CA2300844C - Syringe for medical purposes - Google Patents
Syringe for medical purposes Download PDFInfo
- Publication number
- CA2300844C CA2300844C CA002300844A CA2300844A CA2300844C CA 2300844 C CA2300844 C CA 2300844C CA 002300844 A CA002300844 A CA 002300844A CA 2300844 A CA2300844 A CA 2300844A CA 2300844 C CA2300844 C CA 2300844C
- Authority
- CA
- Canada
- Prior art keywords
- plunger
- plunger rod
- dual chamber
- elements
- syringe according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
- A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/3151—Means for blocking or restricting the movement of the rod or piston by friction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
Abstract
The syringe for medical purposes consists of a syringe barrel (1), at least one stopper (2) arranged therein and displaceable by means of a plunger rod (3), and a finger support (4) which is connected to the end of the syringe barrel (1) and which is provided with an opening (5) for passage of the plunger rod (3). In particular, it is formed as a dual-chamber syringe in which the pharmaceutical agent and the solvent are arranged in a distal and a proximal chamber (7, 8), separated from each other by means of an additional stopper (6) until application when they can be brought together via a by-pass. The plunger rod (3) is provided with radially projecting detent elements (10, 13), for whose passage through the finger support (4) at least one recess (11) is provided in the rim of the opening (5). The detent elements (10, 13) are arranged several in a row in the axial direction of the plunger rod (3) and/or are arranged around the longitudinal axis of the plunger rod (3), alternately offset by a specific angle of rotation. An elastically sprung compression element (12) is provided in the area of the recess (11) on the rim which abuts against the plunger rod (3) or the detent elements (10), respectively.
Description
Svrin~e for Medical Purposes Field of the Invention The invention concerns medical devices, in particular syringes.
Background of the Invention In dual-chamber medical syringes, it is often important to mix a pharmaceutical agent, which is in a powder-like form, with a solvent free of contamination, immediately prior to application, i.e. to reconstitute the material to be injected. This process must be carried out as smoothly as possible in order to achieve an optimal restoration of the material to be injected to its original state. To this end, it has already been proposed that the plunger of the syringe be provided with a thread, so that the screw motion of the plunger rod ensures the steady propulsion of the plunger at a reduced speed.
Furthermore, it is often necessary to administer the reconstituted substance portion-wise, as is desired when raising weak in neural therapy, for instance.
Summary of the Invention An object of the invention is to provide a syringe such that, first, a controlled reconstitution process is ensured and next, a portion-wise administration of the reconstituted substance is made possible.
In accordance with one aspect of the present invention there is provided a dual chamber syringe for medical purposes comprising: a syringe barrel, and arranged in it a stopper displaceable by means of a plunger rod. and a linger support which is connected to the end of the syringe barrel and which is provided with an opening for passage of the plunger rod said opening having a rim, and in which a pharmaceutical agent and a solvent are arranged in a distal and proximal chamber, being separated by a second stopper, until depression of the plunger causes the pharmaceutical agent and solvent to mix via a by-pass, wherein the plunger rod is provided with radially projecting detent elements, whose passage through the finger support is permitted by providing at least one recess in the rim of the opening, while the detent elements are arranged several in a row in the axial direction of the plunger rod and/or are axially arranged around the longitudinal axis of the plunger rod, alternately offset -1 a-by a specific angle of rotation, and with an elastically sprung compression element provided in the area of the recess on the rim which abuts against the plunger rod or the detent elements, respectively.
Background of the Invention In dual-chamber medical syringes, it is often important to mix a pharmaceutical agent, which is in a powder-like form, with a solvent free of contamination, immediately prior to application, i.e. to reconstitute the material to be injected. This process must be carried out as smoothly as possible in order to achieve an optimal restoration of the material to be injected to its original state. To this end, it has already been proposed that the plunger of the syringe be provided with a thread, so that the screw motion of the plunger rod ensures the steady propulsion of the plunger at a reduced speed.
Furthermore, it is often necessary to administer the reconstituted substance portion-wise, as is desired when raising weak in neural therapy, for instance.
Summary of the Invention An object of the invention is to provide a syringe such that, first, a controlled reconstitution process is ensured and next, a portion-wise administration of the reconstituted substance is made possible.
In accordance with one aspect of the present invention there is provided a dual chamber syringe for medical purposes comprising: a syringe barrel, and arranged in it a stopper displaceable by means of a plunger rod. and a linger support which is connected to the end of the syringe barrel and which is provided with an opening for passage of the plunger rod said opening having a rim, and in which a pharmaceutical agent and a solvent are arranged in a distal and proximal chamber, being separated by a second stopper, until depression of the plunger causes the pharmaceutical agent and solvent to mix via a by-pass, wherein the plunger rod is provided with radially projecting detent elements, whose passage through the finger support is permitted by providing at least one recess in the rim of the opening, while the detent elements are arranged several in a row in the axial direction of the plunger rod and/or are axially arranged around the longitudinal axis of the plunger rod, alternately offset -1 a-by a specific angle of rotation, and with an elastically sprung compression element provided in the area of the recess on the rim which abuts against the plunger rod or the detent elements, respectively.
Detailed Description of the Invention According to the invention a plunger rod is provided with radially projecting detent elements, for whose passage through the forger support at least one recess is provided in the rim of the opening, with the detent elements in the axial direction of the plunger rod arranged alternately and multiply one after the other and/or axially and alternately displaced by a specific angle of rotation around the longitudinal axis of the plunger rod, and with an elastically sprung compression element provided in the area of the recess on the rim abutting against the plunger rod or the detent elements, respectively.
An advantage achieved by the invention is that during the reconstitution of the pharmaceutical substance the axially arranged detent elements are delayed to a certain extent by the flexible compression elements so that transfer of the solvent to the distal chamber, that is to the cannula-side chamber, proceeds comparatively slowly as opposed to a smooth plunger rod. In contrast, the detent elements that are alternately and successively offset by a specific angle of rotation permit the sequential injection of portions of the substance, since each subsequent detent element always forms a limit stop checking further progress of the injection. Further injection is possible only after the plunger has been rotated accordingly.
In an advantageous embodiment of the invention, the detent elements are efficaciously arranged in diametrically opposed pairs. With alternately arranged detent elements, it is preferred that the angle of rotation between the detent elements be 90 degrees.
In order to achieve an optimal reconstitution of the pharmaceutical product, on the one hand, and to prevent the plunger rod being pressed too far into the syringe barrel, on the other hand, thereby causing a portion of the usually expensive pharmaceutical substance to escape via the cannula, provision has been made according to the invention so that the part of the plunger rod which is equipped with detent elements in its axial direction is of such a length that the solvent is completely transferred to the distal chamber as soon as the last detent element has passed over the compression element. Normally, this is succeeded by a further detent element offset in terms of its angle of rotation so that, initially, further displacement of the syringe plunger is then prevented before the subsequent deairing of the syringe barrel and the injection.
An advantage achieved by the invention is that during the reconstitution of the pharmaceutical substance the axially arranged detent elements are delayed to a certain extent by the flexible compression elements so that transfer of the solvent to the distal chamber, that is to the cannula-side chamber, proceeds comparatively slowly as opposed to a smooth plunger rod. In contrast, the detent elements that are alternately and successively offset by a specific angle of rotation permit the sequential injection of portions of the substance, since each subsequent detent element always forms a limit stop checking further progress of the injection. Further injection is possible only after the plunger has been rotated accordingly.
In an advantageous embodiment of the invention, the detent elements are efficaciously arranged in diametrically opposed pairs. With alternately arranged detent elements, it is preferred that the angle of rotation between the detent elements be 90 degrees.
In order to achieve an optimal reconstitution of the pharmaceutical product, on the one hand, and to prevent the plunger rod being pressed too far into the syringe barrel, on the other hand, thereby causing a portion of the usually expensive pharmaceutical substance to escape via the cannula, provision has been made according to the invention so that the part of the plunger rod which is equipped with detent elements in its axial direction is of such a length that the solvent is completely transferred to the distal chamber as soon as the last detent element has passed over the compression element. Normally, this is succeeded by a further detent element offset in terms of its angle of rotation so that, initially, further displacement of the syringe plunger is then prevented before the subsequent deairing of the syringe barrel and the injection.
For sequential injection of the pharmaceutical product it is efficacious that the spacing of the detent elements, offset each relative to the other by a specific angle of rotation, is dimensioned in such a way that a portion is injected which is predetermined by the possible travel of the plunger rod between two detent elements. According to the invention, plunger rods with appropriate intervals between the detent elements are provided for injecting different portions. This permits easy setting of the required portion through the use of a specified plunger rod, for which purpose the plunger rods can be clearly marked, for instance with distinctive colours.
The recess in the rim of the passage opening in the finger support has for this purpose a rectangular shape, although others, e.g. sector patterns, are possible.
The compression element is advantageously shaped like a lip and is arranged behind the recess in the rim, facing the lumen of the syringe barrel.
Finally, it is expedient according to the invention that the detent elements are cuboid or wedge-shaped in profile, with the wedge angle pointing towards the stopper.
The invention is described in more detail below by means of typical embodiments shown in the drawings:
Fig. 1 in Subfigures a-f shows the step-by-step preparation of a dual-chamber syringe for injection.
Fig. 2 in Subfigures a-a shows the sequential administration of portions of the pharmaceutical substance contained in the syringe barrel.
The syringe for medical purposes shown in the drawing consists first of a syringe barrel 1 in which is arranged a normal stopper 2 displaceable by means of a plunger rod 3.
A finger support 4 is connected to one end of the syringe barrel 1. The finger support 4 is provided with an opening 5 for the plunger rod 3.
A further stopper 6 is arranged in the syringe barrel 1 and divides the barrel into two separate chambers 7, 8. The pharmaceutical agent is in powder form, usually freeze-dried, and is located in the distal chamber 7, whereas the proximal chamber 8 is filled with its associated solvent. By applying pressure on the plunger rod 3, the solvent can be transferred via a by-pass 9 to the cannula-side chamber 7 containing the pharmaceutical agent, whereby the middle stopper 6 separating the two chambers 6, 7 from each other is displaced into the region of the by-pass 9.
In order to prevent the solvent from streaming too quickly into the distal chamber 7, the plunger rod 3 is provided with radially projecting detent elements 10, whose passage through the finger support 4 is permitted by providing recesses 11 in the passage opening 5. The detent elements 10 are arranged multiply in succession in the axial direction of the plunger rod 3, while an elastically sprung compression element 12 is provided in the region of the recess 11 in the rim. This compression element 12 abuts against the plunger rod 3 or the detent elements 10, respectively, so that a slow mixture of the solvent with the pharmaceutical substance is ensured.
In addition, as more particularly shown in Fig. 2, further detent elements 13 are provided which are axially arranged around the longitudinal axis of the plunger rod 3, alternately offset by a specific angle of rotation. These detent elements 13 each acts on the finger support 4 as a limit stop and serve to inject sequentially portions of the substance contained in the syringe barrel 1. Each time one of the detent elements 13 strikes the forger support 4, the plunger rod 3 must be rotated through a specific angle of rotation dictated by the arrangement of the detent elements 13, so that the detent element 13 that just served as a limit stop can pass through the recess 11 at the rim, thereby permitting injection of a further portion until the next detent element 13 strikes the forger support 4.
As shown in the drawing, the detent elements 10, 13 are arranged in diametrically opposed pairs. Furthermore, the angles of rotation between the alternately arranged detent elements 13 are each 90 degrees, as also shown in the drawing.
The part of the plunger rod 3 which is axially provided with detent elements 10 is of such a length that the solvent is completely transferred to the distal chamber 7 as soon as the last detent element 10 has passed the compression element 12. This results in a slowing of the plunger rod 3 during the transfer of the solvent into the distal chamber 7, and ends (expediently by an offset detent element 13 striking the forger support) precisely at the moment the two stoppers 2, 6 abut against each other.
In order to be able to administer specific portions of the pharmaceutical substance in precisely the correct dosage, the spacing of the detent elements 13, offset relative to each other by a specific angle of rotation, is dimensioned in such a way that the travel of the plunger rod 3 between two neighbouring detent elements results in the injection of precisely the desired portion.
In order to permit injection of different portions, it is sufficient to provide various plunger rods 3 with appropriate spacing between the detent elements. To prevent mixups, these plunger rods 3 can be clearly marked, for instance with distinctive colours, and can be included with the syringe individually or as a selection.
The recess 11 in the rim of the passage opening 5 is normally rectangular in shape, although other shapes, e.g. arc shapes or sector patterns, are possible.
The compression element 12 is shaped like a lip and is located behind the recess 11 in the rim, facing the lumen of the syringe barrel 1.
As is also shown in the drawing, the detent elements 10, 13 are cuboid or wedge-shaped in profile, whereby in the latter case, the wedge angle points toward the stopper 2.
Fig. 1, Subfigure a, shows the syringe in its initial position in which it still has a cap 14 at the end of the cannula side. In Subfigure b, the cannula 1 S is already fitted, while the solvent has already been transferred to the distal chamber 7 and both the stoppers 2, 6 are abutting against each other. In this position, the plunger rod 3 is prevented from being moved because one detent element 13 prevents further progress forwards. In Subfigure c, the plunger rod 3 has been rotated 90 degrees, and the detent elements 13 that just served as limit stops can pass through the recess 11 at the rim into the interior of the syringe barrel 1.
The recess in the rim of the passage opening in the finger support has for this purpose a rectangular shape, although others, e.g. sector patterns, are possible.
The compression element is advantageously shaped like a lip and is arranged behind the recess in the rim, facing the lumen of the syringe barrel.
Finally, it is expedient according to the invention that the detent elements are cuboid or wedge-shaped in profile, with the wedge angle pointing towards the stopper.
The invention is described in more detail below by means of typical embodiments shown in the drawings:
Fig. 1 in Subfigures a-f shows the step-by-step preparation of a dual-chamber syringe for injection.
Fig. 2 in Subfigures a-a shows the sequential administration of portions of the pharmaceutical substance contained in the syringe barrel.
The syringe for medical purposes shown in the drawing consists first of a syringe barrel 1 in which is arranged a normal stopper 2 displaceable by means of a plunger rod 3.
A finger support 4 is connected to one end of the syringe barrel 1. The finger support 4 is provided with an opening 5 for the plunger rod 3.
A further stopper 6 is arranged in the syringe barrel 1 and divides the barrel into two separate chambers 7, 8. The pharmaceutical agent is in powder form, usually freeze-dried, and is located in the distal chamber 7, whereas the proximal chamber 8 is filled with its associated solvent. By applying pressure on the plunger rod 3, the solvent can be transferred via a by-pass 9 to the cannula-side chamber 7 containing the pharmaceutical agent, whereby the middle stopper 6 separating the two chambers 6, 7 from each other is displaced into the region of the by-pass 9.
In order to prevent the solvent from streaming too quickly into the distal chamber 7, the plunger rod 3 is provided with radially projecting detent elements 10, whose passage through the finger support 4 is permitted by providing recesses 11 in the passage opening 5. The detent elements 10 are arranged multiply in succession in the axial direction of the plunger rod 3, while an elastically sprung compression element 12 is provided in the region of the recess 11 in the rim. This compression element 12 abuts against the plunger rod 3 or the detent elements 10, respectively, so that a slow mixture of the solvent with the pharmaceutical substance is ensured.
In addition, as more particularly shown in Fig. 2, further detent elements 13 are provided which are axially arranged around the longitudinal axis of the plunger rod 3, alternately offset by a specific angle of rotation. These detent elements 13 each acts on the finger support 4 as a limit stop and serve to inject sequentially portions of the substance contained in the syringe barrel 1. Each time one of the detent elements 13 strikes the forger support 4, the plunger rod 3 must be rotated through a specific angle of rotation dictated by the arrangement of the detent elements 13, so that the detent element 13 that just served as a limit stop can pass through the recess 11 at the rim, thereby permitting injection of a further portion until the next detent element 13 strikes the forger support 4.
As shown in the drawing, the detent elements 10, 13 are arranged in diametrically opposed pairs. Furthermore, the angles of rotation between the alternately arranged detent elements 13 are each 90 degrees, as also shown in the drawing.
The part of the plunger rod 3 which is axially provided with detent elements 10 is of such a length that the solvent is completely transferred to the distal chamber 7 as soon as the last detent element 10 has passed the compression element 12. This results in a slowing of the plunger rod 3 during the transfer of the solvent into the distal chamber 7, and ends (expediently by an offset detent element 13 striking the forger support) precisely at the moment the two stoppers 2, 6 abut against each other.
In order to be able to administer specific portions of the pharmaceutical substance in precisely the correct dosage, the spacing of the detent elements 13, offset relative to each other by a specific angle of rotation, is dimensioned in such a way that the travel of the plunger rod 3 between two neighbouring detent elements results in the injection of precisely the desired portion.
In order to permit injection of different portions, it is sufficient to provide various plunger rods 3 with appropriate spacing between the detent elements. To prevent mixups, these plunger rods 3 can be clearly marked, for instance with distinctive colours, and can be included with the syringe individually or as a selection.
The recess 11 in the rim of the passage opening 5 is normally rectangular in shape, although other shapes, e.g. arc shapes or sector patterns, are possible.
The compression element 12 is shaped like a lip and is located behind the recess 11 in the rim, facing the lumen of the syringe barrel 1.
As is also shown in the drawing, the detent elements 10, 13 are cuboid or wedge-shaped in profile, whereby in the latter case, the wedge angle points toward the stopper 2.
Fig. 1, Subfigure a, shows the syringe in its initial position in which it still has a cap 14 at the end of the cannula side. In Subfigure b, the cannula 1 S is already fitted, while the solvent has already been transferred to the distal chamber 7 and both the stoppers 2, 6 are abutting against each other. In this position, the plunger rod 3 is prevented from being moved because one detent element 13 prevents further progress forwards. In Subfigure c, the plunger rod 3 has been rotated 90 degrees, and the detent elements 13 that just served as limit stops can pass through the recess 11 at the rim into the interior of the syringe barrel 1.
Subfigure d shows the deairing of the syringe completed; Subfigure a indicates that after puncturing the vessel during injection, the plunger rod 2 is pulled back slightly in order to check whether blood appears at the distal end of the syringe. In this event, injection may take place until the syringe barrel 1 has been completely emptied according to Subfigure f.
Fig. 2 continues from the situation shown in Fig. 1 b, and Subfigures b-a demonstrate how, by each respective rotation of the plunger rod 3, several (here, a total of four) portions can be sequentially injected. After injection of each portion, the plunger rod 3 must be rotated so that after serving as a limit stop, each detent element 13 can pass through the recess 11 in the rim into the interior of the syringe barrel 1.
Fig. 2 continues from the situation shown in Fig. 1 b, and Subfigures b-a demonstrate how, by each respective rotation of the plunger rod 3, several (here, a total of four) portions can be sequentially injected. After injection of each portion, the plunger rod 3 must be rotated so that after serving as a limit stop, each detent element 13 can pass through the recess 11 in the rim into the interior of the syringe barrel 1.
Claims (17)
1. A dual chamber syringe for medical purposes comprising:
a syringe barrel, and arranged in it a stopper displaceable by means of a plunger rod, and a finger support which is connected to the end of the syringe barrel and which is provided with an opening for passage of the plunger rod said opening having a rim, and in which a pharmaceutical agent and a solvent are arranged in a distal and a proximal chamber, being separated by a second stopper, until depression of the plunger causes the pharmaceutical agent and solvent to mix via a by-pass, wherein the plunger rod is provided with radially projecting detent elements, whose passage through the linger support is permitted by providing at least one recess in the rim of the opening, while the decent elements are arranged several in a row in the axial direction of the plunger rod and/or are axially arranged around the longitudinal axis of the plunger rod, alternately offset by a specific angel of rotation, and with an elastically sprung compression element provided in the area of the recess on the rim which abuts against the plunger rod or the detent elements, respectively.
a syringe barrel, and arranged in it a stopper displaceable by means of a plunger rod, and a finger support which is connected to the end of the syringe barrel and which is provided with an opening for passage of the plunger rod said opening having a rim, and in which a pharmaceutical agent and a solvent are arranged in a distal and a proximal chamber, being separated by a second stopper, until depression of the plunger causes the pharmaceutical agent and solvent to mix via a by-pass, wherein the plunger rod is provided with radially projecting detent elements, whose passage through the linger support is permitted by providing at least one recess in the rim of the opening, while the decent elements are arranged several in a row in the axial direction of the plunger rod and/or are axially arranged around the longitudinal axis of the plunger rod, alternately offset by a specific angel of rotation, and with an elastically sprung compression element provided in the area of the recess on the rim which abuts against the plunger rod or the detent elements, respectively.
2. A dual chamber syringe according to Claim 1, wherein the detent elements are arranged in diametrically opposed pairs.
3. A dual chamber syringe according to Claim 1 or 2, wherein radially offset detents are offset by an angle of about 90 degrees.
4. A dual chamber syringe according to Claim 1, 2 or 3, wherein the detest elements occupy such a length on the plunger that the solvent is completely transferred to the distal chamber as soon as the last detest element has passed the compression element.
5. A dual chamber syringe according to any one of Claims 1 to 4, wherein spacing of the detest elements, offset relative to each other by a specific angle of rotation, is dimensioned in such a way that a portion is injected which is predetermined by the stroke of the plunger rod between two decent elements.
6. A dual chamber syringe according to Claim 5, wherein plunger rods with appropriate spacing between the detent elements are provided for injecting different portions.
7. A dual chamber according to any one of Claims 1 to 6, wherein the recess in the rim of the passage opening has a rectangular shape.
8. A dual chamber syringe according to any one of Claims 1 to 6, wherein the recess in the rim of the passage opening has an arc shape or sector pattern.
9. A dual chamber syringe according to any one of Claims 1 to 8, wherein the compression element is shaped like a lip and is arranged behind the recess in the rim, facing the lumen of the syringe barrel.
10. A dual chamber syringe according to any one of Claims 1 to 9, wherein the detent elements are cuboid or wedge-shaped in profile, with the wedge angle pointing towards the stopper.
11. A dual chamber medical syringe comprising:
a barrel having a back end and a cannula end, the barrel having a chamber at the back end and a chamber at the cannula end, the chambers being designed to contain and separate pharmaceutical substance and solvent until it is desired to mix the pharmaceutical substance and solvent by depression of the plunger; and a plunger, wherein the plunger has ai least two radially projecting decent elements spaced at predetermined distances longitudinally on the plunger, and the back end of the barrel has al compression clement which resiliently abuts the detest elements, the compression element having at least one recess permitting passage of the detest elements. thereby permitting the controlled passage of the plunger into the barrel.
a barrel having a back end and a cannula end, the barrel having a chamber at the back end and a chamber at the cannula end, the chambers being designed to contain and separate pharmaceutical substance and solvent until it is desired to mix the pharmaceutical substance and solvent by depression of the plunger; and a plunger, wherein the plunger has ai least two radially projecting decent elements spaced at predetermined distances longitudinally on the plunger, and the back end of the barrel has al compression clement which resiliently abuts the detest elements, the compression element having at least one recess permitting passage of the detest elements. thereby permitting the controlled passage of the plunger into the barrel.
12. A dual chamber syringe according to Claim 11, wherein the at least two detent elements occupying different longitudinal positions on the plunger occupy different radial positions on the plunger such that the plunger must be rotated between the different radial positions to permit passage of the detent elements through the recess.
13. A dual chamber syringe according to Claim 12, wherein the different radial positions are separated by an angle of approximately 90 degrees.
14. A dual chamber syringe according to Claim 11, 12 or 13, wherein the detent elements are arranged in diametrically opposed pairs.
15. A dual chamber syringe according to Claim 11, wherein the detents are so arranged that when the pharmaceutical substance and the solvent are completely mixed, the plunger must be rotated for further depression.
16. A syringe according to any one of Claims 11 to 15, wherein the predetermined distance between at least two detents corresponds to a desired dosage volume of injectable material.
17. A dual chamber syringe according to Claim 16, wherein different plungers can be used with different predetermined distances in order to dispense different volumes of injectable material.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19912322.5-41 | 1999-03-19 | ||
DE19912322A DE19912322A1 (en) | 1999-03-19 | 1999-03-19 | Syringe for medical purposes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2300844A1 CA2300844A1 (en) | 2000-09-19 |
CA2300844C true CA2300844C (en) | 2006-09-19 |
Family
ID=7901587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002300844A Expired - Lifetime CA2300844C (en) | 1999-03-19 | 2000-03-17 | Syringe for medical purposes |
Country Status (9)
Country | Link |
---|---|
US (1) | US6419656B1 (en) |
EP (1) | EP1038543B1 (en) |
JP (1) | JP3458188B2 (en) |
AT (1) | ATE214955T1 (en) |
CA (1) | CA2300844C (en) |
DE (2) | DE19912322A1 (en) |
DK (1) | DK1038543T3 (en) |
ES (1) | ES2171318T3 (en) |
PT (1) | PT1038543E (en) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6196998B1 (en) | 1994-12-12 | 2001-03-06 | Becton Dickinson And Company | Syringe and tip cap assembly |
DE10036594A1 (en) * | 2000-07-27 | 2002-02-07 | Pfeiffer Erich Gmbh & Co Kg | Delivery unit, especially for pharmaceuticals, comprises a container composed of separate chambers which hold a media component, an actuating unit and a connection between the chambers |
DE10140704A1 (en) * | 2001-08-18 | 2003-03-06 | Vetter & Co Apotheker | Process for mixing a poorly soluble pharmaceutical substance with a solvent and syringe to apply the process |
JP4838955B2 (en) † | 2001-08-21 | 2011-12-14 | 武田薬品工業株式会社 | Two-chamber prefilled syringe |
GB0217285D0 (en) | 2002-07-25 | 2002-09-04 | Cambridge Consultants | Syringes |
US6972006B2 (en) * | 2002-09-18 | 2005-12-06 | G6 Science Corp. | Syringe device with resistive ridges and methods of use |
DE10340586A1 (en) * | 2003-09-03 | 2005-04-07 | Tecpharma Licensing Ag | Mixing device for multi-chamber ampoule |
AU2004299086B2 (en) * | 2003-12-16 | 2011-03-03 | Idexx Laboratories, Inc. | Tissue sampling device and method |
US7101354B2 (en) | 2004-05-03 | 2006-09-05 | Infusive Technologies, Llc | Mixing syringe with and without flush |
US7998106B2 (en) | 2004-05-03 | 2011-08-16 | Thorne Jr Gale H | Safety dispensing system for hazardous substances |
US20080132852A1 (en) * | 2004-07-28 | 2008-06-05 | Kleyhan Gennady I | Dosage device |
DE102004056617A1 (en) * | 2004-11-24 | 2006-06-01 | Arthur Fabian | Medical double-chamber syringe made of plastic |
US9463139B2 (en) | 2004-12-30 | 2016-10-11 | Byeong Seon Chang | Compact medication reconstitution device and method |
US20060157507A1 (en) * | 2004-12-30 | 2006-07-20 | Chang Byeong S | Multi-functional container closure delivery system |
US20060144869A1 (en) * | 2004-12-30 | 2006-07-06 | Chang Byeong S | Container closure delivery system |
US7959600B2 (en) * | 2004-12-30 | 2011-06-14 | Byeong S. Chang | Container closure delivery system |
CN101111281B (en) | 2005-02-01 | 2013-02-06 | 因特利杰克特有限公司 | Devices, systems, and methods for medicament delivery |
EP1893257A1 (en) * | 2005-05-16 | 2008-03-05 | Mallinckrodt, Inc. | Multi-stage syringe and methods of using the same |
US7780695B2 (en) | 2005-06-30 | 2010-08-24 | Codman & Shurtleff, Inc. | Chemically based vascular occlusion device deployment |
DE102005038495A1 (en) | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Double chamber container and method for its filling |
DE102005038368A1 (en) | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Double chamber container for lyophilization, method for its filling and its use |
DE102005038497A1 (en) * | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Double chamber container without bypass |
DE102005038458A1 (en) * | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Double-chamber container without bypass in the cylindrical body |
US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
JP4150389B2 (en) * | 2005-09-05 | 2008-09-17 | 日本ケミカルリサーチ株式会社 | Injection device |
JP4834389B2 (en) * | 2005-11-29 | 2011-12-14 | 前田産業株式会社 | Injection device |
US20070185438A1 (en) * | 2006-02-09 | 2007-08-09 | Shlomo Haimi | Multi-chamber mixing ampoule |
GB2437924B (en) * | 2006-05-11 | 2010-12-22 | Owen Mumford Ltd | Injection device |
US7674243B2 (en) * | 2006-05-17 | 2010-03-09 | Alcon Inc. | Ophthalmic injection device using piezoelectric array |
US7887521B2 (en) * | 2006-05-17 | 2011-02-15 | Alcon Research, Ltd. | Ophthalmic injection system |
US7811252B2 (en) * | 2006-05-17 | 2010-10-12 | Alcon Research, Ltd. | Dosage control device |
US7862540B2 (en) * | 2006-05-17 | 2011-01-04 | Alcon Research, Ltd. | Ophthalmic injection device using shape memory alloy |
US20070270768A1 (en) * | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
US20070270750A1 (en) * | 2006-05-17 | 2007-11-22 | Alcon, Inc. | Drug delivery device |
US7871399B2 (en) * | 2006-05-17 | 2011-01-18 | Alcon Research, Ltd. | Disposable ophthalmic injection device |
US20070268340A1 (en) * | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Ophthalmic Injection System and Method Using Piezoelectric Array |
DE102006038123C5 (en) * | 2006-08-14 | 2012-05-03 | Tecpharma Licensing Ag | Injection device with mechanical lock |
FR2905682B1 (en) * | 2006-09-13 | 2011-05-20 | Becton Dickinson France | CONTAINER, MEDICAL DEVICE AND METHOD FOR CONTAINING AND EXPULTING A PRODUCT. |
US20080097379A1 (en) * | 2006-09-26 | 2008-04-24 | Alcon Manufacturing, Ltd. | Ophthalmic injection method |
US20080125712A1 (en) * | 2006-09-26 | 2008-05-29 | Alcon Manufacturing, Ltd. | Ophthalmic injection system |
US20080097390A1 (en) * | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
US20080281292A1 (en) * | 2006-10-16 | 2008-11-13 | Hickingbotham Dyson W | Retractable Injection Port |
ATE490752T1 (en) * | 2006-10-16 | 2010-12-15 | Alcon Res Ltd | UNIVERSAL RECHARGEABLE ASSEMBLY WITH LIMITED REUSABILITY FOR AN OPHTHALMIC HANDPIECE |
WO2008108887A2 (en) * | 2006-10-16 | 2008-09-12 | Alcon Research, Ltd. | Method of operating ophthalmic hand piece with disposable end |
US9022970B2 (en) * | 2006-10-16 | 2015-05-05 | Alcon Research, Ltd. | Ophthalmic injection device including dosage control device |
SE530568C2 (en) | 2006-11-13 | 2008-07-08 | Medtentia Ab | Medical device for improving function of heart valve, has flange unit connected to loop-shaped support and provided to be arranged against annulus when loop shaped support abut heart valve |
CA2574746A1 (en) * | 2007-01-22 | 2008-07-22 | Duoject Medical Systems Inc. | Syringe having venting structure and method for mixing two substances in a syringe |
US20080275387A1 (en) * | 2007-05-03 | 2008-11-06 | Yeadon Stephen C | Hemostatic medical device |
US20090018548A1 (en) * | 2007-07-13 | 2009-01-15 | Charles Steven T | Pneumatically-Powered Intraocular Lens Injection Device with Removable Cartridge |
US20090018512A1 (en) * | 2007-07-13 | 2009-01-15 | Charles Steven T | Pneumatically-Powered Ophthalmic Injector |
US7740619B2 (en) * | 2007-08-01 | 2010-06-22 | Alcon Research, Ltd. | Spring driven ophthalmic injection device with safety actuator lockout feature |
US20090036842A1 (en) * | 2007-08-03 | 2009-02-05 | Raffi Pinedjian | Consumable Activation Lever For Injection Device |
US7629768B2 (en) * | 2007-08-03 | 2009-12-08 | Alcon Research, Ltd. | Easy cleaning C-shaped charging base |
WO2009019673A2 (en) * | 2007-08-07 | 2009-02-12 | Shlomo Haimi | Multi-chamber mixing ampoule |
KR101439466B1 (en) * | 2007-11-08 | 2014-09-15 | 주식회사 엘지생명과학 | Device and kit for drug injection |
ES2905719T3 (en) | 2008-05-14 | 2022-04-11 | Biolyph Llc | Reagent mixture preparation and dispensing device and associated methods |
EP2193817A1 (en) * | 2008-12-02 | 2010-06-09 | Sanofi-Aventis Deutschland GmbH | Drive assembly suitable for use in a medication delivery device and medication delivery device |
US8372036B2 (en) | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
US8394068B2 (en) | 2009-07-10 | 2013-03-12 | Becton, Dickinson And Company | Flush syringe assembly |
JP5385074B2 (en) * | 2009-09-29 | 2014-01-08 | テルモ株式会社 | Drug infusion tool |
US8177747B2 (en) | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
EP2533908B1 (en) * | 2010-02-12 | 2015-08-12 | Medmix Systems AG | Discharge device having a locking element |
ES2669185T3 (en) | 2010-06-29 | 2018-05-24 | Biolyph, Llc | Reagent Preparation Set |
JP4757951B1 (en) * | 2010-10-19 | 2011-08-24 | 株式会社アルテ | Two-chamber syringe |
WO2012067619A1 (en) | 2010-11-18 | 2012-05-24 | Biolyph, Llc | Reagent preparation and dispensing device |
EP2648782A1 (en) | 2010-12-06 | 2013-10-16 | Novo Nordisk Health Care AG | Wheel operated drug delivery device |
US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
WO2012110057A1 (en) | 2011-02-15 | 2012-08-23 | Chemisches Institut Schaefer Ag | Cefuroxime safety kit |
US10092688B2 (en) | 2011-05-13 | 2018-10-09 | Laura Jean Robinson | Medicament kit and method of use |
AR088689A1 (en) | 2011-11-09 | 2014-06-25 | Sanofi Aventis Deutschland | DRIVE ASSEMBLY FOR A MEDICATION ADMINISTRATION DEVICE AND A MEDICATION ADMINISTRATION DEVICE THAT INCLUDES A DRIVE ASSEMBLY |
US8834449B2 (en) | 2012-01-23 | 2014-09-16 | Ikomed Technologies, Inc. | Mixing syringe |
US9751056B2 (en) | 2012-01-23 | 2017-09-05 | Merit Medical Systems, Inc. | Mixing syringe |
JP6177767B2 (en) * | 2012-04-24 | 2017-08-09 | テルモ株式会社 | Syringes and fittings |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
US9731076B2 (en) * | 2012-06-29 | 2017-08-15 | Ethicon, Inc. | Multi-compartment pre-filled mixing syringes with bypass |
WO2014165868A1 (en) * | 2013-04-03 | 2014-10-09 | Armstrong Sean Terrence | Syringe and an accessory therefor |
WO2014162551A1 (en) * | 2013-04-04 | 2014-10-09 | テルモ株式会社 | Syringe |
US9308508B2 (en) | 2013-07-22 | 2016-04-12 | Kianoosh Peyvan | Sequential delivery device and method |
US20160296703A1 (en) | 2013-11-05 | 2016-10-13 | 3P Innovation Limited | A Pharmaceutical Component-Mixing Delivery Assembly |
CA2956074A1 (en) | 2014-07-24 | 2016-01-28 | Teleflex Medical Incorporated | Dose divider syringe |
AU2015315285B2 (en) | 2014-09-09 | 2019-04-04 | Byeong Seon Chang | Solution delivery device and method |
US20160144122A1 (en) * | 2014-11-26 | 2016-05-26 | Fisher Clinical Services GmbH | Syringe Assembly with Plunger Rod Backstop and Method of Use |
EP3028946A1 (en) | 2014-12-05 | 2016-06-08 | F. Hoffmann-La Roche AG | Preparing a double chamber container |
US10695495B2 (en) | 2015-03-24 | 2020-06-30 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
US10576206B2 (en) | 2015-06-30 | 2020-03-03 | Kaleo, Inc. | Auto-injectors for administration of a medicament within a prefilled syringe |
US10182939B2 (en) | 2015-09-16 | 2019-01-22 | Novartis Ag | Hydraulic injector and methods for intra-ocular lens insertion |
CH711657A2 (en) * | 2015-10-19 | 2017-04-28 | Tecpharma Licensing Ag | Device for administering an active substance and method for operating this device. |
CH711656A2 (en) * | 2015-10-19 | 2017-04-28 | Tecpharma Licensing Ag | Device for administering an active substance and method for operating this device. |
CN117065151A (en) * | 2017-12-13 | 2023-11-17 | 里珍纳龙药品有限公司 | Device and method for accurate dose delivery |
US11083847B2 (en) | 2018-01-26 | 2021-08-10 | Becton, Dickinson And Company | Flush syringe with flip cap |
EP3880277A2 (en) | 2018-11-13 | 2021-09-22 | Credence Medsystems, Inc. | System and method for multiple site injection |
JP2022543523A (en) | 2019-08-09 | 2022-10-13 | カレオ,インコーポレイテッド | Device and method for delivery of substances in pre-filled syringes |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH268694A (en) * | 1950-04-17 | 1950-05-31 | Ag Mediglass | Injection syringe and method for making the same. |
FR1412547A (en) * | 1964-08-20 | 1965-10-01 | Comptoir De Diffusion De Produ | Injection syringe |
GB1230522A (en) * | 1968-05-20 | 1971-05-05 | ||
DE2810370A1 (en) * | 1978-03-10 | 1979-09-20 | Wolfram Dr Med Breunig | Medical and chemical syringe - has locking devices in cylinder securing piston in different positions |
DK0440846T3 (en) * | 1990-02-07 | 1993-07-12 | Vetter & Co Apotheker | Double chamber syringe and application method |
NZ247392A (en) * | 1992-04-30 | 1995-05-26 | Takeda Chemical Industries Ltd | Prefilled syringe containing two substances mixed before injection |
US5380295A (en) * | 1992-12-14 | 1995-01-10 | Mallinckrodt Medical, Inc. | Delivery apparatus with mechanism preventing rearward movement of a piston disposed therein |
-
1999
- 1999-03-19 DE DE19912322A patent/DE19912322A1/en not_active Ceased
- 1999-11-10 ES ES99122359T patent/ES2171318T3/en not_active Expired - Lifetime
- 1999-11-10 DK DK99122359T patent/DK1038543T3/en active
- 1999-11-10 EP EP99122359A patent/EP1038543B1/en not_active Expired - Lifetime
- 1999-11-10 DE DE59901059T patent/DE59901059D1/en not_active Expired - Lifetime
- 1999-11-10 PT PT99122359T patent/PT1038543E/en unknown
- 1999-11-10 AT AT99122359T patent/ATE214955T1/en active
-
2000
- 2000-03-13 JP JP2000068793A patent/JP3458188B2/en not_active Expired - Lifetime
- 2000-03-17 CA CA002300844A patent/CA2300844C/en not_active Expired - Lifetime
- 2000-03-20 US US09/528,513 patent/US6419656B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE59901059D1 (en) | 2002-05-02 |
US6419656B1 (en) | 2002-07-16 |
ES2171318T3 (en) | 2002-09-01 |
CA2300844A1 (en) | 2000-09-19 |
EP1038543B1 (en) | 2002-03-27 |
JP2000271218A (en) | 2000-10-03 |
DK1038543T3 (en) | 2002-07-08 |
ATE214955T1 (en) | 2002-04-15 |
PT1038543E (en) | 2002-07-31 |
DE19912322A1 (en) | 2000-09-28 |
JP3458188B2 (en) | 2003-10-20 |
EP1038543A1 (en) | 2000-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2300844C (en) | Syringe for medical purposes | |
CN111712287B (en) | Medical device provided with a safety needle cover for injecting a composition | |
US11383044B2 (en) | Autoinjector having a settable dose | |
EP2279020B1 (en) | Devices for controlled-depth injection | |
US20030004467A1 (en) | Multi-dose syringe driver | |
US9867948B2 (en) | Administering device with priming function | |
EP2077879B1 (en) | Container, device and method to store and expel a product | |
US7976509B2 (en) | Injection device with secured dosing button | |
JP2010528792A (en) | Double chamber carpul | |
CN108136128B (en) | Multi-chamber syringe unit and method for preparing multi-chamber syringe | |
PL198728B1 (en) | Injector device and method for its operation | |
WO2012118687A1 (en) | Manually operated injector with restricted injection sequence | |
CN115038480A (en) | Variable dose syringe | |
US20090054850A1 (en) | Pusher with a coupling element | |
CN108601898B (en) | Multi-chamber syringe unit | |
CN112714653B (en) | Alternative device for adjusting a dose for a device for administering a product with a limiting mechanism | |
CN112292167B (en) | Force reduction in an injection device | |
US20190255260A1 (en) | Syringe-connector device for the separate administration of controlled quantities at least two products in a single injection | |
JP2023522394A (en) | Mechanism unit for drug delivery device and drug delivery device | |
WO2024074519A1 (en) | Injection device and method of preparing an injection device for injection | |
WO2022233752A1 (en) | Coded housing components for an injection device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20200317 |