CA2277110A1 - Collagen-polysaccharide matrix for bone and cartilage repair - Google Patents

Collagen-polysaccharide matrix for bone and cartilage repair Download PDF

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Publication number
CA2277110A1
CA2277110A1 CA002277110A CA2277110A CA2277110A1 CA 2277110 A1 CA2277110 A1 CA 2277110A1 CA 002277110 A CA002277110 A CA 002277110A CA 2277110 A CA2277110 A CA 2277110A CA 2277110 A1 CA2277110 A1 CA 2277110A1
Authority
CA
Canada
Prior art keywords
collagen
bone
cartilage repair
polysaccharide matrix
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002277110A
Other languages
French (fr)
Other versions
CA2277110C (en
Inventor
Linshu Liu
Robert C. Spiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Spine LLC
Original Assignee
Orquest, Inc.
Linshu Liu
Robert C. Spiro
Depuy Acromed, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orquest, Inc., Linshu Liu, Robert C. Spiro, Depuy Acromed, Inc. filed Critical Orquest, Inc.
Publication of CA2277110A1 publication Critical patent/CA2277110A1/en
Application granted granted Critical
Publication of CA2277110C publication Critical patent/CA2277110C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof

Abstract

A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
CA002277110A 1997-01-15 1998-01-15 Collagen-polysaccharide matrix for bone and cartilage repair Expired - Fee Related CA2277110C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/783,650 1997-01-15
US08/783,650 US5866165A (en) 1997-01-15 1997-01-15 Collagen-polysaccharide matrix for bone and cartilage repair
PCT/US1998/000838 WO1998031345A1 (en) 1997-01-15 1998-01-15 Collagen-polysaccharide matrix for bone and cartilage repair

Publications (2)

Publication Number Publication Date
CA2277110A1 true CA2277110A1 (en) 1998-07-23
CA2277110C CA2277110C (en) 2003-04-22

Family

ID=25129980

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002277110A Expired - Fee Related CA2277110C (en) 1997-01-15 1998-01-15 Collagen-polysaccharide matrix for bone and cartilage repair

Country Status (11)

Country Link
US (2) US5866165A (en)
EP (2) EP0994694B1 (en)
JP (1) JP3348861B2 (en)
AT (1) ATE252886T1 (en)
AU (1) AU727430B2 (en)
CA (1) CA2277110C (en)
DE (1) DE69819329T2 (en)
DK (1) DK0994694T3 (en)
ES (1) ES2209107T3 (en)
NZ (1) NZ336480A (en)
WO (1) WO1998031345A1 (en)

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