CA2303820A1 - Metal compounds, mixed or sulphated, as phosphate binders - Google Patents

Metal compounds, mixed or sulphated, as phosphate binders Download PDF

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Publication number
CA2303820A1
CA2303820A1 CA002303820A CA2303820A CA2303820A1 CA 2303820 A1 CA2303820 A1 CA 2303820A1 CA 002303820 A CA002303820 A CA 002303820A CA 2303820 A CA2303820 A CA 2303820A CA 2303820 A1 CA2303820 A1 CA 2303820A1
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CA
Canada
Prior art keywords
sulphate
metal compound
calcium
mixed metal
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002303820A
Other languages
French (fr)
Other versions
CA2303820C (en
Inventor
Norman Bryson Roberts
Maurice Webb
Benjamin Joseph Rankin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytochroma Development Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2303820A1 publication Critical patent/CA2303820A1/en
Application granted granted Critical
Publication of CA2303820C publication Critical patent/CA2303820C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F11/00—Compounds of calcium, strontium, or barium
    • C01F11/18—Carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F5/00—Compounds of magnesium
    • C01F5/24—Magnesium carbonates
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/009—Compounds containing, besides iron, two or more other elements, with the exception of oxygen or hydrogen

Abstract

A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30 %, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30 % by weight of the total phosphate present, over a pH range from 2-8.

Claims (14)

1. A solid mixed metal compound for use as a medicament, which mixed metal compound is obtainable by formation of a precipitate thereof from a solution of a mixture of metallic salts, which mixed metal compound is free from aluminium and contains the metals iron (III) and at least one of magnesium, calcium, lanthanum and cerium and has a phosphate binding capacity of at least 30% by weight of the total weight of the phosphate present, over a pH range of 2-8.
2. A solid mixed metal compound according to claim 1, having a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 3-7.
3. A solid mixed metal compound according to any preceding claim, which contains at least one of hydroxyl and carbonate ions.
4. A solid mixed metal compound according to claim 3, which additionally contains at least one of sulphate, chloride and oxide.
5. A solid mixed metal compound for use as a medicament, which mixed metal compound is a hydroxy carbonate containing each of iron (III) and magnesium, free from aluminium and having a phosphate binding capacity of at least 30% by weight of the total weight of the phosphate present, over a pH range of 2-8.
6. Use, in a method of preparing a medicament for treatment of hyperphosphataemia, of a mixed metal compound according to any preceding claim.
7. Use, in a method of preparing a medicament for treatment of hyperphosphataemia, of a metal sulphate material selected from at least one of calcium, lanthanum and cerium sulphate compounds treated with an alkali solution.
8. Use according to claim 7, wherein the alkali is sodium hydroxide.
9. Use according to claim 8, wherein the metal sulphate is treated with an aqueous sodium hydroxide solution.
10. Use according to any one of claims 7 to 9, wherein the metal sulphate compound is calcium sulphate.
11. A metal sulphate material, for use as a medicament, selected from at least one of calcium, lanthanum and cerium sulphate compounds treated with an aqueous solution of an alkaline hydroxide, which said material comprises a solid material.
12. A metal sulphate material according to claim 11, which metal sulphate material has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8.
13. A method of preparing a metal sulphate material, which method comprises treating a metal sulphate comprising a solid material selected from at least one of calcium, lanthanum and cerium sulphate with an alkali solution.
14. A method according to claim 13, wherein the metal sulphate is calcium sulphate.
CA2303820A 1997-09-19 1998-09-18 Metal compounds, mixed or sulphated, as phosphate binders Expired - Lifetime CA2303820C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9720061.2A GB9720061D0 (en) 1997-09-19 1997-09-19 Metal compounds as phosphate binders
GB9720061.2 1997-09-19
PCT/GB1998/002834 WO1999015189A1 (en) 1997-09-19 1998-09-18 Metal compounds, mixed or sulphated, as phosphate binders

Publications (2)

Publication Number Publication Date
CA2303820A1 true CA2303820A1 (en) 1999-04-01
CA2303820C CA2303820C (en) 2010-06-15

Family

ID=10819414

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2303820A Expired - Lifetime CA2303820C (en) 1997-09-19 1998-09-18 Metal compounds, mixed or sulphated, as phosphate binders

Country Status (20)

Country Link
US (4) US6926912B1 (en)
EP (2) EP1015002B1 (en)
JP (3) JP4149659B2 (en)
KR (2) KR100823565B1 (en)
CN (2) CN1268347C (en)
AT (2) ATE332699T1 (en)
AU (1) AU9173398A (en)
BR (1) BR9812223A (en)
CA (1) CA2303820C (en)
CY (2) CY1106174T1 (en)
DE (2) DE69835217T2 (en)
DK (2) DK1015002T3 (en)
ES (2) ES2268788T3 (en)
GB (1) GB9720061D0 (en)
HK (1) HK1098390A1 (en)
HU (2) HU230611B1 (en)
NZ (1) NZ503136A (en)
PL (1) PL194211B1 (en)
PT (2) PT1015002E (en)
WO (1) WO1999015189A1 (en)

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