CA2300176A1 - Latent reactive polymers with biologically active moieties - Google Patents
Latent reactive polymers with biologically active moieties Download PDFInfo
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- CA2300176A1 CA2300176A1 CA002300176A CA2300176A CA2300176A1 CA 2300176 A1 CA2300176 A1 CA 2300176A1 CA 002300176 A CA002300176 A CA 002300176A CA 2300176 A CA2300176 A CA 2300176A CA 2300176 A1 CA2300176 A1 CA 2300176A1
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- polybifunctional
- reagent
- pendent
- bioactive groups
- reagent according
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0047—Enzymes, e.g. urokinase, streptokinase
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/087—Acrylic polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8128—Antithrombin III
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Abstract
A polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
Claims (23)
1. A polybifimctional reagent comprising a plurality of molecules each comprising a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, the reagent being capable, upon activation of the photoreactive moieties, of forming a bulk material or surface coating in order to promote the attraction of such complimentary groups.
2. A polybifunctional reagent according to claim 1, wherein the photoreactive moieties can be activated to form intermolecular covalent bonds between the reagent molecule and a biomaterial surface in order to form a coating thereon.
3. A polybifunctional reagent according to claim 1, wherein the photoreactive moieties can be activated to form intermolecular covalent bonds between adjacent reagent molecules in order to form a bulk material.
4. A polybifunctional reagent according to claim 1, wherein the bioactive groups participate in a specific binding reaction with complementary molecules or cell receptors.
5. A polybifunctional reagent according to claim 4, wherein the bioactive groups are each, independently, selected from the group consisting of proteins, peptides, amino acids, carbohydrates, and nucleic acids, each being capable of binding noncovalently to specific and complimentary portions of molecules or cells.
6. A polybifunetional reagent according to claim 1, wherein the bioactive groups each have a known or identifiable complementary binding partner and are each, independently, selected from the group consisting of antithrombotic agents, cell attachment factors, receptors, ligands, growth factors, antibiotics, enzymes and nucleic acids.
7. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise antithrombotic agents selected from the group consisting of heparin, hirudin, lysine, prostaglandins, streptokinase, urokinase, and plasminogen activator.
8. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise cell attachment factors selected from the group consisting of surface adhesion molecules and cell-cell adhesion molecules.
9. A polybifunctional reagent according to claim 8 wherein the bioactive groups comprise surface adhesion molecules selected from the group consisting of laminin, fibronectin, collagen, vitronectin, tenascin, fibrinogen, thrombospondin, osteopontin, von Willibrand Factor, and bone sialoprotein and active domains thereof.
10. A polybifunctional reagent according to claim 8 wherein the bioactive groups comprise cell-cell adhesion molecules selected from the group consisting of N-cadherin and P-cadherin and active domains thereof.
11. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise growth factors selected from the group consisting of fibroblastic growth factors, epidermal growth factor, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factor, bone moiphogenic proteins and other bone growth factors, and neural growth factors.
12. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise a ligand or receptor selected from the group consisting of antibodies, antigens, avidin, streptavidin, biotin, heparin, type IV collagen, protein A, and protein G.
13. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise an antibiotic selected from the group consisting of antibiotic peptides.
14. A polybifunctional reagent according to claim 6 wherein the bioactive groups compnse enzymes.
15. A polybifunctional reagent according to claim 6 wherein the bioactive groups comprise nucleic acid sequences capable of selectively binding complimentary nucleic acid sequences.
16. A polybifunctional reagent according to claim 1 wherein the polymeric backbone comprises a synthetic polymer selected from the group consisting of addition type polymers, such as the vinyl polymers.
17. A polybifunctional reagent according io claim 1 wherein the photogroups each comprise a photoactivatable ketone.
18. A polybifunctional reagent comprising a synthetic polymeric backbone bearing (a) one or more pendent photoreactive moieties in the form of photoactivatable ketones, and (b) two or more pendent bioactive groups selected from the group consisting of proteins, peptides, amino acids, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
19. A method of coating a biomaterial surface, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, (b) contacting the surface with the reagent, and (c) activating the photoreactive moieties in order to crosslink the reagent molecules to themselves and/or to the surface.
20. A method according to claim 19 wherein the reagent is coated on the surface by spraying, dipping or brushing.
21. A method for forming a bulk biomaterial, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, and (b) activating the reagent to form a bulk biomaterial.
22. A coated biomaterial surface, comprising the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups.
23. A bulk material comprising the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/916,913 | 1997-08-15 | ||
US08/916,913 US6121027A (en) | 1997-08-15 | 1997-08-15 | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
PCT/US1998/016605 WO1999008717A2 (en) | 1997-08-15 | 1998-08-11 | Latent reactive polymers with biologically active moieties |
Publications (2)
Publication Number | Publication Date |
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CA2300176A1 true CA2300176A1 (en) | 1999-02-25 |
CA2300176C CA2300176C (en) | 2010-10-12 |
Family
ID=25438061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2300176A Expired - Lifetime CA2300176C (en) | 1997-08-15 | 1998-08-11 | Latent reactive polymers with biologically active moieties |
Country Status (7)
Country | Link |
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US (3) | US6121027A (en) |
EP (3) | EP2148201B1 (en) |
JP (2) | JP5175013B2 (en) |
AU (1) | AU734759B2 (en) |
CA (1) | CA2300176C (en) |
DE (1) | DE69830177T2 (en) |
WO (1) | WO1999008717A2 (en) |
Families Citing this family (375)
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US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
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JP2002515932A (en) * | 1997-04-18 | 2002-05-28 | カリフォルニア インスティチュート オブ テクノロジー | Multifunctional polymeric tissue coating |
AU768490B2 (en) * | 1997-08-15 | 2003-12-11 | Surmodics, Inc. | Latent reactive polymers with biologically active moieties |
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US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
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DE19818077A1 (en) * | 1998-04-22 | 1999-10-28 | Biotechnolog Forschung Gmbh | Fixing substrate molecules in gel matrixes |
WO1999055396A1 (en) * | 1998-04-27 | 1999-11-04 | Surmodics, Inc. | Bioactive agent release coating |
US7241730B2 (en) | 1998-08-27 | 2007-07-10 | Universitat Zurich | Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides |
US6514768B1 (en) * | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
WO2001066164A1 (en) * | 1999-04-22 | 2001-09-13 | Eidgenossisch Technische Hochschule Zurich | Modified protein matrices |
ATE419528T1 (en) * | 1999-04-28 | 2009-01-15 | Eidgenoess Tech Hochschule | POLYIONIC COATINGS FOR ANALYTICAL AND SENSOR DEVICES |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US7682647B2 (en) | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
US6759054B2 (en) | 1999-09-03 | 2004-07-06 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol composition and coating |
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-
1997
- 1997-08-15 US US08/916,913 patent/US6121027A/en not_active Expired - Lifetime
-
1998
- 1998-08-11 AU AU91973/98A patent/AU734759B2/en not_active Ceased
- 1998-08-11 EP EP09174433.4A patent/EP2148201B1/en not_active Expired - Lifetime
- 1998-08-11 DE DE69830177T patent/DE69830177T2/en not_active Expired - Lifetime
- 1998-08-11 EP EP98944435A patent/EP1003561B1/en not_active Expired - Lifetime
- 1998-08-11 EP EP05006595.2A patent/EP1577670B1/en not_active Expired - Lifetime
- 1998-08-11 WO PCT/US1998/016605 patent/WO1999008717A2/en active IP Right Grant
- 1998-08-11 CA CA2300176A patent/CA2300176C/en not_active Expired - Lifetime
- 1998-08-11 JP JP2000509453A patent/JP5175013B2/en not_active Expired - Lifetime
-
2000
- 2000-06-09 US US09/591,564 patent/US6514734B1/en not_active Expired - Lifetime
-
2003
- 2003-02-03 US US10/357,131 patent/US20030181423A1/en not_active Abandoned
-
2011
- 2011-11-18 JP JP2011252803A patent/JP5175383B2/en not_active Expired - Lifetime
Also Published As
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EP1003561A2 (en) | 2000-05-31 |
JP2012063361A (en) | 2012-03-29 |
EP2148201B1 (en) | 2014-10-15 |
JP5175383B2 (en) | 2013-04-03 |
EP2148201A1 (en) | 2010-01-27 |
JP5175013B2 (en) | 2013-04-03 |
AU734759B2 (en) | 2001-06-21 |
DE69830177T2 (en) | 2006-02-23 |
CA2300176C (en) | 2010-10-12 |
EP1577670B1 (en) | 2015-01-28 |
AU9197398A (en) | 1999-03-08 |
WO1999008717A2 (en) | 1999-02-25 |
US6514734B1 (en) | 2003-02-04 |
US20030181423A1 (en) | 2003-09-25 |
EP1577670A2 (en) | 2005-09-21 |
JP2003532434A (en) | 2003-11-05 |
DE69830177D1 (en) | 2005-06-16 |
EP1577670A3 (en) | 2005-12-07 |
EP1003561B1 (en) | 2005-05-11 |
WO1999008717A3 (en) | 1999-05-06 |
US6121027A (en) | 2000-09-19 |
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