CA2307280A1 - Analyte assay using particulate labels - Google Patents

Analyte assay using particulate labels Download PDF

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Publication number
CA2307280A1
CA2307280A1 CA002307280A CA2307280A CA2307280A1 CA 2307280 A1 CA2307280 A1 CA 2307280A1 CA 002307280 A CA002307280 A CA 002307280A CA 2307280 A CA2307280 A CA 2307280A CA 2307280 A1 CA2307280 A1 CA 2307280A1
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Prior art keywords
particle
light
particles
scattered
analyte
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CA002307280A
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French (fr)
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CA2307280C (en
Inventor
Juan Yguerabide
Evangelina E. Yguerabide
David E. Kohne
Jeffrey T. Jackson
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University of California
Life Technologies Corp
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Individual
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Priority to CA2719432A priority Critical patent/CA2719432A1/en
Publication of CA2307280A1 publication Critical patent/CA2307280A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1425—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its control arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493—Particle size
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones

Abstract

Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.

Claims (63)

1. A method for selection of a particle type for detection of an analyte by light scattering, said method comprising the steps of:
a) providing light scattering signal strength versus particle size information for candidate particles; and b) selecting a particle of a size between 1 and 500 nm inclusive which provides acceptable dynamic range, acceptable low concentration detection sensitivity, and acceptable detection resolution based on said information, wherein the acceptable dynamic range, acceptable low concentration detection sensitivity, and acceptable detection resolution are determined by the concentration levels expected for said analyte in samples to be analyzed and are sufficient to allow non-evanescent light scattered from one or more said particles to be detected by a human eye with less than 500 times magnification and without electronic amplification.
2. The method of claim 1, wherein said detection of an analyte by light scattering is performed in a solid-phase assay, and said selecting further comprises identification of a light scattering particle which co-optimizes particle density and particle size, thereby providing a useful combination of signal strength and dynamic range.
3. The method of claim 2, wherein the light scattering signal consists of an integrated scattered light signal.
4. The method of claim 2, wherein the light scattering signal consists of light scattered from an individual particle or a single aggregate containing a plurality of particles.
5. The method of claim 1, wherein said detection of an analyte is performed in a liquid phase assay.
6. The method of claim 5, wherein the light scattering signal consists of an integrated scattered light signal.
7. The method of claim 5, wherein the light scattering signal consists of light scattered from an individual particle or a single aggregate containing a plurality of particles.
8. A method for specific detection of one or more analytes in a sample, comprising the steps of:
specifically associating any said one or more analytes in said sample with a scattered-light detectable particle of a size between 1 and 500 nm inclusive;
illuminating any said particles associated with said analytes with non-evanescent wave light under conditions which produce scattered light from said particle and in which light scattered from one or more said particles can be detected by a human eye with less than 500 times magnification and without electronic amplification; and detecting said light scattered by any said particles under said conditions as a measure of the presence of said one or more analytes, wherein said particles or a multi-particle structure comprising a plurality of said particles is detected singly, wherein said particles are flowed by at least one detector.
9. The method of claim 8, wherein said particles are flowed by said at least one detector in a structure selected from the group consisting of capillaries, microchannels, and spectrophotometric or flow cytometry flow cells.
10. The method of claim 8, wherein said analyte comprises a nucleic acid sequence, and at least one scattered light detectable particle is attached to at least two probe nucleic acid strands, wherein said at least two probe nucleic acid strands bind to different regions of said nucleic acid sequence; and said detecting further comprises flowing said nucleic acid sequences by the detector one at a time and distinguishing single particles from two or more particles, wherein detection of two or more particles is indicative of the presence of said nucleic acid sequence.
11. The method of claim 8, wherein said analyte comprises a cell or a cellular constituent and said detecting further comprises discriminating light scattering of said scattered light detectable particles from light scattering from said cell.
12. The method of claim 11, wherein said discriminating comprises providing two detectors such that the relative levels of cell specific light scattering and particle specific light scattering differ for said two detectors.
13. The method of claim 8, wherein said detecting provides a light scattering signal consisting of light scattered from an individual particle or a single aggregate containing a plurality of particles.
14. The method of claim 8, wherein said detecting provides a light scattering signal the characteristics which comprise at least one of intensity, polarization , wavelength, and angle of observation.
15. The method of claim 8, wherein said detecting provides a light scattering signal indicative of changes in one or more properties of the scattered light detectable properties of individual particles or multi-particle aggregates as said particles or aggregates move in a solution.
16. The method of claim 8, wherein a plurality of different particles with different sizes or compositions or both are distinguishably detected, each said different particle specifically associating with a different analyte.
17. A method for specific detection of one or more analytes in a sample, comprising the steps of:
specifically associating any said one or more analytes in said sample with a scattered-light detectable particle of a size between 1 and 500 nm inclusive;
illuminating any said particles associated with said analytes with non-evanescent wave light under conditions which produce scattered light from said particle and in which light scattered from one or more said particles can be detected by a human eye with less than 500 times magnification and without electronic amplification; and detecting said light scattered by any said particles under said conditions as a measure of the presence of said one or more analytes, wherein said detecting comprises spatially discriminating or classifying or both scattered light from said particles, thereby separately identifying individual particles or mufti-particle structures.
18. The method of claim 17, wherein said discriminating or classifying comprises electronic image processing and analysis.
19. The method of claim 17, wherein said detection of an analyte by light scattering is performed in a solid-phase assay.
20. The method of claim 17, wherein said detection of an analyte is performed in a liquid phase assay.
21. The method of claim 17, wherein the characteristics of the light scattering signal measured comprise at least one of intensity, polarization, wavelength, and angle of observation.
22. The method of claim 17, wherein the light scattering signal measured detects changes in one or more properties of the scattered light detectable properties of individual particles or mufti-particle aggregates as said particles or aggregates move in a solution.
23. The method of claim 17, wherein a plurality of different particles with different sizes or compositions or both are distinguishably detected, each said different particle specifically associating with a different analyte.
24. A method for specific detection of one or more analytes in a sample, comprising the steps of:
specifically associating any said one or more analytes in said sample with a scattered-light detectable particle of a size between 1 and 500 nm inclusive, illuminating any said particles associated with said analytes with non-evanescent wave light under conditions which produce scattered light from said particle and in which light scattered from one or more said particles can be detected by a human eye with less than 500 times magnification and without electronic amplification, and detecting said light scattered by any said particles under said conditions as a measure of the presence of said one or more analytes, wherein said scattered light detectable particles also possess magnetic or electrophoretic properties, and said properties are used to localize said particles during performance of an assay or to separate particles associated with any said one or more analytes from particles not so associated or both.
25. The method of claim 24, wherein said detection of an analyte by light scattering is performed in a solid-phase assay.
26. The method of claim 24, wherein said detection of an analyte is performed in a liquid phase assay.
27. The method of claim 24, wherein the characteristics of the light scattering signal measured comprise at least one of intensity, polarization, wavelength, and angle of observation.
28. The method of claim 24, wherein the light scattering signal measured detects changes in one or more properties of the scattered light detectable properties of individual particles or multi-particle aggregates as said particles or aggregates move in a solution.
29. The method of claim 24, wherein a plurality of different particles with different sizes or compositions or both are distinguishably detected, each said different particle specifically associating with a different analyte.
30. A method for specific detection of one or more nucleic acid analytes comprising target nucleic acid sequences in a sample, comprising the steps of:
specifically associating any of said one or more nucleic acid analytes in said sample with a scattered-light detectable particle of a size between 1 and 500 nm inclusive, wherein said specific associating involves specific hybridization of at least one analyte-specific nucleic acid probe with any of said one or more nucleic acid analytes, wherein said particle is directly attached to a said probe or a said probe has a ligand for attachment of said particle, illuminating any said particles associated with said nucleic acid analytes with non-evanescent wave light under conditions which produce scattered light from said particle and in which light scattered from one or more said particles can be detected by a human eye with less than 500 times magnification and without electronic amplification, and detecting said light scattered by any said particles under said conditions as a measure of the presence of said one or more nucleic acid analytes.
31. The method of claim 30, wherein said detection of an analyte by light scattering is performed in a solid-phase assay.
32. The method of claim 30, wherein said detection of an analyte is performed in a liquid phase assay.
33. The method of claim 30, wherein said one or more nucleic acid analytes comprise a plurality of target nucleic acid sequences;
said plurality of nucleic acid analytes or a plurality of nucleic acid probes are attached in separate spots to a solid surface; and light scattering from one or more of said separate spots is detected as a measure of the presence or amount of at least one of said one or more nucleic acid analytes in said sample.
34. The method of claim 33, wherein determination of an integrated scattered light intensity of a said spot is used as an indicator of the amount of said nucleic acid analyte in said sample.
35. The method of claim 33, wherein the number of said scattered light detectable particles in at least a portion of a said spot is used as an indicator of the amount of a said nucleic acid analyte in said sample.
36. The method of claim 35, wherein the light scattering signals from individual scattered light detectable particles in said at least a portion of a said spot are summed to provide a summed light scattering signal indicative of the amount of a said nucleic acid analyte in said sample.
37. The method of claim 33, wherein light scattering from each said spot is detected by scanning of said separate spots.
38. The method of claim 33, wherein light scattering from each said spot is detected using separate detectors for each said spot.
39. The method of claim 33, wherein light scattering from each said spot is detected using simultaneous imaging of said plurality of spots.
40. The method of claim 39, wherein at least one image of said plurality of spots is analyzed using electronic image processing.
41. The method of claim 33, wherein said plurality of spots comprises an array.
42. The method of claim 41, wherein said array is adapted for sequencing by hybridization or determination of expression level of at least one nucleic acid sequence.
43. The method of claim 30 wherein a plurality of different particles with different sizes or compositions or both are distinguishably detected, each said different particle specifically associating with a different nucleic acid analyte.
44. A method for identifying the presence or amount of at least one cell type or organism in a sample, comprising detecting the presence or amount of at least one scattered light detectable particle of a size between 1 and 500 nm inclusive specifically associated with said at least one cell type or organism:
wherein said at least one scattered light detectable particle is illuminated with non-evanescent wave light under conditions which produce scattered light from said at least one particle and in which light scattered from said at least one particle can be detected by a human eye with less than 500 times magnification and without electronic amplification, and light scattered by any of said at least one particle is detected as a measure of the presence or amount of any of said at least one cell type or organism.
45. The method of claim 44, wherein said identifying the amount of said cell type or organism further comprises determining the amount of cells or organisms with at least one of said particles specifically associated with said cell or organism relative to cells or organisms without said at least one of said particles specifically associated therewith.
46. The method of claim 44, wherein the presence or amount of at least one of a plurality of different yell types or organisms is distinguished or identified using a plurality of different particle types, wherein each of said plurality of different particle types specifically associates with a different cell type or organism, and the light scattering signal from each of said plurality of different particle types is distinguishable from each of the other particle types of said plurality of different particle types.
47. The method of claim 44, wherein the presence or amount of at least one of a plurality of different cell types or organisms is distinguished or identified using a plurality of different particle types, wherein each of said plurality of different particle types specifically associates with at least one of said plurality of different cell types or organisms, and the light scattering signal from each of said plurality of different particle types is distinguishable from each of the other particle types of said plurality of different particle types.
48. The method of claim 44, wherein said determining the presence or amount of at least one cell type or organism comprises identifying said at least one cell type or organism.
49. The method of claim 44, wherein said particle is intracellular.
50. The method of claim 44, wherein a said particle comprises gold or silver or both.
51. A method for detecting the presence or amount of at least one analyte in a cell type or organism, comprising the step of detecting the presence or amount of at least one scattered light detectable particle of a size between 1 and 500 nm inclusive specifically associated with said at least one cell type or organism:
wherein said at least one scattered light detectable particle is illuminated with non-evanescent wave light under conditions which produce scattered light from said at least one particle and in which light scattered from said at least one particle can be detected by a human eye with less than 500 times magnification and without electronic amplification, and light scattered by any of said at least one particle is detected as a measure of the presence or amount of said at least one analyte in a said cell type or organism.
52. The method of claim 51, wherein at least one said analyte is an intracellular protein.
53. The method of claim 51, wherein said at least one analyte is a plurality of analytes, and said at least one scattered light detectable particle is a plurality of distinguishable particles.
54. A method for monitoring a cell or organism, comprising the steps of:
placing at least one scattered light detectable particle of a size between 1 and 500 nm inclusive within a cell; and detecting the presence of at least one said scattered light detectable particle within said cell or organism as an indication of the presence of said cell or organism, wherein said at least one scattered light detectable particle is illuminated with non-evanescent wave light under conditions which produce scattered light from said at least one particle and in which light scattered from said at least one particle can be detected by a human eye with less than 500 times magnification and without electronic amplification.
55. A method for identifying or characterizing a potential pharmaceutical agent, comprising the steps of:
screening a library comprising a plurality of potential targets or a plurality of potential pharmaceutical agents to detect an interaction between a target and a said potential pharmaceutical agent, wherein said screening comprises specifically associating any of said plurality of potential targets or potential pharmaceutical agents or an expression product or mRNA with a scattered-light detectable particle of a size between 1 and 500 nm inclusive, illuminating any said particles associated with any said plurality of potential targets or potential pharmaceutical agents or expression product or mRNA with non-evanescent wave light under conditions which produce scattered light from said particle and in which light scattered from one or more said particles can be detected by a human eye with less than 500 times magnification and without electronic amplification, and detecting said light scattered by any said particles under said conditions such that detection of said light is indicative of a said interaction.
56. The method of claim 55, wherein said interaction comprises a binding interaction between a target or potential target and a said potential pharmaceutical agent.
57. The method of claim 55, wherein said interaction comprises modulation of a drug target system.
58. The method of claim 57, wherein said determination of said modulation comprises determination of the level of expression of a component of said system.
59. The method of claim 55, wherein said detecting said light scattered by any said particles is performed in a homogeneous assay.
60. The method of claim 55, wherein said plurality of potential targets or plurality of potential pharmaceutical agents is in a spatially addressable library.
61. The method of claim 55, wherein each of said plurality of potential pharmaceutical agents is attached to a solid substrate particle.
62. The method of claim 61, wherein a said scattered-light detectable particle also comprise a magnetic or ferro-electric composition, and said method further comprises manipulating the position of said particles associated with a said potential pharmaceutical agent attached to a said solid substrate particle.
63. The method of claim 55, wherein the amount of said expression product or mRNA is altered by said interaction.
CA2307280A 1997-10-17 1998-10-16 Analyte assay using particulate labels Expired - Fee Related CA2307280C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2719432A CA2719432A1 (en) 1997-10-17 1998-10-16 Analyte assay using particulate labels

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/953,713 US6586193B2 (en) 1996-04-25 1997-10-17 Analyte assay using particulate labels
US08/953,713 1997-10-17
PCT/US1998/023160 WO1999020789A1 (en) 1997-10-17 1998-10-16 Analyte assay using particulate labels

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CA2719432A Division CA2719432A1 (en) 1997-10-17 1998-10-16 Analyte assay using particulate labels

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CA2307280A1 true CA2307280A1 (en) 1999-04-29
CA2307280C CA2307280C (en) 2010-12-14

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US (7) US6586193B2 (en)
EP (1) EP1023456A1 (en)
JP (1) JP4247770B2 (en)
CN (1) CN100379876C (en)
AU (1) AU1294399A (en)
BR (1) BR9814821A (en)
CA (2) CA2719432A1 (en)
HK (1) HK1034291A1 (en)
IL (1) IL135696A (en)
RU (1) RU2217498C2 (en)
WO (1) WO1999020789A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109957503A (en) * 2017-12-14 2019-07-02 长光华大基因测序设备（长春）有限公司 A kind of processing chip and its application for high-throughput gene sequencing equipment

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
ES2287956T3 (en) 1996-07-29 2007-12-16 Nanosphere Inc. NANOPARTICLES THAT HAVE OLIGONUCLEOTIDES UNITED TO THE SAME AND USES OF THE SAME.
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
EP1060455A4 (en) * 1998-02-10 2002-08-07 Ey Lab Inc Reflectometry system with compensation for specimen holder topography and with lock-rejection of system noise
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
AU1219800A (en) * 1998-10-20 2000-05-08 Ljl Biosystems, Inc. Improvements in luminescence assays
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
WO2001051665A2 (en) 2000-01-13 2001-07-19 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2001071322A2 (en) * 2000-03-22 2001-09-27 Goh M Cynthia Method and apparatus for multiple-analyte assay
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7875442B2 (en) 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US8288128B2 (en) 2004-11-18 2012-10-16 Eppendorf Array Technologies S.A. Real-time quantification of multiple targets on a micro-array
WO2001090748A2 (en) * 2000-05-19 2001-11-29 Iowa State University Research Foundation, Inc. High-throughput methods of distinguishing at least one molecule individually in a sample comprising multiple molecules and systems for use therein
US6784981B1 (en) 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US6602669B2 (en) 2000-07-11 2003-08-05 Northwestern University Method of detection by enhancement of silver staining
EP1319179B1 (en) * 2000-07-19 2008-03-05 Genisphere Inc. Methods for detecting and assaying nucleic acid sequences
US20020049682A1 (en) * 2000-09-01 2002-04-25 Nobuko Yamamoto Authentication certificate, authentication certificate issuance system, and authentication system
WO2002025630A2 (en) * 2000-09-20 2002-03-28 Molecular Reflections Microfabricated ultrasound array for use as resonant sensors
WO2002029411A2 (en) * 2000-10-03 2002-04-11 Minerva Biotechnologies Corporation Magnetic in situ dilution
US20030175994A1 (en) * 2000-10-05 2003-09-18 Yoram Palti Geometrically efficient particle agglutination, particularly to detect low affinity
WO2002040998A2 (en) * 2000-11-17 2002-05-23 Zeptosens Ag Kit and method for determining multiple analytes
WO2002068932A2 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
FR2824001B1 (en) * 2001-04-26 2003-10-10 Bio Merieux METHOD FOR DEPOSITING A SPOT OF A PRODUCT OF INTEREST, AND APPLICATION FOR ISOLATING AND / OR DETERMINING AN ANALYTE
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US6714299B2 (en) 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
US20030013083A1 (en) * 2001-07-16 2003-01-16 Tsai Tenlin S. Particle analysis as a detection system for particle-enhanced assays
WO2003021231A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Method and apparatus for normalization and deconvolution of assay data
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
CA2460212C (en) 2001-09-06 2013-01-22 Genomic Profiling Systems, Inc. Rapid and sensitive detection of cells and viruses
JP3685119B2 (en) * 2001-10-18 2005-08-17 株式会社日立製作所 Biomolecule recovery method
WO2003081202A2 (en) 2001-11-09 2003-10-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
JP2005509871A (en) * 2001-11-20 2005-04-14 エグザクト サイエンシーズ コーポレイション Automated sample preparation method and apparatus
GR1004178B (en) * 2001-11-29 2003-03-05 "����������" Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
JP3856214B2 (en) * 2002-03-11 2006-12-13 横河電機株式会社 Fluorescence intensity enhancement beads
US20040038264A1 (en) * 2002-05-14 2004-02-26 Souza Glauco R. Fractal dimension analysis of nanoparticle aggregates using angle dependent light scattering for the detection and characterization of nucleic acids and proteins
KR20040044336A (en) * 2002-11-12 2004-05-28 마쯔시다덴기산교 가부시키가이샤 Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same
WO2004046100A2 (en) * 2002-11-15 2004-06-03 University Of Maryland, Baltimore Release of the self-quenching of fluorescence near silver metallic surfaces
JP2004184312A (en) * 2002-12-05 2004-07-02 Yokogawa Electric Corp Biopolymer detection method and biochip
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
AU2003292599A1 (en) * 2002-12-20 2004-07-14 Shigeki Higashiyama Method of screening cell growth inhibitor and cell growth inhibitor
JP4740111B2 (en) * 2003-02-13 2011-08-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Methods and compositions for detecting and analyzing polynucleotide binding protein interactions using light collecting multichromophores
US20080050842A1 (en) * 2003-02-15 2008-02-28 Golovlev Valeri V Method of visualization and quanitification of biopolymer molecules immobilized on solid support
US20040161862A1 (en) * 2003-02-15 2004-08-19 Golovlev Valeri V. Method of visualization and quantification of biopolymer molecules immobilized on solid support
JP2007524347A (en) * 2003-02-27 2007-08-30 ナノスフェアー　インコーポレイテッド Label-free gene expression profiling using universal nanoparticle probes in microarray format assays
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7641971B2 (en) * 2003-08-13 2010-01-05 Crane Company Metal-treated particles for remediation
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US7352467B2 (en) * 2003-10-24 2008-04-01 University Of Washington Surface plasmon resonance imaging system and method
US20050112586A1 (en) * 2003-11-24 2005-05-26 Roland Janzen Method and composition for stabilizing liquid reagents
US7329391B2 (en) * 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
WO2005066613A1 (en) 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
AU2005207302B2 (en) * 2004-01-14 2010-05-20 Luminex Corporation Methods for altering one or more parameters of a measurement system
CN102357352B (en) 2004-01-26 2015-08-12 哈佛大学 Fluid delivery system and method
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
CN1667418B (en) * 2004-03-10 2010-10-06 马杰 Multifunctional portable unit for measurement, analysis and diagnosis
US7623234B2 (en) * 2004-03-22 2009-11-24 Quantaspec, Inc. System and method for detecting and identifying an analyte
US20070095393A1 (en) * 2004-03-30 2007-05-03 Piero Zucchelli Devices and methods for programmable microscale manipulation of fluids
US7771660B2 (en) * 2004-05-04 2010-08-10 University Of North Carolina At Chapel Hill Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles
AU2005246415B8 (en) 2004-05-19 2011-09-01 Vp Holding, Llc Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS
US20050287680A1 (en) * 2004-06-25 2005-12-29 Srivatsa Venkatasubbarao Multianalyte assay method
KR101170859B1 (en) 2004-07-30 2012-08-02 바이오비질런트 시스템즈 인코포레이티드 Pathogen and particle detector system and method
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US7750352B2 (en) * 2004-08-10 2010-07-06 Pinion Technologies, Inc. Light strips for lighting and backlighting applications
US20060046279A1 (en) * 2004-08-24 2006-03-02 Truong Palestrina R Analytical methods utilizing real-time energy/particle interaction-based determination techniques
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
EP1808407B1 (en) * 2004-09-30 2014-12-31 Japan Science and Technology Agency Method of patterning self-organizing material, patterned substrate of self-organizing material and method of producing the same, and phosomask using patterned substrate of self-organizing material
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7405831B2 (en) * 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
WO2006105110A2 (en) * 2005-03-29 2006-10-05 Inverness Medical Switzerland Gmbh Assay device and methods
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7991242B2 (en) 2005-05-11 2011-08-02 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons, having image distortion correction functionality
CA2608119A1 (en) 2005-05-11 2006-11-16 Optosecurity Inc. Method and system for screening luggage items, cargo containers or persons
US20070036026A1 (en) * 2005-05-16 2007-02-15 Laibinis Paul E Magnetic Particle Systems and Methods
US20070081163A1 (en) * 2005-06-03 2007-04-12 Minhua Liang Method and apparatus for scanned beam microarray assay
CN101223560B (en) * 2005-07-15 2012-12-12 百维吉伦特系统有限公司 Pathogen and particle detector system and method
US20070031282A1 (en) * 2005-08-04 2007-02-08 Piero Zucchelli Devices and methods for interfacing microfluidic devices with fluid handling devices
US20070030482A1 (en) * 2005-08-08 2007-02-08 Zhenghua Ji Spectrophotometer with adjustable light pathlength
US7791728B2 (en) 2005-08-11 2010-09-07 Hewlett-Packard Development Company, L.P. System for optically analyzing a substance with a selected single-wavelength
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
NZ566020A (en) 2005-09-09 2012-08-31 Novartis Ag Prion-specific peptoid reagents
US20120231453A1 (en) * 2005-09-13 2012-09-13 Affymetrix, Inc. Brownian Microbarcodes for Bioassays
EP2485052B1 (en) * 2005-09-13 2015-05-06 Affymetrix, Inc. Encoded microparticles
WO2007038478A2 (en) 2005-09-26 2007-04-05 Rapid Micro Biosystems, Inc Cassette containing growth medium
CA2632261A1 (en) * 2005-12-05 2007-06-14 Guava Technologies Particle-based analyte characterization
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
FI120560B (en) * 2005-12-21 2009-11-30 Outotec Oyj Method for determining elemental and / or mineral content
JP2009524832A (en) 2006-01-24 2009-07-02 ライフ テクノロジーズ コーポレーション Device and method for quantifying analytes
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
JP2009530598A (en) * 2006-03-17 2009-08-27 ビバクタ、リミテッド Chemical detector
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
ATE514086T1 (en) 2006-05-09 2011-07-15 Koninkl Philips Electronics Nv DETECTION OF TARGET MOLECULES IN A SAMPLE USING A MAGNETIC FIELD
US7899232B2 (en) 2006-05-11 2011-03-01 Optosecurity Inc. Method and apparatus for providing threat image projection (TIP) in a luggage screening system, and luggage screening system implementing same
KR20090027643A (en) * 2006-05-17 2009-03-17 루미넥스 코포레이션 Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US7531774B2 (en) * 2006-06-05 2009-05-12 General Dynamics Advanced Information Systems, Inc. Measurement-diverse imaging and wavefront sensing with amplitude and phase estimation
US20100035243A1 (en) * 2006-07-10 2010-02-11 Nanosphere, Inc. Ultra-sensitive detection of analytes
JP4756270B2 (en) * 2006-07-13 2011-08-24 独立行政法人産業技術総合研究所 Optical spectroscopy measurement method and apparatus
US8494210B2 (en) 2007-03-30 2013-07-23 Optosecurity Inc. User interface for use in security screening providing image enhancement capabilities and apparatus for implementing same
EP2059811A2 (en) * 2006-08-18 2009-05-20 3M Innovative Properties Company Methods of detection using acousto-mechanical detection systems
US8207509B2 (en) * 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP5151097B2 (en) * 2006-09-01 2013-02-27 株式会社リコー Composite metal nanoparticles, multiphoton absorption reaction materials and reaction products containing composite metal nanoparticles, and multiphoton absorption reaction aids containing composite metal nanoparticles
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20100151553A1 (en) * 2006-12-29 2010-06-17 Bjork Jason W Method of detection of bioanalytes by acousto-mechanical detection systems comprising the addition of liposomes
WO2008088249A1 (en) * 2007-01-17 2008-07-24 Hemocue Ab Apparatus for determining positions of objects contained in a sample
SE530789C2 (en) * 2007-01-17 2008-09-09 Hemocue Ab Apparatus and method for position determination of objects contained in a sample
WO2008089495A2 (en) 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
CA2681722A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
CN101754812B (en) 2007-05-04 2013-06-26 克拉洛诊断仪器公司 Fluidic connectors and microfluidic systems
JP4803125B2 (en) * 2007-05-10 2011-10-26 ソニー株式会社 Bead group, method for producing the bead group, and method using the bead group
US9199247B2 (en) * 2007-05-29 2015-12-01 Invitrogen Dynal As Magnetic separation rack
GB0724404D0 (en) 2007-05-29 2008-01-30 Invitrogen Dynal As A sample vessel retaining portion
US8094307B2 (en) * 2007-07-05 2012-01-10 Baxter International Inc. Method and apparatus for measuring the presence and concentration of pharmaceutical substances in a medical fluid administered by a medication delivery system
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US8384033B2 (en) * 2007-11-09 2013-02-26 The Royal Institute For The Advancement Of Learning/Mcgill University Quantification of an absorber through a scattering medium
US20100323457A1 (en) * 2007-12-03 2010-12-23 Tokyo Institute Of Technology Biosensing method using coated magnetic fine particles and biosensing apparatus for biosensing method
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009081406A2 (en) * 2007-12-26 2009-07-02 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Method and apparatus for monitoring processes in living cells
CA2711151A1 (en) 2008-01-03 2009-09-24 University Of Central Florida Research Foundation, Inc. Detection of analytes using metal nanoparticle probes and dynamic light scattering
KR100962290B1 (en) * 2008-02-13 2010-06-11 성균관대학교산학협력단 Method of detecting bioproducts using localized surface plasmon resonance sensor of gold nanoparticles
JP5344828B2 (en) * 2008-02-28 2013-11-20 富士フイルム株式会社 Sensing device
US8008068B2 (en) * 2008-02-29 2011-08-30 Light Pointe Medical, Inc. Nonhemolytic optical sensor with enhanced reflectance
US20090219509A1 (en) * 2008-02-29 2009-09-03 Hiroshi Nomura Optical sensor with enhanced reflectance
KR20100135797A (en) 2008-03-12 2010-12-27 유니버시티 오브 버지니아 페이턴트 파운데이션 Detection of polymeric analytes
US7995854B2 (en) * 2008-03-28 2011-08-09 Tandent Vision Science, Inc. System and method for identifying complex tokens in an image
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
US20110189692A1 (en) * 2008-04-30 2011-08-04 Novartis Ag Assay for pathogenic conformers
US7796256B2 (en) * 2008-05-05 2010-09-14 Fluid Imaging Technologies, Inc. Oil-immersion enhanced imaging flow cytometer
WO2010008870A1 (en) * 2008-06-24 2010-01-21 Estill, James, A. Small angle light scattering assay system and method for detecting malaria infection
DE102008035770A1 (en) * 2008-07-31 2010-02-18 Eads Deutschland Gmbh Optical particle detector and detection method
US9151943B2 (en) 2008-08-04 2015-10-06 Fluid Imaging Technologies, Inc. System and method for monitoring birefringent particles in a fluid
US8345239B1 (en) 2008-08-04 2013-01-01 Fluid Imaging Technologies, Inc. System and method for monitoring birefringent particles in a fluid
TW201017149A (en) 2008-08-06 2010-05-01 Invitrox Inc Use of focused light scattering techniques in biological applications
DK3629011T3 (en) 2008-09-16 2024-01-29 Pacific Biosciences California Inc INTEGRATED OPTICAL DEVICE
US11865534B2 (en) 2008-09-24 2024-01-09 First Light Diagnostics, Inc. Imaging analyzer for testing analytes
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
CA2647953A1 (en) * 2008-12-29 2010-06-29 Sqi Diagnostics Systems Inc. Multiplex analyte detection
DK2391451T3 (en) 2009-02-02 2018-10-15 Opko Diagnostics Llc STRUCTURES FOR MANAGING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES
EP2223650A1 (en) * 2009-02-25 2010-09-01 The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Method and apparatus for imaging tissue topography
JP2012519170A (en) 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー INSITU method for monitoring EMT status of tumor cells in vivo
GB0904934D0 (en) * 2009-03-23 2009-05-06 Geneseqe As Method and apparatus for detecting molecules
US8477186B2 (en) * 2009-04-06 2013-07-02 Sumco Corporation Apparatus for removing reflected light
WO2010120686A2 (en) * 2009-04-13 2010-10-21 Parsons J Kellogg Methods for the diagnosis and treatment of benign prostatic hyperplasia
US8153987B2 (en) * 2009-05-22 2012-04-10 Jordan Valley Semiconductors Ltd. Automated calibration methodology for VUV metrology system
WO2011056215A1 (en) * 2009-11-03 2011-05-12 Landers James P Versatile, visible method for detecting polymeric analytes
WO2011057029A1 (en) 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
HUE053571T2 (en) 2009-11-24 2021-07-28 Opko Diagnostics Llc Fluid mixing and delivery in microfluidic systems
KR101422573B1 (en) * 2009-11-26 2014-07-25 삼성전자 주식회사 Centrifugal Micro-fluidic Device and Method to measure biological makers from liquid specimen
CN102667447B (en) * 2009-11-30 2016-03-23 通用电气健康护理生物科学股份公司 For the method and system that bonding behavior is analyzed
US10545090B2 (en) * 2009-11-30 2020-01-28 Ge Healthcare Bio-Sciences Ab Method and system for more reliable determination of interaction parameters for low affinity analytes
US9339813B2 (en) 2009-12-18 2016-05-17 Koninklijke Philips N.V. Substance determining apparatus
US20110223587A1 (en) * 2010-03-11 2011-09-15 Schulman Joseph D Optical particle characterization system
US20110223586A1 (en) * 2010-03-11 2011-09-15 David Karabinus Optical particle characterization system
EP2369325A1 (en) 2010-03-12 2011-09-28 Eppendorf Ag Array analysis for online detection
CN102971629B (en) * 2010-04-15 2016-10-12 数码传感有限公司 Microarray
CA3016967C (en) 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
WO2011140387A1 (en) 2010-05-05 2011-11-10 Blue Ocean Biomedical, Llc Diagnostic instrument and flow process
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US20130260396A1 (en) 2010-05-25 2013-10-03 Arryx, Inc. Holographic fluctuation microscopy apparatus and method for determining mobility of particle and/or cell dispersions
WO2012032955A1 (en) * 2010-09-10 2012-03-15 オリンパス株式会社 Optical analysis method using optical measurement in multiple wavelength bands
JP5945506B2 (en) * 2010-11-25 2016-07-05 オリンパス株式会社 Optical analysis apparatus and optical analysis method using wavelength characteristics of light of single luminescent particles
KR102523324B1 (en) 2011-02-16 2023-04-18 가부시키가이샤 한도오따이 에네루기 켄큐쇼 Light-emitting element
CN103492859B (en) * 2011-02-28 2017-05-24 皇家飞利浦有限公司 Substance determining apparatus
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (en) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Rapid cell purification systems
EP2693200B1 (en) * 2011-03-29 2019-06-12 Hamamatsu Photonics K.K. Terahertz-wave spectrometer
CN105606577B (en) 2011-06-24 2019-08-13 贝克顿·迪金森公司 Absorption spectrum scans flow cytometry
TW202242379A (en) * 2011-08-29 2022-11-01 美商安美基公司 Methods and apparati for nondestructive detection of undissolved particles in a fluid
KR102067367B1 (en) 2011-09-07 2020-02-11 라피스캔 시스템스, 인코포레이티드 X-ray inspection method that integrates manifest data with imaging/detection processing
FR2981283B1 (en) * 2011-10-13 2014-08-29 Chambre De Commerce Et De L Ind De Paris Au Titre De Son Etablissement D Enseignement Superieur Esie MICROFLUIDIC DEVICE FOR ANALYZING A FLUID UNDER PRESSURE.
US8994945B2 (en) 2011-10-27 2015-03-31 Fluid Imaging Technologies, Inc. Method of treatment analysis with particle imaging
PL2776550T3 (en) 2011-11-07 2018-05-30 Rapid Micro Biosystems, Inc. Cassette for sterility testing
EP2618130A1 (en) * 2012-01-17 2013-07-24 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
BR112014019298A2 (en) * 2012-02-04 2021-01-19 Douglas Scientific METHOD AND APPARATUS FOR QUICK ANALYSIS, HIGH SENSITIVITY, LOW VOLUME SAMPLES OF BIOLOGICAL MATERIALS
MY193914A (en) 2012-03-05 2022-11-01 Oy Arctic Partners Ab Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
EP4060016A1 (en) 2012-04-16 2022-09-21 Rapid Micro Biosystems, Inc. Cell culturing device
US8879797B2 (en) 2012-05-25 2014-11-04 Fluid Imaging Technologies, Inc. System and method for total internal reflection enhanced imaging flow cytometry
EA030193B1 (en) * 2012-07-27 2018-07-31 Инджендер Текнолоджиз Лимитед Method and system for microfluidic particle orientation and/or sorting
KR101384386B1 (en) 2012-10-25 2014-04-10 전남대학교산학협력단 Apparatus for measuring physical properties of low permeable rocks
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
EP2932266A4 (en) 2012-12-17 2016-11-30 Leukodx Ltd Systems and methods for determining a chemical state
US9759722B2 (en) * 2012-12-17 2017-09-12 Leukodx Ltd. Systems and methods for determining a chemical state
CN105324489A (en) * 2013-03-04 2016-02-10 韦拉克斯生物医学股份有限公司 Multi-analyte assay
KR20150125000A (en) * 2013-03-05 2015-11-06 에프. 호프만-라 로슈 아게 Method and system for determining a biological response of a target to a soluble candidate sbstance
ES2741001T3 (en) 2013-03-13 2020-02-07 Opko Diagnostics Llc Mixing fluids in fluid systems
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
CN103267854B (en) * 2013-05-03 2015-08-05 西安交通大学 A kind of method strengthening detection paper signal
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
SG10201803850YA (en) * 2013-11-12 2018-06-28 Agency Science Tech & Res Quantitative real-time and end-point colorimetric pcr device
EP3087370B1 (en) * 2013-12-23 2022-02-16 Siemens Healthineers Nederland B.V. Detection apparatus for detecting particles on a surface
US9645070B2 (en) * 2014-06-03 2017-05-09 The Regents Of The University Of California Nanoparticle analyzer
US10133048B2 (en) * 2014-07-09 2018-11-20 Ntp Nano Tech Projects S.R.L. Laser optical coupling for nanoparticles detection
KR102587637B1 (en) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
JP2018048811A (en) * 2015-01-30 2018-03-29 京セラ株式会社 Sensing method of detection object
US10458990B1 (en) * 2015-03-06 2019-10-29 Scanit Technologies, Inc. Spore state discrimination
EP3278115A2 (en) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
EP3591439B1 (en) * 2015-08-28 2021-11-17 National University Corporation Gunma University Charged particle radiation measuring method and charged particle radiation measuring device
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
CN105259086B (en) * 2015-10-29 2018-03-27 广东美的制冷设备有限公司 The detection method and detecting system of dust concentration
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
EP3387447A4 (en) 2015-12-11 2019-08-28 Opko Diagnostics, LLC Fluidic systems involving incubation samples and/or reagents
JP6155452B1 (en) * 2016-02-16 2017-07-05 国立大学法人電気通信大学 Particle detection device on substrate
EP3420563A4 (en) 2016-02-22 2020-03-11 Rapiscan Systems, Inc. Systems and methods for detecting threats and contraband in cargo
ITUA20161345A1 (en) * 2016-03-04 2017-09-04 Eltek Spa SENSOR DEVICE FOR CONTAINERS OF LIQUID SUBSTANCES
AU2017345814B2 (en) * 2016-10-21 2022-07-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular nanotags
CN106829856A (en) * 2016-12-14 2017-06-13 佛山旋疯纳米科技有限公司 A kind of cluster ions beam nanoprocessing plant control unit and its control method
JP7305611B2 (en) 2017-03-17 2023-07-10 アプトン バイオシステムズ インコーポレイテッド Methods of sequencing and high-resolution imaging
WO2018175039A1 (en) 2017-03-20 2018-09-27 Miller John F Measuring electrophoretic mobility
JP7168230B2 (en) * 2017-06-06 2022-11-09 ノースウエスタン ユニバーシティ Trans-interfacial magnetic separation
US11156960B2 (en) * 2017-08-08 2021-10-26 California Institute Of Technology Focusing light inside scattering media with magnetic particle guided wavefront shaping
CN109387460A (en) * 2017-08-14 2019-02-26 阅美测量系统（上海）有限公司 A kind of observation of pollution particle and test device and analysis method
WO2019051181A1 (en) * 2017-09-08 2019-03-14 President And Fellows Of Harvard College Nanosensor methods and apparatuses for determination of analytes
CN109864747B (en) * 2017-12-05 2023-08-25 心脏起搏器股份公司 Multimode analyte sensor optoelectronic interface
US20210341369A1 (en) * 2018-05-18 2021-11-04 President And Fellows Of Harvard College Sample analysis with mirrors
US11557042B2 (en) * 2018-06-12 2023-01-17 King Abdullah University Of Science And Technology Single-camera particle tracking system and method
JP7219390B2 (en) * 2018-06-29 2023-02-08 澁谷工業株式会社 Cell observation device
CN109254022B (en) * 2018-10-24 2021-07-20 首钢智新迁安电磁材料有限公司 Method for measuring grain size
CN109542186A (en) * 2018-12-12 2019-03-29 深圳市福瑞康科技有限公司 A kind of cabinet main box, cabinet and flash detecting device
CN109738393B (en) * 2019-01-10 2021-03-05 上海奥普生物医药股份有限公司 Optical detection device and specific protein analyzer
CN110127771B (en) * 2019-05-31 2022-03-01 重庆科技学院 Regulation and aggregation method of ferroferric oxide nanoparticles
CN113049455B (en) * 2019-12-26 2023-04-14 中核北方核燃料元件有限公司 Cladding fuel particle and nuclear core traceability diameter auxiliary measuring device
CN112014369B (en) * 2020-08-25 2024-02-09 上海市皮肤病医院 System and method for ultrasensitive digital chromatography rapid detection of analytes
EP4271996A1 (en) * 2020-12-31 2023-11-08 3M Innovative Properties Company Nanopatterned films with patterned surface chemistry
AU2021221727A1 (en) * 2021-04-20 2022-11-03 Martin Terence Cole IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR
WO2022240656A1 (en) * 2021-05-10 2022-11-17 The Regents Of The University Of California Methods of analyzing shaped particles containing cells using fluorescence activated cell sorting
CN113340894B (en) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 Detection method of non-transparent particles
CN113552041B (en) * 2021-06-08 2022-10-11 上海交通大学 Exosome subtype analysis method based on single particle imaging
US11828175B2 (en) 2021-07-08 2023-11-28 Saudi Arabian Oil Company Systems and methods for measuring phase flow rates of a multiphase production fluid
KR102638903B1 (en) * 2021-12-21 2024-02-22 공주대학교 산학협력단 Apparatus and method for vision analyzing surface fine abrasive particle of abrasive tool
US20230194517A1 (en) * 2021-12-21 2023-06-22 Bio-Rad Laboratories, Inc. Multiplex detection in high resolution devices through measurement of localized fluorescence ratios
CN114295550A (en) * 2021-12-31 2022-04-08 电子科技大学长三角研究院(湖州) Optical flow control device based on surface lattice resonance and application thereof
CN114152574B (en) * 2021-12-31 2023-10-17 天津工业大学 Portable water quality analyzer for detecting integrity of membrane assembly and detection method thereof
CN114491387B (en) * 2022-04-06 2022-07-12 天津美腾科技股份有限公司 Method and device for arranging identification equipment of dry separator, electronic equipment and separation system
CN116448637B (en) * 2023-06-14 2023-09-08 北京建工环境修复股份有限公司 Method for detecting nano plastic by modified gold particle marked dark field microscopic imaging

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4210384A (en) * 1976-09-11 1980-07-01 Carl Zeiss-Stiftung Inverted-design optical microscope
NL7807532A (en) 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4245031A (en) * 1979-09-18 1981-01-13 E. I. Du Pont De Nemours And Company Photopolymerizable compositions based on salt-forming polymers and polyhydroxy polyethers
US4420558A (en) 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
JPS60149130A (en) * 1984-01-17 1985-08-06 Hitachi Ltd Method for pattern detection
US4624923A (en) * 1984-06-08 1986-11-25 Yeda Research And Development Company Limited Metal-coated polyaldehyde microspheres
US4752567A (en) 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US4877647A (en) * 1986-04-17 1989-10-31 Kansas State University Research Foundation Method of coating substrates with solvated clusters of metal particles
US4929400A (en) * 1986-04-28 1990-05-29 California Institute Of Technology Production of monodisperse, polymeric microspheres
US4851329A (en) 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
US4876208A (en) * 1987-01-30 1989-10-24 Yellowstone Diagnostics Corporation Diffraction immunoassay apparatus and method
DE3789547T2 (en) * 1987-02-13 1994-07-14 Toray Industries Anti-reflective optical object and process for its production.
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US4806583A (en) * 1987-06-19 1989-02-21 Battaglia Charles R Antiglare coating
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
NO164622C (en) 1988-05-11 1990-10-24 Tore Lindmo BINAER IMMUNOMETRIC PARTICLE-BASED METHOD FOR MEASURING SPECIFIC SERUM ANTIGENS USING LIQUID FLOW MICROPHOTOMETRY AND A PREPARED TARGET SET UP THEREOF.
DE3826055A1 (en) * 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh REAGENT-RELEASED TRAEGERMATRIX WITH REAGENT
US5079172A (en) 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5145748A (en) * 1989-06-20 1992-09-08 W.R. Grace & Co. -Conn. Waterproofing system for water-penetrable construction surfaces
US5376556A (en) * 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
JP2899360B2 (en) 1990-05-21 1999-06-02 興和株式会社 Method and apparatus for measuring particles in fluid
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
JP3115641B2 (en) 1991-04-24 2000-12-11 シスメックス株式会社 Particle counting method
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
JP2523227Y2 (en) 1991-07-30 1997-01-22 株式会社堀場製作所 Foreign matter inspection device
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5305073A (en) 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5518887A (en) * 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
DE4404128A1 (en) * 1993-02-19 1994-08-25 Gao Ges Automation Org Security document and method for its manufacture
US5350911A (en) * 1993-04-09 1994-09-27 Hughes Aircraft Company Wavefront error estimation derived from observation of arbitrary unknown extended scenes
DE4414166C1 (en) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Method and device for measuring light scattering on particles
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5728590A (en) * 1994-07-29 1998-03-17 Nanoprobes, Inc. Small organometallic probes
US5498875A (en) * 1994-08-17 1996-03-12 Beckman Instruments, Inc. Signal processing for chemical analysis of samples
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
JP3284056B2 (en) * 1995-09-12 2002-05-20 株式会社東芝 Substrate processing apparatus and pattern forming method
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
WO1997015819A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance light pipe sensor
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
IL126544A (en) * 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
US5856018A (en) * 1996-06-17 1999-01-05 Yazaki Corporation Plastic articles having multi-layer antireflection coatings, and sol-gel process for depositing such coatings
JP2002514046A (en) * 1996-07-08 2002-05-14 バースタイン テクノロジーズ，インコーポレイティド Devices and methods for cleavable signaling factors
US6165798A (en) * 1996-10-10 2000-12-26 University Of British Columbia Optical quantification of analytes in membranes
JPH10206603A (en) * 1997-01-20 1998-08-07 Dainippon Printing Co Ltd Reflection preventive film and manufacture thereof
US6122042A (en) * 1997-02-07 2000-09-19 Wunderman; Irwin Devices and methods for optically identifying characteristics of material objects
WO1998037417A1 (en) 1997-02-20 1998-08-27 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6294327B1 (en) 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
JP3507319B2 (en) * 1997-12-08 2004-03-15 キヤノン株式会社 Optical property measurement device
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6311275B1 (en) * 1998-08-03 2001-10-30 Cisco Technology, Inc. Method for providing single step log-on access to a differentiated computer network
US6171793B1 (en) * 1999-04-19 2001-01-09 Affymetrix, Inc. Method for scanning gene probe array to produce data having dynamic range that exceeds that of scanner
US6627923B1 (en) * 1999-07-12 2003-09-30 Massachusetts Institute Of Technology Resonant microcavities
KR20010108656A (en) * 2000-05-30 2001-12-08 윤종용 Method of programing flash memory
WO2002068932A2 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US6714299B2 (en) * 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
US7555173B2 (en) * 2003-04-09 2009-06-30 Cornell Research Foundation, Inc. Electro-optic modulator on rib waveguide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109957503A (en) * 2017-12-14 2019-07-02 长光华大基因测序设备（长春）有限公司 A kind of processing chip and its application for high-throughput gene sequencing equipment
CN109957503B (en) * 2017-12-14 2022-05-31 长春长光华大智造测序设备有限公司 Process chip for high-throughput gene sequencing equipment and application thereof

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