CA2294200A1 - Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions - Google Patents

Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions Download PDF

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Publication number
CA2294200A1
CA2294200A1 CA002294200A CA2294200A CA2294200A1 CA 2294200 A1 CA2294200 A1 CA 2294200A1 CA 002294200 A CA002294200 A CA 002294200A CA 2294200 A CA2294200 A CA 2294200A CA 2294200 A1 CA2294200 A1 CA 2294200A1
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CA
Canada
Prior art keywords
compositions
membranes
antiadhesion
bioadhesive
bioresorbable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002294200A
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French (fr)
Other versions
CA2294200C (en
Inventor
Herbert E. Schwartz
John M. Blackmore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FzioMed Inc
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Individual
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Publication of CA2294200A1 publication Critical patent/CA2294200A1/en
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Publication of CA2294200C publication Critical patent/CA2294200C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Abstract

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, antiadhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides and polyethers, and to the resulting compositions. The polymers are associated with each other, and are then either dried or are used as fluids. Bioresorbable, bioadhesive, antiadhesion compositions are useful in surgery to prevent the formation of post-surgical adhesions. The compositions are designed to break down in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions.
The antiadhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes can be varied as needed by carefully adjusting the pH of the polymer casting solutions, polysaccharide composition, the polyether composition, or by conditioning the membranes prior to surgical use. Bi- or multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Antiadhesion compositions may also be used to deliver drugs to the surgical site and release them locally.
CA002294200A 1997-06-17 1998-05-28 Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions Expired - Lifetime CA2294200C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/877,649 1997-06-17
US08/877,649 US5906997A (en) 1997-06-17 1997-06-17 Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
PCT/US1998/010814 WO1998058011A1 (en) 1997-06-17 1998-05-28 Bioresorbable antiadhesion of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

Publications (2)

Publication Number Publication Date
CA2294200A1 true CA2294200A1 (en) 1998-12-23
CA2294200C CA2294200C (en) 2008-10-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294200A Expired - Lifetime CA2294200C (en) 1997-06-17 1998-05-28 Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

Country Status (9)

Country Link
US (4) US5906997A (en)
EP (1) EP1002002B1 (en)
JP (1) JP4986311B2 (en)
KR (1) KR100612975B1 (en)
AT (1) ATE376567T1 (en)
AU (1) AU754787B2 (en)
CA (1) CA2294200C (en)
DE (1) DE69838614T2 (en)
WO (1) WO1998058011A1 (en)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
EP0967227A1 (en) * 1998-06-04 1999-12-29 Mitsubishi Gas Chemical Company, Inc. Process for producing carboxypolysaccharide
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
KR20020000143A (en) 1999-02-23 2002-01-04 페어슨 메디칼 인크. Treatment of Trauma
FR2791262B1 (en) * 1999-03-22 2001-09-28 Virbac Sa COMPOSITIONS BASED ON CHONDROITINE AND CHITOSAN FOR THE PROTECTION, TREATMENT OR REPLACEMENT OF CONNECTIVE TISSUES
CA2366880C (en) * 1999-04-02 2013-02-12 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
CN100379462C (en) * 1999-11-09 2008-04-09 电气化学工业株式会社 Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US7592017B2 (en) 2000-03-10 2009-09-22 Mast Biosurgery Ag Resorbable thin membranes
AU2001259177A1 (en) * 2000-04-28 2001-11-12 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6478803B1 (en) 2000-05-19 2002-11-12 Genzyme Corporation Device for delivery of surgical materials
KR20010107067A (en) * 2000-05-25 2001-12-07 김정식 A conglutination inhibitor
US6235796B1 (en) 2000-06-26 2001-05-22 Sarfaraz K. Niazi Use of fluorocarbons for the prevention of surgical adhesions
WO2002016557A2 (en) * 2000-08-21 2002-02-28 Rice University Tissue engineering scaffolds promoting matrix protein production
US20020177680A1 (en) * 2000-08-23 2002-11-28 Hubbell Jeffrey A. Novel polymer compounds
US20030007951A1 (en) * 2000-08-23 2003-01-09 Richard Franklin Treatment of trauma
US6773723B1 (en) * 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US6726920B1 (en) 2000-09-22 2004-04-27 Durect Corporation Implantable drug delivery patch
WO2002034111A2 (en) 2000-10-24 2002-05-02 Cryolife, Inc. In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
AU2001297782B2 (en) * 2000-11-07 2006-03-02 Cryolife, Inc. Expandable foam-like biomaterials and methods
ATE407975T1 (en) * 2000-11-28 2008-09-15 Genzyme Corp POLYMERIC FORMULATIONS THAT INCREASE THE VISCOSITY OF POLYALKYLENE GLYCOL
US6607512B2 (en) 2001-01-09 2003-08-19 Genzyme Corporation Device for delivery of liquid and gel-like surgical materials and methods for use thereof
US7615593B2 (en) * 2001-04-23 2009-11-10 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
AU2002354911B2 (en) 2001-07-16 2007-08-30 Depuy Products, Inc. Meniscus regeneration device and method
EP1416874A4 (en) * 2001-07-16 2007-04-18 Depuy Products Inc Hybrid biologic/synthetic porous extracellular matrix scaffolds
US8025896B2 (en) * 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
WO2003007787A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair and regeneration device and method
AU2002354913B2 (en) * 2001-07-16 2008-07-17 Depuy Products, Inc. Unitary surgical device and method
AU2002322567B2 (en) * 2001-07-16 2007-09-06 Depuy Products, Inc. Devices form naturally occurring biologically derived
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
WO2003020208A2 (en) * 2001-08-31 2003-03-13 Neuron Therapeutics, Inc. Treatment of neurologic hemorrhage
FR2833268B1 (en) * 2001-12-12 2005-07-08 Fabre Pierre Dermo Cosmetique NOVEL ASSOCIATION CONTAINING POLOXAMER AND CHONDROID SULFURIC ACID AND / OR GLYCOPROTEIN AND USE THEREOF
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
CA2419831A1 (en) * 2002-02-28 2003-08-28 Macropore Biosurgery, Inc. Methods for governing bone growth
US6923961B2 (en) 2002-04-30 2005-08-02 Fziomed, Inc. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
EP1542613B1 (en) * 2002-07-31 2019-04-10 Mast Biosurgery AG Resorbable thin membranes
US8048444B2 (en) * 2002-07-31 2011-11-01 Mast Biosurgery Ag Apparatus and method for preventing adhesions between an implant and surrounding tissues
WO2004010854A2 (en) * 2002-07-31 2004-02-05 Mast Biosurgery Ag Apparatus and method for preventing adhesions between an implant and surrounding tissues
CA2495818A1 (en) * 2002-08-20 2004-03-04 John N. Semertzides Compositions comprising epithelial cells for the treatment and prevention of tissue adhesions
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
US7704520B1 (en) 2002-09-10 2010-04-27 Mast Biosurgery Ag Methods of promoting enhanced healing of tissues after cardiac surgery
US20060083767A1 (en) * 2003-02-27 2006-04-20 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
JP4690892B2 (en) * 2003-06-30 2011-06-01 電気化学工業株式会社 Antiadhesive material for spine and spinal cord surgery
US20100266663A1 (en) * 2003-09-10 2010-10-21 Calhoun Christopher J Tissue-treating implantable compositions
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US7332179B2 (en) * 2003-12-12 2008-02-19 Kimberly-Clark Worldwide, Inc. Tissue products comprising a cleansing composition
US7114074B2 (en) * 2003-12-22 2006-09-26 Graphic Security Systems Corporation Method and system for controlling encoded image production using image signatures
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US7737214B2 (en) * 2004-03-15 2010-06-15 Terumo Kabushiki Kaisha Adhesion preventive material
DE102004014633A1 (en) * 2004-03-22 2005-10-13 Aesculap Ag & Co. Kg Composition for adhesion prophylaxis
US20050244480A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Pre-wipes for improving anal cleansing
US20050249772A1 (en) * 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US7758654B2 (en) * 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
US20080091277A1 (en) * 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
KR100895135B1 (en) * 2004-08-13 2009-05-04 마스트 바이오서저리 아게 Surgical prosthesis having biodegradable and nonbiodegradable regions
US7354627B2 (en) * 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US20060140899A1 (en) * 2004-12-28 2006-06-29 Kimberly-Clark Worldwide, Inc. Skin cleansing system comprising an anti-adherent formulation and a cationic compound
US7642395B2 (en) * 2004-12-28 2010-01-05 Kimberly-Clark Worldwide, Inc. Composition and wipe for reducing viscosity of viscoelastic bodily fluids
CN101267831B (en) 2005-04-25 2013-04-24 麻省理工学院 Compositions and methods for promoting hemostasis and other physiological activities
US9119901B2 (en) * 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
JP5319278B2 (en) * 2005-05-27 2013-10-16 ロイヤー バイオメディカル， インク． Bioresorbable polymer matrix and methods of making and using the same
EP1911769B1 (en) * 2005-08-04 2013-10-30 Teijin Limited Cellulose derivative
US20080119878A1 (en) * 2005-08-12 2008-05-22 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
FR2895907B1 (en) * 2006-01-06 2012-06-01 Anteis Sa VISCOELASTIC GEL FOR DERMATOLOGICAL USE
CN100434123C (en) * 2006-02-23 2008-11-19 暨南大学 Porous antisticking agar-collagen film and its prepn process
EP1996115B1 (en) * 2006-03-07 2014-11-26 Axle International Bioactive scaffold for therapeutic and adhesion prevention applications
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
CN101472620A (en) 2006-04-25 2009-07-01 麻省理工学院 Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or affecting other physiological conditions
US20080082170A1 (en) * 2006-09-29 2008-04-03 Peterman Marc M Apparatus and methods for surgical repair
US8114159B2 (en) * 2006-11-20 2012-02-14 Depuy Spine, Inc. Anterior spinal vessel protector
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8486467B1 (en) * 2007-09-20 2013-07-16 Albert G. Prescott Dermal filler and method of using same
US9345809B2 (en) 2007-11-28 2016-05-24 Fziomed, Inc. Carboxymethylcellulose polyethylene glycol compositions for medical uses
WO2009108760A2 (en) 2008-02-26 2009-09-03 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US8745133B2 (en) * 2008-03-28 2014-06-03 Yahoo! Inc. System and method for optimizing the storage of data
EP2280739B1 (en) * 2008-06-03 2012-07-04 Actamax Surgical Materials LLC A tissue coating for preventing undesired tissue-to-tissue adhesions
US20100222881A1 (en) * 2008-10-03 2010-09-02 Ann Prewett Vessel protection device
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
JP5684239B2 (en) 2009-05-04 2015-03-11 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ Ｌｌｃ Biomaterial for track and puncture closure
US9649331B2 (en) 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
JP6042815B2 (en) 2010-10-08 2016-12-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム Anti-adhesion barrier membranes using alginate and hyaluronic acid for biomedical applications
US8946194B2 (en) 2010-10-08 2015-02-03 Board Of Regents, University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
JP5978420B2 (en) * 2011-07-27 2016-08-24 旭化成株式会社 Sheet-like structure comprising carboxyethyl cellulose
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
AU2012347926B2 (en) 2011-12-05 2018-03-15 Incept, Llc Medical organogel processes and compositions
RU2509784C2 (en) * 2012-04-10 2014-03-20 Общество с ограниченной ответственностью "Линтекс" Method of producing porous, film-type materials based on carboxymethyl cellulose
US10086110B2 (en) * 2012-10-30 2018-10-02 The Cleveland Clinic Foundation Multipurpose membranes, methods for forming, and applications thereof
KR101468287B1 (en) * 2013-02-06 2014-12-02 주식회사 제네웰 Macromolecular composition, and method for preparing elastic wound dressing using thereof
KR102340388B1 (en) 2013-09-19 2021-12-17 마이크로벤션, 인코포레이티드 Polymer films
CN110279885B (en) 2013-09-19 2022-07-26 泰尔茂株式会社 Polymer particles
US9688788B2 (en) 2013-11-08 2017-06-27 Terumo Corporation Polymer particles
ES2916210T3 (en) * 2014-05-22 2022-06-29 Univ Copenhagen Composition of aqueous gel and its use
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
WO2017121049A1 (en) 2016-01-15 2017-07-20 Findpiano Information Technology (Shanghai) Co., Ltd. Piano system and operating method thereof
RU2629841C1 (en) * 2016-07-26 2017-09-04 Общество с ограниченной ответственностью "Линтекс" Method for production of anti-adhesion film material based on carboxymethyl cellulose
RU2629842C1 (en) * 2016-07-26 2017-09-04 Общество с ограниченной ответственностью "Линтекс" Method for production of anti-adhesion film material based on carboxymethyl cellulose
RU2634577C1 (en) * 2016-07-26 2017-10-31 Общество с ограниченной ответственностью "Линтекс" Method of obtaining antimiscular film material based on derivatives of cellulose
EP3518994B1 (en) 2016-09-28 2024-02-07 Terumo Corporation Polymer particles
US11872711B2 (en) * 2019-05-10 2024-01-16 The Gillette Company Llc Lubricating member for razor cartridges

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064313A (en) * 1960-06-14 1962-11-20 Hercules Powder Co Ltd Preparation of free acid cellulose ether films
US3328259A (en) * 1964-01-08 1967-06-27 Parachem Corp Dressing for a wound containing a hemostatic agent and method of treating a wound
US3387061A (en) * 1966-05-04 1968-06-04 Union Carbide Corp Chemical reaction product of polycarboxylic acid and a polymeric polyether
US4585858A (en) * 1967-01-03 1986-04-29 Cpc International Inc. Starch-based polyether polyols
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4181718A (en) * 1975-12-29 1980-01-01 Mason Norbert S Polyanion-stabilized aluminum hydrogels
US4301067A (en) * 1979-06-05 1981-11-17 Kureha Kagaku Kogyo Kabushiki Kaisha Chitin containing poly-ion complex
JPS5844711B2 (en) * 1979-07-04 1983-10-05 日東電工株式会社 Water-soluble pressure-sensitive adhesive composition
US4326532A (en) * 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4456596A (en) * 1981-04-13 1984-06-26 Schaefer Rolf Wound healing glycoside compositions
US4768523A (en) * 1981-04-29 1988-09-06 Lifecore Biomedical, Inc. Hydrogel adhesive
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
IN163192B (en) * 1983-10-11 1988-08-20 Fidia Spa
SE456346B (en) * 1984-07-23 1988-09-26 Pharmacia Ab GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION
US4619995A (en) * 1984-12-24 1986-10-28 Nova Chem Limited N,O-carboxymethyl chitosan and preparative method therefor
SE8501022L (en) * 1985-03-01 1986-09-02 Pharmacia Ab FORMAT CREATES AND PROCEDURES FOR ITS PREPARATION
US4616644A (en) * 1985-06-14 1986-10-14 Johnson & Johnson Products, Inc. Hemostatic adhesive bandage
IN166447B (en) * 1985-11-27 1990-05-12 Ethicon Inc
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US4684558A (en) * 1986-06-30 1987-08-04 Nepera Inc. Adhesive polyethylene oxide hydrogel sheet and its production
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5156839A (en) * 1987-05-04 1992-10-20 Mdr Group, Inc. Viscoelastic fluid for use in spine and general surgery and other surgery and therapies and method of using same
US4983585A (en) * 1987-05-04 1991-01-08 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US5068225A (en) * 1987-05-04 1991-11-26 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US4853374A (en) * 1987-06-09 1989-08-01 M.D.R. Group, Inc. Viscoelastic vitreous substitute with UV blocker
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
HU203372B (en) * 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
US5143071A (en) * 1989-03-30 1992-09-01 Nepera, Inc. Non-stringy adhesive hydrophilic gels
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5093319A (en) * 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
GR920100122A (en) * 1991-04-05 1993-03-16 Ethicon Inc Ionically crosslinked carboxyl-containing polysaccharides for adhension prevention.
US5266326A (en) * 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5374446A (en) * 1993-12-10 1994-12-20 Arco Chemical Technology, L.P. Linked esterified alkoxylated polyols useful as reduced calorie fat substitutes
US5621093A (en) * 1995-06-06 1997-04-15 Anika Research, Inc. Steam-sterilizing solid hyaluronic acid
DE69634214T2 (en) * 1995-12-21 2005-12-29 Biotechnology Research And Development Corp., Peoria Compositions of hydroxy-functional polymers
JPH10290830A (en) * 1997-04-18 1998-11-04 Ofutekusu:Kk Adjuvant for operating on eye
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

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US6133325A (en) 2000-10-17
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US5906997A (en) 1999-05-25
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KR20010013927A (en) 2001-02-26
KR100612975B1 (en) 2006-08-16
JP4986311B2 (en) 2012-07-25
AU7698598A (en) 1999-01-04
US6034140A (en) 2000-03-07
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WO1998058011A1 (en) 1998-12-23
US6017301A (en) 2000-01-25

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