CA2267904A1 - Fusogenic liposome composition and method - Google Patents

Fusogenic liposome composition and method

Info

Publication number
CA2267904A1
CA2267904A1 CA002267904A CA2267904A CA2267904A1 CA 2267904 A1 CA2267904 A1 CA 2267904A1 CA 002267904 A CA002267904 A CA 002267904A CA 2267904 A CA2267904 A CA 2267904A CA 2267904 A1 CA2267904 A1 CA 2267904A1
Authority
CA
Canada
Prior art keywords
composition
target cells
liposome
hydrophobic polymers
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002267904A
Other languages
French (fr)
Other versions
CA2267904C (en
Inventor
Francis J. Martin
Samuel Zalipsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Sequus Pharmaceuticals, Inc.
Francis J. Martin
Samuel Zalipsky
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequus Pharmaceuticals, Inc., Francis J. Martin, Samuel Zalipsky, Alza Corporation filed Critical Sequus Pharmaceuticals, Inc.
Priority to CA002505445A priority Critical patent/CA2505445A1/en
Publication of CA2267904A1 publication Critical patent/CA2267904A1/en
Application granted granted Critical
Publication of CA2267904C publication Critical patent/CA2267904C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation

Abstract

A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described.
The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposomes outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a method for using the composition to deliver a compound to target cells, and a method for selecting suitable hydrophobic polymers for use in the composition.
CA002267904A 1996-10-11 1997-10-10 Fusogenic liposome composition and method Expired - Fee Related CA2267904C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002505445A CA2505445A1 (en) 1996-10-11 1997-10-10 Fusogenic liposome composition and method

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2826996P 1996-10-11 1996-10-11
US60/028,269 1996-10-11
PCT/US1997/018838 WO1998016202A2 (en) 1996-10-11 1997-10-10 Fusogenic liposome composition and method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002505445A Division CA2505445A1 (en) 1996-10-11 1997-10-10 Fusogenic liposome composition and method

Publications (2)

Publication Number Publication Date
CA2267904A1 true CA2267904A1 (en) 1998-04-23
CA2267904C CA2267904C (en) 2005-08-02

Family

ID=21842486

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267904A Expired - Fee Related CA2267904C (en) 1996-10-11 1997-10-10 Fusogenic liposome composition and method

Country Status (15)

Country Link
US (1) US5891468A (en)
EP (1) EP0932391B1 (en)
JP (1) JP2001504093A (en)
AT (1) ATE232086T1 (en)
AU (1) AU715063B2 (en)
BR (1) BR9712230A (en)
CA (1) CA2267904C (en)
DE (1) DE69718924T2 (en)
DK (1) DK0932391T3 (en)
ES (1) ES2191833T3 (en)
HK (1) HK1047550A1 (en)
IL (1) IL129292A0 (en)
PT (1) PT932391E (en)
TW (1) TW520297B (en)
WO (1) WO1998016202A2 (en)

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CA2267904C (en) 2005-08-02

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