CA2300049A1 - Compositions, apparatus and methods for facilitating surgical procedures - Google Patents

Compositions, apparatus and methods for facilitating surgical procedures Download PDF

Info

Publication number
CA2300049A1
CA2300049A1 CA002300049A CA2300049A CA2300049A1 CA 2300049 A1 CA2300049 A1 CA 2300049A1 CA 002300049 A CA002300049 A CA 002300049A CA 2300049 A CA2300049 A CA 2300049A CA 2300049 A1 CA2300049 A1 CA 2300049A1
Authority
CA
Canada
Prior art keywords
compositions
methods
patient
surgical
blocker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002300049A
Other languages
French (fr)
Other versions
CA2300049C (en
Inventor
Francis G. Duhaylongsod
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Francis G. Duhaylongsod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University, Francis G. Duhaylongsod filed Critical Duke University
Publication of CA2300049A1 publication Critical patent/CA2300049A1/en
Application granted granted Critical
Publication of CA2300049C publication Critical patent/CA2300049C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart

Abstract

Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient.
The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing is then selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageoulsy may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
CA002300049A 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures Expired - Fee Related CA2300049C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5512797P 1997-08-08 1997-08-08
US60/055,127 1997-08-08
PCT/US1998/016469 WO1999007354A2 (en) 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures

Publications (2)

Publication Number Publication Date
CA2300049A1 true CA2300049A1 (en) 1999-02-18
CA2300049C CA2300049C (en) 2009-03-10

Family

ID=21995793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002300049A Expired - Fee Related CA2300049C (en) 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures

Country Status (8)

Country Link
US (7) US6060454A (en)
EP (1) EP1051168B1 (en)
JP (1) JP2001513495A (en)
AT (1) ATE318595T1 (en)
AU (1) AU758370B2 (en)
CA (1) CA2300049C (en)
DE (1) DE69833665T2 (en)
WO (1) WO1999007354A2 (en)

Families Citing this family (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7225019B2 (en) * 1996-04-30 2007-05-29 Medtronic, Inc. Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
US6904318B2 (en) * 2000-09-26 2005-06-07 Medtronic, Inc. Method and system for monitoring and controlling systemic and pulmonary circulation during a medical procedure
US6628987B1 (en) 2000-09-26 2003-09-30 Medtronic, Inc. Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia
US8036741B2 (en) 1996-04-30 2011-10-11 Medtronic, Inc. Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
US6532388B1 (en) 1996-04-30 2003-03-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6449507B1 (en) * 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US20040199209A1 (en) * 2003-04-07 2004-10-07 Hill Michael R.S. Method and system for delivery of vasoactive drugs to the heart prior to and during a medical procedure
US7269457B2 (en) * 1996-04-30 2007-09-11 Medtronic, Inc. Method and system for vagal nerve stimulation with multi-site cardiac pacing
US6735471B2 (en) * 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
WO1999000059A1 (en) 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
US6711436B1 (en) * 1997-08-08 2004-03-23 Duke University Compositions, apparatus and methods for facilitating surgical procedures
US6479523B1 (en) * 1997-08-26 2002-11-12 Emory University Pharmacologic drug combination in vagal-induced asystole
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US6296630B1 (en) * 1998-04-08 2001-10-02 Biocardia, Inc. Device and method to slow or stop the heart temporarily
US20030060761A1 (en) * 1998-04-21 2003-03-27 Evans Scott M. Kit of parts including a heat exchange catheter for treating heart malady
US7252818B2 (en) * 1998-07-24 2007-08-07 Cardiovascular Biotherapeutics, Inc. Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis
US20050004503A1 (en) * 1998-09-01 2005-01-06 Samson Wilfred J. Method and apparatus for treating acute myocardial infarction with hypothermic perfusion
US6726651B1 (en) * 1999-08-04 2004-04-27 Cardeon Corporation Method and apparatus for differentially perfusing a patient during cardiopulmonary bypass
WO2000029056A2 (en) 1998-11-19 2000-05-25 Corvascular, Inc. Coronary infusion catheter and intra-coronary drug administration methods
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
CA2620783C (en) 1999-04-09 2011-04-05 Evalve, Inc. Methods and apparatus for cardiac valve repair
US7226467B2 (en) 1999-04-09 2007-06-05 Evalve, Inc. Fixation device delivery catheter, systems and methods of use
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US6351668B1 (en) 1999-05-07 2002-02-26 Cedars-Sinai Medical Center Method for inducing ventricular arrhythmias in an animal model system
JP2003503119A (en) 1999-06-25 2003-01-28 エモリ ユニバーシティ Vagal nerve stimulation device and method
AU7368700A (en) * 1999-09-09 2001-04-10 Corvascular, Inc. Bifurcated shunt drug delivery system and methods of use
US6887842B1 (en) * 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
AU4523301A (en) * 1999-12-14 2001-06-25 Radiant Medical, Inc. Method for reducing myocardial infarct by applicaton of intravascular hypothermia
US6447443B1 (en) * 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US6445954B1 (en) 2000-04-04 2002-09-03 Cardiac Pacemakers, Inc. Pulse generator header lead introducer tool
US6454697B1 (en) * 2000-07-18 2002-09-24 Dai-Yuan Wang Cardiac support device and method
US6487446B1 (en) * 2000-09-26 2002-11-26 Medtronic, Inc. Method and system for spinal cord stimulation prior to and during a medical procedure
ATE332668T1 (en) 2000-09-26 2006-08-15 Medtronic Inc MEDICAL DEVICE FOR BLOOD FLOW CONTROL
WO2002026175A1 (en) * 2000-09-28 2002-04-04 Alsius Corporation Venous line catheter and method of operating the same
US20020143237A1 (en) * 2000-10-30 2002-10-03 Katsumi Oneda Inflatable member for an endoscope sheath
US6793661B2 (en) 2000-10-30 2004-09-21 Vision Sciences, Inc. Endoscopic sheath assemblies having longitudinal expansion inhibiting mechanisms
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20040138621A1 (en) 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US6466824B1 (en) 2001-04-23 2002-10-15 Medtronic, Inc. Bi-atrial and/or bi-ventricular patient safety cable and methods regarding same
US6814713B2 (en) * 2001-04-25 2004-11-09 A-Med Systems, Inc. Systems for performing minimally invasive cardiac medical procedures
JP3731071B2 (en) * 2001-07-02 2006-01-05 関西ティー・エル・オー株式会社 Hemodynamic measurement method
WO2003009775A2 (en) * 2001-07-21 2003-02-06 Board Of Regents, The University Of Texas System Method for reducing myocardial cell damage by regional beta blocker therapy
US20060052821A1 (en) 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US6702835B2 (en) 2001-09-07 2004-03-09 Core Medical, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US20030097167A1 (en) * 2001-11-13 2003-05-22 Friedman Paul A. Transesophageal cardiac probe and methods of use
US20080249504A1 (en) 2007-04-06 2008-10-09 Lattouf Omar M Instrument port
US6978176B2 (en) * 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
US20030139469A1 (en) * 2002-01-23 2003-07-24 The Regents Of The University Of California Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US7048754B2 (en) 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US7087034B2 (en) * 2002-09-19 2006-08-08 Mcpherson William E Vascular shunt with audio flow indication
JP2006506211A (en) * 2002-11-15 2006-02-23 プレッシャー プロダクツ メディカル サプライズ インコーポレイテッド Method and apparatus for attaching pacemaker lead wire
US7392094B2 (en) 2002-12-19 2008-06-24 Cardiac Pacemakers, Inc. Implantable lead for septal placement of pacing electrodes
JP2006517807A (en) * 2002-12-30 2006-08-03 パーデュー・リサーチ・ファウンデーション Treatment of central nervous system damage
US8721515B2 (en) * 2003-01-31 2014-05-13 L-Vad Technology, Inc. Rigid body aortic blood pump implant
US8540618B2 (en) 2003-01-31 2013-09-24 L-Vad Technology, Inc. Stable aortic blood pump implant
US20040158194A1 (en) * 2003-02-06 2004-08-12 Wolff Andy And Beiski Ben Z. Oral devices and methods for controlled drug release
US20050015048A1 (en) * 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
US7250041B2 (en) * 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
CA2523267C (en) 2003-04-23 2013-09-03 Biovalve Technologies, Inc. Hydraulically actuated pump for long duration medicament administration
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US10646229B2 (en) 2003-05-19 2020-05-12 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US20040267110A1 (en) * 2003-06-12 2004-12-30 Patrice Tremble Method for detection of vulnerable plaque
US7179224B2 (en) * 2003-12-30 2007-02-20 Cardiothoracic Systems, Inc. Organ manipulator and positioner and methods of using the same
US7727228B2 (en) 2004-03-23 2010-06-01 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US9555223B2 (en) 2004-03-23 2017-01-31 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US8491636B2 (en) * 2004-03-23 2013-07-23 Medtronic Cryopath LP Method and apparatus for inflating and deflating balloon catheters
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US7238883B2 (en) * 2004-08-11 2007-07-03 Cardiac Pacemakers, Inc. Lead assembly with flexible portions and method therefor
CA2748617C (en) 2004-09-27 2014-09-23 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US7781402B2 (en) * 2004-10-12 2010-08-24 Closed Loop Therapies Ltd. Methods and implantable devices for treating supraventricular arrhythmias
WO2006058132A2 (en) * 2004-11-24 2006-06-01 Flea Street Translational, Llc. Sensor-assisted catheter-based procedures
US20080009927A1 (en) * 2005-01-11 2008-01-10 Vilims Bradley D Combination Electrical Stimulating and Infusion Medical Device and Method
US20060155343A1 (en) * 2005-01-11 2006-07-13 Vilims Bradley D Combination electrical stimulating and infusion medical device and method
US8066702B2 (en) 2005-01-11 2011-11-29 Rittman Iii William J Combination electrical stimulating and infusion medical device and method
US7945331B2 (en) * 2005-01-11 2011-05-17 Bradley D. Vilims Combination electrical stimulating and infusion medical device and method
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8260426B2 (en) * 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US7226440B2 (en) * 2005-01-31 2007-06-05 G & L Consulting, Llc Method and device for accessing a pericardial space
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US20070106138A1 (en) * 2005-05-26 2007-05-10 Beiski Ben Z Intraoral apparatus for non-invasive blood and saliva monitoring & sensing
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US8428731B2 (en) 2005-10-27 2013-04-23 Cyberonics, Inc. Sequenced therapy protocols for an implantable medical device
US8694118B2 (en) 2005-10-28 2014-04-08 Cyberonics, Inc. Variable output ramping for an implantable medical device
US7747324B2 (en) * 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US9037247B2 (en) 2005-11-10 2015-05-19 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US7725188B2 (en) * 2006-02-10 2010-05-25 Electrocore Llc Electrical stimulation treatment of hypotension
US20110125203A1 (en) * 2009-03-20 2011-05-26 ElectroCore, LLC. Magnetic Stimulation Devices and Methods of Therapy
US8041428B2 (en) 2006-02-10 2011-10-18 Electrocore Llc Electrical stimulation treatment of hypotension
US8812112B2 (en) * 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
US20070173890A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Stimulation mode adjustment for an implantable medical device
US7996079B2 (en) * 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
CN101400402A (en) 2006-02-10 2009-04-01 电子核心公司 Electrical stimulation treatment of hypotension
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
CN103239773B (en) 2006-03-30 2015-08-26 瓦莱里塔斯公司 Multi-cartridge fluid delivery device
US20100241188A1 (en) * 2009-03-20 2010-09-23 Electrocore, Inc. Percutaneous Electrical Treatment Of Tissue
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) * 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US8781193B2 (en) 2007-03-08 2014-07-15 Sync-Rx, Ltd. Automatic quantitative vessel analysis
US8700130B2 (en) 2007-03-08 2014-04-15 Sync-Rx, Ltd. Stepwise advancement of a medical tool
US10716528B2 (en) 2007-03-08 2020-07-21 Sync-Rx, Ltd. Automatic display of previously-acquired endoluminal images
EP2129284A4 (en) * 2007-03-08 2012-11-28 Sync Rx Ltd Imaging and tools for use with moving organs
US11197651B2 (en) 2007-03-08 2021-12-14 Sync-Rx, Ltd. Identification and presentation of device-to-vessel relative motion
US9968256B2 (en) 2007-03-08 2018-05-15 Sync-Rx Ltd. Automatic identification of a tool
US9629571B2 (en) 2007-03-08 2017-04-25 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
US11064964B2 (en) 2007-03-08 2021-07-20 Sync-Rx, Ltd Determining a characteristic of a lumen by measuring velocity of a contrast agent
US9305334B2 (en) 2007-03-08 2016-04-05 Sync-Rx, Ltd. Luminal background cleaning
US9375164B2 (en) 2007-03-08 2016-06-28 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
US8622991B2 (en) * 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
KR20090128499A (en) 2007-03-19 2009-12-15 인슐린 메디컬 엘티디 Drug delivery device
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7869884B2 (en) * 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US9579506B2 (en) 2008-01-25 2017-02-28 Flint Hills Scientific, L.L.C. Contingent cardio-protection for epilepsy patients
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
CN102089763A (en) * 2008-07-10 2011-06-08 伊西康内外科公司 Medical system which controls delivery of a drug and which includes a backpack pouch
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
CN102245137A (en) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 Device and method for drug delivery
US10362962B2 (en) 2008-11-18 2019-07-30 Synx-Rx, Ltd. Accounting for skipped imaging locations during movement of an endoluminal imaging probe
US9974509B2 (en) 2008-11-18 2018-05-22 Sync-Rx Ltd. Image super enhancement
US9101286B2 (en) 2008-11-18 2015-08-11 Sync-Rx, Ltd. Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points
US9095313B2 (en) 2008-11-18 2015-08-04 Sync-Rx, Ltd. Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe
US9144394B2 (en) 2008-11-18 2015-09-29 Sync-Rx, Ltd. Apparatus and methods for determining a plurality of local calibration factors for an image
US8855744B2 (en) 2008-11-18 2014-10-07 Sync-Rx, Ltd. Displaying a device within an endoluminal image stack
US11064903B2 (en) 2008-11-18 2021-07-20 Sync-Rx, Ltd Apparatus and methods for mapping a sequence of images to a roadmap image
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
FR2944918B1 (en) 2009-04-23 2011-09-16 Pierre Sabin ELECTRICAL CONNECTION SYSTEM BETWEEN AN ELECTRICAL SUPPLY DEVICE AND AN IMPLANTED MEDICAL DEVICE
FR2944920B1 (en) 2009-04-23 2011-09-02 Pierre Sabin SUBCUTANEOUS PERCUTANEOUS ELECTRICAL CONNECTION DEVICE
FR2944919B1 (en) * 2009-04-23 2011-07-29 Pierre Sabin IMPLANTABLE ELECTRICAL CONNECTION DEVICE IN THE HUMAN BODY
US20100298335A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and Methods for Ameliorating or Reducing Presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US9480789B2 (en) * 2009-06-01 2016-11-01 Ethicon Endo-Surgery, Inc. Method and sedation delivery system including a pump assembly and a co-formulation of first and second drugs
US9242042B2 (en) * 2009-07-21 2016-01-26 Ethicon Endo-Surgery, Inc. Drug delivery system including a drug-container holder and a pump assembly
US20110022026A1 (en) 2009-07-21 2011-01-27 Lake Region Manufacturing, Inc. d/b/a Lake Region Medical. Inc. Methods and Devices for Delivering Drugs Using Drug-Delivery or Drug-Coated Guidewires
EP3042615A1 (en) 2009-09-15 2016-07-13 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US8882673B2 (en) * 2010-02-12 2014-11-11 I-Flow Corporation Continuous transversus abdominis plane block
US8620425B2 (en) 2010-04-29 2013-12-31 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8639327B2 (en) 2010-04-29 2014-01-28 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8406868B2 (en) 2010-04-29 2013-03-26 Medtronic, Inc. Therapy using perturbation and effect of physiological systems
US20120016441A1 (en) * 2010-07-19 2012-01-19 Sergei Belov Device for electric pulse stimulation of healing of wounds
US8781582B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US8781583B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US8706223B2 (en) 2011-01-19 2014-04-22 Medtronic, Inc. Preventative vagal stimulation
US8725259B2 (en) 2011-01-19 2014-05-13 Medtronic, Inc. Vagal stimulation
US8718763B2 (en) 2011-01-19 2014-05-06 Medtronic, Inc. Vagal stimulation
US9265897B2 (en) 2011-01-26 2016-02-23 Avent, Inc. Method and corresponding kit for administering a paravertebral block
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
WO2013184782A2 (en) * 2012-06-05 2013-12-12 Muffin Incorporated Catheter systems and methods useful for cell therapy
CA2875346A1 (en) 2012-06-26 2014-01-03 Sync-Rx, Ltd. Flow-related image processing in luminal organs
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
WO2018209313A1 (en) 2017-05-12 2018-11-15 Evalve, Inc. Long arm valve repair clip
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
WO2019204326A1 (en) * 2018-04-16 2019-10-24 Alsar Ltd Partnership Compositions and methods for sustained release of flecainide
EP3563899A1 (en) 2018-05-03 2019-11-06 Biotronik Ag Catheter device for cto recanalisation
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
WO2020163504A1 (en) 2019-02-06 2020-08-13 inQB8 Medical Technologies, LLC Intra-cardiac left atrial and dual support systems
WO2020236631A1 (en) * 2019-05-17 2020-11-26 Alsar Ltd Partnership Flecainide combination and controlled-release formulations for treating heart diseases
US11534303B2 (en) 2020-04-09 2022-12-27 Evalve, Inc. Devices and systems for accessing and repairing a heart valve
WO2021011531A1 (en) 2019-07-15 2021-01-21 Evalve, Inc. Wide clip with nondeformable wings
CA3147410A1 (en) 2019-07-15 2021-01-21 Evalve, Inc. Proximal element actuator fixation and release mechanisms
US11707228B2 (en) 2019-09-26 2023-07-25 Evalve, Inc. Systems and methods for intra-procedural cardiac pressure monitoring
WO2021072209A1 (en) 2019-10-11 2021-04-15 Evalve, Inc. Repair clip for variable tissue thickness
US11622859B2 (en) 2019-11-08 2023-04-11 Evalve, Inc. Medical device delivery system with locking system
WO2021097124A1 (en) 2019-11-14 2021-05-20 Evalve, Inc. Catheter assembly with coaptation aid and methods for valve repair
US11701229B2 (en) 2019-11-14 2023-07-18 Evalve, Inc. Kit with coaptation aid and fixation system and methods for valve repair

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632412A (en) * 1962-05-17
US3640269A (en) * 1969-10-24 1972-02-08 Jose M R Delgado Fluid-conducting instrument insertable in living organisms
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US3866615A (en) * 1973-01-15 1975-02-18 Daigle Claude W Portable electronic cardiac stimulator
SE7610696L (en) * 1976-09-28 1978-03-29 Reenstierna Bertil KIT AND DEVICE FOR INSERTING AND FIXING "PACEMAKER - ELECTROD" IN (HUMAN) HEART
US4166470A (en) * 1977-10-17 1979-09-04 Medtronic, Inc. Externally controlled and powered cardiac stimulating apparatus
US4230119A (en) * 1978-12-01 1980-10-28 Medical Engineering Corp. Micro-hemostat
US4248214A (en) * 1979-05-22 1981-02-03 Robert S. Kish Illuminated urethral catheter
AU7039981A (en) * 1980-05-05 1981-11-26 Chiou, George C.Y. Compositions and methods of lowering intraocular pressure in the hypertensive mammalian eye
US4309776A (en) * 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
NZ197729A (en) * 1980-08-12 1985-03-20 Sanofi Sa 13-oxaprostanoic acid derivatives and pharmaceutical compositions
US4673563A (en) * 1980-10-14 1987-06-16 The University Of Virginia Alumni Patents Foundation Adenosine in the treatment of supraventricular tachycardia
US4404971A (en) * 1981-04-03 1983-09-20 Leveen Harry H Dual balloon catheter
DE3235974A1 (en) * 1981-11-24 1983-06-01 Volkmar Dipl.-Ing. Merkel (FH), 8520 Erlangen DEVICE FOR REMOVAL OR FOR THE EXPANSION OF CONSTRAINTS IN BODY LIQUID LEADING VESSELS
US4445892A (en) * 1982-05-06 1984-05-01 Laserscope, Inc. Dual balloon catheter device
IT1229075B (en) * 1985-04-05 1991-07-17 Fidia Farmaceutici Topical compsn. contg. hyaluronic acid deriv. as vehicle
US4661509A (en) * 1982-09-28 1987-04-28 Gordon Arnold Z Methods for treating leukopenia
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4581017B1 (en) * 1983-03-07 1994-05-17 Bard Inc C R Catheter systems
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4605399A (en) * 1984-12-04 1986-08-12 Complex, Inc. Transdermal infusion device
NO165378C (en) * 1985-11-22 1991-02-06 Ellingsen O & Co MEDICINE-GIVING DEVICE FOR IMPLANTATION IN THE HUMAN BODY.
US4771777A (en) * 1987-01-06 1988-09-20 Advanced Cardiovascular Systems, Inc. Perfusion type balloon dilatation catheter, apparatus and method
AU1159088A (en) * 1987-01-29 1988-08-24 S.B.M. Societa Brevetti Per La Medicina S.R.L. Epi-cardial electrode with an incorporated cardiac radio-frequency receiver (crr) for temporary heart stimulation from the outside, pre-arranged for permanent stimulation
WO1989000829A1 (en) * 1987-07-23 1989-02-09 Terumo Kabushiki Kaisha Catheter tube
US4827906A (en) * 1987-08-31 1989-05-09 Heineman Medical Research Center Apparatus and method for activating a pump in response to optical signals from a pacemaker
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
EP0366807B1 (en) * 1988-03-29 1996-10-23 Nippon Zeon Co., Ltd. Temporary pacing catheter
US4857552A (en) * 1988-06-08 1989-08-15 E. I. Du Pont De Nemours And Co. Stable pharmaceutical composition
US4935004A (en) * 1988-12-20 1990-06-19 Henry Ford Health System Peritoneal dialysis catheter
US4962095A (en) * 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
US5229127A (en) * 1989-03-03 1993-07-20 Mckinzie James W Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives
DE3913142A1 (en) * 1989-04-21 1990-10-31 Roehm Gmbh PHARMACEUTICALLY ACTIVE PTERIDINE DERIVATIVES
CA2019580C (en) * 1989-06-23 2007-03-27 Robert J. Dow Novel methods of treatment using ranolazine and related piperazine derivatives
US5044367A (en) * 1989-06-26 1991-09-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Method and apparatus for switching cardiac stimulation signals
IT1230931B (en) * 1989-06-27 1991-11-08 Chiesi Farma Spa DERIVATIVES OF 2 AMINO 1,2,3,4 TETRAHYDRONAPHTHALENE WITH CARDIOVASCULAR ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SU1731184A1 (en) * 1989-06-30 1992-05-07 Каунасский Медицинский Институт Method for surgically treating supraventricular tachycardia
US5162374A (en) * 1989-11-01 1992-11-10 The University Of Vermont And State Agricultural College Method for reversibly arresting muscle activity
US5176638A (en) * 1990-01-12 1993-01-05 Don Michael T Anthony Regional perfusion catheter with improved drug delivery control
US5116851A (en) * 1990-01-26 1992-05-26 E. R. Squibb & Sons, Inc. Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides
US5083564A (en) * 1990-06-01 1992-01-28 Board Of Regents Of The University Of Oklahoma Method for alleviating and diagnosing symptoms of heart block
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5139789A (en) * 1990-10-17 1992-08-18 Virginia Commonwealth University Cardioplegia solutions that prevent heart cell swelling
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
AR245376A1 (en) * 1991-02-25 1994-01-31 Liliana Rosa Grinfeld Y Robert Arterial profusion nozzle, for extra-corporal circulation and other uses.
DE69224636T2 (en) * 1991-04-24 1998-11-05 Advanced Cardiovascular System INTERCHANGEABLE BALLOON CATHETER WITH INTEGRATED GUIDE WIRE
US5182102A (en) * 1991-07-12 1993-01-26 Alcon Laboratories, Inc. Anti-glaucoma compositions
US5571215A (en) * 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
US5558644A (en) * 1991-07-16 1996-09-24 Heartport, Inc. Retrograde delivery catheter and method for inducing cardioplegic arrest
US5433700A (en) * 1992-12-03 1995-07-18 Stanford Surgical Technologies, Inc. Method for intraluminally inducing cardioplegic arrest and catheter for use therein
US5452733A (en) * 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5458574A (en) * 1994-03-16 1995-10-17 Heartport, Inc. System for performing a cardiac procedure
US5735290A (en) * 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
SE9102340D0 (en) * 1991-08-13 1991-08-13 Astra Ab PHARMACEUTICAL COMPOSITION CONTAINING CARBACHOL AND OTHERCHOLINERGIC SUBSTANCES
GB9119705D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic compounds
US5304209A (en) * 1991-09-24 1994-04-19 Angeion Corporation Remote-control temporary pacemaker
DE4201079C3 (en) * 1992-01-17 1997-09-11 Gramer Eugen Combination preparations for lowering intraocular pressure
US5287861A (en) * 1992-10-30 1994-02-22 Wilk Peter J Coronary artery by-pass method and associated catheter
US5455229A (en) * 1992-12-23 1995-10-03 Eli Lilly And Company Method for minimizing and containing ischemic and reperfusion injury
US5425705A (en) * 1993-02-22 1995-06-20 Stanford Surgical Technologies, Inc. Thoracoscopic devices and methods for arresting the heart
US5569274A (en) * 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5613937A (en) * 1993-02-22 1997-03-25 Heartport, Inc. Method of retracting heart tissue in closed-chest heart surgery using endo-scopic retraction
US5391199A (en) * 1993-07-20 1995-02-21 Biosense, Inc. Apparatus and method for treating cardiac arrhythmias
US5738096A (en) * 1993-07-20 1998-04-14 Biosense, Inc. Cardiac electromechanics
EP0719161B1 (en) * 1993-09-17 2002-04-17 Heartport, Inc. Endovascular system for arresting the heart
US5593428A (en) * 1993-09-27 1997-01-14 Khosrow Jamshidi Emergency external cardiac defibrillator and pacing method and apparatus
US5588949A (en) * 1993-10-08 1996-12-31 Heartport, Inc. Stereoscopic percutaneous visualization system
AU691854B2 (en) * 1993-12-03 1998-05-28 Edwards Lifesciences Ag Cardiopulmonary bypass system for closed-chest intervention
US5795331A (en) * 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
US5501698A (en) * 1994-02-14 1996-03-26 Heartport, Inc. Endoscopic microsurgical instruments and methods
US5428039A (en) * 1994-02-20 1995-06-27 The Center For Innovative Technology Method for electively achieving reversible hyperpolarized cardiac arrest
US5540722A (en) * 1994-05-16 1996-07-30 Physiometrix, Inc. Switch apparatus and method for switching between multiple electrodes for diagnostic and therapeutic procedures
US5478309A (en) * 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
WO1995035065A1 (en) * 1994-06-17 1995-12-28 Heartport, Inc. Surgical stapling instrument and method thereof
US5681278A (en) * 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US5591195A (en) * 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
DE19548658A1 (en) * 1995-12-18 1997-06-19 Biotronik Mess & Therapieg Extracorporeal control device for an implantable medical device
IL125136A (en) * 1996-01-08 2003-07-31 Impulse Dynamics Nv Electrical cardiac muscle controller method and apparatus
US5713925A (en) * 1996-01-11 1998-02-03 Physio-Control Corporation Adapter for isolating pacing and defibrillation signals
US5925054A (en) * 1996-02-20 1999-07-20 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US5913876A (en) * 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US5651378A (en) * 1996-02-20 1997-07-29 Cardiothoracic Systems, Inc. Method of using vagal nerve stimulation in surgery
WO1997040885A1 (en) * 1996-04-30 1997-11-06 Medtronic, Inc. Method and device for electronically controlling the beating of a heart
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
AU3357197A (en) * 1996-09-16 1998-04-02 Impulse Dynamics (Israel) Ltd. Cardiac output controller
AU4980897A (en) * 1996-10-15 1998-05-11 Paul W. Mayer Relative motion canceling platform for surgery
US5873366A (en) * 1996-11-07 1999-02-23 Chim; Nicholas Method for transmyocardial revascularization
US5993443A (en) * 1997-02-03 1999-11-30 Eclipse Surgical Technologies, Inc. Revascularization with heartbeat verification
ATE353689T1 (en) * 1997-07-16 2007-03-15 Metacure Nv DEVICE FOR CONTROLLING A SMOOTH MUSCLE

Also Published As

Publication number Publication date
US6127410A (en) 2000-10-03
US6141589A (en) 2000-10-31
AU758370B2 (en) 2003-03-20
JP2001513495A (en) 2001-09-04
US6060454A (en) 2000-05-09
DE69833665T2 (en) 2006-11-09
CA2300049C (en) 2009-03-10
AU9015698A (en) 1999-03-01
DE69833665D1 (en) 2006-04-27
WO1999007354A3 (en) 1999-04-29
EP1051168A2 (en) 2000-11-15
WO1999007354A2 (en) 1999-02-18
ATE318595T1 (en) 2006-03-15
US6101412A (en) 2000-08-08
US6087394A (en) 2000-07-11
US6043273A (en) 2000-03-28
US6414018B1 (en) 2002-07-02
EP1051168B1 (en) 2006-03-01

Similar Documents

Publication Publication Date Title
CA2300049A1 (en) Compositions, apparatus and methods for facilitating surgical procedures
Huang et al. Closed chest catheter desiccation of the atrioventricular junction using radiofrequency energy—a new method of catheter ablation
US6094596A (en) Transvenous defibrillation lead system for use in middle cardiac vein
Sanders et al. Catheter ablation of sinoatrial node reentrant tachycardia
US6363288B1 (en) CS lead with single site sensing and dual site pacing
CA2608257A1 (en) Body lumen shaping device with cardiac leads
WO2000004950A3 (en) Method and apparatus for dual chamber bi-ventricular pacing and defibrillation
Swarup et al. Ablation of epicardial macroreentrant ventricular tachycardia associated with idiopathic nonischemic dilated cardiomyopathy by a percutaneous transthoracic approach
Blanck et al. Catheter ablation of the left bundle branch for the treatment of sustained bundle branch reentrant ventricular tachycardia
WO1997040885A1 (en) Method and device for electronically controlling the beating of a heart
Biblo et al. Transcatheter radiofrequency ablation of ventricular tachycardia following surgical correction of tetralogy of Fallot
Zucker et al. Dipolar electrode in heart block
Senning Cardiac pacing in retrospect
Gursoy et al. Radiofrequency ablation of symptomatic but benign ventricular arrhythmias
Wieberdink Experimental production of permanent heart block (total or bundle branch block) without circulatory arrest or extracorporeal circulation.
Saksena et al. Low-energy transvenous ablation of the canine atrioventricular conduction system with a suction electrode catheter.
Mounsey et al. Radiofrequency ablation of a Mahaim fiber following localization of Mahaim pathway potentials
Jeffrey The invention and reinvention of cardiac pacing
Lüderitz History of cardiac rhythm disorders
Merino et al. Radiofrequency catheter ablation of ventricular tachycardia from the right ventricle late after myocardial infarction
Hirschberg et al. A new dual chamber single lead system
Holt et al. Antitachycardia pacing: A comparison of burst overdrive, self‐searching and adaptive table scanning programs
Sato et al. The efficacy of radiofrequency catheter ablation for the treatment of ventricular tachycardia associated with cardiomyopathy
IwA et al. Treatment of tachycardia by atrial pacing
Tarjan et al. An Experimental Device for Low-Energy, Precise Ablation of AV Conduction.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed