CA2268156A1 - Bioceramic compositions - Google Patents

Bioceramic compositions

Info

Publication number
CA2268156A1
CA2268156A1 CA002268156A CA2268156A CA2268156A1 CA 2268156 A1 CA2268156 A1 CA 2268156A1 CA 002268156 A CA002268156 A CA 002268156A CA 2268156 A CA2268156 A CA 2268156A CA 2268156 A1 CA2268156 A1 CA 2268156A1
Authority
CA
Canada
Prior art keywords
sites
tissue
cells
useful
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002268156A
Other languages
French (fr)
Other versions
CA2268156C (en
Inventor
Dosuk D. Lee
Christian Rey
Maria Aiolova
Aliassghar Tofighi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LIFE SCIENCE ENTERPRISES Inc
Original Assignee
Etex Corporation
Dosuk D. Lee
Christian Rey
Maria Aiolova
Aliassghar Tofighi
Life Science Enterprises, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/729,342 external-priority patent/US6541037B1/en
Priority claimed from US08/729,354 external-priority patent/US6132463A/en
Application filed by Etex Corporation, Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi, Life Science Enterprises, Inc. filed Critical Etex Corporation
Publication of CA2268156A1 publication Critical patent/CA2268156A1/en
Application granted granted Critical
Publication of CA2268156C publication Critical patent/CA2268156C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30762—Means for culturing cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4648—Means for culturing bone graft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. the invention is useful for both medical and veterinary applications.
CA002268156A 1996-10-16 1997-10-16 Bioceramic compositions Expired - Lifetime CA2268156C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/729,342 1996-10-16
US08/729,342 US6541037B1 (en) 1995-05-19 1996-10-16 Delivery vehicle
US08/729,354 1996-10-16
US08/729,354 US6132463A (en) 1995-05-19 1996-10-16 Cell seeding of ceramic compositions
PCT/US1997/018528 WO1998016209A2 (en) 1996-10-16 1997-10-16 Bioceramic compositions

Publications (2)

Publication Number Publication Date
CA2268156A1 true CA2268156A1 (en) 1998-04-23
CA2268156C CA2268156C (en) 2007-05-29

Family

ID=27111856

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268156A Expired - Lifetime CA2268156C (en) 1996-10-16 1997-10-16 Bioceramic compositions

Country Status (9)

Country Link
US (1) US6972130B1 (en)
EP (1) EP0941079B1 (en)
JP (1) JP4260891B2 (en)
AT (1) ATE381314T1 (en)
AU (1) AU734691B2 (en)
CA (1) CA2268156C (en)
DE (1) DE69738398T2 (en)
ES (1) ES2299183T3 (en)
WO (1) WO1998016209A2 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US8728536B2 (en) 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
AU3556400A (en) 1999-03-17 2000-10-04 Novartis Ag Pharmaceutical compositions
JP4669932B2 (en) * 2000-05-02 2011-04-13 学校法人日本大学 Biomaterial composition and cured product thereof
EP1335686B1 (en) * 2000-10-24 2008-12-17 Warsaw Orthopedic, Inc. Spinal fusion devices
US6730324B2 (en) 2001-04-20 2004-05-04 The University Of British Columbia Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
SE519566C2 (en) * 2001-07-04 2003-03-11 Nobel Biocare Ab Method of Treating Implants by Coating with Calcium Phosphate and Bone Growth Stimulants
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
US9144583B2 (en) 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
US7931687B2 (en) 2002-05-13 2011-04-26 Articular Engineering, Llc Tissue engineered osteochondral implant
CA2498743A1 (en) 2002-09-13 2004-03-25 The University Of British Columbia Calcium phosphate coated implantable medical devices and processes for making same
US20040141903A1 (en) * 2003-01-17 2004-07-22 Howmedica Osteonics Corp. Calcium phosphate cement precursors
FR2850282B1 (en) 2003-01-27 2007-04-06 Jerome Asius INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
EP3254710B1 (en) 2003-04-11 2019-05-22 Etex Corporation Osteoinductive bone material
CN1878565B (en) * 2003-09-12 2011-01-12 惠氏公司 Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
JP2007001865A (en) * 2003-09-16 2007-01-11 Ltt Bio-Pharma Co Ltd Fine particle enclosing fat-soluble medicine, method for producing the same and preparation containing the same
US20050136764A1 (en) 2003-12-18 2005-06-23 Sherman Michael C. Designed composite degradation for spinal implants
KR101218454B1 (en) 2004-04-15 2013-01-04 에텍스 코포레이션 Delayedsetting calcium phosphate pastes
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
JP2006289062A (en) * 2005-03-18 2006-10-26 Pentax Corp Bone filling material using cartilage cell having hypertrophy ability and scaffold
KR20140014294A (en) * 2005-03-31 2014-02-05 리드스 에이비 Method for treating prostate diseases based on local delivery of active substances
WO2006109635A1 (en) 2005-04-06 2006-10-19 Kabushiki Kaisha Sangi Intestinal absorptive anti-tumor agent
US7947759B2 (en) * 2005-08-08 2011-05-24 Angstrom Medica Cement products and methods of making and using the same
WO2007044229A2 (en) * 2005-09-28 2007-04-19 Calcitec, Inc. Surface treatments for calcium phosphate-based implants
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
CA2641860C (en) * 2006-02-09 2015-07-14 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
JP5216601B2 (en) * 2006-03-14 2013-06-19 リッズ エービー Bioabsorbable controlled release composition
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070255422A1 (en) * 2006-04-25 2007-11-01 Mei Wei Calcium phosphate polymer composite and method
US9101505B2 (en) * 2006-04-27 2015-08-11 Brs Holdings, Llc Composite stent
US9155646B2 (en) 2006-04-27 2015-10-13 Brs Holdings, Llc Composite stent with bioremovable ceramic flakes
FR2904553A1 (en) * 2006-08-03 2008-02-08 Isthmes Group Res And Innovati Biocompatible material fabricating method for e.g. percutaneous vertebroplasty, involves activating nucleating agent to develop mixed pseudo-crystalline lattice in condensate for obtaining crystallized biocompatible material
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
JP5484047B2 (en) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス， エルエルシー PDGF-biomatrix composition and method for treating rotator cuff injury
JP2009545407A (en) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド End prosthesis with 3D decomposition control
JP2010503490A (en) * 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Endoprosthesis with adjustable surface features
JP2010503485A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Medical device and method for manufacturing the same
ATE517590T1 (en) 2006-09-15 2011-08-15 Boston Scient Ltd BIOLOGICALLY ERODABLE ENDOPROTHESES
ES2368125T3 (en) * 2006-09-15 2011-11-14 Boston Scientific Scimed, Inc. BIOEROSIONABLE ENDOPROOTHESIS WITH BIOESTABLE INORGANIC LAYERS.
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
EP2106217B1 (en) * 2006-12-12 2019-03-13 Firmenich S.A. Active ingredient delivery system with an amorphous metal salt as carrier
ATE488259T1 (en) 2006-12-28 2010-12-15 Boston Scient Ltd BIOERODIBLE ENDOPROTHES AND PRODUCTION METHODS THEREOF
US20080241256A1 (en) * 2007-03-30 2008-10-02 Liisa Kuhn Targeted active agent delivery system based on calcium phosphate nanoparticles
US11174458B2 (en) 2007-04-23 2021-11-16 Koligo Therapeutics, Inc. Cell separation apparatus and methods of use
US20100317112A1 (en) * 2007-04-27 2010-12-16 Hyunjin Yang Scaffolds increased specific gravity for cell culture and method for manufacturing thereof
US20090081276A1 (en) * 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
WO2009029734A2 (en) 2007-08-28 2009-03-05 Pioneer Surgical Technology, Inc. Cement products and methods of making and using the same
US8062655B2 (en) * 2007-08-31 2011-11-22 Phillips Plastics Corporation Composite scaffold structure
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8105967B1 (en) 2007-10-05 2012-01-31 The United States Of America As Represented By The Secretary Of The Navy Lightweight ballistic armor including non-ceramic-infiltrated reaction-bonded-ceramic composite material
EP2077126A1 (en) * 2008-01-07 2009-07-08 Graftys Analgesic apatitic calcium-phosphate cement
CN102014977B (en) 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 For compositions and the method for Distraction Osteogenesis
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
AU2009291828C1 (en) 2008-09-09 2016-03-17 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
JP2012506733A (en) 2008-10-24 2012-03-22 ウォーソー・オーソペディック・インコーポレーテッド Compositions and methods for promoting bone formation
AU2009319348B2 (en) * 2008-11-27 2014-07-31 Lidds Ab Use of carboxymethylcellulose to control ejectability and solidification of time of compositions one or more bioresorbable ceramics
WO2010094798A1 (en) 2009-02-20 2010-08-26 Dsm Ip Assets B.V. Medical implant
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8574273B2 (en) 2009-09-09 2013-11-05 Innovision, Inc. Bone screws and methods of use thereof
US8778378B2 (en) * 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8388887B2 (en) 2010-04-12 2013-03-05 Biomet Manufacturing Corp. Methods for making textured ceramic implants
US20140044682A1 (en) * 2012-08-10 2014-02-13 Pete O'Heeron Generation of cartilage ex vivo from fibroblasts
US20150335790A1 (en) * 2012-12-18 2015-11-26 University Of Massachusetts Medical School Compositions and methods for templating three-dimensional mineralization
EP2967694B1 (en) 2013-03-15 2022-04-20 INNOVISION, Inc. Bone screws
US20240009231A1 (en) * 2020-09-25 2024-01-11 University Of Cincinnati Method for Pleurodesis and Delivery of Drugs to the Lung and Pleural Space

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157378A (en) 1973-01-11 1979-06-05 Colgate Palmolive Company Process for preparing fluorapatite
DE2843963A1 (en) 1978-10-09 1980-04-24 Merck Patent Gmbh BODY-RESORBABLE SHAPED MATERIAL BASED ON COLLAGEN AND THEIR USE IN MEDICINE
JPS5654841A (en) 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
USRE33221E (en) 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
US4518430A (en) * 1982-04-29 1985-05-21 American Dental Association Health Foundation Dental resptorative cement pastes
USRE33161E (en) 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
US5286763A (en) 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
DE3325111A1 (en) 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt IMPLANTATION MATERIALS
US4612053A (en) * 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
JPS6117409A (en) 1984-07-02 1986-01-25 Meishin Toryo Kk Preparation of amorphous calcium phosphate and bio-compatible composition composed mainly thereof
DE3433210C1 (en) 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Means for filling bone and tooth defects, for bone building, for bone contact layers and for bone and tooth root replacement and use of carbonate apatite for this purpose
JPS62182146A (en) 1985-10-11 1987-08-10 三井東圧化学株式会社 Hardenable material
JPH0720486B2 (en) 1986-10-30 1995-03-08 京セラ株式会社 Calcium phosphate-based bioprosthetic material and method for producing the same
US4778471A (en) * 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US4737411A (en) 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
JPS63170205A (en) 1987-01-09 1988-07-14 Jgc Corp Production of hydroxyapatite
US5085861A (en) 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
DE3709897A1 (en) 1987-03-26 1988-10-06 Ewers Rolf METHOD OF MANUFACTURING A HYDROXYLAPATITE MATERIAL
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5129905A (en) 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5178845A (en) 1988-04-20 1993-01-12 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5047031A (en) 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US4849193A (en) 1988-05-02 1989-07-18 United States Gypsum Company Process of preparing hydroxylapatite
JPH02182261A (en) 1989-01-06 1990-07-16 Olympus Optical Co Ltd Preparation of ceramic member for living body
US5034059A (en) 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide
US5037639A (en) 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5164187A (en) 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
EP0541687B1 (en) 1990-07-27 1997-08-27 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
JP2621622B2 (en) 1990-09-27 1997-06-18 三菱マテリアル株式会社 Hydraulic calcium phosphate cement
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5197985A (en) 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5149368A (en) 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5262166A (en) 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
EP0520690B1 (en) 1991-06-26 1995-11-02 Nitta Gelatin Inc. Calcium phosphate type hardening material for repairing living hard tissue
JP2686684B2 (en) 1991-08-27 1997-12-08 寅雄 大塚 Tube mesh knitted with hydroxyapatite and knitted with biosoluble fibers
US5605713A (en) 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
US5281265A (en) 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
ATE208217T1 (en) 1992-02-28 2001-11-15 Cohesion Tech Inc INJECTABLE CERAMIC COMPOUNDS AND METHOD FOR THEIR PRODUCTION AND USE
JPH05305134A (en) 1992-04-30 1993-11-19 Japan Steel Works Ltd:The Porous calcium phosphate material for bone formation
GB9215356D0 (en) 1992-07-20 1992-09-02 Univ Reading The Bone materials
WO1994004657A1 (en) 1992-08-13 1994-03-03 The Trustees Of The University Of Pennsylvania Bioactive material template for in vitro synthesis of bone tissue
JP3170059B2 (en) * 1992-08-25 2001-05-28 誠 大塚 Calcium phosphate drug sustained-release body and method for producing the same
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
JPH07277712A (en) * 1992-12-18 1995-10-24 Hokkaido Sogo Gijutsu Kenkyusho:Kk Production of natural hydroxyapatite by fluidized bed baking method
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5522893A (en) 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US5565502A (en) 1993-03-24 1996-10-15 Children's Medical Center Corporation Isolation of the calcium-phosphate crystals of bone
GB9310321D0 (en) 1993-05-19 1993-06-30 Queen Mary & Westfield College Method for the preparation of carbonated hydroxyapatite compositions
RU2077329C1 (en) 1993-07-21 1997-04-20 Акционерное общество закрытого типа "ОСТИМ" Agent for osseous tissue growth stimulation
US5525148A (en) 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5496399A (en) 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US5700289A (en) 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture

Also Published As

Publication number Publication date
JP2001524937A (en) 2001-12-04
WO1998016209A3 (en) 1998-10-01
EP0941079B1 (en) 2007-12-19
CA2268156C (en) 2007-05-29
DE69738398D1 (en) 2008-01-31
AU734691B2 (en) 2001-06-21
WO1998016209A2 (en) 1998-04-23
ATE381314T1 (en) 2008-01-15
DE69738398T2 (en) 2008-12-04
AU4902597A (en) 1998-05-11
JP4260891B2 (en) 2009-04-30
ES2299183T3 (en) 2008-05-16
US6972130B1 (en) 2005-12-06
EP0941079A1 (en) 1999-09-15

Similar Documents

Publication Publication Date Title
CA2268156A1 (en) Bioceramic compositions
Søballe et al. Tissue ingrowth into titanium and hydroxyapatite‐coated implants during stable and unstable mechanical conditions
Costantino et al. Hydroxyapatite cement: I. Basic chemistry and histologic properties
Moore et al. The evaluation of a biphasic calcium phosphate ceramic for use in grafting long‐bone diaphyseal defects
EP1094851B1 (en) Material for bone reconstruction
Urist et al. Bone regeneration under the influence of a bone morphogenetic protein (BMP) beta tricalcium phosphate (TCP) composite in skull trephine defects in dogs.
US6541037B1 (en) Delivery vehicle
US6277151B1 (en) Cartilage growth from cell seeded ceramic compositions
US8690874B2 (en) Composition and process for bone growth and repair
PINHOLT et al. Alveolar ridge augmentation in rats by Bio‐Oss
WO1998016209A9 (en) Bioceramic compositions
JP2007533376A (en) Delayed solidification calcium phosphate paste
JPH11506659A (en) Biocompatible hydroxyapatite formulations and uses thereof
DE69737504D1 (en) CERAMIC IMPLANTS AND COMPOSITIONS WITH OSTEOINDUCTIVE ACTIVE SUBSTANCES
MXPA02000877A (en) Cartilage or bone matrix as a nucleic acid delivery vehicle.
US6599517B1 (en) Bone tissue restoring composition
EP0968729B1 (en) Bone regeneration material
Ono et al. In vivo strength enhancement of hydroxyapatite combined with rhBMP-2
EP2033598A1 (en) Calcium phosphate based delivery of growth and differentiation factors to compromised bone
Passuti et al. Bone substitutes
Epinette et al. Experimental Data Regarding Macroporous Biphasic-Calcium Phosphate Ceramics: Can they replace bone grafting?
Lee David Knaack!, Maria Aiolova', Ali Tofighi', Anthony Catalano', Christian Rey, Berthold Nies
Nathan Osteogenesis induced by bone marrow in a collagen-ceramic composite

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20171016