CA2303339A1 - A pharmaceutical composition for treating dysmenorrhea and premature labor - Google Patents

A pharmaceutical composition for treating dysmenorrhea and premature labor Download PDF

Info

Publication number
CA2303339A1
CA2303339A1 CA002303339A CA2303339A CA2303339A1 CA 2303339 A1 CA2303339 A1 CA 2303339A1 CA 002303339 A CA002303339 A CA 002303339A CA 2303339 A CA2303339 A CA 2303339A CA 2303339 A1 CA2303339 A1 CA 2303339A1
Authority
CA
Canada
Prior art keywords
premature labor
pharmaceutical composition
composition
beta
treating dysmenorrhea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002303339A
Other languages
French (fr)
Other versions
CA2303339C (en
Inventor
Howard L. Levine
William J. Bologna
Dominique De Ziegler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia Laboratories Bermuda Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26738031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2303339(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2303339A1 publication Critical patent/CA2303339A1/en
Application granted granted Critical
Publication of CA2303339C publication Critical patent/CA2303339C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants

Abstract

The present invention teaches a composition comprising a .beta.-adrenergic agonist in a bioadhesive carrier. Preferably, the composition comprises terbutaline in polycarbophil. The present invention additionally teaches the local administration of a .beta.-adrenergic agonist for the purpose of treating or preventing dysmenorrhea or premature labor. Using this composition and the method of treatment provides sufficient local levels of the drug to provide therapeutic efficacy, but avoids many untoward adverse events.
CA002303339A 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor Expired - Lifetime CA2303339C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5878997P 1997-09-12 1997-09-12
US60/058,789 1997-09-12
US09/145,172 US6126959A (en) 1997-09-12 1998-09-01 Pharmaceutical composition for treating dysmenorrhea and premature labor
US09/145,172 1998-09-01
PCT/US1998/018538 WO1999013862A2 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor

Publications (2)

Publication Number Publication Date
CA2303339A1 true CA2303339A1 (en) 1999-03-25
CA2303339C CA2303339C (en) 2006-12-12

Family

ID=26738031

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303339A Expired - Lifetime CA2303339C (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor

Country Status (20)

Country Link
US (2) US6126959A (en)
EP (1) EP1011632B1 (en)
JP (1) JP2002503637A (en)
KR (1) KR100575386B1 (en)
CN (1) CN1186009C (en)
AT (1) ATE253892T1 (en)
AU (1) AU738460B2 (en)
BR (1) BR9812134A (en)
CA (1) CA2303339C (en)
DE (1) DE69819748T2 (en)
DK (1) DK1011632T3 (en)
ES (1) ES2210813T3 (en)
HK (1) HK1025055A1 (en)
HU (1) HUP0003784A3 (en)
IL (1) IL134564A0 (en)
NO (1) NO329203B1 (en)
NZ (1) NZ502926A (en)
PT (1) PT1011632E (en)
RO (1) RO120814B1 (en)
WO (1) WO1999013862A2 (en)

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US7341737B2 (en) * 1997-06-11 2008-03-11 Kimberly-Clark Worldwide, Inc. Medicated tampon
DE69819748T2 (en) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. MEDICINES FOR TREATING DYSMENORRHEA AND PREVIOUS BLIES
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
US6818672B1 (en) * 1999-10-05 2004-11-16 Columbia Laboratories, Inc. Treating endometriosis or infertility, or improving fertility
UA74168C2 (en) * 1999-10-05 2005-11-15 Коламбіа Леборетеріс (Бермуда) Лімітед Use of beta-adrenergic agonist for treating endometriosis and infertility as well as for improving fertility
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US7709026B2 (en) 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
CN101327326A (en) * 2001-10-29 2008-12-24 哥伦比亚实验室(百慕大群岛)有限公司 Vaginally administered anti-dysrhythmic agents for treating pelvic pain and infertility
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US20080182841A1 (en) * 2001-10-29 2008-07-31 Levine Howard L Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US8425892B2 (en) * 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
FR2841223B1 (en) 2002-06-19 2004-10-15 Sleever Int PACKAGING FOR OBJECTS (S) OF HEAT SHRINKABLE MATERIAL WITH ESSENTIALLY SMOOTH INTERNAL OR EXTERNAL SIDE
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
PE20040134A1 (en) * 2002-07-25 2004-03-06 Pharmacia Corp PRAMIPEXOL ONCE-A-DAY DOSAGE FORM
PE20040321A1 (en) * 2002-08-22 2004-07-15 Novartis Consumer Health Sa TOPICAL COMPOSITION INCLUDING DICLOFENACO
ATE400270T1 (en) * 2002-12-18 2008-07-15 Ferrer Int PHARMACEUTICAL COMPOSITIONS CONTAINING SERTACONAZOLE FOR VAGINAL USE
ES2237298B1 (en) 2003-07-16 2006-11-01 Italfarmaco, S.A. SEMISOLID MUCOADHESIVE FORMULATIONS.
EP1660101A4 (en) * 2003-08-21 2010-02-24 Access Pharma Inc Liquid formulations for the prevention and treatment of mucosal diseases and disorders
EP2431026A1 (en) * 2004-08-13 2012-03-21 Boehringer Ingelheim International GmbH Extended release pellet formulation containing Pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
ES2355735T5 (en) * 2004-08-13 2014-06-27 Boehringer Ingelheim International Gmbh Formulation in extended-release tablets containing pramipexole or a pharmaceutically acceptable salt thereof, method of manufacture and use
US7481815B2 (en) * 2004-09-23 2009-01-27 Synthes (U.S.A.) Coplanar X-ray guided aiming arm for locking of intramedullary nails
US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7708726B2 (en) 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
CA2641665A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Modified release formulation
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
WO2008091592A1 (en) 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
US8445436B2 (en) * 2007-12-03 2013-05-21 Florida State University Research Foundation, Inc. Oxytocin and melatonin compositions and associated methods for inducing labor
US8992589B2 (en) 2007-12-03 2015-03-31 The Florida State University Research Foundation, Inc. Using light to regulate uterine contractions
ES2344673B1 (en) 2008-08-07 2011-05-03 Italfarmaco, S.A. USE OF ESTRIOL IN THE PREPARATION OF A PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH RISK OF POTOLOGIATUMORAL.
BRPI0803568B8 (en) * 2008-08-14 2021-05-25 Biolab San Us Farm Ltda mucoadhesive composition
ES2344675B1 (en) 2008-12-19 2011-04-28 Italfarmaco, S.A. USE OF ESTRIOL IN THE PREPARATION OF A PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH RISK OF VARIUM VARCOLOGY.
GB2484977A (en) * 2010-10-29 2012-05-02 Biocopea Ltd Treatment of a Th-1 mediated disease
MX2014000066A (en) 2011-06-28 2014-05-01 Medicis Pharmaceutical Corp High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis.
AU2016356884A1 (en) * 2015-11-16 2018-06-21 Fundación Para La Investigación Médica Aplicada Novel compounds as inhibitors of dna methyltransferases

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AU565354B2 (en) * 1983-11-14 1987-09-10 Bio-Mimetics Inc. Bioadhesive compositions and methods of treatment therewith
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USD345211S (en) 1992-04-06 1994-03-15 Columbia Laboratories, Inc. Dispensing vial for feminine hygiene products
US5508045A (en) * 1992-10-09 1996-04-16 The Regents Of The University Of California Method and agents for control and management of labor during pregnancy
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
USD375352S (en) 1994-03-14 1996-11-05 Columbia Laboratories, Inc. Dispensing vial for feminine hygiene products
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US5667492A (en) 1994-10-07 1997-09-16 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
FR2725343B1 (en) * 1994-10-10 1998-01-02 Jean Claude Attali INSECTICIDE AND PARASITICIDE COMPLEX, AND METHOD FOR DESINSECTIZATION AND DESTRUCTION OF ECTOPARASITES
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WO1998023292A1 (en) * 1996-11-29 1998-06-04 Monsanto Company Lubricious self-standing (intact) gel for oral delivery of biologically-active ingredients
US6197327B1 (en) * 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
DE69819748T2 (en) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. MEDICINES FOR TREATING DYSMENORRHEA AND PREVIOUS BLIES

Also Published As

Publication number Publication date
NO329203B1 (en) 2010-09-13
RO120814B1 (en) 2006-08-30
ES2210813T3 (en) 2004-07-01
DK1011632T3 (en) 2004-03-29
US20020012677A1 (en) 2002-01-31
KR20010030588A (en) 2001-04-16
NZ502926A (en) 2001-10-26
NO20001287L (en) 2000-03-10
KR100575386B1 (en) 2006-05-03
NO20001287D0 (en) 2000-03-10
US6699494B2 (en) 2004-03-02
CA2303339C (en) 2006-12-12
IL134564A0 (en) 2001-04-30
HUP0003784A3 (en) 2001-12-28
EP1011632B1 (en) 2003-11-12
WO1999013862A2 (en) 1999-03-25
CN1186009C (en) 2005-01-26
DE69819748T2 (en) 2004-09-30
CN1270514A (en) 2000-10-18
PT1011632E (en) 2004-03-31
US6126959A (en) 2000-10-03
ATE253892T1 (en) 2003-11-15
EP1011632A2 (en) 2000-06-28
BR9812134A (en) 2000-07-18
WO1999013862A3 (en) 1999-05-14
AU9131198A (en) 1999-04-05
JP2002503637A (en) 2002-02-05
AU738460B2 (en) 2001-09-20
HUP0003784A2 (en) 2001-08-28
HK1025055A1 (en) 2000-11-03
DE69819748D1 (en) 2003-12-18

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Effective date: 20180910