CA2286191A1 - Membrane apparatus with enhanced mass transfer via active mixing - Google Patents

Membrane apparatus with enhanced mass transfer via active mixing Download PDF

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Publication number
CA2286191A1
CA2286191A1 CA002286191A CA2286191A CA2286191A1 CA 2286191 A1 CA2286191 A1 CA 2286191A1 CA 002286191 A CA002286191 A CA 002286191A CA 2286191 A CA2286191 A CA 2286191A CA 2286191 A1 CA2286191 A1 CA 2286191A1
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CA
Canada
Prior art keywords
gas
fluid
flow path
blood
path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002286191A
Other languages
French (fr)
Inventor
Harvey S. Borovetz
Philip Litwak
Mark Gartner
Gary D. Reeder
Patricia Sawzik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
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Individual
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Filing date
Publication date
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Publication of CA2286191A1 publication Critical patent/CA2286191A1/en
Abandoned legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • B01D63/04Hollow fibre modules comprising multiple hollow fibre assemblies
    • B01D63/043Hollow fibre modules comprising multiple hollow fibre assemblies with separate tube sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16Rotary, reciprocated or vibrated modules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D65/00Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08Prevention of membrane fouling or of concentration polarisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698Blood oxygenators with or without heat-exchangers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/14Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/20Specific housing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/20Specific housing
    • B01D2313/206Specific housing characterised by the material
    • B01D2313/2061Organic, e.g. polymeric material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2321/00Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20By influencing the flow
    • B01D2321/2033By influencing the flow dynamically
    • B01D2321/2041Mixers; Agitators
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2321/00Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20By influencing the flow
    • B01D2321/2083By reversing the flow
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00Gas and liquid contact apparatus
    • Y10S261/28Blood oxygenators

Abstract

A blood membrane oxygenator (10) having a housing (12) defining a blood flow path (13), a rotor hub in the form of a double lumen shaft (14), and a plurality of distributor disks (16) each having a plurality of hollow fibers (48) which extend across the housing blood flow path (13). The plurality of distributor disks (16) rotate within the housing (12) to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.

Description

'~,I'PL$ OF TH8 INV821TIDN
D~~tANS APPARATtTS 9PITB
8N8ANCED MA88 TRANSFER VIA ACTIVE bLIBING
~AC1CGRODND l,~,F T88 INVSt~ITION
S 1. Field of the Iaveatioa This invention relates to a mass transfer apparatus which actively mixes a first mass with a second mass wherein the, mass transfer apparatus has hollow fiber membranes carrying the first mass Which are rotated or agitated within the second mass thus providing three-dimensional mass transfer. More particularly, this invention concerns a blood oxygenator comprising a rotor hub and a plurality of rotor members each having a plurality of hollow fiber membranes wherein the rotor hub supplies the hollow fiber membranes with oxygen and the plurality of rotor members rotate within the venous blood such that the oxygen which diffuses across the hollow fiber membranes is actively mixed with the venous blood flow.
2. Desori~tioa of Related Art The use of membrane oxygenators to oxygenate blood is well known in the art. One type of conventional membrane oxygenator employs bundles of hollow fibers retained within a cylindrical .housing wherein oxygen is pumped through the hollow fibers in the same direction.as the blood. The hollow fibers consist of a microporous membrane which is impermeable to blood and permeable to gas. Gas exchange takes place when venous blood flows through the housing and contacts the hollow fibers. Based on the law of diffusion the oxygen diffuses across the hollow fiber walls and enriches venous blood in contact with these hollow fibers. Examples of this type of membrane oxygenator are described in U.S. Patent No.
4,620,965 issued to Fukusawa et al. and U.S. Patent No.

4,698,207 issued to Hringham et al. The disadvantage to this type of membrane oxygenator is that a blood boundary layer is fornned around the hollow fibers which retards oxygenation of blood that does not directly contact the hollow fibers.
Another type of conventional membrane oxygenator provides more efficient oxygenation of blood by positioning blood flow substantially perpendicular or at an angle to the hollow fiber membranes carrying the oxygen. Examples of this type of membrane oxygenator are described in U.S.
Patent No. 4,639,353 issued to Takemura et al., U.S. Patent No. 3,998,593 issued to Yoshida et al. and U.S. Patent No.
4,490,331 issued to Steg, Jr. A drawback to these designs is that the permeability of the hollow fiber membranes decreases over time and the oxygenator becomes less efficient.
Yet another type of membrane oxygenator discloses moving a part of the oxygenator in order to provide increased mixing of blood flow. Examples of this type of membrane oxygenator are described in U.S. Patent Nos.
3,674,440 and 3,841,837 issued to Kitrilakis and Kitrilakis et al., respectively, (the Kitrilakis Patents) and U.S.
Patent No. 3,026,871 issued to Thomas (the Thomas Patent).
The Kitrilakis Patents disclose a blood flow path and an oxygen flow path positioned between a rotor and a stator and separated by a membrane and a wafer. When the rotor rotates relative to the stator, mixing of blood flow occurs resulting in disruption of the blood boundary layer.
Although this type of oxygenator provides a degree of mixing of blood, this type of mixing results in destruction of the red blood cells.
The Thomas Patent discloses rotating a cylindrical, semi-permeable membrane containing oxygen in a housing wherein blood contacts and flows over the membrane and oxygen is transferred through the rotating membrane to the WO 98/46339 PCT/fJS98/06965 blood. One disadvantage of this type of membrane oxygenator is that the permeability to oxygen and carbon .
dioxide of semipermeable membranes is poor.
Yet another type of blood oxygenator device comprises short microporous fiber sheets which are folded, twisted and woven around a hollow shaft that carries the inlet and outlet gas flows. The device is implanted into the vascular system of a patient and rotated to cause mixing of the blood. This type of device ie explained in greater detail in "A Dynamic Intravascular Lung," ABAIO Journal 1994. The problem with this type of blood oxygenator is that the number of fiber sheets that are able to be incorporated into the device is limited because the device is an intravascular device and therefore, anatomical space is limited. Furthermore, the rotation of the device within the blood vessel may destroy the cells lining the blood vessel.
Nowhere in the cited related art is there disclosed or suggested a membrane oxygenator which provides effective blood oxygenation to sustain a patient for extended durations while also providing a compact oxygenator design.
Theref ore , there is a def finite need f or a blood membrane oxygenator incorporating an active mixing component which provides for effective blood oxygenation.
2 s sv~~Y og T~ =NVr~rr=orr Accordingly, the present invention provides a blood oxygenator having a housing defining a blood path, a rotor hub defining an oxygen path, and at least one rotor defining a blood path and having a plurality of hollow fibers extending across the rotor blood path and being in fluid communication with the rotor hub oxygen path such that when oxygen flows through and diffuses across the plurality of hollow fibers and the rotor rotates about the rotor hub, active mixing of the blood occurs resulting in disruption of the blood boundary layer surrounding the hollow fibers.
Preferably, the rotor is a distributor disk having two oxygen return channels, two oxygen supply channels, a first spoke defining an oxygen inlet path, a second spoke defining an oxygen outlet path and a plurality of hollow fibers extending across the diameter of the disk and in fluid communication with the return and supply channels.
The present invention preferably provides a plurality of distributor disks positioned on the rotor hub thus, providing additional hollow fibers and increased surface area of the hollow fibers at which oxygenation of the blood takes place. The specific number of distributor disks is dependent upon the amount of surface area necessary for the specific patient. For example, a larger patient requires greater oxygen delivery and thus, more disks, however, fewer disks are necessary for a smaller patient. Further, the present invention provides for the surface area of the hollow fibers to be increased by increasing the number.of hollow fibers on each distributor disk. Hollow fibers can extend from both the first and second faces of each of the distributor disk. Hy increasing or decreasing the number of distributor disks and hollow fibers used in the blood oxygenator of the present invention, the blood oxygenator capacity can be tailored to the specific patient application.
The present invention further pravidea for each of the plurality of rotors to be able to rotate independently of one another such that while some rotors rotate in the clockwise direction the other rotors simultaneously rotate in the counter-clockwise direction thus, providing an enhanced mixing of blood. Also, the plurality of rotors can be rotated in a back and forth motion such that the rotors repeatedly rotate approximately 360 degrees or leas, and then reverse direction resulting in the blood being agitated and the blood boundary layer being disrupted.
Baffles are preferably positioned between the plurality of rotors in the blood oxygenator of the present invention in order to provide an increased mixing of the blood.
The rotor hub preferably takes the form of a double lumen shaft defining an oxygen inlet path and an oxygen outlet path.
The present invention provides for the plurality.of hollow fibers to be microporous such that the fibers are impermeable to liquid and are permeable to gas. The present invention further provides for the opportunity of the surfaces of the hollow fibers to be coated with a material which would decrease the wetability of the microporous structure. An example of the type of material used for these purposes is silicone rubber, although numerous other polymer coatings could be used.
The present invention provides a blood oxygenator that can be used to treat patients having acute as well as chronic lung diseases.
Other details, objects and advantages of the present preferred invention will become more apparent with the following description of the present preferred invention.
8RIEF DESCRIPTION O~ THE DRA9PIN~~
The accompanying drawings describe the present preferred invention in which:
Figure 1 is a perspective view of the preferred embodiment of the present invention blood membrane oxygenator illustrating the venous blood inlet and arterial blood outlet.
Figure 2 ie a front plan view of the blood oxygenator shown in Figure 1 illustrating the venous blood inlet.
Figure 3 is a side plan view of the blood oxygenator shown in Figure 1 further illustrating an oxygen inlet and an oxygen outlet.
Figure 4 is a cutaway perspective view of the blood oxygenator shown in Figure 1 With some of the cylindrical section of the housing and the rotors eliminated in order to more clearly illustrate one embodiment of the baffles.
Figure 5a is a cross-sectional view of the blood oxygenator shown in Figure 1 taken along line V-V and illustrating the gas flow path.
Figure 5b is the cross-sectional view of the blood oxygenator shown in Figure 1 taken along line V-V and illustrating the blood flow path.
Figure 6 is a perspective view of a plurality of hollow fiber distributor disks mounted on a double lumen shaft of the present preferred invention.
Figure 7 is a perspective view of one of the hollow fiber distributor disks shown in Figure 6.
Figure 8 is a perspective view of one of the hollow fiber distributor disks shown in Figure 6 with the hollow fiber members eliminated therefrom.
Figure 9 is a side plan view of the hollow fiber distributor disk shown in Figure 8.
Figure 10 is a cross-sectional view of the hollow fiber distributor disk shown in Figure 9 taken along line X-X.
Figure 11 is an enlarged view of a hollow fiber distributor disk shown in Figure 5a illustrating the fluid connection of the hollow fibers with the channels of the distributor disk.
Figure 12 is a side plan view of the hollow fiber distributor disk shown in Figure 8.
Figure 13 is a cross-sectional view of the blood oxygenator shown in Figure 5 taken along line XIII-XIII
which illustrates the baffles.
Figure 14 is a cross-sectional view of a blood oxygenator similar to the blood oxygenator shown in Figure 5a which employs a series of drive rollers to impart the rotational movement to the distributor disks.
DI3TA~~ DBSCRIFTION OF T8E PRBSRSfr PR8F8RRS~ I1~VTNTI0~1 ~rlthough this invention is suitable for other uses it will be described as being used as a blodd oxygenator to support a patient. Such description is for purposes of explanation and is not intended to limit the scope of this invention. For example, the present invention can be used as a kidney dialysis machine.
Figures 1-5 illustrate a present preferred embodiment of a blood oxygenator 10 comprising a housing 12 defining a blood flow path 13, a rotor hub in the form of a double lumen shaft 14, and a plurality of rotors each comprising a hollow fiber distributor disks 16. The housing 12 encases the rotor hub 14 and the hollow fiber distributor disks 16.
The housing has a venous blood inlet 18, an arterial blood outlet 20, an oxygen supply inlet 22 and a gas outlet 24 and is preferably made from polycarbonate. Within the housing 12 is an inlet chamber 25 and an outlet chamber 27.
The double lumen shaft defines an oxygen inlet path 29 and a gas outlet path 31. The oxygen inlet path 29 is in fluid communication with the oxygen supply inlet 22 and the gas outlet path 31 is in fluid communication with gas outlet 24.
Referring to Figures 5-13, each of the plurality of hollow fiber distributor disks 16 is fixedly mounted on the double lumen shaft 14. Each of the hollow fiber distributor disks 16 comprises (Figure 11) an interior ' surface 28, an exterior surface 30 concentric to the interior surface 28, a first face 32, a second face 34, a first spoke 36 and a second spoke 38 and a plurality of hollow fibers 48. The first face 32 and the second face 34 each have an arcuate-shaped supply channel 40 and an arcuate-shaped return channel 42. The supply channels 40 and the return channels 42 are spaced apart a defined length 44. The first spoke 36 defines an oxygen supply path and is connected at its distal end 39 to the distributor disk 16 and is connected at the proximal end 41 to the oxygen inlet path 29 of the double lumen shaft I4.
The second spoke 38 defines a gas return path and is connected at its distal end 47 to the distributor disk 16 and is connected at the proximal end 46 to the gas outlet path 31 of the double lumen shaft 14. Each of the first and second spokes 36, 38 act as a support for the distributor disk 16.
A plurality of microporous hollow fibers 48 extend across the diameter of the distributor disk 16 and weave around the double lumen shaft 14. The hollow fibers 48 extend across the first face 32 and the second face 34 of the distributor disk 16. The plurality of hollow fibers 48 are connected to the supply and return channels 40, 42.of the distributor disks 16 by potting material 49 which can be an epoxy resin. A Y-shaped return tunnel 50 and a Y-shaped supply tunnel 52 shown in greater detail in Figures 10 and 11 connect the supply and return channels 40, 42 with the first and second spokes 36 and 38, respectively.
The hollow fibers 48 are made from a microporous material which is permeable to gases and impermeable to liquids. However, if the present invention is used in a kidney dialysis machine the material of the hollow fibers 48 would have to be permeable to fluid. For oxygenation, the preferred material is polypropylene; however, other materials depending upon the application such as polyethylene can be used to form the hollow fibers 48.
Sets of baffles 54, shown in greater detail in Figures 5 and 13, are interspersed between the distributor disks 16. The baffles 54 are integral disks extending from the inner wall of the device housing 12 toward the center of the blood flow path, thereby defining a partition 69 within the housing 12 in which a distributor disk 16 will rotate.
Each baffle 54 defines a central opening 55 of sufficient diameter to allow flow from one segment of the housing 12 to the next. Additionally, the surfaces of each baffle 54 will have an elevated rib or flute 59 which will sezve to provide direction to blood flowing off the surface of the rotating distributing disks 16. The baffle cross section can take many other shapes.
The distributor disks 16 rotate about the axis of the double lumen shaft 14. The distributor disks 16 can either rotate in one direction or in a back and forth motion.
When rotating in one direction all of the distributor disks rotate in either clockwise or counter-clockwise direction.
When the distributor disks 16 are rotating in a back and forth manner each of the distributor disks 16 rotate in one direction for a specified angle and then change directions and rotate in the opposite direction for a specified angle.
This back and forth motion agitates the blood surrounding the hollow fibers 48 thus, disrupting the blood boundary layer. The distributor disks 16 are actuated using a conventional electric motor 60. However, other motor technologies can be used.
Referring to Figures 5a and 5b, the present preferred embodiment provides for the following blood flow paths and oxygen flow paths. Oxygen enters through the oxygen supply inlet 22, proceeds through the inlet chamber 25, and flows through the oxygen inlet path 29 of the double lumen shaft 14. The oxygen is then transported into the plurality of first spokes 36 which are in fluid communication with the double lumen shaft inlet path 29 at the first spokes proximal end 41 and in fluid communication with the Y-shaped supply tunnels 52 at its distal end 39. The oxygen then passes through the tunnels 52 and supply channels 40 and enters the hollow fibers 48, flows through the hollow fibers 48 extending across the diameter of the distributor disks 16 where the oxygen exchange takes place. In accordance with the law of diffusion, oxygen travels across the walls of the microporous hollow fibers 48 into the venous blood while simultaneously carbon dioxide contained within the venous blood travels across the walls of the hollow fibers 48 into the return gas flow path. The oxygen/carbon dioxide mixture within the hollow fibers 48 enters the return channels 42 of the distributor disks 16 and is transmitted through the Y-shaped return tunnels 50 to the second spoke 38 and then to the gas outlet path 31 of the double lumen shaft 14.
Referring to Figure 5b, venous blood enters the blood inlet 18, flows through the cylindrical portion 13 of the housing 12 where the venous blood contacts the- hollow fibers 48 of the rotating distributor disks 16. The venous blood flow path is substantially perpendicular to the hollow fibers 48 and provides for a degree of mixing and cross-flow of blood which results in a disruption of the blood boundary layer. Further, the rotation of the hollow fibers 48 on each of the distributor disks 16 and the presence of the baffles 54 between the rotating distributor disks 16 provides for a greater degree of mixing of blood resulting in enhanced oxygenation. The venous blood directly contacts and surrounds the walls of the hollow fibers 48 providing three-dimensional oxygenation. The oxygen-enriched blood then exits through the arterial blood outlet 20. By rotating the distributor disks 16 which carry the hollow fibers 48 through the venous blood, three dimensional mixing and efficient oxygenation are realized.
Referring to Figure 14, alternating counter-rotation of the distributor disks 16 can be achieved by a series of drive rollers 62, rotating in opposite directions, which firmly contact the outer edge of the distributor disks 16 thereby imparting rotational movement to the distributor disk 16. When rotating in the alternating counter-rotation manner some of the distributor disks 16 rotate clockwise while the other distributor disks 16 simultaneously rotate counter-clockwise. This alternating counter-rotation provides for disruption of the boundary layer of blood contacting the hollow fibers 48 resulting in increased oxygenation. Alternatively, the disks 16 could be mounted on coaxial shafts which are turned in opposite directions to impart counter-rotation of the alternating distributor disks 16.
While the present invention has been described herein, it is distinctly understood that the invention is not limited thereto but may be otherwise variously embodied in the scope of the following claims and any equivalent thereof.

Claims (13)

We claim:
1. A mass transfer apparatus comprising:

(a) a housing defining a first fluid path and having a first fluid inlet, a first fluid outlet, a second fluid inlet and a second fluid outlet;

(b) a rotor hub defining at least one second fluid flow path which is in fluid communication with the second fluid flow inlet and the second fluid flow outlet;
(c) at least one rotor defining a first fluid flow path and defining at least one second fluid flow path in fluid communication with the rotor hub at least one second fluid flow path; and (d) a plurality of hollow fibers each in fluid communication with the at least one rotor second fluid flow path and extending across the housing first fluid flow path such that when a first fluid flows through the housing first fluid flow path and a second fluid flows through and diffuses across the plurality of hollow fibers and the rotor rotates about the rotor hub, a fluid exchange between the first and second fluids occurs through the walls of the plurality of hollow fibers.
2. A gas transfer apparatus comprising:

(a) a housing defining a fluid flow path and having a fluid inlet, a fluid outlet, a gas inlet and a gas outlet;

(b) a rotor hub defining at least one gas flow path in fluid communication with the gas inlet and the gas outlet;

(c) at least one rotor defining a fluid flow path and defining at least one gas flow path wherein the at least one gas flow path is in fluid communication with the rotor hub at least one gas flow path;
(d) a plurality of hollow fibers, each of the plurality of hollow fibers extending across the at least one rotor fluid flow path and in fluid communication with the at least one gas flow path; and wherein when a fluid flows through the housing path and a gas flows through and diffuses across the plurality of hollow fibers and the at least one rotor is rotated about the rotor hub, the fluid will be enriched by the gas as a result of the gas directly contacting and surrounding the plurality of hollow fibers and the mixing of the fluid.
3. The gas transfer apparatus of Claim 2 further comprising a means for rotating the at least one rotor.
4. The gas transfer apparatus of Claim 2 wherein the disks have channels milled therein and the plurality of hollow fibers extend from the channels of the disks.
5. The gas transfer apparatus of Claim 2 wherein the plurality of hollow fibers are made from a microporous material which is substantially impermeable to fluid and permeable to gas.
6. The gas transfer apparatus of Claim 2 wherein the hollow shaft is a double lumen shaft defining a gas inlet path and a gas exit path.
7. The gas transfer apparatus of Claim 3 wherein the at least one rotor is a plurality of rotors.
8. The gas transfer apparatus of Claim 7 wherein the rotating means independently rotate each of the plurality of rotors such that some of the plurality of rotors can rotate clockwise while other of the plurality of rotors can simultaneously rotate counter-clockwise.
9. The gas transfer apparatus of Claim 2 wherein the fluid flow path is substantially perpendicular to the plurality of hollow fiber.
10. The gas transfer apparatus of Claim 2 further comprising an agitator which rotates the rotor hub and the at least one rotor in a back-and-forth motion.
11. The gas transfer apparatus of Claim 2 further comprising a plurality of baffles between the fluid flow inlet and the at least one rotor.
12. The gas transfer apparatus of Claim 2 wherein the at least one rotor has a first face and a second face and the plurality of hollow fibers extend from both the first face and the second face.
13. A blood oxygenator comprising:
(a) a housing defining a blood flow path and having a venous blood inlet, an arterial blood outlet, an oxygen inlet and an oxygen outlet;
(b) a double lumen shaft defining a gas inlet path and a gas outlet path wherein the double lumen shaft gas inlet path is in fluid communication with the housing gas inlet and the double lumen shaft gas outlet is in fluid communication with the housing gas outlet; and (c) a plurality of distributor disks mounted on the double lumen shaft and each defining a blood flow path, each of the plurality of distributor disks having:

(i) an exterior surface;
(ii) an interior surface concentric to the exterior surface;
(iii) a first face extending between the exterior and interior surfaces and defining a first supply channel and a first return channel;
(iv) a second face extending between the exterior and interior surfaces and substantially parallel to the first face and defining a second supply channel and a second return channel;
(v) a first spoke defining an oxygen inlet path in fluid communication with both the double lumen shaft oxygen inlet path and the first and second supply channels;
(vi) a second spoke defining an oxygen outlet path in fluid communication with both the double lumen shaft oxygen outlet path and the first and second return channels; and (vii) a plurality of hollow fibers extending across the distributor disk blood flow path and each of the plurality of hollow fibers in fluid communication with the first spoke oxygen inlet path and the second spoke oxygen outlet path; and wherein when blood flows through the housing flow path and oxygen flows through and diffuses across the plurality of hollow fibers and the plurality of distributor disks rotate about the double lumen shaft, three-dimensional mixing and efficient oxygenation of blood occurs.
CA002286191A 1997-04-11 1998-04-07 Membrane apparatus with enhanced mass transfer via active mixing Abandoned CA2286191A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/837,048 1997-04-11
US08/837,048 US6106776A (en) 1997-04-11 1997-04-11 Membrane apparatus with enhanced mass transfer via active mixing
PCT/US1998/006965 WO1998046339A1 (en) 1997-04-11 1998-04-07 Membrane apparatus with enhanced mass transfer via active mixing

Publications (1)

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CA2286191A1 true CA2286191A1 (en) 1998-10-22

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US (2) US6106776A (en)
EP (1) EP0973602B1 (en)
AT (1) ATE302645T1 (en)
AU (1) AU6891298A (en)
CA (1) CA2286191A1 (en)
DE (1) DE69831320D1 (en)
WO (1) WO1998046339A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6106776A (en) * 1997-04-11 2000-08-22 University Of Pittsburgh Membrane apparatus with enhanced mass transfer via active mixing
US6723284B1 (en) * 1997-04-11 2004-04-20 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
US6428747B1 (en) * 1998-12-30 2002-08-06 Cardiovention, Inc. Integrated extracorporeal blood oxygenator, pump and heat exchanger system
US6454999B1 (en) * 1998-12-30 2002-09-24 Cardiovention, Inc. Integrated blood pump and oxygenator system having extended blood flow path
US6929777B1 (en) 2001-07-26 2005-08-16 Ension, Inc. Pneumatically actuated integrated life support system
US20050042131A1 (en) * 2003-08-20 2005-02-24 Gartner Mark J. Blood oxygenator with spacers
DE102005023152A1 (en) 2004-12-21 2006-06-22 Rwth Aachen Oxygenator for use especially in dialysis operates by pumping blood through a continuously moving exchange wall, especially a hollow fiber bundle
WO2006118817A1 (en) * 2005-04-21 2006-11-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Paracorporeal respiratory assist lung
US8585968B2 (en) 2006-04-21 2013-11-19 Scott W. Morley Method and system for purging moisture from an oxygenator
US8915158B2 (en) * 2006-06-02 2014-12-23 MicroZeus, LLC Methods and systems for micro transmissions
GB2442209B (en) 2006-09-28 2012-01-18 Probe Scient Ltd Molecular exchange device
US8631788B2 (en) * 2007-06-02 2014-01-21 Arnold J. Landé Artificial gills for deep diving without incurring the bends and for scavenging O2 from and dispelling CO2 into water or thin air
GB2457469B (en) * 2008-02-13 2012-11-07 Probe Scient Ltd Molecular exchange device
GB2457468B (en) 2008-02-13 2012-11-21 Probe Scient Ltd molecular exchange device
KR101095817B1 (en) * 2009-02-10 2011-12-21 주식회사 하이닉스반도체 Semiconductor apparatus and fabrication method thereof
CN103316591B (en) * 2013-07-10 2015-04-15 威士邦(厦门)环境科技有限公司 Fan-shaped rotary film separation device
US20220347603A1 (en) * 2021-04-30 2022-11-03 Pall Corporation Filter disk segments

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU36810A1 (en) * 1958-01-30
US3332746A (en) * 1963-03-29 1967-07-25 Single Cell Res Foundation Inc Pulsatile membrane oxygenator apparatus
US3291568A (en) * 1964-04-06 1966-12-13 Richard D Santter Cardio-pulmonary by-pass oxygenator unit
GB1128181A (en) * 1965-01-20 1968-09-25 Goran Heden An apparatus for dialysis, heat exchange or gas exchange
US3396849A (en) * 1966-05-10 1968-08-13 Univ Minnesota Membrane oxygenator-dialyzer
US3480401A (en) * 1967-08-22 1969-11-25 North American Rockwell Blood oxygenation apparatus
US3579810A (en) * 1969-06-13 1971-05-25 Us Army Method of making capillary assemblies for oxygenators and the like
US3674440A (en) * 1970-05-07 1972-07-04 Tecna Corp Oxygenator
BE793624A (en) * 1972-01-10 1973-05-02 Baxter Laboratories Inc DEVICE FOR THE TRANSFER OF MASSES, PRESENTING A WOUND TUBULAR DIFFISION MEMBRANE
FR2198759B1 (en) * 1972-09-12 1976-06-04 Rhone Poulenc Ind
US3841837A (en) * 1972-10-05 1974-10-15 Tecna Corp Oxygenator
US3907504A (en) * 1973-04-06 1975-09-23 Gen Electric Blood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US3998593A (en) * 1973-07-02 1976-12-21 Seisan Kaihatsu Kagaku Kenkyusho Membrane blood oxygenator
US3927980A (en) * 1973-08-22 1975-12-23 Baxter Laboratories Inc Oxygen overpressure protection system for membrane-type blood oxygenators
US4033724A (en) * 1975-05-15 1977-07-05 Senko Medical Instrument Mfg. Co. Ltd. Oxygenator having a variable capacity oxygenating tube
US4163721A (en) * 1977-04-04 1979-08-07 Cobe Laboratories, Inc. Edge sealed pleated membrane
US4165287A (en) * 1977-04-04 1979-08-21 Cobe Laboratories, Inc. Potting pleated membrane
US4158693A (en) * 1977-12-29 1979-06-19 Texas Medical Products, Inc. Blood oxygenator
US4151088A (en) * 1978-01-23 1979-04-24 Baxter Travenol Laboratories, Inc. Membrane diffusion device with integral heat exchanger and reservoir
US4179364A (en) * 1978-05-05 1979-12-18 Baxter Travenol Laboratories, Inc. Diffusion device for blood
US4212741A (en) * 1978-04-10 1980-07-15 Brumfield Robert C Blood processing apparatus
US4312757A (en) * 1979-04-09 1982-01-26 Brumfield Robert C Methods and means for circulating a dialysate
US4239625A (en) * 1979-04-25 1980-12-16 Cobe Laboratories, Inc. Potting pleated membrane
US4476685A (en) * 1981-05-11 1984-10-16 Extracorporeal Medical Specialties, Inc. Apparatus for heating or cooling fluids
US4574876A (en) * 1981-05-11 1986-03-11 Extracorporeal Medical Specialties, Inc. Container with tapered walls for heating or cooling fluids
US4402420A (en) * 1981-12-07 1983-09-06 Extracorporeal Medical Specialties, Inc. Dual function port cap
US4490331A (en) * 1982-02-12 1984-12-25 Steg Jr Robert F Extracorporeal blood processing system
US4424190A (en) * 1982-02-22 1984-01-03 Cordis Dow Corp. Rigid shell expansible blood reservoir, heater and hollow fiber membrane oxygenator assembly
US4455230A (en) * 1982-04-26 1984-06-19 Cobe Laboratories, Inc. Pleated membrane transfer device utilizing potting and thixotropic adhesive
US4818490A (en) * 1982-04-26 1989-04-04 Cobe Laboratories, Inc. Integral blood oxygenator
US4487558A (en) * 1982-08-23 1984-12-11 Extracorporeal Medical Specialties, Inc. Peristaltic pump
US4573884A (en) * 1982-08-23 1986-03-04 Extracorporeal Medical Specialties, Inc. Peristaltic pump
US4620965A (en) * 1982-09-22 1986-11-04 Terumo Corporation Hollow fiber-type artificial lung
US5034135A (en) * 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
US4902476A (en) 1983-01-14 1990-02-20 Baxter International Inc. Heat exchanger and blood oxygenator apparatus
IT1172716B (en) * 1983-11-03 1987-06-18 Graziano Azzolini FILTER FOR HEMODIALYSIS AND / OR HEMOFILTRATION AND / OR PLASMAFERESIS
US4735775A (en) 1984-02-27 1988-04-05 Baxter Travenol Laboratories, Inc. Mass transfer device having a heat-exchanger
JPS60193469A (en) * 1984-03-14 1985-10-01 三菱レイヨン株式会社 Hollow yarn membrane type artificial lung
US4639353A (en) * 1984-04-24 1987-01-27 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow-fiber membrane
ZA8680B (en) 1985-01-08 1987-08-26 Mcneilab Inc Mass transfer device having a microporous,spirally wound hollow fiber membrane
US4698207A (en) * 1986-07-14 1987-10-06 Baxter Travenol Laboratories, Inc. Integrated membrane oxygenator, heat exchanger and reservoir
US4876066A (en) 1986-07-14 1989-10-24 Baxter International Inc. Integrated membrane oxygenator, heat exchanger and reservoir
US4766768A (en) * 1987-10-22 1988-08-30 Sundstrand Data Control, Inc. Accelerometer with isolator for common mode inputs
FR2627592B1 (en) * 1988-02-22 1990-07-27 Sagem PENDULUM ACCELEROMETER NOT SERVED WITH RESONANT BEAM
JPH0696098B2 (en) * 1988-05-27 1994-11-30 株式会社クラレ Hollow fiber type fluid treatment equipment
US5011469A (en) * 1988-08-29 1991-04-30 Shiley, Inc. Peripheral cardiopulmonary bypass and coronary reperfusion system
US5236665A (en) * 1988-10-20 1993-08-17 Baxter International Inc. Hollow fiber treatment apparatus and membrane oxygenator
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
US5124127A (en) 1989-01-26 1992-06-23 Shiley, Incorporated Hollow fiber blood oxygenator
US5005413A (en) * 1989-02-27 1991-04-09 Sundstrand Data Control, Inc. Accelerometer with coplanar push-pull force transducers
US5316724A (en) * 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5578267A (en) 1992-05-11 1996-11-26 Minntech Corporation Cylindrical blood heater/oxygenator
US5037383A (en) * 1990-05-21 1991-08-06 Northwestern University Intravascular lung assist device and method
US5270005A (en) * 1990-09-07 1993-12-14 Baxter International Inc. Extracorporeal blood oxygenation system incorporating integrated reservoir-membrane oxygenerator-heat exchanger and pump assembly
US5271743A (en) * 1991-03-27 1993-12-21 Hattler Brack G System to optimize the transfer of gas through membranes
US5143630A (en) * 1991-05-30 1992-09-01 Membrex, Inc. Rotary disc filtration device
US5263924A (en) * 1991-09-25 1993-11-23 Baxter International Inc. Integrated low priming volume centrifugal pump and membrane oxygenator
US5311932A (en) * 1992-06-05 1994-05-17 Gas Research Institute Process and apparatus for enhancing in-tube heat transfer by chaotic mixing
WO1994003266A1 (en) * 1992-08-03 1994-02-17 Maloney James V Jr Improved mass and thermal transfer means for use in heart lung machines, dialyzers, and other applications
US5312589A (en) * 1993-03-04 1994-05-17 Electromedics, Inc. Gas transfer apparatus
BR9305166A (en) * 1993-12-21 1995-10-17 Zerbini E J Fundacao Improvements introduced in blood oxygenator
US5411706A (en) 1994-02-09 1995-05-02 Hubbard; Lloyd C. Pump/oxygenator with blood recirculation
IL113556A (en) * 1994-05-11 1998-04-05 Allied Signal Inc Double-ended tuning fork
IT1271104B (en) 1994-11-25 1997-05-26 Dideco Spa BLOOD OXYGENATOR WITH A LAYER OF MICROPOROUS MEMBRANE CAPILLARIES.
US5770149A (en) 1995-10-31 1998-06-23 Baxter International Extracorporeal blood oxygenation system having integrated blood pump, heat exchanger and membrane oxygenator
US5823987A (en) 1996-01-11 1998-10-20 Medtronic, Inc. Compact membrane-type blood oxygenator with concentric heat exchanger
US6106776A (en) * 1997-04-11 2000-08-22 University Of Pittsburgh Membrane apparatus with enhanced mass transfer via active mixing

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US6348175B1 (en) 2002-02-19
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ATE302645T1 (en) 2005-09-15
US6106776A (en) 2000-08-22

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