax-based spherical core, preparation processes and cosmetic uses
CA2121237A1 (en) Tcmtb on a solid carrier in powdered form, method of manufacture and method of use
CA2024690A1 (en) Coating composition and tire coated therewith
CA2221204A1 (en) Confectionery coating

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed