CA2281846A1 - Matrices for separation and separation exploiting said matrices - Google Patents
Matrices for separation and separation exploiting said matrices Download PDFInfo
- Publication number
- CA2281846A1 CA2281846A1 CA002281846A CA2281846A CA2281846A1 CA 2281846 A1 CA2281846 A1 CA 2281846A1 CA 002281846 A CA002281846 A CA 002281846A CA 2281846 A CA2281846 A CA 2281846A CA 2281846 A1 CA2281846 A1 CA 2281846A1
- Authority
- CA
- Canada
- Prior art keywords
- separation
- matrices
- matrix
- exploiting
- micropores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/524—Physical parameters structural properties
- G01N2030/528—Monolithic sorbent material
Abstract
A matrix comprising a core showing a system of micropores and a surface in which the micropore system has openings. The characterising feature is that the surface is coated with a polymer (I) having such a large molecular weight that it cannot penetrate into the micropores. The matrix can be particulate or in the shape of a monolith. Use of the matrix to separate components in a liquid medium, preferably aqueous, via partition to the matrix. The separation may be based on affinity or on the size and shape of the components.
Batchwise as well as chromatographic procedures are comprised.
Batchwise as well as chromatographic procedures are comprised.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9700769-4 | 1997-03-04 | ||
SE9700769A SE9700769D0 (en) | 1997-03-04 | 1997-03-04 | Matrices for separation and separation that utilize the matrices |
PCT/SE1998/000387 WO1998039094A1 (en) | 1997-03-04 | 1998-03-04 | Matrices for separation and separation exploiting said matrices |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2281846A1 true CA2281846A1 (en) | 1998-09-11 |
CA2281846C CA2281846C (en) | 2007-07-03 |
Family
ID=20406014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002281846A Expired - Lifetime CA2281846C (en) | 1997-03-04 | 1998-03-04 | Matrices for separation and separation exploiting said matrices |
Country Status (10)
Country | Link |
---|---|
US (1) | US6572766B1 (en) |
EP (1) | EP0980288B1 (en) |
JP (1) | JP4135812B2 (en) |
AT (1) | ATE308380T1 (en) |
AU (1) | AU729313B2 (en) |
CA (1) | CA2281846C (en) |
DE (1) | DE69832166T2 (en) |
ES (1) | ES2251766T3 (en) |
SE (1) | SE9700769D0 (en) |
WO (1) | WO1998039094A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9601368D0 (en) * | 1996-04-11 | 1996-04-11 | Pharmacia Biotech Ab | Process for the production of a porous cross-linked polysaccharide gel |
SE9904272D0 (en) * | 1999-11-25 | 1999-11-25 | Amersham Pharm Biotech Ab | A method for selective removal of a substance from samples containing compounds having nucleic acid structure |
WO2003049833A1 (en) * | 2001-11-27 | 2003-06-19 | Ciphergen Biosystems, Inc. | Composite chromatographic sorbent of mineral oxide beads with hydroxyapatite-filled pores |
US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
US7347976B2 (en) | 2001-12-20 | 2008-03-25 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix |
US20050061745A1 (en) * | 2002-06-26 | 2005-03-24 | Teledyne Isco, Inc. | Separation system, components of a separation system and methods of making and using them |
US7473367B2 (en) * | 2002-06-26 | 2009-01-06 | Dionex Corporation | Monolithic column |
US6749749B2 (en) * | 2002-06-26 | 2004-06-15 | Isco, Inc. | Separation system, components of a separation system and methods of making and using them |
WO2004011142A1 (en) * | 2002-07-26 | 2004-02-05 | Applera Corporation | Device and method for purification of nucleic acids |
US20040016702A1 (en) * | 2002-07-26 | 2004-01-29 | Applera Corporation | Device and method for purification of nucleic acids |
SE0202551D0 (en) * | 2002-08-27 | 2002-08-27 | Amersham Biosciences Ab | Chromatographic two-layer particles |
US7981600B2 (en) * | 2003-04-17 | 2011-07-19 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene |
US8137548B2 (en) * | 2003-10-17 | 2012-03-20 | Zirchrom Separations, Inc. | Chelator-modified inorganic oxide particles |
US7939249B2 (en) | 2003-12-24 | 2011-05-10 | 3M Innovative Properties Company | Methods for nucleic acid isolation and kits using a microfluidic device and concentration step |
US20050181378A1 (en) * | 2004-02-18 | 2005-08-18 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
US20060160122A1 (en) * | 2004-02-18 | 2006-07-20 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
WO2005079984A1 (en) * | 2004-02-18 | 2005-09-01 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
US20050196856A1 (en) * | 2004-02-18 | 2005-09-08 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
SE0400490D0 (en) | 2004-02-26 | 2004-02-26 | Amersham Biosciences Ab | Plasmid purification |
SE0502485L (en) * | 2005-11-09 | 2007-05-10 | Peter Viberg | particles |
WO2007063701A1 (en) * | 2005-12-02 | 2007-06-07 | Sekisui Chemical Co., Ltd. | Hydrophilic polymer microparticle, filler for ion exchange liquid chromatography, and method for production of filler for ion exchange liquid chromatography |
US10562007B2 (en) * | 2007-07-25 | 2020-02-18 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
EP2268393A4 (en) | 2008-04-22 | 2013-08-14 | Ge Healthcare Bio Sciences Ab | Chromatography medium |
EP2315839A4 (en) * | 2008-08-25 | 2012-03-21 | Ge Healthcare Bio Sciences | Simple load and elute process for purification of genomic dna |
US20120156779A1 (en) * | 2009-08-27 | 2012-06-21 | Ge Healthcare Bio-Sciences Ab | Method for cell expansion |
WO2011035282A1 (en) * | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
JP2013520647A (en) | 2010-02-19 | 2013-06-06 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Method for producing chromatographic media |
US9259729B2 (en) * | 2010-04-26 | 2016-02-16 | Ge Healthcare Bio-Sciences Ab | Method for production of chromatography media |
JP5631271B2 (en) * | 2010-07-28 | 2014-11-26 | ローム アンド ハース カンパニーRohm And Haas Company | Method for making and using improved chromatographic media |
JP5474881B2 (en) * | 2010-07-28 | 2014-04-16 | ローム アンド ハース カンパニー | Method for making and using improved chromatographic media |
EP2931400B1 (en) * | 2012-12-14 | 2021-07-07 | Cytiva BioProcess R&D AB | Method for cleaning of packed bed chromatography columns |
EP2999709A4 (en) | 2013-05-20 | 2016-12-07 | Shantha Biotechnics Private Ltd | Purification of polysaccharide protein conjugates |
US9731249B2 (en) * | 2014-04-15 | 2017-08-15 | Ut-Battelle, Llc | Polymeric molecular sieve membranes for gas separation |
US10875008B2 (en) * | 2015-01-19 | 2020-12-29 | Showa Denko Materials Co., Ltd. | Separation material |
JP6746919B2 (en) * | 2016-01-15 | 2020-08-26 | 日立化成株式会社 | Separation material and column |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959251A (en) | 1970-06-25 | 1976-05-25 | Exploaterings Aktiebolaget T.B.F. | Stabilized agar product and method for its stabilization |
LU73094A1 (en) * | 1975-07-29 | 1977-03-24 | ||
JPS56115727A (en) * | 1980-02-19 | 1981-09-11 | Kuraray Co Ltd | Carrier for immobilizing physiologically active substance |
ATE15378T1 (en) * | 1980-06-27 | 1985-09-15 | Akzo Nv | POROUS, INORGANIC SUPPORT MATERIAL COVERED WITH A FIXED ORGANIC PHASE, APPLICATION FOR CHROMATOGRAPHY AND ITS PRODUCTION PROCESS. |
SE8205908D0 (en) * | 1982-10-18 | 1982-10-18 | Pharmacia Diagnostics Ab | SET TO IMAGE POLYMER LAYER |
SE8302758L (en) | 1983-05-17 | 1984-11-18 | Pharmacia Ab | SET FOR DISTRIBUTION OF DISULPHIDE BINDINGS AND THEREFORE |
SE470261B (en) | 1984-05-17 | 1993-12-20 | Jerker Porath | Adsorbent for the separation and immobilization of proteins, methods of preparing an adsorbent, and its use for biopolymer fractionation |
SE470099B (en) | 1984-05-17 | 1993-11-08 | Jerker Porath | Sulfone activated thioether adsorbents for separation of eg protein |
US4544485A (en) | 1984-08-31 | 1985-10-01 | Purdue Research Foundation | Chromatographic method and means |
US4794002A (en) * | 1985-11-01 | 1988-12-27 | Monsanto Company | Modified polymeric surfaces and process for preparing same |
US4746572A (en) * | 1986-11-28 | 1988-05-24 | E. I. Dupont De Nemours And Company | Structures surface modified with bidentate silanes |
US4871711A (en) * | 1986-12-29 | 1989-10-03 | Aluminum Company Of America | Active material produced from metal oxide/hydroxide particles and phosphate esters |
ATE179901T1 (en) | 1989-07-06 | 1999-05-15 | Perseptive Biosystems Inc | CHROMATOGRAPHY METHOD |
US5030352A (en) * | 1990-01-25 | 1991-07-09 | Purdue Research Foundation | Coated media for chromatography |
DK164303C (en) | 1990-05-14 | 1992-10-19 | Vik Consult | INSULATION FOR A PIPE OR CHANNEL WITH A RELATIVE LOW SURFACE TEMPERATURE AND PROCEDURE FOR PREPARING THE INSULATION |
DK165090D0 (en) | 1990-07-09 | 1990-07-09 | Kem En Tec As | CONLOMERATED PARTICLES |
US5128291A (en) * | 1990-12-11 | 1992-07-07 | Wax Michael J | Porous titania or zirconia spheres |
SE9101149D0 (en) | 1991-04-17 | 1991-04-17 | Pharmacia Lkb Biotech | BEADS FOR DOWN STREAM PROCESSING |
US5306561A (en) | 1992-02-20 | 1994-04-26 | Cornell Research Foundation, Inc. | Preparation of surface-functional polymer particles |
SE9200827D0 (en) | 1992-03-18 | 1992-03-18 | Pharmacia Lkb Biotech | SUPET POROUS POLYSACCHARIDE GELS |
US5906734A (en) * | 1992-06-19 | 1999-05-25 | Biosepra Inc. | Passivated porous polymer supports and methods for the preparation and use of same |
US5316680A (en) | 1992-10-21 | 1994-05-31 | Cornell Research Foundation, Inc. | Multimodal chromatographic separation media and process for using same |
ATE161866T1 (en) * | 1992-10-21 | 1998-01-15 | Cornell Res Foundation Inc | SELECTIVE PORE SIZE CHEMICAL MODIFICATION OF POROUS MATERIALS |
US5653875A (en) * | 1994-02-04 | 1997-08-05 | Supelco, Inc. | Nucleophilic bodies bonded to siloxane and use thereof for separations from sample matrices |
SE9401960L (en) | 1994-06-07 | 1995-12-08 | Sven Oscarsson | Alkali resistant protein adsorbent |
US5522994A (en) | 1995-02-01 | 1996-06-04 | Cornell Research Foundation, Inc. | Single column chromatographic determination of small molecules in mixtures with large molecules |
SE9600590D0 (en) | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Methods for chromatographic separation of peptides and nucleic acid and new high-affinity ion exchange matrix |
SE9700768D0 (en) | 1997-03-04 | 1997-03-04 | Pharmacia Biotech Ab | Procedure for introducing functionality |
-
1997
- 1997-03-04 SE SE9700769A patent/SE9700769D0/en unknown
-
1998
- 1998-03-04 EP EP98908407A patent/EP0980288B1/en not_active Revoked
- 1998-03-04 AU AU66442/98A patent/AU729313B2/en not_active Expired
- 1998-03-04 DE DE69832166T patent/DE69832166T2/en not_active Revoked
- 1998-03-04 ES ES98908407T patent/ES2251766T3/en not_active Expired - Lifetime
- 1998-03-04 US US09/380,050 patent/US6572766B1/en not_active Expired - Lifetime
- 1998-03-04 JP JP53844798A patent/JP4135812B2/en not_active Expired - Lifetime
- 1998-03-04 CA CA002281846A patent/CA2281846C/en not_active Expired - Lifetime
- 1998-03-04 WO PCT/SE1998/000387 patent/WO1998039094A1/en active IP Right Grant
- 1998-03-04 AT AT98908407T patent/ATE308380T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2001514745A (en) | 2001-09-11 |
ATE308380T1 (en) | 2005-11-15 |
US6572766B1 (en) | 2003-06-03 |
EP0980288A1 (en) | 2000-02-23 |
DE69832166T2 (en) | 2006-08-03 |
EP0980288B1 (en) | 2005-11-02 |
WO1998039094A1 (en) | 1998-09-11 |
DE69832166D1 (en) | 2005-12-08 |
SE9700769D0 (en) | 1997-03-04 |
AU6644298A (en) | 1998-09-22 |
AU729313B2 (en) | 2001-02-01 |
JP4135812B2 (en) | 2008-08-20 |
CA2281846C (en) | 2007-07-03 |
ES2251766T3 (en) | 2006-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20180305 |