CA2294040A1 - Retentate chromatography and protein chip arrays with applications in biology and medicine - Google Patents

Retentate chromatography and protein chip arrays with applications in biology and medicine Download PDF

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Publication number
CA2294040A1
CA2294040A1 CA002294040A CA2294040A CA2294040A1 CA 2294040 A1 CA2294040 A1 CA 2294040A1 CA 002294040 A CA002294040 A CA 002294040A CA 2294040 A CA2294040 A CA 2294040A CA 2294040 A1 CA2294040 A1 CA 2294040A1
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Prior art keywords
biology
medicine
applications
retentate chromatography
protein chip
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CA002294040A
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French (fr)
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CA2294040C (en
Inventor
T. William Hutchens
Tai-Tung Yip
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Aspira Womens Health Inc
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Individual
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectively conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
CA002294040A 1997-06-20 1998-06-19 Retentate chromatography and protein chip arrays with applications in biology and medicine Expired - Fee Related CA2294040C (en)

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US5433397P 1997-06-20 1997-06-20
US60/054,333 1997-06-20
US6748497P 1997-12-01 1997-12-01
US60/067,484 1997-12-01
PCT/US1998/012843 WO1998059360A1 (en) 1997-06-20 1998-06-19 Retentate chromatography and protein chip arrays with applications in biology and medicine

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