CA2276170A1 - Sustained analgesia achieved with buprenorphine - Google Patents

Sustained analgesia achieved with buprenorphine Download PDF

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Publication number
CA2276170A1
CA2276170A1 CA002276170A CA2276170A CA2276170A1 CA 2276170 A1 CA2276170 A1 CA 2276170A1 CA 002276170 A CA002276170 A CA 002276170A CA 2276170 A CA2276170 A CA 2276170A CA 2276170 A1 CA2276170 A1 CA 2276170A1
Authority
CA
Canada
Prior art keywords
buprenorphine
dosing interval
day
additional
manner indicative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002276170A
Other languages
French (fr)
Other versions
CA2276170C (en
Inventor
Robert F. Reder
Paul D. Goldenheim
Robert F. Kaiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro-Celtique, S.A.
Robert F. Reder
Paul D. Goldenheim
Robert F. Kaiko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26715643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2276170(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique, S.A., Robert F. Reder, Paul D. Goldenheim, Robert F. Kaiko filed Critical Euro-Celtique, S.A.
Publication of CA2276170A1 publication Critical patent/CA2276170A1/en
Application granted granted Critical
Publication of CA2276170C publication Critical patent/CA2276170C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The use of buprenorphine in the preparation of a medicament for a method of effectively treating pain in humans is achieved by administering buprenorphine in a manner indicative of first order pharmacokinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in a manner indicative of zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
CA002276170A 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine Expired - Lifetime CA2276170C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3891997P 1997-02-24 1997-02-24
US60/038,919 1997-02-24
US08/939,068 US5968547A (en) 1997-02-24 1997-09-29 Method of providing sustained analgesia with buprenorphine
US08/939,068 1997-09-29
PCT/US1998/003584 WO1998036728A2 (en) 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine

Publications (2)

Publication Number Publication Date
CA2276170A1 true CA2276170A1 (en) 1998-08-27
CA2276170C CA2276170C (en) 2007-12-04

Family

ID=26715643

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002276170A Expired - Lifetime CA2276170C (en) 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine

Country Status (22)

Country Link
US (15) US5968547A (en)
EP (9) EP2301493A1 (en)
JP (1) JP2000511936A (en)
KR (1) KR100703101B1 (en)
CN (2) CN1252705A (en)
AT (3) ATE538765T1 (en)
AU (2) AU2004218685B2 (en)
BR (1) BR9815439A (en)
CA (1) CA2276170C (en)
CZ (2) CZ299414B6 (en)
DE (2) DE05011213T1 (en)
DK (4) DK0964677T3 (en)
ES (4) ES2423925T3 (en)
HK (3) HK1096847A1 (en)
HU (3) HU230374B1 (en)
IL (4) IL131561A0 (en)
NO (11) NO322515B1 (en)
NZ (1) NZ337386A (en)
PL (1) PL196086B1 (en)
PT (4) PT2305194E (en)
SI (3) SI1570823T1 (en)
WO (1) WO1998036728A2 (en)

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AU774779B2 (en) 2004-07-08
ATE556682T1 (en) 2012-05-15
NO2016013I1 (en) 2016-07-18
ATE336212T1 (en) 2006-09-15
CZ299414B6 (en) 2008-07-16
NO333139B1 (en) 2013-03-11
EP1731152B1 (en) 2013-05-01
IL131561A (en) 2010-05-31
EP1570823A2 (en) 2005-09-07
BR9815439A (en) 2001-10-16
NO20151450A1 (en) 1999-10-22
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US9642850B2 (en) 2017-05-09
PL196086B1 (en) 2007-12-31
HK1096847A1 (en) 2007-06-15
ES2271988T3 (en) 2007-04-16
DE69835584D1 (en) 2006-09-28
PT2305194E (en) 2012-08-14
EP2305191A1 (en) 2011-04-06
US6344212B2 (en) 2002-02-05
NO329734B1 (en) 2010-12-13
AU2008261134A1 (en) 2009-01-15
US20130197020A1 (en) 2013-08-01
EP1570823B1 (en) 2011-12-28
CA2276170C (en) 2007-12-04
WO1998036728A2 (en) 1998-08-27
CN1827107A (en) 2006-09-06
NZ337386A (en) 2001-06-29
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HU230374B1 (en) 2016-03-29
NO340067B1 (en) 2017-03-06
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PL335306A1 (en) 2000-04-10
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US20010002259A1 (en) 2001-05-31
SI2305194T1 (en) 2012-10-30
NO20131533L (en) 1999-10-22
DK1570823T3 (en) 2012-02-20
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AU6184198A (en) 1998-09-09
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USRE41571E1 (en) 2010-08-24
IL131561A0 (en) 2001-01-28
KR20000075648A (en) 2000-12-26
HK1103621A1 (en) 2007-12-28
US20030198675A1 (en) 2003-10-23
EP1570823A3 (en) 2006-01-18
USRE41489E1 (en) 2010-08-10
US6231886B1 (en) 2001-05-15
ES2380023T3 (en) 2012-05-07
NO994087D0 (en) 1999-08-24
AU2008261134B2 (en) 2012-08-02
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