CA2281420A1 - Preparation of pharmaceutically-active granules - Google Patents
Preparation of pharmaceutically-active granules Download PDFInfo
- Publication number
- CA2281420A1 CA2281420A1 CA002281420A CA2281420A CA2281420A1 CA 2281420 A1 CA2281420 A1 CA 2281420A1 CA 002281420 A CA002281420 A CA 002281420A CA 2281420 A CA2281420 A CA 2281420A CA 2281420 A1 CA2281420 A1 CA 2281420A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically
- preparation
- coating
- active granules
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Abstract
The present invention provides a core of predominately microcrystalline cellulose, on which an active drug is layered onto the core via solution coating. The coated particles have a narrower particle size distribution than coated granules provided by other processes. An optional final coating of a pharmaceutically acceptable polymeric coating is provided to provide tastemaking or controlled release, and protection of the drug-layered particles.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/148,251 | 1998-09-04 | ||
US09/148,251 US5997905A (en) | 1998-09-04 | 1998-09-04 | Preparation of pharmaceutically active particles |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2281420A1 true CA2281420A1 (en) | 2000-03-04 |
CA2281420C CA2281420C (en) | 2008-11-18 |
Family
ID=22524956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002281420A Expired - Fee Related CA2281420C (en) | 1998-09-04 | 1999-09-03 | Preparation of pharmaceutically-active granules |
Country Status (9)
Country | Link |
---|---|
US (2) | US5997905A (en) |
EP (1) | EP1000615B1 (en) |
JP (1) | JP2000109426A (en) |
CN (1) | CN1151844C (en) |
AU (1) | AU773833B2 (en) |
BR (1) | BR9904039A (en) |
CA (1) | CA2281420C (en) |
DE (1) | DE69921941T2 (en) |
ES (1) | ES2233003T3 (en) |
Families Citing this family (81)
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US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
WO2000019982A1 (en) | 1998-10-01 | 2000-04-13 | Powderject Research Limited | Spray coated microparticles for use in needleless syringes |
US20050214227A1 (en) * | 1999-03-08 | 2005-09-29 | Powderject Research Limited | Microparticle formulations for sustained-release of bioactive compounds |
ES2162746B1 (en) * | 1999-10-21 | 2003-02-16 | Lipotec Sa | MICROCAPSULES FOR THE STABILIZATION OF COSMETIC, PHARMACEUTICAL OR FOOD PRODUCTS. |
WO2001034684A1 (en) * | 1999-11-12 | 2001-05-17 | R.P. Scherer Technologies, Inc. | Microcrystalline cellulose cushioning granules |
DK1267880T4 (en) * | 2000-02-29 | 2010-05-17 | Bristol Myers Squibb Co | Entecavir low dose formulation and its use |
US6392034B1 (en) | 2000-05-17 | 2002-05-21 | Jh Biotech, Inc. | Microcrystalline cellulose |
US20020051821A1 (en) * | 2000-09-08 | 2002-05-02 | Sung-Yun Kwon | Aliginate particle formulation |
CA2437762C (en) * | 2001-02-23 | 2010-08-10 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
US20030096791A1 (en) * | 2001-05-31 | 2003-05-22 | Cima Labs Inc. | Taste masking of highly water-soluble drugs |
WO2003020241A2 (en) * | 2001-09-05 | 2003-03-13 | Vectura Limited | Functional powders for oral delivery |
US6982094B2 (en) * | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
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EA200801812A1 (en) * | 2003-09-17 | 2009-06-30 | Янссен Фармацевтика Н.В. | CONJUGATED HETEROCYCLIC COMPOUNDS |
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US5780055A (en) * | 1996-09-06 | 1998-07-14 | University Of Maryland, Baltimore | Cushioning beads and tablet comprising the same capable of forming a suspension |
US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
-
1998
- 1998-09-04 US US09/148,251 patent/US5997905A/en not_active Expired - Lifetime
-
1999
- 1999-09-02 BR BR9904039-5A patent/BR9904039A/en not_active Application Discontinuation
- 1999-09-02 AU AU47350/99A patent/AU773833B2/en not_active Ceased
- 1999-09-03 CA CA002281420A patent/CA2281420C/en not_active Expired - Fee Related
- 1999-09-03 CN CNB991186117A patent/CN1151844C/en not_active Expired - Fee Related
- 1999-09-03 ES ES99307051T patent/ES2233003T3/en not_active Expired - Lifetime
- 1999-09-03 DE DE69921941T patent/DE69921941T2/en not_active Expired - Lifetime
- 1999-09-03 JP JP11250489A patent/JP2000109426A/en active Pending
- 1999-09-03 EP EP99307051A patent/EP1000615B1/en not_active Expired - Lifetime
- 1999-11-02 US US09/431,899 patent/US6149943A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1000615A2 (en) | 2000-05-17 |
CA2281420C (en) | 2008-11-18 |
AU4735099A (en) | 2000-03-16 |
EP1000615A3 (en) | 2000-05-31 |
US5997905A (en) | 1999-12-07 |
DE69921941D1 (en) | 2004-12-23 |
US6149943A (en) | 2000-11-21 |
ES2233003T3 (en) | 2005-06-01 |
AU773833B2 (en) | 2004-06-10 |
DE69921941T2 (en) | 2005-12-01 |
EP1000615B1 (en) | 2004-11-17 |
BR9904039A (en) | 2001-01-16 |
JP2000109426A (en) | 2000-04-18 |
CN1249950A (en) | 2000-04-12 |
CN1151844C (en) | 2004-06-02 |
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