CA2284801A1 - Diagnostic devices and apparatus for the controlled movement of reagents without membranes - Google Patents

Diagnostic devices and apparatus for the controlled movement of reagents without membranes Download PDF

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Publication number
CA2284801A1
CA2284801A1 CA002284801A CA2284801A CA2284801A1 CA 2284801 A1 CA2284801 A1 CA 2284801A1 CA 002284801 A CA002284801 A CA 002284801A CA 2284801 A CA2284801 A CA 2284801A CA 2284801 A1 CA2284801 A1 CA 2284801A1
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Prior art keywords
elements
membranes
assay
devices
reagents
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CA002284801A
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French (fr)
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CA2284801C (en
Inventor
Kenneth Francis Buechler
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Alere San Diego Inc
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Individual
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Priority to CA002565926A priority Critical patent/CA2565926C/en
Publication of CA2284801A1 publication Critical patent/CA2284801A1/en
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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Abstract

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away from the zone.
The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.
CA 2284801 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes Expired - Lifetime CA2284801C (en)

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CA002565926A CA2565926C (en) 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes

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US08/828,041 US6156270A (en) 1992-05-21 1997-03-27 Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US08/828,041 1997-03-27
PCT/US1998/005681 WO1998043739A2 (en) 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes

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EP (1) EP1019193B1 (en)
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AT (1) ATE242054T1 (en)
AU (1) AU6579098A (en)
CA (1) CA2284801C (en)
DE (1) DE69815365T2 (en)
WO (1) WO1998043739A2 (en)

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