CA2269919A1 - Skin vibration method for topical targeted delivery of beneficial agents into hair follicles - Google Patents
Skin vibration method for topical targeted delivery of beneficial agents into hair folliclesInfo
- Publication number
- CA2269919A1 CA2269919A1 CA002269919A CA2269919A CA2269919A1 CA 2269919 A1 CA2269919 A1 CA 2269919A1 CA 002269919 A CA002269919 A CA 002269919A CA 2269919 A CA2269919 A CA 2269919A CA 2269919 A1 CA2269919 A1 CA 2269919A1
- Authority
- CA
- Canada
- Prior art keywords
- skin
- hair follicles
- delivery
- hair
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
- A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2205/00—Devices for specific parts of the body
- A61H2205/02—Head
- A61H2205/021—Scalp
Abstract
The present invention provides methods and apparatuses for use in providing rapid, selective and effective targeted delivery of beneficial substances into hair follicles by use of a vibrator (1) for vibrating a chamber with a substance (2) to be delivered to the skin (3). The invention relies on the use of a vibrational method of delivery of substances of different size from small molecules up to particles compatible with the diameter of hair strand into the hair bulb. The skin is subjected to the vibration of about 1 Hz to about 100 Hz frequency, and 0.1 mm to about 10 mm amplitude, an amount which is sufficient to cause mechanical shifts in different directions of skin structure without damage. This results in follicle effective uptake of the tested substances such as carbon particles of different size as well as melanin. The methods and apparatuses of the present invention are particularly useful in conjunction with photosensitizing agents and electromagnetic irradiation. Such a combination is used to target the delivery ofagent within hair follicles and then subsequently activate the agent.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/755,139 US5830177A (en) | 1996-11-22 | 1996-11-22 | Skin vibration method for topical targeted delivery of beneficial agents into hair follicles |
US08/755,139 | 1996-11-22 | ||
PCT/US1997/020345 WO1998022031A1 (en) | 1996-11-22 | 1997-11-10 | Skin vibration method for topical targeted delivery of beneficial agents into hair follicles |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2269919A1 true CA2269919A1 (en) | 1998-05-28 |
CA2269919C CA2269919C (en) | 2008-06-03 |
Family
ID=25037888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002269919A Expired - Fee Related CA2269919C (en) | 1996-11-22 | 1997-11-10 | Skin vibration method for topical targeted delivery of beneficial agents into hair follicles |
Country Status (6)
Country | Link |
---|---|
US (2) | US5830177A (en) |
EP (1) | EP0975267A4 (en) |
JP (1) | JP2001505099A (en) |
AU (1) | AU731559B2 (en) |
CA (1) | CA2269919C (en) |
WO (1) | WO1998022031A1 (en) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
DE19925904C1 (en) | 1999-06-07 | 2001-02-01 | Disetronic Licensing Ag | Unit for subcutaneous application of an injectable product comprises a system which indicates whether the protection sleeve of the injection needle is in its fully retracted position |
US7405080B2 (en) * | 2000-03-23 | 2008-07-29 | Voellmy Richard W | Compositions and methods relating to prevention of chemotherapy-induced alopecia |
US6980854B2 (en) * | 2001-04-06 | 2005-12-27 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs |
US7496401B2 (en) * | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7010343B2 (en) | 2001-04-06 | 2006-03-07 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7083580B2 (en) * | 2001-04-06 | 2006-08-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7520875B2 (en) * | 2001-04-06 | 2009-04-21 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US6748266B2 (en) * | 2001-04-06 | 2004-06-08 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
WO2003020227A1 (en) * | 2001-09-03 | 2003-03-13 | Richard Voellmy | Compositions and methods relating to prevention of chemotherapy-induced alopecia |
US7264629B2 (en) * | 2001-11-09 | 2007-09-04 | Qlt, Inc. | Photodynamic therapy for the treatment of hair loss |
CN100401962C (en) * | 2002-05-21 | 2008-07-16 | 皇家飞利浦电子股份有限公司 | Apparatus for treating a person's skin |
AU2003293582A1 (en) * | 2002-12-18 | 2004-07-22 | Mark L. Witten | Stimulation of hair regrowth |
KR100495815B1 (en) * | 2003-02-26 | 2005-06-16 | 황하욱 | Hair generator |
WO2004093788A2 (en) * | 2003-04-17 | 2004-11-04 | The Trustees Of Columbia University In The City Ofnew York | Desmoglein 4 is a novel gene involved in hair growth |
US8721573B2 (en) | 2003-09-04 | 2014-05-13 | Simon Fraser University | Automatically adjusting contact node for multiple rib space engagement |
CA2439667A1 (en) * | 2003-09-04 | 2005-03-04 | Andrew Kenneth Hoffmann | Low frequency vibration assisted blood perfusion system and apparatus |
US8734368B2 (en) | 2003-09-04 | 2014-05-27 | Simon Fraser University | Percussion assisted angiogenesis |
US20090069728A1 (en) * | 2004-07-30 | 2009-03-12 | Andrew Kenneth Hoffmann | Randomic vibration for treatment of blood flow disorders |
US8870796B2 (en) * | 2003-09-04 | 2014-10-28 | Ahof Biophysical Systems Inc. | Vibration method for clearing acute arterial thrombotic occlusions in the emergency treatment of heart attack and stroke |
US20060025683A1 (en) * | 2004-07-30 | 2006-02-02 | Ahof Biophysical Systems Inc. | Hand-held imaging probe for treatment of states of low blood perfusion |
EP1479363B1 (en) * | 2003-09-25 | 2006-05-17 | Power-Wrap International Trading GmbH | Application of cosmetics in the skin |
WO2005070073A2 (en) * | 2004-01-08 | 2005-08-04 | Nuccitelli Richard Ph D | Application of the kelvin probe techinique to mammalian skin and other epithelial structures |
US7315691B1 (en) | 2004-01-15 | 2008-01-01 | Wax Figures, Inc. | Wax dispenser for hot wax applications |
WO2005105157A2 (en) | 2004-04-23 | 2005-11-10 | The Trustees Of Columbia University In The City Ofnew York | INHIBITION OF HAIRLESS PROTEIN mRNA |
US8168600B2 (en) | 2004-04-23 | 2012-05-01 | Isis Pharmaceuticals, Inc. | Compositions and methods for topical delivery of oligonucleotides |
WO2006012752A1 (en) * | 2004-08-06 | 2006-02-09 | John Kennedy | Therapy device and related accessories, compositions, and treatment methods |
US20060047281A1 (en) | 2004-09-01 | 2006-03-02 | Syneron Medical Ltd. | Method and system for invasive skin treatment |
US20060130266A1 (en) * | 2004-12-16 | 2006-06-22 | Brown Marc B | Dermal drug delivery system |
US8694088B2 (en) * | 2005-01-07 | 2014-04-08 | Bioelectromed Corp. | Hand-held electric field imager for measuring the electric field in mammalian skin and other epithelial structures |
US8597187B2 (en) * | 2005-01-07 | 2013-12-03 | Bioelectromed Corp. | Hand-held electric field imager for measuring the surface topography of mammalian skin and other epithelial structures |
US20110015549A1 (en) * | 2005-01-13 | 2011-01-20 | Shimon Eckhouse | Method and apparatus for treating a diseased nail |
EP1863511A2 (en) * | 2005-02-23 | 2007-12-12 | UAB Research Foundation | Alkyl-glycoside enhanced vaccination |
CA2535276A1 (en) * | 2006-02-06 | 2007-08-06 | John Kennedy | Therapy device and system and method for reducing harmful exposure to electromagnetic radiation |
US20100028968A1 (en) * | 2006-05-17 | 2010-02-04 | Clinton Rubin | Biomechanical treatment for obesity and diabetes |
US20080135643A1 (en) * | 2006-12-08 | 2008-06-12 | Kimberly-Clark Worldwide, Inc. | Pulsating spray dispensers |
DE102007007614A1 (en) * | 2007-02-13 | 2008-08-14 | Beiersdorf Ag | Process for the maintenance and protection of physiological skin balance and / or activation of skin regeneration |
DE102007007612A1 (en) * | 2007-02-13 | 2008-08-14 | Beiersdorf Ag | Method for depigmenting the skin |
US20080287931A1 (en) * | 2007-05-18 | 2008-11-20 | Jones Dennis R | Use of iontophoresis and ultrasound to deliver melanin or other chromophores for laser hair removal |
KR101626167B1 (en) | 2008-01-17 | 2016-05-31 | 시네론 메디컬 리미티드 | A hair removal apparatus for personal use and the method of using same |
JP2011509791A (en) | 2008-01-24 | 2011-03-31 | シネロン メディカル リミテッド | Apparatus, device and method for adipose tissue treatment |
EP2260096A4 (en) * | 2008-02-29 | 2013-07-17 | Univ New York State Res Found | Methods of applying physical stimuli to cells |
US20090299266A1 (en) * | 2008-06-02 | 2009-12-03 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US10441764B2 (en) * | 2008-06-09 | 2019-10-15 | Robert E. Akridge | Sonic applicator for skin formulations |
US9314293B2 (en) | 2008-07-16 | 2016-04-19 | Syneron Medical Ltd | RF electrode for aesthetic and body shaping devices and method of using same |
US20100017750A1 (en) | 2008-07-16 | 2010-01-21 | Avner Rosenberg | User interface |
KR101523807B1 (en) | 2008-09-21 | 2015-05-28 | 시네론 메디컬 리미티드 | A method and apparatus for personal skin treatment |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
US9278230B2 (en) | 2009-02-25 | 2016-03-08 | Syneron Medical Ltd | Electrical skin rejuvenation |
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BRPI1011316B8 (en) * | 2009-05-26 | 2021-06-22 | Massachusetts Gen Hospital | apparatus for administering a substance to skin tissue |
EP2506773B1 (en) | 2009-12-06 | 2018-08-15 | Syneron Medical Ltd. | Apparatus for personal skin treatment |
US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
DK3222266T3 (en) | 2010-08-27 | 2018-06-06 | Sienna Biopharmaceuticals Inc | COMPOSITIONS AND METHODS OF TARGETED THERMO REGULATION |
WO2012051495A2 (en) | 2010-10-15 | 2012-04-19 | The Research Foundation Of State University Of New York | Compositions and methods for enhancing the biological response to chemical agents and physical stimuli |
FR2973687A1 (en) * | 2011-04-08 | 2012-10-12 | Oreal | PROCESS FOR TREATING SCALP |
ES2629903T3 (en) | 2012-10-11 | 2017-08-16 | Nanocomposix, Inc. | Compositions and method of silver nanoplates |
US9032576B2 (en) | 2012-12-19 | 2015-05-19 | Newton Medical, Llc | Apparatus with elliptical movement for microdermabrasion and topical delivery of treatments |
US10194935B2 (en) * | 2013-12-31 | 2019-02-05 | L'oreal | Shear-induced dermal infusion |
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US1594636A (en) * | 1924-04-18 | 1926-08-03 | Fitzgerald Mfg Co | Liquid-reservoir applicator for massage vibrators |
US2369881A (en) * | 1942-02-17 | 1945-02-20 | Dan S Berns | Vibrating shampoo device |
FR73607E (en) * | 1957-08-13 | 1960-09-05 | Method and apparatus for making up and removing make-up | |
GB1077143A (en) * | 1964-09-30 | 1967-07-26 | Norman Alexander Macleod | Improvements in an applicator for use in the therapeutic treatment of skin |
US3727607A (en) * | 1971-07-01 | 1973-04-17 | O Dill | Vibratory massaging device |
DE2242079A1 (en) * | 1972-08-26 | 1974-03-07 | Bruns Dieter | DEVICE FOR THE SIMULTANEOUS APPLICATION OF MASSAGE MOVEMENTS AND THERAPEUTICALLY EFFECTIVE IRRITATION CURRENTS |
JPS594666Y2 (en) * | 1977-08-19 | 1984-02-10 | 日東工器株式会社 | Pine surgery |
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JPH0538753Y2 (en) * | 1984-10-20 | 1993-09-30 | ||
SU1602522A1 (en) * | 1988-01-27 | 1990-10-30 | Томский Медицинский Институт | Method of treating psoriatic arthropathy patients |
US5165131A (en) * | 1989-12-29 | 1992-11-24 | Staar Development Co., S.A. | Teeth cleaning apparatus |
US5076305A (en) * | 1990-08-13 | 1991-12-31 | Kevin T. Williams | Apparatus for cleaning by rapid vibration |
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US5425728A (en) * | 1991-10-29 | 1995-06-20 | Tankovich; Nicolai I. | Hair removal device and method |
JP2668631B2 (en) * | 1993-03-19 | 1997-10-27 | 英二 岡田 | Method for brushing an electric toothbrush having a predetermined frequency |
US5311632A (en) * | 1993-05-12 | 1994-05-17 | Center Leslie T | Ultrasonic plaque removal device |
US5400466A (en) * | 1993-08-10 | 1995-03-28 | Alderman; Robert J. | Vacuum cleaner with air vibration suction nozzle |
US5415629A (en) * | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
-
1996
- 1996-11-22 US US08/755,139 patent/US5830177A/en not_active Expired - Lifetime
-
1997
- 1997-11-10 JP JP52369898A patent/JP2001505099A/en active Pending
- 1997-11-10 CA CA002269919A patent/CA2269919C/en not_active Expired - Fee Related
- 1997-11-10 EP EP97948200A patent/EP0975267A4/en not_active Withdrawn
- 1997-11-10 AU AU54312/98A patent/AU731559B2/en not_active Ceased
- 1997-11-10 WO PCT/US1997/020345 patent/WO1998022031A1/en not_active Application Discontinuation
-
1998
- 1998-10-29 US US09/182,034 patent/US6080127A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2001505099A (en) | 2001-04-17 |
EP0975267A1 (en) | 2000-02-02 |
WO1998022031A1 (en) | 1998-05-28 |
US5830177A (en) | 1998-11-03 |
AU5431298A (en) | 1998-06-10 |
EP0975267A4 (en) | 2001-10-24 |
AU731559B2 (en) | 2001-04-05 |
CA2269919C (en) | 2008-06-03 |
US6080127A (en) | 2000-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151110 |