CA2301135A1 - Rapidly disintegrating methylcellulose tablets - Google Patents

Rapidly disintegrating methylcellulose tablets Download PDF

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Publication number
CA2301135A1
CA2301135A1 CA002301135A CA2301135A CA2301135A1 CA 2301135 A1 CA2301135 A1 CA 2301135A1 CA 002301135 A CA002301135 A CA 002301135A CA 2301135 A CA2301135 A CA 2301135A CA 2301135 A1 CA2301135 A1 CA 2301135A1
Authority
CA
Canada
Prior art keywords
rapidly disintegrating
methylcellulose tablets
disintegrating methylcellulose
tablets
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002301135A
Other languages
French (fr)
Other versions
CA2301135C (en
Inventor
Bruce Daggy
Naresh I. Metha
Priyashri Nayak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Smithkline Beecham Corporation
Bruce Daggy
Naresh I. Metha
Priyashri Nayak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation, Bruce Daggy, Naresh I. Metha, Priyashri Nayak filed Critical Smithkline Beecham Corporation
Priority to CA002550041A priority Critical patent/CA2550041A1/en
Priority to CA002550132A priority patent/CA2550132A1/en
Publication of CA2301135A1 publication Critical patent/CA2301135A1/en
Application granted granted Critical
Publication of CA2301135C publication Critical patent/CA2301135C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1 N hydrochloric acid as well as water.
CA002301135A 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets Expired - Fee Related CA2301135C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002550041A CA2550041A1 (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets
CA002550132A CA2550132A1 (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5689997P 1997-08-22 1997-08-22
US60/056,899 1997-08-22
US8766298P 1998-06-02 1998-06-02
US60/087,662 1998-06-02
PCT/US1998/017405 WO1999009958A1 (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA002550132A Division CA2550132A1 (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets
CA002550041A Division CA2550041A1 (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets

Publications (2)

Publication Number Publication Date
CA2301135A1 true CA2301135A1 (en) 1999-03-04
CA2301135C CA2301135C (en) 2007-04-24

Family

ID=26735831

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301135A Expired - Fee Related CA2301135C (en) 1997-08-22 1998-08-21 Rapidly disintegrating methylcellulose tablets

Country Status (16)

Country Link
US (9) US6350469B1 (en)
EP (1) EP1005329A4 (en)
JP (1) JP2001513545A (en)
KR (3) KR20070040424A (en)
CN (2) CN1215833C (en)
AR (1) AR017512A1 (en)
AU (1) AU741326B2 (en)
BR (1) BR9811980A (en)
CA (1) CA2301135C (en)
CO (1) CO4960651A1 (en)
EA (1) EA004803B1 (en)
MY (2) MY135183A (en)
NZ (1) NZ502891A (en)
PL (1) PL338858A1 (en)
TW (1) TWI222869B (en)
WO (1) WO1999009958A1 (en)

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FR2798289B1 (en) * 1999-09-15 2004-12-31 Cll Pharma QUICKLY DELITING MOUTH GALENIC FORMS AND THEIR PREPARATION METHOD
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Also Published As

Publication number Publication date
TWI222869B (en) 2004-11-01
US20050089564A1 (en) 2005-04-28
US20050089562A1 (en) 2005-04-28
NZ502891A (en) 2002-06-28
US7125562B2 (en) 2006-10-24
US20030215505A1 (en) 2003-11-20
CA2301135C (en) 2007-04-24
US20050089563A1 (en) 2005-04-28
MY135183A (en) 2008-02-29
EA004803B1 (en) 2004-08-26
CO4960651A1 (en) 2000-09-25
EP1005329A1 (en) 2000-06-07
US20050089565A1 (en) 2005-04-28
AU741326B2 (en) 2001-11-29
US6350469B1 (en) 2002-02-26
KR20010023197A (en) 2001-03-26
AU9202298A (en) 1999-03-16
BR9811980A (en) 2000-08-15
AR017512A1 (en) 2001-09-12
WO1999009958A1 (en) 1999-03-04
PL338858A1 (en) 2000-11-20
EP1005329A4 (en) 2006-06-14
CN1660054A (en) 2005-08-31
US20050089560A1 (en) 2005-04-28
CN1276719A (en) 2000-12-13
CN1215833C (en) 2005-08-24
EA200000246A1 (en) 2000-08-28
KR100743767B1 (en) 2007-07-30
US20050089561A1 (en) 2005-04-28
KR20070116291A (en) 2007-12-07
KR20070040424A (en) 2007-04-16
US20020086052A1 (en) 2002-07-04
JP2001513545A (en) 2001-09-04
MY128046A (en) 2007-01-31

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