CA2286759C - Apparatus for withdrawing a liquid from a closed container - Google Patents

Apparatus for withdrawing a liquid from a closed container Download PDF

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Publication number
CA2286759C
CA2286759C CA002286759A CA2286759A CA2286759C CA 2286759 C CA2286759 C CA 2286759C CA 002286759 A CA002286759 A CA 002286759A CA 2286759 A CA2286759 A CA 2286759A CA 2286759 C CA2286759 C CA 2286759C
Authority
CA
Canada
Prior art keywords
container
liquid
storage medium
container according
connection portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002286759A
Other languages
French (fr)
Other versions
CA2286759A1 (en
Inventor
Johannes Geser
Heinrich Kladders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2286759A1 publication Critical patent/CA2286759A1/en
Application granted granted Critical
Publication of CA2286759C publication Critical patent/CA2286759C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67DDISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/02Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67DDISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/02Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
    • B67D7/0277Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants using negative pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B9/00Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
    • B05B9/03Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67DDISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/06Details or accessories
    • B67D7/76Arrangements of devices for purifying liquids to be transferred, e.g. of filters, of air or water separators
    • B67D7/763Arrangements of devices for purifying liquids to be transferred, e.g. of filters, of air or water separators of air separators

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicinal Preparation (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • External Artificial Organs (AREA)
  • Packages (AREA)
  • Closures For Containers (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Water Treatment By Sorption (AREA)
  • Cleaning By Liquid Or Steam (AREA)

Abstract

For the withdrawal of a liquid from a closed container which is in a fluctuating position in space in a portable piece of equipment, precautions are to be taken so that the liquid can be withdrawn as completely as possible and in a trouble-free manner.
A closed container is provided with an open-pore porous storage medium which is in the form of an integral body. It preferably fills only a part of the container, it is disposed at least in the region of the end of the withdrawal connection portion, and it touches the liquid at least at times. The storage medium serves as a pre-storage means for the liquid and as a bubble barrier. It constantly holds a certain amount of the liquid in the proximity of the end of the withdrawal connection portion, even if the end thereof is above the level of liquid in the container.
The container provided with the storage medium can be used as an active substance deposit for a liquid medicament in an atomiser in the form of a hand unit, with which an inhalable aerosol can be produced.

Description

Apparatus for withdrawing a liquid from a closed container The invention concerns an apparatus nor withdrawing a liquid from a closed container. The container is provided with a wi_hdrawal connection portion through which the liquid is taken from the container and passed to further use thereof. The container is in a fluctuating S position in space if it is part of a portable piece of equipment.
The invention aims to make it possible to take a liquid from a closed container when the container is in any position in space so that the liquid withdrawn from the container can be used in the appropriate fashion and in a trouble-free manner.
It is known for a liquid to be discharged downwardly from a rigic container through a discharge connection portion or to be w-_tzdrawn upwardly or laterally by means of a tube or hose which projects into the container. The discharged flow of liquid is bubble-free and uninterrupted as long as the liquid completely covers the discharge connection portion or as long as the end of the tube completely dips into the liquid. Those conditions can be easily observed when dealing with a container which is in a fixed position in space. The liquid in the container can be virtually completely withdrawn therefrom.
In portable pieces of equipment in contrast a rigid liquid container can adopt any position in space. As long as one of the conditions specified. for a container involving a fixed position in space is met, a bubble-free and uninterrupted flow of liquid can also be taken from a container whose position in space fluctuates. It is however not possible for the liquid in the container to be completely withdraw therefrom.
It is further known to dispose in the rigid container a =oil bag which contains the liquid and which collapses to the extent that liquid is taken from the foil bag (collapsible bags. Experience has shown than the liquid can no longer be withdrawn from the bag as soon as the foil comes to bear against the discharge connection or the end of the tube e_ hose. Experience has shown that this can occv,:r before the foil bag is empty.
Accordingly an aspect of the invention is to provide an apparatus with which a liquid can be almost completely withdrawn in a trouble-free manner from a closed container, the container being provided with a withdrawal connection portion, containing a liquid and involving a position that fluctuates in space.
According to an aspect of the invention, there is provided closed container containing a liquid, said container having a spatially fluctuating position and being provided with a device for withdrawing the liquid, the container being provided with a withdrawal nozzle which is a rigid or flexible tube and projects into the container, and inside the container there is a storage medium containing capillaries which is constructed as an open-pored porous integral body located inside the container, at least in the region of the end of the withdrawal nozzle, characterised in that the storage medium is mounted outside the withdrawal nozzle and is at least intermittently in contact with the liquid.
According to another aspect of the invention, there is provided a storage medium which has open-pore porosity and which is in the form of an integral body. The storage medium is disposed within the container at least in the region of the end of the withdrawal connection portion.
It touches the liquid at least at times. For total withdrawal of the liquid the storage medium preferably bears against a part of the inside wall of the container.
The storage medium can be disposed outside the withdrawal connection portion in front of the end thereof and can surround the withdrawal connection portion which projects into the container, at least over a part of the length of the withdrawal connection portion, within the - 2a -container. In another embodiment it fills the major part of the container volume. In a further embodiment the storage medium is disposed substantially in the interior of the withdrawal connection portion at the end thereof. In a further construction the storage medium is disposed in the interior of the withdrawal connection portion at the end thereof and surrounds the withdrawal connection portion which projects into the container, at least over a part of its length.
It may be desirable to provide a cavity in the storage medium in the region of the end of the withdrawal connection portion.
The storage medium is either a body of stable shape comprising sintered powder or a wadding, a fleece, a knitted portion or a woven portion of fibres or an open-pore body, for example a sponge. It may also be a non-sintered powder which completely fills a part of the container volume, in which case the partial volume filled with powder is separated from the remaining volume of the container by a liquid-permeable wall.
The powder or the fibres forming the storage medium may comprise plastic material, ceramic, glass, metal or a natural substance.
Powders for example of polyolel=in or polyester are suitable as plastic powders. Powders of ceramic or glass for example of A1203, Si02, Ti02 and Na-A1-silicate are also suitable. Metal powders may comprise Ni, A1, high-quality steel or bronze. The particle size is 0.5 to 500 um.
Suitable fibres are those comprising plastic material, for example polyolefin or polyester, glass or metal or metal alloys, for example steel. The fibre diameter is 5 to 100 pm.
The withdrawal connection portion may be a rigid tube or a flexible hose. Instead of passing through the cover or through the bottom the withdrawal connection portion may pass through the container wall into the interior thereof at any location. The end of the withdrawal connection portion possibly terminates flush with the inside wall surface of the container. In that case the storage medium is fixed to the container wall in front of the end of the withdrawal connection portion.
If the container is rigid and if a considerable reduced pressure is not to occur in the container the container is provided with a vent valve which possibly operates automatically.
The storage medium is permeated by capillaries and serves as a pre-storage means for the liquid. It constantly holds a certain amount o the liquid in the proximity of the end of the withdrawal connection portion, even if the~ end of the withdrawal connection portion itself is above the level of liquid in the container. When the container is in that spatial position the liquid is withdrawn from the storage medium. As soon as the spatial position of the container changes and the storage medium is again in contact with liquid, it sucks itself full again with liquid.
The storage medium preferably fills only a part of the container volume.
The apparatus according to the invention has the following advantages:
- it permits the withdrawal connection portion to be supplied with liquid, irrespective of position, as long as the maximum possible volume flow in the withdrawal connection portion is less than the maximum possible volume flow of the liquid in t=he storage medium, 1~
- the liquid can be withdrawn, free from gas bubbles, the storaa_e medium serving as a bubble barrier, - the liquid can also be withdrawn virtually completely and in a trouble-free manner from a foil bag, - the storage medium acts as a :Filter for the liquid, and - the liquid can be virtual_Ly completely withdrawn from the container by means of a storage medium which bears against a part of the inside wall surface of the container.
The apparatus according to t:he invention is a particularly attractive proposition for the storage of a medicament dissolved in a solvent, for producing an aerosol for inhalative application. Suitable solvents are for example water or ethanol or mixtures thereof. Suitable medicaments are for example Berotec, Atrovent, Berodual, Salbutamol, Combivent, Oxivent, Ba 679, BEA 2108 and others.
The apparatus according to the invention can be used in a particular .embodiment as an active substance deposit for atomisers, as are disclosed for example in PCT application W091/14468 or PCT/EP96/04351. Even when withdrawing small amounts of liquid in the.
range of between 10 and 40 microlitrE:s the apparatus according to the invention guarantees that the solution is taken in a bubble-free condition from the ~storage medium which is generally of a volume of between 2 and 6 millilitres.
The apparatus according to the invention will now be described in greater detail by way of example with reference to the drawings.
Figure 1 is a view in axial section through a cylindrical container 1 with a flat bottom, which is closed by a cover 2. A vent valve 3 is mounted in the cover. The H~ithdrawal connection portion 4 is in the form of a rigid tube which is fixed in the cover and which projects into the container. Over its entire length in the container, the withdrawal connection portion is surrounded by the storage medium 5 which is in the form of a cylindrical body and which touches the bottom of the container. A cavity 6 is provided in the storage medium in the area around the end of the withdrawal connection portion.

Figure 2 shows a further embodiment of the apparatus according to the invention. The withdrawal connection portion is disposed in the bottom of the container. The storage medium 8 which is fixed on the bottom of the container is disposed in front of the end of the withdrawal 5 connection portion which does not proje=ct into the container.
Figure 3 shows an embodiment in which the rigid withdrawal connection portion 9 extends almost as far as the bottom of the container. The withdrawal connection portion terminates in a storage medium 10 in powder form, on which there lies a liquid-permeable wire mesh 11 which is connected at its edge to the container wall. A wire mesh is also disposed in front of the intake end of the withdrawal connection portion 9. The wire meshes retain the storage medium in powder form in the part of the volume of the container, which is provided therefor.
Figure 4 shows a further embodiment. In this case however the storage medium 12 does not touch the bottom of the container.
Figure 5a shows an axial longitudinal section through a cylindrical container 1 and Figure 5b is a view in cross-section perpendicularly to the axis of the container in the plane indicated in Figure 5a. The withdrawal connection portion 13 is flexible. The one-piece storage medium 14 is disposed at the end of the withdrawal connection portion, Which extends into the container. The storage medium touches the cylindrical inside wall surface and the bottom of the container; it is of a bar-like configuration on the axis of the container, it extends as far as the cover of the container and it surrounds the end of the withdrawal con:aection portion.
Figure 6a is an axial longitudinal section through a cylindrical container 1 and Figure 6b is a cross-section perpendicularly to the axis of the container in the plane indic:ate:d in Figure 6a. In this case the one-piece storage medium 16 is of a cross-section formed by four arms.
The end of the withdrawal connection portion 17 which is disposed in the bottom of the container is surrounded by the storage medium. The limbs of the storage medium touch the inside well surface and the bottom of the cylindrical container.
Figure 7a shows an axial longitudinal section through a cylindrical container 1 and Figure 7b shows a cross-section perpendicularly to the axis of thE: container in the plane indicated in Figure 7a. The apparatus according to the invention is of a similar design configuration to that shown in Figures 5a and 5b. The one-piece storage medium 18 comprises four bars 19a, 19b, 19c and 19d which touch the inside wall surface of the cont<sinE:r and extend from the cover to the bottom. At the bottom of the container the bars go into a four-armed star 20, from which a cylindrical bar 21 projects at the centre. The cylindrical bar 21 extends as far a;a the cover of the container and surrounds the end of the withdrawal connection portion.
Figure 8 shows a longitudinal section through an egg-shaped container 22, into which a flexible withdrawal connection portion 23 projects. The storage medium 24 is disposed at the end of the connection portion 23. Irrespective of the position of the container the storage medium constantly touches the inside wall surface of the container in the region in which the liquid is to be found.
Figure 9 shows an axial longitudinal section through a cylindrical container 1, into which a withdrawal connection portion 25 projects.
Disposed at the end of the withdrawal connection portion is the storage medium 26 which touches the bottom of the container and which fills the end of the withdrawal connection portion.
Figure 10 shows an axial longitudinal section through a container 27, the bottom 28 of which is curved. Disposed in the container is a foil bag 29 filled with the liquid. The withdrawal connection portion 30 projects through the cover into the ~~ontainer, the end thereof being surrounded by the cylindrical storage medium 31. A cavity 32 is provided in the storage medium at the end of the withdrawal connection portion.
Example 1: Apparatus for aerosol production An aerosol is produced from a liquid by the liquid flowing under high pressure through a nozzle and being atomised outside the nozzle. The high pressure required for that purpo:~e in the liquid can be achieved only if the liquid is withdrawn from the container in a bubble-free condition.
t The aerosol producer is provi<~ed with an apparatus as shown in Figure 1. The storage medium comprises sintered polyethylene.
Commercially available polyethylene powder (manufacturer: Hoechst AG, Type GUR 4120) is of a mean grain size of 120 um. In this case the apparatus. according to the invention serves as a bubble barrier and a pre-storage means for the liquid.
Example 2: Apparatus for withdrawing a:Liquid under a protective gas A deformable foil bag is filled to approximately 800 of its volume with a liquid which is under a protective gas and which is to be taken dropwise from the bag. At its discharge end the withdrawal connection portion has a non-return valve. The storage medium in the form of a felt ball of polyester fibre of a diameter of 18 um is fixed to the end of the withdrawal connection portion, which projects into the bag.
When the bag is compressed by hand the liquid issues dropwise from the withdrawal connection portion. The bag collapses to the extent that liquid is taken therefrom. The non-return valve at the discharge end of the withdrawal connection portion prev~=nts air from penetrating into the foil bag. After each actuation of the apparatus, the felt ball at the intake end of the withdrawal connection portion is sucked full of liquid again. The felt ball acts as a pre-storage means for the liquid and as a barrier for the protective gas. It contains more liquid than is taken from the felt ball upon actuation of the apparatus.
The felt ball permits the liquid present in the bag to be virtually completely withdrawn therefrom. It also prevents the intake end of the withdrawal connection portion i_rom being closed off by the foil disposed in front of same. The protective gas isssues through the withdrawal connection portion only when the liquid has been virtuall}~
totally withdrawn from the foil bag.

Claims (12)

CLAIMS:
1. Closed container containing a liquid, said container having a spatially fluctuating position and being provided with a device for withdrawing the liquid, the container being provided with a withdrawal nozzle which is a rigid or flexible tube and projects into the container, and inside the container there is a storage medium containing capillaries which is constructed as an open-pored porous integral body located inside the container, at least in the region of the end of the withdrawal nozzle, characterised in that the storage medium is mounted outside the withdrawal nozzle and is at least intermittently in contact with the liquid.
2. Container according to claim 1, characterised in that the withdrawal nozzle is located above the level of the liquid in the container.
3. Container according to claims 1 or 2, characterised in that the storage medium surrounds the withdrawal nozzle projecting into the container at least over part of its length inside the container or fills the majority of the volume of the container.
4. Container according to any of claims 1 to 3, characterised in that the storage medium is in contact with the inner wall of the container.
5. Container according to any of claims 1 to 4, characterised in that a cavity is formed in the storage medium in the region of the end of the withdrawal nozzle.
6. Container according to claim 5, characterised in that the cavity is constructed so that the end of the withdrawal nozzle does not come into contact with the storage medium.
7. Container according to any of claims 1 to 6, characterised in that the storage medium is a dimensionally stable body of sintered body or a non-sintered powder is used as the storage medium which totally fills part of the volume of the container, the partial volume filled with powder being separated from the remainder of the volume of the container by a liquid-permeable wall, or the storage medium is a woven or knitted structure or a fleece or pad of fibres.
8. Container according to claim 7, characterised in that the powder or the fibres which form the storage medium consist of plastics, ceramics, glass, metal or a natural material.
9. Container according to any of claims 1 to 7, characterised by a foil bag disposed inside the container.
10. Use of a container according to any one of claims 1 to 9 for storing active substance for nebulisers.
11. Use of a container according to claim 10 for dispensing quantities of liquid in the range from 10 to 40 microlitres.
12. Use of a container according to claim 10 or 11 for storing a medicament dissolved in a solvent.
CA002286759A 1997-04-16 1998-04-09 Apparatus for withdrawing a liquid from a closed container Expired - Fee Related CA2286759C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19715893.5 1997-04-16
DE19715893A DE19715893C2 (en) 1997-04-16 1997-04-16 Device for removing a liquid from a closed container
PCT/EP1998/002074 WO1998046522A1 (en) 1997-04-16 1998-04-09 Device for withdrawing a liquid from a closed container

Publications (2)

Publication Number Publication Date
CA2286759A1 CA2286759A1 (en) 1998-10-22
CA2286759C true CA2286759C (en) 2006-08-22

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ID=7826700

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002286759A Expired - Fee Related CA2286759C (en) 1997-04-16 1998-04-09 Apparatus for withdrawing a liquid from a closed container

Country Status (40)

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US (1) US6250508B1 (en)
EP (1) EP0975547B1 (en)
JP (1) JP3570729B2 (en)
KR (1) KR100587205B1 (en)
CN (1) CN1124973C (en)
AR (1) AR015585A1 (en)
AT (1) ATE250556T1 (en)
AU (1) AU738492B2 (en)
BG (1) BG63253B1 (en)
BR (1) BR9809392A (en)
CA (1) CA2286759C (en)
CO (1) CO4780039A1 (en)
CZ (1) CZ294383B6 (en)
DE (2) DE19715893C2 (en)
DK (1) DK0975547T3 (en)
EE (1) EE04427B1 (en)
EG (1) EG21908A (en)
ES (1) ES2202850T3 (en)
HK (1) HK1024900A1 (en)
HR (1) HRP980205B1 (en)
HU (1) HUP0002357A3 (en)
ID (1) ID22773A (en)
IL (1) IL132392A (en)
MX (1) MXPA99009389A (en)
MY (1) MY118834A (en)
NO (1) NO315974B1 (en)
NZ (1) NZ500214A (en)
PE (1) PE70099A1 (en)
PL (1) PL187017B1 (en)
PT (1) PT975547E (en)
RU (1) RU2222491C2 (en)
SA (1) SA98181132B1 (en)
SK (1) SK285287B6 (en)
TR (1) TR199902597T2 (en)
TW (1) TW403714B (en)
UA (1) UA64748C2 (en)
UY (1) UY24957A1 (en)
WO (1) WO1998046522A1 (en)
YU (1) YU49241B (en)
ZA (1) ZA983095B (en)

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HUP0002357A2 (en) 2000-11-28
UY24957A1 (en) 1998-10-06
RU2222491C2 (en) 2004-01-27
SK141099A3 (en) 2000-06-12
JP3570729B2 (en) 2004-09-29
DE19715893C2 (en) 1999-04-29
NO315974B1 (en) 2003-11-24
NZ500214A (en) 2001-09-28
EG21908A (en) 2002-04-30
SK285287B6 (en) 2006-10-05
KR20010006486A (en) 2001-01-26
PL187017B1 (en) 2004-04-30
EP0975547B1 (en) 2003-09-24
BG63253B1 (en) 2001-07-31
EE9900462A (en) 2000-06-15
CZ294383B6 (en) 2004-12-15
CO4780039A1 (en) 1999-05-26
PE70099A1 (en) 1999-08-10
CA2286759A1 (en) 1998-10-22
AU7430498A (en) 1998-11-11
BR9809392A (en) 2000-06-13
DK0975547T3 (en) 2003-10-27
HK1024900A1 (en) 2000-10-27
CZ365999A3 (en) 2000-06-14
TW403714B (en) 2000-09-01
IL132392A0 (en) 2001-03-19
YU49241B (en) 2004-12-31
EP0975547A1 (en) 2000-02-02
ES2202850T3 (en) 2004-04-01
KR100587205B1 (en) 2006-06-08
DE59809726D1 (en) 2003-10-30
EE04427B1 (en) 2005-02-15
PL336270A1 (en) 2000-06-19
ID22773A (en) 1999-12-09
YU52899A (en) 2000-12-28
CN1252774A (en) 2000-05-10
PT975547E (en) 2004-02-27
HRP980205B1 (en) 2000-08-31
BG103782A (en) 2000-04-28
JP2001509761A (en) 2001-07-24
UA64748C2 (en) 2004-03-15
SA98181132B1 (en) 2006-08-20
TR199902597T2 (en) 2000-07-21
NO995061L (en) 1999-12-15
IL132392A (en) 2003-02-12
WO1998046522A1 (en) 1998-10-22
CN1124973C (en) 2003-10-22
MY118834A (en) 2005-01-31
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US6250508B1 (en) 2001-06-26
ZA983095B (en) 1998-10-16
DE19715893A1 (en) 1998-11-12
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AU738492B2 (en) 2001-09-20
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MXPA99009389A (en) 2004-09-01

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