CA2278616A1 - Adenoviruses having altered hexon proteins - Google Patents

Adenoviruses having altered hexon proteins Download PDF

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Publication number
CA2278616A1
CA2278616A1 CA002278616A CA2278616A CA2278616A1 CA 2278616 A1 CA2278616 A1 CA 2278616A1 CA 002278616 A CA002278616 A CA 002278616A CA 2278616 A CA2278616 A CA 2278616A CA 2278616 A1 CA2278616 A1 CA 2278616A1
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Prior art keywords
adenovirus
serotype
hexon
subgenus
replaced
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CA002278616A
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French (fr)
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CA2278616C (en
Inventor
Soumitra Roy
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Genetic Therapy Inc
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Publication of CA2278616A1 publication Critical patent/CA2278616A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors

Abstract

An adenovirus wherein at least one portion of at least one loop region of the hexon is changed. In one embodiment, the adenovirus, prior to modification, is of a first serotype, and at least a portion of at least one loop region of the hexon is removed and replaced with at least a portion of at least one loop region of the hexon of an adenovirus of a second serotype. Such modified adenoviruses do not have epitopes which are recognized by neutralizing antibodies to the unmodified adenovirus of the first serotype.

Claims (10)

1. A modified adenovirus wherein said adenovirus, prior to modification, is of a first serotype, said first serotype being within a first subgenus, and, wherein, in the modified adenovirus at least a portion of at least one loop region of the hexon of said adenovirus is removed and replaced with at least a portion of at least one loop region of the hexon of an adenovirus of a second serotype, said second serotype being within a second subgenus.
2. The adenovirus of Claim 1 wherein at least a portion of at least one of the L1 and L2 loop regions of the hexon of said adenovirus of said first serotype is removed and replaced with at least a portion of at least one of the L1 and L2 loop regions of the hexon of said adenovirus of said second serotype.
3. The adenovirus of Claim 2 wherein at least a portion of each of the L1, L2, and L4 loop regions of the hexon of said adenovirus of said first serotype is removed and replaced with at least a portion of each of the L1, L2, and L4 loop regions of the hexon of said adenovirus of said second serotype.
4. The adenovirus of Claim 3 wherein the L1, L2, and L4 loop regions of the hexon of said adenovirus of said first serotype are removed and replaced with the L1, L2, and L4 loop regions of the hexon of said adenovirus of said second serotype.
5. The adenovirus of Claim 1 wherein said adenovirus of said first serotype is an adenovirus of a serotype within Subgenus C, and said adenovirus of said second serotype is an adenovirus of a serotype within a subgenus selected from the group consisting of Subgenera A, H, D, E, and F.
6. The adenovirus of Claim 5 wherein said adenovirus of said second serotype is an adenovirus of a serotype within a subgenus selected from the group consisting of Subgenus A and Subgenus F.
7. The adenovirus of Claim 5 wherein said adenovirus of said first serotype is selected from the group consisting of Adenovirus 2 and Adenovirus 5.
8. The adenovirus of Claim 1 wherein said adenovirus of said first serotype is Adenovirus 5, and said adenovirus of said second serotype is Adenovirus 12.
9. The adenovirus of Claim 1 wherein said adenovirus further includes at least one DNA sequence encoding a heterologous protein.
10. A method of providing a therapeutic effect in a host, comprising:
administering to a host the adenovirus of Claim 9 in an amount effective to provide a therapeutic effect in a host.
CA2278616A 1997-01-24 1998-01-22 Adenoviruses having altered hexon proteins Expired - Fee Related CA2278616C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/788,674 1997-01-24
US08/788,674 US5922315A (en) 1997-01-24 1997-01-24 Adenoviruses having altered hexon proteins
PCT/US1998/001113 WO1998032842A1 (en) 1997-01-24 1998-01-22 Adenoviruses having altered hexon proteins

Publications (2)

Publication Number Publication Date
CA2278616A1 true CA2278616A1 (en) 1998-07-30
CA2278616C CA2278616C (en) 2012-03-20

Family

ID=25145213

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2278616A Expired - Fee Related CA2278616C (en) 1997-01-24 1998-01-22 Adenoviruses having altered hexon proteins

Country Status (8)

Country Link
US (1) US5922315A (en)
EP (1) EP1007641A4 (en)
JP (1) JP2001510998A (en)
AU (1) AU735806B2 (en)
CA (1) CA2278616C (en)
IL (1) IL130899A0 (en)
NZ (1) NZ336829A (en)
WO (1) WO1998032842A1 (en)

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JP2001510998A (en) 2001-08-07
EP1007641A1 (en) 2000-06-14
NZ336829A (en) 2001-03-30
EP1007641A4 (en) 2001-07-18
AU735806B2 (en) 2001-07-19
WO1998032842A1 (en) 1998-07-30
CA2278616C (en) 2012-03-20
US5922315A (en) 1999-07-13
IL130899A0 (en) 2001-01-28
AU6033998A (en) 1998-08-18

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