CA2268840A1 - Benzimidazole-2-carbamates for the treatment of viral infections and cancer - Google Patents

Benzimidazole-2-carbamates for the treatment of viral infections and cancer

Info

Publication number
CA2268840A1
CA2268840A1 CA002268840A CA2268840A CA2268840A1 CA 2268840 A1 CA2268840 A1 CA 2268840A1 CA 002268840 A CA002268840 A CA 002268840A CA 2268840 A CA2268840 A CA 2268840A CA 2268840 A1 CA2268840 A1 CA 2268840A1
Authority
CA
Canada
Prior art keywords
viral infections
benzimidazole
carbamates
cancer
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002268840A
Other languages
French (fr)
Other versions
CA2268840C (en
Inventor
James Berger Camden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAF Technologies and Research LLC
Original Assignee
The Procter & Gamble Company
James Berger Camden
The University Of Arizona Foundation
Uaf Technologies And Research Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company, James Berger Camden, The University Of Arizona Foundation, Uaf Technologies And Research Llc filed Critical The Procter & Gamble Company
Publication of CA2268840A1 publication Critical patent/CA2268840A1/en
Application granted granted Critical
Publication of CA2268840C publication Critical patent/CA2268840C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide is disclosed.
The particular fungicide used is a benzimidazole derivative having formula (I), wherein R is selected from the group consisting of H, carboxyl (-CO2H). hydroxyl, amino or esters (-CO2R') wherein R' is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl wherein the alkyl groups have from 1-8 carbons or CH3CH2(OCH2CH2)n- or CH3CH2CH2(OCH2CH2CH2)n- or (CH3)2CH-(OCH(CH3)CH2)n- wherein n is from 1-3, the pharmaceutically acceptable salts thereof, or mixtures thereof.
CA002268840A 1997-05-16 1997-11-26 Benzimidazole-2-carbamates for the treatment of viral infections and cancer Expired - Fee Related CA2268840C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/857,811 US6506783B1 (en) 1997-05-16 1997-05-16 Cancer treatments and pharmaceutical compositions therefor
US08/857,811 1997-05-16
PCT/US1997/021565 WO1998051304A1 (en) 1997-05-16 1997-11-26 Benzimidazole-2-carbamates for the treatment of viral infections and cancer

Publications (2)

Publication Number Publication Date
CA2268840A1 true CA2268840A1 (en) 1998-11-19
CA2268840C CA2268840C (en) 2006-10-03

Family

ID=25326784

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268840A Expired - Fee Related CA2268840C (en) 1997-05-16 1997-11-26 Benzimidazole-2-carbamates for the treatment of viral infections and cancer

Country Status (22)

Country Link
US (13) US6506783B1 (en)
EP (1) EP0956017B1 (en)
JP (1) JP2001527523A (en)
KR (1) KR20000049065A (en)
CN (1) CN1254282A (en)
AR (1) AR010008A1 (en)
AT (1) ATE363904T1 (en)
AU (1) AU728690B2 (en)
BR (1) BR9714634A (en)
CA (1) CA2268840C (en)
CZ (1) CZ125299A3 (en)
DE (1) DE69737793D1 (en)
HU (1) HUP0001170A3 (en)
IL (1) IL129352A0 (en)
NO (1) NO991700L (en)
NZ (1) NZ335159A (en)
PE (1) PE11099A1 (en)
PL (1) PL335541A1 (en)
SK (1) SK47099A3 (en)
TR (1) TR199901528T2 (en)
WO (1) WO1998051304A1 (en)
ZA (1) ZA979096B (en)

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US6864275B1 (en) 2005-03-08
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US6420411B1 (en) 2002-07-16
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US6900235B1 (en) 2005-05-31
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US6077862A (en) 2000-06-20
US6984654B2 (en) 2006-01-10
US6710065B1 (en) 2004-03-23
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CN1254282A (en) 2000-05-24
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