CA2296364A1 - Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent - Google Patents
Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent Download PDFInfo
- Publication number
- CA2296364A1 CA2296364A1 CA002296364A CA2296364A CA2296364A1 CA 2296364 A1 CA2296364 A1 CA 2296364A1 CA 002296364 A CA002296364 A CA 002296364A CA 2296364 A CA2296364 A CA 2296364A CA 2296364 A1 CA2296364 A1 CA 2296364A1
- Authority
- CA
- Canada
- Prior art keywords
- volume
- plasma constituent
- methods
- blood processing
- processing systems
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/003—Sedimentation tanks provided with a plurality of compartments separated by a partition wall
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2405—Feed mechanisms for settling tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/245—Discharge mechanisms for the sediments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
Abstract
A blood processing chamber (22) separates blood into constituents including a plasma constituent that includes a platelet volume.
An optical monitor (98) detects the optical density of the plasma constituent and generates a first output indicative of the optical density.
A processing element (100) integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element (72) generates a third output based, at least in part, upon the integrated output, which encompasses parameters for storing the platelet volume.
An optical monitor (98) detects the optical density of the plasma constituent and generates a first output indicative of the optical density.
A processing element (100) integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element (72) generates a third output based, at least in part, upon the integrated output, which encompasses parameters for storing the platelet volume.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/896,665 | 1997-07-18 | ||
US08/896,665 US5958250A (en) | 1995-06-07 | 1997-07-18 | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
PCT/US1998/012924 WO1999003557A1 (en) | 1997-07-18 | 1998-06-22 | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2296364A1 true CA2296364A1 (en) | 1999-01-28 |
CA2296364C CA2296364C (en) | 2008-05-06 |
Family
ID=25406599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002296364A Expired - Lifetime CA2296364C (en) | 1997-07-18 | 1998-06-22 | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
Country Status (8)
Country | Link |
---|---|
US (2) | US5958250A (en) |
EP (1) | EP1015089B1 (en) |
JP (1) | JP2001510171A (en) |
CN (1) | CN1140311C (en) |
BR (1) | BR9811513A (en) |
CA (1) | CA2296364C (en) |
DE (1) | DE69839093T2 (en) |
WO (1) | WO1999003557A1 (en) |
Families Citing this family (72)
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US5651766A (en) * | 1995-06-07 | 1997-07-29 | Transfusion Technologies Corporation | Blood collection and separation system |
US6312607B1 (en) * | 1995-06-07 | 2001-11-06 | Baxter International Inc. | Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent |
US5958250A (en) * | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
US6254784B1 (en) * | 1997-10-30 | 2001-07-03 | Baxter International Inc. | Optical interface detection system for centrifugal blood processing |
US6334842B1 (en) * | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
JP3817091B2 (en) * | 1999-07-02 | 2006-08-30 | テルモ株式会社 | Cell number measuring device |
US7011761B2 (en) * | 1999-09-03 | 2006-03-14 | Baxter International Inc. | Red blood cell processing systems and methods which control red blood cell hematocrit |
US6284142B1 (en) * | 1999-09-03 | 2001-09-04 | Baxter International Inc. | Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing |
US6294094B1 (en) | 1999-09-03 | 2001-09-25 | Baxter International Inc. | Systems and methods for sensing red blood cell hematocrit |
US6348156B1 (en) | 1999-09-03 | 2002-02-19 | Baxter International Inc. | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
US7142988B1 (en) * | 1999-09-07 | 2006-11-28 | Monsanto Company | Method and information system for non-random selection of uniform structural and functional features for tissue and plant product processing |
US6730054B2 (en) * | 1999-10-16 | 2004-05-04 | Baxter International Inc. | Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit |
US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
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US6808503B2 (en) | 2001-03-06 | 2004-10-26 | Baxter International Inc. | Automated system and method for pre-surgical blood donation and fluid replacement |
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US6878105B2 (en) * | 2001-08-16 | 2005-04-12 | Baxter International Inc. | Red blood cell processing systems and methods with deliberate under spill of red blood cells |
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US7479123B2 (en) | 2002-03-04 | 2009-01-20 | Therakos, Inc. | Method for collecting a desired blood component and performing a photopheresis treatment |
US7186230B2 (en) * | 2002-03-04 | 2007-03-06 | Therakos, Inc | Method and apparatus for the continuous separation of biological fluids into components |
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US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
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AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
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US6982038B2 (en) * | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
US20050049539A1 (en) * | 2003-09-03 | 2005-03-03 | O'hara Gerald P. | Control system for driving fluids through an extracorporeal blood circuit |
ITMI20031715A1 (en) * | 2003-09-05 | 2005-03-06 | Dideco Spa | CONTROL DEVICE IN THE DIFFERENTIATED COLLECTION OF THE |
US7060018B2 (en) | 2003-09-11 | 2006-06-13 | Cobe Cardiovascular, Inc. | Centrifuge apparatus for processing blood |
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US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
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-
1997
- 1997-07-18 US US08/896,665 patent/US5958250A/en not_active Expired - Lifetime
-
1998
- 1998-06-22 CN CNB988073757A patent/CN1140311C/en not_active Expired - Lifetime
- 1998-06-22 JP JP2000502846A patent/JP2001510171A/en active Pending
- 1998-06-22 CA CA002296364A patent/CA2296364C/en not_active Expired - Lifetime
- 1998-06-22 BR BR9811513-8A patent/BR9811513A/en not_active Application Discontinuation
- 1998-06-22 DE DE69839093T patent/DE69839093T2/en not_active Expired - Lifetime
- 1998-06-22 EP EP98930444A patent/EP1015089B1/en not_active Expired - Lifetime
- 1998-06-22 WO PCT/US1998/012924 patent/WO1999003557A1/en active IP Right Grant
-
1999
- 1999-08-25 US US09/382,893 patent/US6183651B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69839093T2 (en) | 2009-02-05 |
WO1999003557A1 (en) | 1999-01-28 |
EP1015089A1 (en) | 2000-07-05 |
CA2296364C (en) | 2008-05-06 |
CN1268067A (en) | 2000-09-27 |
US6183651B1 (en) | 2001-02-06 |
EP1015089B1 (en) | 2008-02-06 |
US5958250A (en) | 1999-09-28 |
EP1015089A4 (en) | 2000-12-20 |
JP2001510171A (en) | 2001-07-31 |
DE69839093D1 (en) | 2008-03-20 |
BR9811513A (en) | 2000-09-26 |
CN1140311C (en) | 2004-03-03 |
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Effective date: 20180622 |