CA2285904C - Exchangeable oscillating pipette needle - Google Patents
Exchangeable oscillating pipette needle Download PDFInfo
- Publication number
- CA2285904C CA2285904C CA002285904A CA2285904A CA2285904C CA 2285904 C CA2285904 C CA 2285904C CA 002285904 A CA002285904 A CA 002285904A CA 2285904 A CA2285904 A CA 2285904A CA 2285904 C CA2285904 C CA 2285904C
- Authority
- CA
- Canada
- Prior art keywords
- oscillating
- pipette needle
- oscillating arm
- pipette
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/103—General features of the devices using disposable tips
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
An exchangeable oscillating pipette needle for an automatic analyzer for examining biological body fluids is described, in which the analyzer has a holder which is provided with a tension spring and with which the oscillating arm, carrying the pipette needle and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.
Description
Dade Behring Marburg GmbH 1998/B003-1179 Dr. Pfe/Mi Exchangeable oscillating pipette needle The invention relates to an exchangeable oscillating pipette needle for an automatic analyzer for examining biological body fluids.
It is known that in automatic analyzers which are used for examining biological body fluids, the required reagents are introduced into a measurement cell by means of an oscillating pipette needle. The pipette needle also has the role of ensuring that the body fluid to be examined is thoroughly mixed with the reagents. For this purpose, it is necessary for the pipette needle to be moved in oscillations. When introducing the reagents, and during the subsequent oscillations, there is a risk of the sensitive pipette needle colliding with the measurement cell or other apparatus parts, being damaged as a result, and having to be replaced because it is no longer fit for use. To date, exchanging the pipette needle has been associated with considerable technical effort, which can only be provided by a suitably trained service engineer. Not only do the pipette needle and other mechanical parts need to be exchanged, but also the motor and the means of heating the pipette needle. The associated lost time and the costs involved led to the need to develop a new construction for an oscillating pipette needle which allows the personnel operating the analyzer to exchange a damaged pipette needle quickly and in a straightforward way without having to call on the services of a specially trained engineer.
It has now been found that this object is solved by an oscillating pipette needle for an automatic analyzer for examining biological body fluids, in which, for the purpose of introducing the pipette needle into the analyzer and withdrawing it from the latter, a holder 1 is provided which is equipped with a tension spring 3 and with which the oscillating arm, carrying the pipette needle 4 and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.
The construction of the exchangeable oscillating pipette needle according to the invention is illustrated by appended Figures 1 through 4.
Fig. 1 shows the mutual engagement of holder 1 and oscillating arm 2 in a view from the right-hand side.
Fig. 2 shows the mutual engagement of holder 1 and oscillating arm 2 in a view from the left-hand side.
Fig. 3 shows the holder 1 with the oscillating arm 2 from the front.
Fig. 4 shows a front view of the exchangeable oscillating pipette needle according to the invention, with eccentric motor attached.
Fig. 5 shows a side view of the exchangeable oscillating pipette needle from the side.
Fig. 6 shows a front view of the oscillating pipette needle, with a section of the prism.
Fig. 1 shows in detail that the oscillating arm 2 bearing on the holder 1 is in contact with a sensor 5.
If the pipette needle secured on the oscillating arm 2 strikes against a solid object, then the oscillating arm 2 lifts and the flow of electrical current is interrupted by the sensor 5 secured on the plate 10.
It is known that in automatic analyzers which are used for examining biological body fluids, the required reagents are introduced into a measurement cell by means of an oscillating pipette needle. The pipette needle also has the role of ensuring that the body fluid to be examined is thoroughly mixed with the reagents. For this purpose, it is necessary for the pipette needle to be moved in oscillations. When introducing the reagents, and during the subsequent oscillations, there is a risk of the sensitive pipette needle colliding with the measurement cell or other apparatus parts, being damaged as a result, and having to be replaced because it is no longer fit for use. To date, exchanging the pipette needle has been associated with considerable technical effort, which can only be provided by a suitably trained service engineer. Not only do the pipette needle and other mechanical parts need to be exchanged, but also the motor and the means of heating the pipette needle. The associated lost time and the costs involved led to the need to develop a new construction for an oscillating pipette needle which allows the personnel operating the analyzer to exchange a damaged pipette needle quickly and in a straightforward way without having to call on the services of a specially trained engineer.
It has now been found that this object is solved by an oscillating pipette needle for an automatic analyzer for examining biological body fluids, in which, for the purpose of introducing the pipette needle into the analyzer and withdrawing it from the latter, a holder 1 is provided which is equipped with a tension spring 3 and with which the oscillating arm, carrying the pipette needle 4 and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.
The construction of the exchangeable oscillating pipette needle according to the invention is illustrated by appended Figures 1 through 4.
Fig. 1 shows the mutual engagement of holder 1 and oscillating arm 2 in a view from the right-hand side.
Fig. 2 shows the mutual engagement of holder 1 and oscillating arm 2 in a view from the left-hand side.
Fig. 3 shows the holder 1 with the oscillating arm 2 from the front.
Fig. 4 shows a front view of the exchangeable oscillating pipette needle according to the invention, with eccentric motor attached.
Fig. 5 shows a side view of the exchangeable oscillating pipette needle from the side.
Fig. 6 shows a front view of the oscillating pipette needle, with a section of the prism.
Fig. 1 shows in detail that the oscillating arm 2 bearing on the holder 1 is in contact with a sensor 5.
If the pipette needle secured on the oscillating arm 2 strikes against a solid object, then the oscillating arm 2 lifts and the flow of electrical current is interrupted by the sensor 5 secured on the plate 10.
Fig. 2 shows the knife edge of the oscillating arm 2 in a prism bearing of the holder 1.
From Fig. 3 it will be seen that the oscillating arm 2 is mounted upstream of the holder 1 and a sensor 5 is arranged on a plate 10 and switches off the analyzer when the pipette needle strikes against a solid object.
Fig. 4 shows a front view of the exchangeable oscillating pipette needle illustrating the drive motor with the eccentrically rotating shaft 6 and a drive fork 7 in which the eccentric engages for the purpose of generating oscillations.
Fig. 5 shows a side view of the exchangeable oscillating pipette needle with the holder 1, the oscillating arm 2, the tension spring 3, the pipette needle 4, the grips 8 for exchanging the pipette needle, and the connection piece 9 which is provided for the admission of reagents.
These illustrations show that the exchangeable oscillating pipette needle consists of two subsidiary groups, namely the oscillating arm 2 with the pipette needle 4, and a rigidly secured holder 1. A tension spring 3, connected to the holder 1 in a non-releasable manner, can engage in an insert opening of the ribs 11 of the oscillating arm 2 and can thus press the latter against the holder 1. In this way, a restoring force acts on the oscillating arm 2 and ensures that it does not leave its defined position during oscillation.
To avoid damaging the pipette needle, it is of the utmost importance that it retains its predetermined positions during the entire examination and that collisions with solid parts of the analyzer or of the measurement cell can be avoided. According to the invention, this is ensured by a secure and reproducible positioning of the oscillating arm by means of prism and knife edge, the knife-edge bearing being secured on ribs 11 which ensure lateral fixing of the oscillating arm 2.
Although the main object of the present invention is to make it possible to replace a damaged oscillating pipette needle in a simple way, the need for such replacement should of course be reduced by the fact that damage to the pipette needle 4 is largely ruled out. This is made possible by the flexible mounting, afforded by the tension spring 3, of the oscillating arm 2, which permits a vertical movement of the oscillating arm 2. If the pipette needle 4 strikes against a solid object, then it slides out of the prism mounting of the holder 1, moves upward and in so doing interrupts the current flow by triggering the sensor 5.
The analyzer is in this way immediately switched off and destruction of the pipette needle is avoided.
However, if replacement of the pipette needle is required, then the oscillating arm 2 can be pushed upward from the knife-edge bearing, released from the tension spring 3 and removed in a single maneuver. To do this, the grip 8 need simply be held with two fingers and pushed upward.
When using the oscillating pipette needle according to the invention, it is advantageous for it to be able to be heated. The oscillations needed for thoroughly mixing the reagents with the body fluid to be examined are generated by the eccentric motor equipped with an eccentrically rotating shaft 6, or else by an eccentrically mounted roller.
Whereas the oscillating pipette needles used to date are incorporated rigidly and in a fixed manner in the analyzer, according to the invention this applies only to the mounting of the oscillating arm. Thus, according to the invention, it is no longer necessary to unscrew the entire pipette system and change it completely. It is now enough to replace only the oscillating arm carrying the pipette needle. This is such a simple procedure that the personnel operating the analyzer can perform this repair by means of a single maneuver in which the damaged oscillating pipette needle is exchanged for a corresponding replacement part. Thus, according to the invention, a solution is provided which permits rapid and inexpensive repair of a damaged oscillating pipette needle.
List of reference symbols:
1 Holder 2 Oscillating arm 3 Tension spring 4 Heatable pipette needle 5 Sensor 6 Drive motor with eccentric 7 Drive fork for eccentric 8 Grip for exchanging 9 Admission for reagents 10 Plate 11 Ribs
From Fig. 3 it will be seen that the oscillating arm 2 is mounted upstream of the holder 1 and a sensor 5 is arranged on a plate 10 and switches off the analyzer when the pipette needle strikes against a solid object.
Fig. 4 shows a front view of the exchangeable oscillating pipette needle illustrating the drive motor with the eccentrically rotating shaft 6 and a drive fork 7 in which the eccentric engages for the purpose of generating oscillations.
Fig. 5 shows a side view of the exchangeable oscillating pipette needle with the holder 1, the oscillating arm 2, the tension spring 3, the pipette needle 4, the grips 8 for exchanging the pipette needle, and the connection piece 9 which is provided for the admission of reagents.
These illustrations show that the exchangeable oscillating pipette needle consists of two subsidiary groups, namely the oscillating arm 2 with the pipette needle 4, and a rigidly secured holder 1. A tension spring 3, connected to the holder 1 in a non-releasable manner, can engage in an insert opening of the ribs 11 of the oscillating arm 2 and can thus press the latter against the holder 1. In this way, a restoring force acts on the oscillating arm 2 and ensures that it does not leave its defined position during oscillation.
To avoid damaging the pipette needle, it is of the utmost importance that it retains its predetermined positions during the entire examination and that collisions with solid parts of the analyzer or of the measurement cell can be avoided. According to the invention, this is ensured by a secure and reproducible positioning of the oscillating arm by means of prism and knife edge, the knife-edge bearing being secured on ribs 11 which ensure lateral fixing of the oscillating arm 2.
Although the main object of the present invention is to make it possible to replace a damaged oscillating pipette needle in a simple way, the need for such replacement should of course be reduced by the fact that damage to the pipette needle 4 is largely ruled out. This is made possible by the flexible mounting, afforded by the tension spring 3, of the oscillating arm 2, which permits a vertical movement of the oscillating arm 2. If the pipette needle 4 strikes against a solid object, then it slides out of the prism mounting of the holder 1, moves upward and in so doing interrupts the current flow by triggering the sensor 5.
The analyzer is in this way immediately switched off and destruction of the pipette needle is avoided.
However, if replacement of the pipette needle is required, then the oscillating arm 2 can be pushed upward from the knife-edge bearing, released from the tension spring 3 and removed in a single maneuver. To do this, the grip 8 need simply be held with two fingers and pushed upward.
When using the oscillating pipette needle according to the invention, it is advantageous for it to be able to be heated. The oscillations needed for thoroughly mixing the reagents with the body fluid to be examined are generated by the eccentric motor equipped with an eccentrically rotating shaft 6, or else by an eccentrically mounted roller.
Whereas the oscillating pipette needles used to date are incorporated rigidly and in a fixed manner in the analyzer, according to the invention this applies only to the mounting of the oscillating arm. Thus, according to the invention, it is no longer necessary to unscrew the entire pipette system and change it completely. It is now enough to replace only the oscillating arm carrying the pipette needle. This is such a simple procedure that the personnel operating the analyzer can perform this repair by means of a single maneuver in which the damaged oscillating pipette needle is exchanged for a corresponding replacement part. Thus, according to the invention, a solution is provided which permits rapid and inexpensive repair of a damaged oscillating pipette needle.
List of reference symbols:
1 Holder 2 Oscillating arm 3 Tension spring 4 Heatable pipette needle 5 Sensor 6 Drive motor with eccentric 7 Drive fork for eccentric 8 Grip for exchanging 9 Admission for reagents 10 Plate 11 Ribs
Claims (8)
1. An oscillating pipette needle for an automatic analyzer for examining biological body fluids, wherein, for the purpose of introducing the pipette needle into the analyzer and withdrawing it from the latter, a holder (1) is provided which is equipped with a tension spring (3) and with which an oscillating arm (2), carrying the pipette needle (4) and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.
2. The oscillating pipette needle as claimed in claim 1, wherein the knife-edge bearing is secured on ribs (11) which ensure a lateral fixing of the oscillating arm (2).
3. The oscillating pipette needle as claimed in claim 2, wherein the tension spring (3) can engage in an insert opening of the ribs (11) of the oscillating arm (2) and can press the latter against the holder (1).
4. The oscillating pipette needle as claimed in claims 1 through 3, wherein the pipette needle (4) can be heated.
5. The oscillating pipette needle as claimed in claims 1 through 4, wherein the oscillating arm (2) has a drive fork (7) in which an eccentric rotating shaft (6) engages for the purpose of generating oscillations.
6. The oscillating pipette needle as claimed in claims 1 through 5, wherein a connection piece (9) for admission of reagents is provided on the oscillating arm (2).
7. The oscillating pipette needle as claimed in claims 1 through 6, wherein the oscillating arm (2) can be moved in the vertical direction upon assembly, and a sensor (5) arranged on a plate (10) then switches the analyzer off.
8. The oscillating pipette needle as claimed in claims 1 through 7, wherein the oscillating arm (2) has grips (8) for exchanging the pipette needle.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19847759A DE19847759A1 (en) | 1998-10-16 | 1998-10-16 | Interchangeable vibrating pipette needle |
| DE19847759.7 | 1998-10-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2285904A1 CA2285904A1 (en) | 2000-04-16 |
| CA2285904C true CA2285904C (en) | 2008-04-15 |
Family
ID=7884694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002285904A Expired - Fee Related CA2285904C (en) | 1998-10-16 | 1999-10-13 | Exchangeable oscillating pipette needle |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6447728B1 (en) |
| EP (1) | EP0994356B1 (en) |
| JP (1) | JP4469038B2 (en) |
| AT (1) | ATE313804T1 (en) |
| CA (1) | CA2285904C (en) |
| DE (2) | DE19847759A1 (en) |
| ES (1) | ES2252899T3 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660228B1 (en) * | 1998-03-02 | 2003-12-09 | Cepheid | Apparatus for performing heat-exchanging, chemical reactions |
| US6706245B2 (en) * | 2000-03-10 | 2004-03-16 | Teledyne Tekmar Company | Three stage needle for use with an autosampler |
| US20010048894A1 (en) * | 2000-03-10 | 2001-12-06 | Schmidt Harry W. | Vial handling system with improved vial gripper |
| US6872362B2 (en) * | 2000-03-10 | 2005-03-29 | Teledyne Tekmar Company | Vial handling system with improved mixing mechanism |
| US20020025581A1 (en) * | 2000-03-10 | 2002-02-28 | Schmidt Harry W. | Vial handling system with improved sample extraction |
| JP2002001092A (en) * | 2000-06-22 | 2002-01-08 | Shimadzu Corp | Apparatus for discharging liquid |
| AU2003903254A0 (en) * | 2003-06-27 | 2003-07-10 | Invetech Pty Ltd | Method and apparatus for sampling a fluid |
| FR2857750B1 (en) * | 2003-07-18 | 2008-04-18 | C2 Diagnostics | DEVICE AND METHOD FOR SAMPLING AN ANALYSIS AUTOMATE |
| FR2860731B1 (en) * | 2003-10-14 | 2006-01-21 | Maxmat S A | APPARATUS FOR MIXING A CHEMICAL OR BIOCHEMICAL ANALYZER WITH PIPELINE DRIVE OF A PIPETTE |
| WO2005103725A1 (en) * | 2004-04-20 | 2005-11-03 | Tecan Trading Ag | Device for conveying or examining liquids |
| CN1866029B (en) * | 2006-04-21 | 2010-11-03 | 珠海森龙生物科技有限公司 | Sample charging mechanism of biochemical analyzer |
| US20090038076A1 (en) * | 2007-08-09 | 2009-02-12 | Giduck John P | Flexible litter |
| JP5872816B2 (en) * | 2011-08-03 | 2016-03-01 | シスメックス株式会社 | Sample analyzer |
| WO2014058880A1 (en) * | 2012-10-09 | 2014-04-17 | Misono Kunio | Stirring devices |
| EP2778688B1 (en) * | 2013-03-13 | 2019-10-30 | Siemens Healthcare Diagnostics Products GmbH | Holding device for a pipetting needle |
| CN104034908B (en) * | 2014-04-22 | 2015-08-19 | 深圳市库贝尔生物科技有限公司 | A kind of new automatic Biochemical Analyzer |
| CN103926417B (en) * | 2014-04-22 | 2015-09-30 | 深圳市库贝尔生物科技有限公司 | A kind of method simultaneously realizing specimen needle sampling, application of sample and stirring |
| CN103941031B (en) * | 2014-04-22 | 2015-11-25 | 深圳市库贝尔生物科技有限公司 | Integrated sample pin application of sample and stirring system |
| CN104111180B (en) * | 2014-05-23 | 2017-01-18 | 苏州日和科技有限公司 | Automatic-positioning vibration sampler |
| CN104111344B (en) * | 2014-05-23 | 2016-04-13 | 苏州日和科技有限公司 | The full-automatic sample introduction mechanism of a kind of flow cytometer |
| EP3096148B1 (en) | 2015-05-20 | 2024-01-03 | Siemens Healthcare Diagnostics Products GmbH | Pipetting device |
| US11579861B2 (en) | 2016-02-12 | 2023-02-14 | Nutanix, Inc. | Virtualized file server smart data ingestion |
| US11372014B2 (en) * | 2016-05-12 | 2022-06-28 | Siemens Healthcare Diagnostics Inc. | Clinical analyzer probe crash detection mechanism and process |
| CN105842472A (en) * | 2016-05-24 | 2016-08-10 | 湖南迪赛生物科技有限公司 | Multifunctional rotational sample feeding device |
| TWI766942B (en) | 2017-02-13 | 2022-06-11 | 美商海科生醫有限責任公司 | Apparatuses and methods for mixing fluid or media by vibrating a pipette using transient and steady-state intervals |
| CN106967584A (en) * | 2017-05-04 | 2017-07-21 | 南昌大学 | A kind of automated cell suspension blows and beats evenly mixing device |
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| ES2110023T3 (en) * | 1992-05-15 | 1998-02-01 | Behring Diagnostics Gmbh | PIPETEO DEVICE. |
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| JP3001087B2 (en) * | 1995-10-18 | 2000-01-17 | 株式会社日立製作所 | Automatic analyzer and method |
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| AUPP441798A0 (en) * | 1998-06-30 | 1998-07-23 | Australian Biomedical Corporation Limited | Laboratory sampling probe positioning apparatus |
| JP3525757B2 (en) * | 1998-09-18 | 2004-05-10 | 株式会社日立製作所 | Chemical analyzer |
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-
1998
- 1998-10-16 DE DE19847759A patent/DE19847759A1/en not_active Withdrawn
-
1999
- 1999-09-16 DE DE59912957T patent/DE59912957D1/en not_active Expired - Lifetime
- 1999-09-16 AT AT99118340T patent/ATE313804T1/en active
- 1999-09-16 EP EP99118340A patent/EP0994356B1/en not_active Expired - Lifetime
- 1999-09-16 ES ES99118340T patent/ES2252899T3/en not_active Expired - Lifetime
- 1999-10-13 CA CA002285904A patent/CA2285904C/en not_active Expired - Fee Related
- 1999-10-15 JP JP29347099A patent/JP4469038B2/en not_active Expired - Fee Related
- 1999-10-15 US US09/418,585 patent/US6447728B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2252899T3 (en) | 2006-05-16 |
| EP0994356A3 (en) | 2002-05-22 |
| ATE313804T1 (en) | 2006-01-15 |
| JP2000117123A (en) | 2000-04-25 |
| DE19847759A1 (en) | 2000-04-20 |
| CA2285904A1 (en) | 2000-04-16 |
| EP0994356A2 (en) | 2000-04-19 |
| EP0994356B1 (en) | 2005-12-21 |
| JP4469038B2 (en) | 2010-05-26 |
| DE59912957D1 (en) | 2006-01-26 |
| US6447728B1 (en) | 2002-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |