CA2293487A1 - Dispenser with doses counter - Google Patents

Dispenser with doses counter Download PDF

Info

Publication number
CA2293487A1
CA2293487A1 CA002293487A CA2293487A CA2293487A1 CA 2293487 A1 CA2293487 A1 CA 2293487A1 CA 002293487 A CA002293487 A CA 002293487A CA 2293487 A CA2293487 A CA 2293487A CA 2293487 A1 CA2293487 A1 CA 2293487A1
Authority
CA
Canada
Prior art keywords
container
housing
dispenser
indexing mechanism
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002293487A
Other languages
French (fr)
Other versions
CA2293487C (en
Inventor
Peter John Brand
James William Godfrey
Paul Kenneth Rand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Limited
Peter John Brand
James William Godfrey
Paul Kenneth Rand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9711889.7A external-priority patent/GB9711889D0/en
Priority claimed from GBGB9721875.4A external-priority patent/GB9721875D0/en
Application filed by Glaxo Group Limited, Peter John Brand, James William Godfrey, Paul Kenneth Rand filed Critical Glaxo Group Limited
Publication of CA2293487A1 publication Critical patent/CA2293487A1/en
Application granted granted Critical
Publication of CA2293487C publication Critical patent/CA2293487C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0076—Mechanical counters having a display or indicator on a drum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered

Abstract

There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5); a container (2), locatable within said housing (1), having an outlet (3), wherein said container (2) dispenses through said outlet (3) in response to movement of the container (2), relative to the housing (1);
and an actuation indicator having an indexing mechanism (13, 43) actuatable by movement of the container (2) relative to the housing (1). A couple mechanism (13, 43) is provided which couples the indexing mechanism (13, 43) to the container (2) to compensate for any variation in pre-actuation positionings of the indexing mechanism and container.
CA002293487A 1997-06-10 1998-06-08 Dispenser with doses counter Expired - Lifetime CA2293487C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9711889.7A GB9711889D0 (en) 1997-06-10 1997-06-10 Aerosol dispenser
GB9711889.7 1997-06-10
GBGB9721875.4A GB9721875D0 (en) 1997-10-16 1997-10-16 Aerosol dispenser
GB9721875.4 1997-10-16
PCT/EP1998/003379 WO1998056446A1 (en) 1997-06-10 1998-06-08 Dispenser with doses' counter

Publications (2)

Publication Number Publication Date
CA2293487A1 true CA2293487A1 (en) 1998-12-17
CA2293487C CA2293487C (en) 2005-12-13

Family

ID=26311681

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002293488A Expired - Lifetime CA2293488C (en) 1997-06-10 1998-06-08 Dispenser with doses counter
CA2293484A Expired - Lifetime CA2293484C (en) 1997-06-10 1998-06-08 Dispenser with doses counter
CA002293487A Expired - Lifetime CA2293487C (en) 1997-06-10 1998-06-08 Dispenser with doses counter

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002293488A Expired - Lifetime CA2293488C (en) 1997-06-10 1998-06-08 Dispenser with doses counter
CA2293484A Expired - Lifetime CA2293484C (en) 1997-06-10 1998-06-08 Dispenser with doses counter

Country Status (35)

Country Link
US (6) US6431168B1 (en)
EP (5) EP1475116A3 (en)
JP (3) JP3487867B2 (en)
KR (1) KR100493837B1 (en)
CN (1) CN1150038C (en)
AP (1) AP1126A (en)
AR (1) AR012939A1 (en)
AT (4) ATE215389T1 (en)
AU (3) AU742913B2 (en)
BR (3) BR9809980A (en)
CA (3) CA2293488C (en)
CO (1) CO4830464A1 (en)
DE (4) DE69826039T2 (en)
DK (3) DK1163922T3 (en)
EA (1) EA001396B1 (en)
EG (1) EG21520A (en)
ES (4) ES2249834T3 (en)
HK (1) HK1023956A1 (en)
HR (1) HRP980304B1 (en)
HU (1) HU228280B1 (en)
ID (1) ID24128A (en)
IL (1) IL133219A (en)
IN (1) IN192609B (en)
IS (1) IS2177B (en)
MA (1) MA24562A1 (en)
MY (1) MY124574A (en)
NO (1) NO331497B1 (en)
NZ (1) NZ501379A (en)
PE (1) PE99099A1 (en)
PL (1) PL188988B1 (en)
PT (3) PT986412E (en)
RS (1) RS49632B (en)
TR (1) TR199903066T2 (en)
TW (1) TW533865U (en)
WO (3) WO1998056444A1 (en)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
EP1047467B1 (en) * 1998-01-16 2004-06-23 1263152 Ontario Inc. Indicating device for use with a dispensing device
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6729330B2 (en) 1998-05-05 2004-05-04 Trudell Medical International Indicating device for aerosol container
US7436511B2 (en) * 1999-01-22 2008-10-14 Sensys Medical, Inc. Analyte filter method and apparatus
GB2348928B (en) 1999-04-07 2001-10-31 Bespak Plc Improvements in or relating to dispensing apparatus
GB9917892D0 (en) 1999-07-31 1999-09-29 Glaxo Group Ltd Marking method
GB9918626D0 (en) 1999-08-07 1999-10-13 Glaxo Group Ltd Valve
CN1144744C (en) 1999-10-16 2004-04-07 葛兰素集团有限公司 Device housing for aerosol container
GB2360218A (en) * 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US6871849B2 (en) * 2000-03-27 2005-03-29 Heidelberger Druckcmaschinen Ag Delivery for a sheet-processing machine, especially a rotary printing machine
GB2364649A (en) * 2000-05-17 2002-02-06 Orion Corp Inhaler with Dose Counter
PE20020075A1 (en) * 2000-06-23 2002-02-05 Norton Healthcare Ltd DOSE COUNTER DEVICE FOR MEDICATION INHALER
EP1357965B1 (en) * 2001-01-25 2014-09-24 Clinical Designs Limited Dispenser for medicament
GB2372542B (en) * 2001-02-23 2003-08-20 Bespak Plc Dosage counting devices
GB2385640B (en) * 2001-02-23 2003-10-15 Bespak Plc Dosage counting devices
US6613010B2 (en) * 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US6745760B2 (en) 2001-05-15 2004-06-08 Trudell Medical International Medicament applicator
TWI324934B (en) * 2001-08-28 2010-05-21 Schering Corp Pharmaceutical compositions for the treatment of asthma
US7004164B2 (en) * 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
AU2003212529B2 (en) 2002-03-22 2008-07-10 Clinical Designs Limited Can fixture
EP1369139A1 (en) 2002-06-03 2003-12-10 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
GB0212896D0 (en) * 2002-06-05 2002-07-17 Trumeter Company Ltd Counter
WO2004001664A1 (en) 2002-06-21 2003-12-31 Glaxo Group Limited Actuation indicator for a dispensing device
GB0216831D0 (en) * 2002-07-19 2002-08-28 Glaxo Group Ltd Medicament dispenser
US6857427B2 (en) * 2002-09-04 2005-02-22 Ric Investments, Inc. Interactive character for use with an aerosol medication delivery system
FR2846308B1 (en) * 2002-10-28 2006-02-10 Valois Sas FLUID PRODUCT DISPENSING DEVICE WITH DOSE INDICATOR
FR2846453B1 (en) * 2002-10-28 2005-01-28 Valois Sas ELECTRONIC DISPLAY DEVICE AND FLUID PRODUCT DELIVERY DEVICE HAVING SUCH A DISPLAY DEVICE
EP1585561A2 (en) * 2002-10-30 2005-10-19 Glaxo Group Limited Tubular nozzles for use in systems for delivering medicaments
US7575003B2 (en) * 2002-11-04 2009-08-18 Bang & Olufsen Medicom A/S Device for dispension
GB0226021D0 (en) 2002-11-07 2002-12-18 Corporate Intellectual Propert A container
GB0226020D0 (en) 2002-11-07 2002-12-18 Glaxo Group Ltd A holder
GB0226022D0 (en) * 2002-11-07 2002-12-18 Corporate Intellectual Propert Device
US6979668B2 (en) * 2002-12-16 2005-12-27 Generex Pharmaceuticals Incorporated Cleaning compound for and method of cleaning valves and actuators of metered dose dispensers containing pharmaceutical compositions
AU2003293361A1 (en) * 2002-12-18 2004-07-29 Glaxo Group Limited Drug delivery system with vented mouthpiece
GB0301366D0 (en) 2003-01-21 2003-02-19 Glaxo Group Ltd A fixation device
GB0302812D0 (en) * 2003-02-07 2003-03-12 Wickham Mark D Metering valves for dispensers
GB0304000D0 (en) * 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
JP4805814B2 (en) * 2003-03-04 2011-11-02 ノートン・ヘルスケアー リミテッド Medicine dispensing device having a display indicating the state of the internal medicine reservoir
DE10319646B3 (en) * 2003-05-02 2004-09-02 Hilti Ag Drive medium container for setting device, has data memory identification unit on the container in which drive medium level data can be stored and from which the data can be read out
FR2854878B1 (en) 2003-05-15 2006-03-31 Valois Sas FLUID PRODUCT DISPENSER.
US7703454B2 (en) * 2003-07-14 2010-04-27 Vortran Medical Technology Inhaler with breath actuated dose counter
US7600512B2 (en) * 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
US20050028815A1 (en) * 2003-07-23 2005-02-10 Deaton Daniel M. Apparatus for electronic dosage counter
GB0321296D0 (en) * 2003-09-11 2003-10-15 Trumeter Company Ltd Counting device
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
JP2007509941A (en) * 2003-10-28 2007-04-19 グラクソ　グループ　リミテッド Inhalation pharmaceutical preparation using lactose anhydride and its administration method
GB0327112D0 (en) 2003-11-21 2003-12-24 Clincial Designs Ltd Dispenser and reservoir
GB0328635D0 (en) 2003-12-10 2004-01-14 3M Innovative Properties Co Dose counter for dispensers
GB0328502D0 (en) 2003-12-10 2004-01-14 3M Innovative Properties Co Metered dose dispensers and assemblies therefor
GB0328859D0 (en) 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
US7100530B2 (en) * 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
EP1730676B1 (en) * 2004-02-16 2013-08-28 Glaxo Group Limited Counter for use with a medicament dispenser
DE102004050468A1 (en) * 2004-03-08 2005-09-29 Friedrich Sanner Gmbh & Co Kg Spritzgusswerk Spray device for dosed delivery of pharmaceutically active substances comprises an observation window and a counting device with a rotatable ring indicating the number of tank activation strokes made
PL1725285T3 (en) 2004-03-10 2020-03-31 Glaxo Group Limited A dispensing device with restricting member
FR2871450B1 (en) * 2004-06-14 2006-09-22 Valois Sas DEVICE FOR DISPENSING FLUID PRODUCT
SE0401773D0 (en) 2004-07-02 2004-07-02 Astrazeneca Ab An inhalation and a method for assessing said inhalation device
SE0401787D0 (en) * 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device counter
SE0401786D0 (en) 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device
GB0416801D0 (en) * 2004-07-28 2004-09-01 Reckitt Benckiser Uk Ltd Apparatus and method of using the same
GB2417024B (en) * 2004-08-11 2007-01-03 Bespak Plc Improvements in metering valves for dispensers
WO2006027333A1 (en) * 2004-09-04 2006-03-16 Alfred Von Schuckmann Inhaler device
DE102005036197B4 (en) * 2004-09-04 2013-12-24 Alfred Von Schuckmann Inhale device
US7543582B2 (en) 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
DE102005033398A1 (en) 2004-11-10 2006-05-11 Alfred Von Schuckmann Inhale device
GB0425518D0 (en) * 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
FR2879574B1 (en) * 2004-12-17 2011-01-21 Valois Sas DEVICE FOR DISPENSING FLUID PRODUCT.
GB0428204D0 (en) 2004-12-23 2005-01-26 Clinical Designs Ltd Medicament container
US7743945B2 (en) 2005-01-20 2010-06-29 Trudell Medical International Dispensing device
CN101155590A (en) 2005-02-10 2008-04-02 葛兰素集团有限公司 Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
EP1858528A2 (en) * 2005-02-10 2007-11-28 Glaxo Group Limited Process for crystallizing lactose particles for use in pharmaceutical formulations
FR2883400B1 (en) * 2005-03-16 2007-06-15 Valois Sas DOSAGE INDICATING DEVICE FOR DISPENSING FLUID OR PULVERULENT PRODUCTS
TWI442951B (en) * 2005-04-14 2014-07-01 Astrazeneca Ab Inhaler counter
CA2607743A1 (en) * 2005-05-12 2006-11-23 Kos Life Sciences, Inc. Dose counter for metered dose inhalers
ES2397096T3 (en) 2005-08-24 2013-03-04 Boehringer Ingelheim International Gmbh Atomizer comprising a counter and an end of a drive lock
JP5295769B2 (en) * 2005-08-31 2013-09-18 ティツー・バイオシステムズ・インコーポレーテッド NMR apparatus for detecting analytes
GB0518400D0 (en) 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
US20070099883A1 (en) * 2005-10-07 2007-05-03 Cheryl Lynn Calis Anhydrous mometasone furoate formulation
GB2434753B (en) * 2005-11-22 2008-03-12 Bespak Plc Aerosol dispensing apparatus
EP1792660A1 (en) * 2005-12-02 2007-06-06 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
GB0602049D0 (en) * 2006-02-01 2006-03-15 Trumeter Company Ltd Inhaler
GB0605150D0 (en) 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
CA2649509A1 (en) 2006-04-20 2007-11-01 Glaxo Group Limited Novel compounds
WO2007124406A2 (en) 2006-04-21 2007-11-01 3M Innovative Properties Company Dose counter
GB2448838B (en) 2006-05-26 2009-02-11 Consort Medical Plc Improvements in or relating to dispensing apparatus
GB0610541D0 (en) * 2006-05-26 2006-07-05 Bespak Plc Improvements in or relating to dispensing apparatus
GB0611587D0 (en) 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
US20070295329A1 (en) * 2006-06-13 2007-12-27 Lieberman Eric A Dose indicator
US8141550B2 (en) 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
WO2008067254A2 (en) * 2006-11-27 2008-06-05 Abbott Respiratory Llc Nasal drug delivery device and method
JP4828403B2 (en) * 2006-12-28 2011-11-30 株式会社吉野工業所 Drug release device
GB2448112B (en) * 2007-01-16 2011-08-17 Bespak Plc Improvements in or relating to dispensing apparatus
US7836880B2 (en) * 2007-01-17 2010-11-23 Kevin Innocenzi Pressurized metered dose inhaler system
US20080210231A1 (en) * 2007-01-31 2008-09-04 Abbott Laboratories Metered dose inhaler cleaning method and apparatus
GB0706405D0 (en) * 2007-04-02 2007-05-09 3M Innovative Properties Co Dose counter
DE102007045438B4 (en) * 2007-09-22 2016-09-01 Boehringer Ingelheim International Gmbh Inhale device
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
JP5088795B2 (en) * 2008-05-30 2012-12-05 株式会社吉野工業所 Liquid ejector
JP5502858B2 (en) 2008-06-05 2014-05-28 グラクソ グループ リミテッド 4-Carboxamide indazole derivatives useful as inhibitors of PI3 kinase
JP2011527602A (en) * 2008-07-11 2011-11-04 マップ ファーマシューティカルズ， インコーポレイテッド Container for aerosol drug delivery
DE102008044770A1 (en) * 2008-08-28 2010-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Drive unit for dose counter
US20100139653A1 (en) * 2008-10-01 2010-06-10 Judy Schloss Ventilator interface
ES2402241T3 (en) 2008-10-22 2013-04-30 Trudell Medical International Modular Spray Supply System
NZ574666A (en) * 2009-02-05 2009-04-30 Nexus6 Ltd A medicament inhaler holder that uses optical means to count and display the number of doses used
JP5656880B2 (en) 2009-03-09 2015-01-21 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 4-oxadiazol-2-yl-indazole as an inhibitor of PI3 kinase
GB0904059D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
EP2406249A1 (en) 2009-03-10 2012-01-18 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
JP2012520845A (en) 2009-03-17 2012-09-10 グラクソ グループ リミテッド Pyrimidine derivatives used as Itk inhibitors
CA2755773A1 (en) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of btb and cnc homology 1, basic leucine zipper transcription factor 1 (bach 1) gene expression using short interfering nucleic acid (sina)
WO2010107952A2 (en) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20120035247A1 (en) 2009-03-19 2012-02-09 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
JP2012520685A (en) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of GATA binding protein 3 (GATA3) gene expression using small interfering nucleic acids (siNA)
EP2411520A2 (en) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2010111468A2 (en) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
EA201171175A1 (en) 2009-03-27 2012-05-30 Мерк Шарп Энд Домэ Корп. PHK-MEDIATED INTERFERENCE INHIBITING EXPRESSION OF A CELL INTERCEPTIVE ADHESION MOLECULE 1 (ICAM-1) WITH USING A SHORT INTERFERATING NUCLEINIC ACID (IC) -1
US20120022142A1 (en) 2009-03-27 2012-01-26 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
JP2012521760A (en) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of apoptosis signal-regulated kinase 1 (ASK1) gene expression using small interfering nucleic acids (siNA)
PL2239003T3 (en) 2009-03-30 2015-04-30 Arven Ilac Sanayi Ve Ticaret As A counter for a dry powder inhaler device
AU2010243613B2 (en) 2009-04-30 2015-05-07 Glaxo Group Limited Oxazole substituted indazoles as PI3-kinase inhibitors
KR101740209B1 (en) * 2009-05-27 2017-05-25 이노 테라퓨틱스 엘엘씨 Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery
AU2013224758B2 (en) * 2009-07-30 2016-05-12 Ivax International B.V. Dose counter for a metered-dose inhaler
CA2769249C (en) * 2009-07-30 2014-11-18 Ivax International B.V. Dose counter for a metered-dose inhaler
US9216261B2 (en) 2009-07-30 2015-12-22 Ivax International B.V. Dose counter for a metered-dose inhaler
US8539945B2 (en) 2009-08-18 2013-09-24 Teva Pharmaceutical Industries Ltd. Dose counter and recording method
GB2473070B (en) 2009-09-01 2011-09-28 Consort Medical Plc Dispensing apparatus
GB0920499D0 (en) 2009-11-23 2010-01-06 3M Innovative Properties Co Dose counter
US20120238559A1 (en) 2009-12-03 2012-09-20 Glaxo Group Limited Novel compounds
JP2013512880A (en) 2009-12-03 2013-04-18 グラクソ グループ リミテッド Indazole derivatives as PI3-kinase inhibitors
EP2507223A1 (en) 2009-12-03 2012-10-10 Glaxo Group Limited Benzpyrazole derivatives as inhibitors of p13 kinases
GB0921555D0 (en) 2009-12-09 2010-01-27 3M Innovative Properties Co Dose indicator
WO2011110575A1 (en) 2010-03-11 2011-09-15 Glaxo Group Limited Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases
EA026245B1 (en) 2010-05-18 2017-03-31 Ивакс Фармасьютикалз Аэрлэнд Inhaler for inhalation of a medicinal substance and inhaler assembly method
US9326987B2 (en) 2010-09-08 2016-05-03 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
JP5965402B2 (en) 2010-09-08 2016-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ N- [5- [4- (5-{[(2R, 6S) -2,6-dimethyl-4-morpholinyl] methyl} -1,3-oxazol-2-yl) -1H-indazol-6-yl ] -2- (Methyloxy) -3-pyridinyl] methanesulfonamide polymorphs and salts
WO2012035055A1 (en) 2010-09-17 2012-03-22 Glaxo Group Limited Novel compounds
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
KR101904074B1 (en) 2011-05-04 2018-10-04 시플라 리미티드 A dose counter
NZ595367A (en) 2011-09-23 2012-02-24 Nexus6 Ltd A dose counting mechanism adapted to enclose a medicament delivery device
GB201118845D0 (en) 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser
RU2014128386A (en) 2012-02-06 2016-03-27 ГлаксоСмитКлайн Интеллекчуал Проперти (N 2) Лимитед PI3K Cough Inhibitors
EP2877467B1 (en) 2012-07-26 2016-11-02 Glaxo Group Limited 2-(azaindol-2-yl)benzimidazoles as pad4 inhibitors
US9872964B2 (en) 2012-08-22 2018-01-23 Presspart Gmbh & Co. Kg Metered dose inhaler counter and metered-dose inhaler including such a counter
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
WO2014083026A1 (en) 2012-11-30 2014-06-05 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
US8807131B1 (en) 2013-06-18 2014-08-19 Isonea Limited Compliance monitoring for asthma inhalers
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
EP3046921A4 (en) 2013-09-22 2017-02-22 Calitor Sciences, LLC Substituted aminopyrimidine compounds and methods of use
EP3057587A1 (en) 2013-10-17 2016-08-24 GlaxoSmithKline Intellectual Property Development Limited Pi3k inhibitor for treatment of respiratory disease
WO2015055691A1 (en) 2013-10-17 2015-04-23 Glaxosmithkline Intellectual Property Development Limited Pi3k inhibitor for treatment of respiratory disease
EP3139984B1 (en) * 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Nebulizer
WO2015169732A1 (en) * 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Container, nebulizer and use
WO2016059645A1 (en) * 2014-10-14 2016-04-21 Cadila Healthcare Limited A dose counter
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
WO2016159889A1 (en) 2015-04-02 2016-10-06 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
WO2016185279A1 (en) 2015-05-21 2016-11-24 Glaxosmithkline Intellectual Property Development Limited Benzoimidazole derivatives as pad4 inhibitors
ES2745552T3 (en) 2015-07-20 2020-03-02 Pearl Therapeutics Inc Aerosol delivery systems
US20210315915A1 (en) 2015-11-18 2021-10-14 Glaxosmithkline Intellectual Property (No.2) Limited Pharmaceutical compositions of ribavirin
JP2019512208A (en) 2016-01-21 2019-05-16 ティー２ バイオシステムズ，インコーポレーテッド NMR method and system for detecting bacteria quickly
GB201602527D0 (en) 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
GB201610450D0 (en) 2016-06-15 2016-07-27 Tech Partnership The Plc Counting mechanism
WO2018029126A1 (en) 2016-08-08 2018-02-15 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
EP3300753B1 (en) 2016-09-30 2018-12-12 Presspart Gmbh & Co. Kg Metered dose inhaler for dispensing aerosol doses
GB201706102D0 (en) 2017-04-18 2017-05-31 Glaxosmithkline Ip Dev Ltd Chemical compounds
GB201712081D0 (en) 2017-07-27 2017-09-13 Glaxosmithkline Ip Dev Ltd Chemical compounds
MX2020007521A (en) 2018-01-17 2022-12-05 Glaxosmithkline Ip Dev Ltd Pi4kiiibeta inhibitors.
WO2019143874A1 (en) 2018-01-20 2019-07-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
US11291182B2 (en) * 2018-02-05 2022-04-05 Nexfeed LLP Device for facilitating and tracking the feeding of an animal
EP3790611A1 (en) * 2018-05-11 2021-03-17 Biocorp Production S.A. Handheld metered dose inhaler
CN111977192B (en) * 2020-09-14 2022-01-07 孟庆萍 Pill quantitative pouring device
US11142391B1 (en) * 2020-10-15 2021-10-12 Ac Avalanche Llc Dispenser for pressurized canister
WO2022179967A1 (en) 2021-02-23 2022-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Vadadustat for treating covid-19 in a hospitalized subject
KR20240003479A (en) * 2022-07-01 2024-01-09 주식회사 케이티앤지 Inhaler
CN117205413B (en) * 2023-11-07 2024-02-13 正大天晴(广州)医药有限公司 Dose indicator

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB893717A (en) 1960-02-23 1962-04-11 Syncro Mist Controls Inc Fluid control valve actuator device
US3119557A (en) * 1961-10-05 1964-01-28 United States Steel Corp Counter operator for pressurized paint can
US3212718A (en) 1964-04-23 1965-10-19 Edward H Green Indicating plate for spray canisters
CH444761A (en) * 1965-12-10 1968-02-29 Ebauches Sa Magnetic drive device for watchmaking
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3487886A (en) 1967-07-20 1970-01-06 Joseph Sunnen Means for indicating the remaining contents of a container
NL7003794A (en) 1969-03-20 1970-09-22
DE1954623B2 (en) 1969-10-30 1973-02-15 Siemens AG, 1000 Berlin u 8000 München DIGITAL PLACERS USING MAGNETIC FIELD-DEPENDENT RESISTORS
GB1317315A (en) 1970-12-17 1973-05-16 English Numbering Machines Mechanical impulse counter
US3722461A (en) * 1972-07-07 1973-03-27 Sutra Import Corp Scoring counter
GB1392945A (en) 1972-08-23 1975-05-07 Fisons Ltd Inhalation device
US3822808A (en) * 1973-03-20 1974-07-09 Tokico Ltd Fuel supplying apparatus having a reversible plate type flow indicator
US4037719A (en) * 1976-06-01 1977-07-26 Alan Perlmutter Cigarette counting case
US4106503A (en) 1977-03-11 1978-08-15 Richard R. Rosenthal Metering system for stimulating bronchial spasm
DE2725876C2 (en) * 1977-06-08 1982-11-25 J. Hengstler Kg, 7209 Aldingen Rewinding device with film frame counter
DE2735117A1 (en) 1977-08-04 1979-02-15 Hengstler Kg PLUG-IN DEVICE
US4160900A (en) 1978-01-11 1979-07-10 General Motors Corporation Mileage switch and latch means
DE7817128U1 (en) 1978-06-08 1978-09-21 J. Hengstler Kg, 7209 Aldingen KEY RESET DEVICE WITH RESET RAKE
DE2827315C2 (en) 1978-06-22 1985-01-17 J. Hengstler Kg, 7209 Aldingen Setting device for preset counters that can be reset to rotate
DE2828907C2 (en) 1978-06-30 1982-03-25 J. Hengstler Kg, 7209 Aldingen Preselectable setting counter with stationary setting roller mechanism and a signaling device acting axially via cams
US4311050A (en) * 1979-08-27 1982-01-19 Bessman Samuel P Reservoir for medicaments
GB2063075B (en) 1979-11-07 1983-11-09 Sterwin Ag Dose indicator for inhalers
DE3047491A1 (en) 1980-12-17 1982-07-15 J. Hengstler Kg, 7209 Aldingen Presettable counter with mechanical drive - has damage prevention with combination adjustment wheels acted upon by external latches
AT377110B (en) 1981-10-29 1985-02-11 Mattig Kg Anton ELECTROMECHANICAL COUNTER
GB2114790A (en) 1981-12-18 1983-08-24 Trumeter Company Limited Bi-directional prescaling counter
DE3203137C2 (en) * 1982-01-30 1986-05-22 J. Hengstler Kg, 7209 Aldingen Zero setting device for a roller counter
DE3244836C2 (en) 1982-12-03 1984-09-27 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Inhalation device with a metering device for inhalants
DE3302160A1 (en) * 1983-01-22 1984-07-26 Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell OPERATING DOSING DEVICE
US4495944A (en) * 1983-02-07 1985-01-29 Trutek Research, Inc. Inhalation therapy apparatus
JPS6029886A (en) * 1983-07-29 1985-02-15 Dai Ichi Seiko Co Ltd Zero resetting type counter
GB8323199D0 (en) 1983-08-30 1983-09-28 Dearing Lambert P R Container for medicines
ES277095Y (en) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. SUPPLIER-DISPENSER OF INJECTABLE PRODUCTS
DE3405352A1 (en) 1984-02-15 1985-08-22 Paul Dr.med. 4300 Essen Behrendt Device for the application of paste-like substances, especially of pharmaceuticals or cosmetics
SE8401796D0 (en) 1984-04-02 1984-04-02 Draco Ab dosing device
FI76929C (en) 1984-09-25 1989-01-10 Etelae Haemeen Keuhkovammayhdi Inhalation dosing device intended for accurate dosing of disposable drugs given for respiratory illness in the examination stage and / or drugs given as a spray during treatment.
DK481884D0 (en) * 1984-10-09 1984-10-09 Karl Holm MEDICAL ORAL OR SWALLOW SPRAY APPLIANCES
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
GB2170780A (en) 1985-02-09 1986-08-13 Trumeter Company Limited Dispensing device having counting mechanism
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
DE3511870C1 (en) 1985-04-01 1986-06-26 J. Hengstler Kg, 7209 Aldingen Pulse counters as electromechanical counters with voice coil drives
EP0220132B1 (en) 1985-10-24 1991-03-06 Sandoz Ag Time delayed total-release aerosol dispensers
DE3545703C1 (en) 1985-12-21 1987-05-14 Hengstler Kg Zero or reset device for roller counters
DE8602238U1 (en) * 1986-01-29 1986-04-10 Josef Wischerath GmbH & Co KG, 5000 Köln Mouth pipe with a spray head for dispensing a medium to be inhaled from a spray can
US4809692A (en) * 1986-01-31 1989-03-07 Trudell Medical Pediatric asthmatic medication inhaler
SE8601351D0 (en) * 1986-03-24 1986-03-24 Nilsson Sven Erik MANAGED ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBJECTS
US4705811A (en) * 1986-04-07 1987-11-10 The Dow Chemical Company Expandable polymeric composition and method
AU598250B2 (en) 1986-04-25 1990-06-21 Glaxo Group Limited Indicating device
GB8612886D0 (en) 1986-05-28 1986-07-02 Gocman B Pressurised inhaler alarm
GB2195544A (en) 1986-08-04 1988-04-13 Universal Precision Moulders L Inhaler
FR2606506B1 (en) 1986-11-06 1992-12-31 Valois MEASURING VAPORIZER DEVICE PROVIDED WITH A MEANS FOR COUNTING EMITTED DOSES
GB2199308A (en) 1987-01-02 1988-07-06 John Burdon Timed drug package dispenser
DE3705962A1 (en) * 1987-02-25 1988-09-08 Hengstler Gmbh MECHANICAL ROLL COUNTER
DK166948B1 (en) 1988-02-10 1993-08-09 Dcp Af 1988 As DOSING UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A FLUID, SUCH AS INSULIN, FROM A GLASS STUBLE
DE8805055U1 (en) * 1988-04-16 1988-06-09 Hengstler Gmbh, 7209 Aldingen, De
DE3827639A1 (en) * 1988-08-16 1990-02-22 Basf Ag CATALYST FOR THE OXIDATION AND AMMONOXIDATION OF (ALPHA), SS-UNSATURATED HYDROCARBONS
DE3828463A1 (en) * 1988-08-22 1990-03-01 Vdo Schindling DEVICE FOR ADJUSTING A RESETTABLE COUNTER
IE62780B1 (en) * 1988-09-10 1995-02-22 Fisons Plc Inhalation devices with a reduced risk of blockage
US5148355A (en) * 1988-12-24 1992-09-15 Technology Applications Company Limited Method for making printed circuits
US5718355A (en) 1989-02-03 1998-02-17 Senetics, Inc. Indicator device responsive to axial force for use with inhaler
US5009338A (en) * 1989-02-03 1991-04-23 Senetics Corporation Indicator cap for a medicine bottle
US5242067A (en) * 1989-02-03 1993-09-07 Senetics, Inc. Adaptor for indicator device
US5261548A (en) * 1989-02-03 1993-11-16 Senetics, Inc. Indicator cap for use with threaded or bayonet lug container
NZ244576A (en) * 1989-02-08 1994-11-25 Becton Dickinson Co Syringe barrel with contrast band opposite indicia to improve readability
SE466684B (en) 1989-03-07 1992-03-23 Draco Ab DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION
US4955371A (en) * 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
GB8919131D0 (en) 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
US5042467A (en) * 1990-03-28 1991-08-27 Trudell Medical Medication inhaler with fitting having a sonic signalling device
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
DE4027669A1 (en) * 1990-08-31 1992-03-05 Pfeiffer Erich Gmbh & Co Kg DISCHARGE DEVICE FOR MEDIA
DE4027670A1 (en) * 1990-08-31 1992-03-05 Pfeiffer Erich Gmbh & Co Kg DISCHARGE DEVICE FOR MEDIA
DE59107710D1 (en) * 1990-08-31 1996-05-30 Pfeiffer Erich Gmbh & Co Kg Discharge device for media
JPH0450059U (en) * 1990-09-05 1992-04-27
IT1243820B (en) 1990-10-09 1994-06-28 Elettro Plastica Spa CONTADOSI DEVICE FOR DISPENSING DOSES OF FLUID PRODUCT, PARTICULARLY FOR PHARMACEUTICAL USE
GB9025654D0 (en) * 1990-11-26 1991-01-09 Riker Laboratories Inc Device
WO1994016759A1 (en) * 1991-03-05 1994-08-04 Miris Medical Corporation An automatic aerosol medication delivery system and methods
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
WO1992017231A1 (en) * 1991-03-28 1992-10-15 Innomed, Inc. Microelectronic inhaler having a counter and timer
JP3230056B2 (en) * 1991-07-02 2001-11-19 インヘイル・インコーポレーテッド Device for forming an aerosolized dose of a drug
IT222834Z2 (en) 1991-07-23 1995-05-08 Sandoz Prodotti Farmaceutici S BUTTON-TYPE DOSING DEVICE WITH STROKE NUMBER COUNTER
US5328486A (en) 1991-11-19 1994-07-12 American Cyanamid Company Syringe for dispensing multiple dosages
GB2262452B (en) 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
GB2263068B (en) 1991-12-19 1996-05-01 Minnesota Mining & Mfg Inhalation device
US5363842A (en) * 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5300042A (en) * 1992-03-02 1994-04-05 Kossoff-Sukel, Inc. Medication dispensing apparatus
GB9205823D0 (en) 1992-03-18 1992-04-29 Heywood Roy V Medicine containers
GB9211436D0 (en) 1992-05-29 1992-07-15 Norton Healthcare Ltd Dose indicating device
US5284133A (en) * 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5358117A (en) * 1992-08-25 1994-10-25 James Adams Medicine container cap with time indicator
US5279422A (en) * 1992-08-25 1994-01-18 Adams James E Medicine container cap with time indicator
JPH0626891U (en) * 1992-09-09 1994-04-12 株式会社ラジカルスタッフ Inhaler counter display
US5259499A (en) * 1992-12-10 1993-11-09 St. Francis Research Institute System and apparatus for accurate drug inventory control
EP0674533B1 (en) * 1992-12-18 1999-03-10 Schering Corporation Inhaler for powdered medications
US6012450A (en) * 1993-01-29 2000-01-11 Aradigm Corporation Intrapulmonary delivery of hematopoietic drug
US5433343A (en) 1993-07-30 1995-07-18 Meshberg; Philip Delivery system for measured quantities of liquids, especially medications
US5505192A (en) 1993-11-12 1996-04-09 New-Med Corporation Dispenser monitoring system
DE4422710C1 (en) * 1994-06-29 1995-09-14 Boehringer Ingelheim Kg Inhaler with storage container for aerosol
US5411173A (en) * 1993-12-17 1995-05-02 Weinstein; Albert Counter attachment for product dispensers
US5564414A (en) 1994-05-26 1996-10-15 Walker; William F. Pressurized and metered medication dose counter on removable sleeve
FR2721106B1 (en) * 1994-06-10 1996-09-13 Step Dose counter for inhalers.
US5482030A (en) 1994-06-13 1996-01-09 Klein; David Aerosol and non-aerosol spray counter
US5464970A (en) * 1994-06-16 1995-11-07 Delco Electronics Corporation Multiple counter assembly
US5817822A (en) 1994-06-24 1998-10-06 Novartis Corporation Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
US5645534A (en) 1994-06-24 1997-07-08 Becton Dickinson And Company Time of last injection indicator for medication delivery pen
SE9404140D0 (en) * 1994-11-29 1994-11-29 Astra Ab Dose indicating device
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US5772074A (en) * 1995-03-31 1998-06-30 Waterbury Companies, Inc. Device and method for indicating the dispensing of a predetermined amount of a material
EP1870122A3 (en) * 1995-04-14 2008-03-12 SmithKline Beecham Corporation Metered dose inhaler
US6029659A (en) * 1995-04-17 2000-02-29 Solar Shield Corporation Inhalation device with counter
US5809997A (en) * 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US5625659A (en) * 1995-05-19 1997-04-29 Gojo Industries, Inc. Method and apparatus for electronically measuring dispenser usage
US6139669A (en) * 1995-06-07 2000-10-31 Super Sack Mfg. Corp. Anti-microbial shoe linings, sock liners and socks and process for manufacture of same
US5826571A (en) 1995-06-08 1998-10-27 Innovative Devices, Llc Device for use with metered dose inhalers (MDIS)
DE19549033C1 (en) * 1995-12-28 1997-05-28 Boehringer Ingelheim Int Mechanical counter for a dosing device
US5676129A (en) * 1996-03-14 1997-10-14 Oneida Research Services, Inc. Dosage counter for metered dose inhaler (MDI) systems using a miniature pressure sensor
FR2750780B1 (en) 1996-07-05 1998-10-30 Valois DOSER COUNTER
US5816228A (en) * 1997-02-19 1998-10-06 Avl Powertrain Engineering, Inc. Fuel injection system for clean low viscosity fuels
US5794612A (en) * 1997-04-02 1998-08-18 Aeromax Technologies, Inc. MDI device with ultrasound sensor to detect aerosol dispensing
US5871007A (en) * 1997-06-09 1999-02-16 Chase Marketing International L.L.C. Throat spray counting mechanism
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
US6327037B1 (en) * 1997-11-12 2001-12-04 Chien Chou Optical rotation angle polarimeter
US6142339A (en) 1998-01-16 2000-11-07 1263152 Ontario Inc. Aerosol dispensing device
EP1047467B1 (en) * 1998-01-16 2004-06-23 1263152 Ontario Inc. Indicating device for use with a dispensing device
US5924303A (en) * 1998-03-09 1999-07-20 California Innovations Inc. Insulated soft-sided portable case having externally accessible receptacle
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6336453B1 (en) * 1999-04-30 2002-01-08 Trudell Medical International Indicating device for aerosol container
US6729330B2 (en) * 1998-05-05 2004-05-04 Trudell Medical International Indicating device for aerosol container
US6260549B1 (en) * 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6223744B1 (en) * 1999-03-16 2001-05-01 Multi-Vet Ltd. Wearable aerosol delivery apparatus
US6202642B1 (en) * 1999-04-23 2001-03-20 Medtrac Technologies, Inc. Electronic monitoring medication apparatus and method
US6234166B1 (en) * 1999-06-30 2001-05-22 Acktar Ltd. Absorber-reflector for solar heating
US6565743B1 (en) * 1999-08-31 2003-05-20 Kimberly-Clark Worldwide, Inc. Portable purification container with cumulative use indicator
US6516799B1 (en) * 1999-09-08 2003-02-11 Sapphire Design, Inc. Inhalation counter device
FR2799858B1 (en) * 1999-10-19 2002-01-18 Valois Sa DOSAGE COUNTER AND FLUID PRODUCT DISPENSER INCORPORATING SUCH A COUNTER
FR2817847B1 (en) 2000-12-08 2003-03-28 Tebro DEVICE FOR DISPENSING FLUID OR POWDERY PRODUCT
DE10063013B4 (en) * 2000-12-16 2011-06-30 Dr. Johannes Heidenhain GmbH, 83301 Angle measuring device
WO2004001664A1 (en) * 2002-06-21 2003-12-31 Glaxo Group Limited Actuation indicator for a dispensing device

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HUP0003328A3 (en) 2001-04-28
BR9809554A (en) 2000-06-20
TW533865U (en) 2003-05-21
DE69831739D1 (en) 2005-11-03
TR199903066T2 (en) 2000-07-21
DE69831739T2 (en) 2006-04-27
EA001396B1 (en) 2001-02-26
US20030209239A1 (en) 2003-11-13
ES2227031T3 (en) 2005-04-01
ES2175737T3 (en) 2002-11-16
NO331497B1 (en) 2012-01-16
EP1163922A2 (en) 2001-12-19
IL133219A0 (en) 2001-03-19
HRP980304B1 (en) 2003-06-30
CA2293484A1 (en) 1998-12-17
AP1126A (en) 2002-12-05
EP0988077A1 (en) 2000-03-29
US8245704B2 (en) 2012-08-21
AU741693B2 (en) 2001-12-06
KR20010013630A (en) 2001-02-26
DK0986412T3 (en) 2002-07-22
US6474331B1 (en) 2002-11-05
ATE274952T1 (en) 2004-09-15
US20020195102A1 (en) 2002-12-26
US6360739B1 (en) 2002-03-26
US6431168B1 (en) 2002-08-13
EP0986412A1 (en) 2000-03-22
PT988077E (en) 2004-03-31
RS49632B (en) 2007-08-03
ID24128A (en) 2000-07-06
JP3487867B2 (en) 2004-01-19
PL337316A1 (en) 2000-08-14
KR100493837B1 (en) 2005-06-08
CA2293488A1 (en) 1998-12-17
CA2293487C (en) 2005-12-13
ATE215389T1 (en) 2002-04-15
EG21520A (en) 2001-11-28
AU742913B2 (en) 2002-01-17
AU8213898A (en) 1998-12-30
AU741218B2 (en) 2001-11-29

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