CA2298856A1 - Living tissue equivalents - Google Patents

Living tissue equivalents Download PDF

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Publication number
CA2298856A1
CA2298856A1 CA002298856A CA2298856A CA2298856A1 CA 2298856 A1 CA2298856 A1 CA 2298856A1 CA 002298856 A CA002298856 A CA 002298856A CA 2298856 A CA2298856 A CA 2298856A CA 2298856 A1 CA2298856 A1 CA 2298856A1
Authority
CA
Canada
Prior art keywords
living tissue
tissue equivalents
region
tissue
tissue equivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002298856A
Other languages
French (fr)
Other versions
CA2298856C (en
Inventor
Paul D. Kemp
Eugene Bell
David T. Kagan
Valerie Mason
John Cavallaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organogenesis Inc
Original Assignee
Organogenesis, Inc.
Paul D. Kemp
Eugene Bell
David T. Kagan
Valerie Mason
John Cavallaro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis, Inc., Paul D. Kemp, Eugene Bell, David T. Kagan, Valerie Mason, John Cavallaro filed Critical Organogenesis, Inc.
Publication of CA2298856A1 publication Critical patent/CA2298856A1/en
Application granted granted Critical
Publication of CA2298856C publication Critical patent/CA2298856C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The present invention provides an apparatus for determining the interaction of tissue and at least one agent by use of at least one tissue equivalent, the apparatus comprising a first and a second region defined by a permeable means provided with a collagen gel on which the tissue equivalent is disposed, whereby the tissue equivalent defines the first region and the permeable member defines the second region.
CA002298856A 1989-09-15 1990-08-24 Living tissue equivalents Expired - Fee Related CA2298856C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40805289A 1989-09-15 1989-09-15
US07/408,052 1989-09-15
CA002023968A CA2023968C (en) 1989-09-15 1990-08-24 Living tissue equivalents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002023968A Division CA2023968C (en) 1989-09-15 1990-08-24 Living tissue equivalents

Publications (2)

Publication Number Publication Date
CA2298856A1 true CA2298856A1 (en) 1991-03-16
CA2298856C CA2298856C (en) 2004-11-16

Family

ID=23614662

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002023968A Expired - Fee Related CA2023968C (en) 1989-09-15 1990-08-24 Living tissue equivalents
CA002298856A Expired - Fee Related CA2298856C (en) 1989-09-15 1990-08-24 Living tissue equivalents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002023968A Expired - Fee Related CA2023968C (en) 1989-09-15 1990-08-24 Living tissue equivalents

Country Status (12)

Country Link
US (1) US5536656A (en)
EP (1) EP0418035B1 (en)
JP (1) JPH03151977A (en)
KR (1) KR940001379B1 (en)
AT (1) ATE119194T1 (en)
AU (1) AU6215690A (en)
CA (2) CA2023968C (en)
DE (1) DE69017324T2 (en)
DK (1) DK0418035T3 (en)
ES (1) ES2071778T3 (en)
IE (1) IE903340A1 (en)
IL (1) IL95429A (en)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
DE69017324D1 (en) 1995-04-06
IE903340A1 (en) 1991-04-10
IL95429A (en) 1997-09-30
JPH0553505B2 (en) 1993-08-10
KR910005893A (en) 1991-04-27
KR940001379B1 (en) 1994-02-21
CA2023968A1 (en) 1991-03-16
EP0418035B1 (en) 1995-03-01
DK0418035T3 (en) 1995-07-10
DE69017324T2 (en) 1995-08-03
JPH03151977A (en) 1991-06-28
IL95429A0 (en) 1991-06-30
CA2298856C (en) 2004-11-16
AU6215690A (en) 1991-08-01
EP0418035A1 (en) 1991-03-20
US5536656A (en) 1996-07-16
CA2023968C (en) 2000-05-02
ATE119194T1 (en) 1995-03-15
ES2071778T3 (en) 1995-07-01

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