CA2307285A1 - Agent for prophylaxis and treatment of glaucoma - Google Patents

Agent for prophylaxis and treatment of glaucoma Download PDF

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Publication number
CA2307285A1
CA2307285A1 CA002307285A CA2307285A CA2307285A1 CA 2307285 A1 CA2307285 A1 CA 2307285A1 CA 002307285 A CA002307285 A CA 002307285A CA 2307285 A CA2307285 A CA 2307285A CA 2307285 A1 CA2307285 A1 CA 2307285A1
Authority
CA
Canada
Prior art keywords
glaucoma
prophylaxis
treatment
agent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002307285A
Other languages
French (fr)
Other versions
CA2307285C (en
Inventor
Mitsuyoshi Azuma
Yukuo Yoshida
Mitsunori Waki
Masayoshi Uehata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Mitsubishi Tanabe Pharma Corp
Original Assignee
Senju Pharmaceutical Co., Ltd.
Mitsuyoshi Azuma
Yukuo Yoshida
Mitsunori Waki
Masayoshi Uehata
Welfide Corporation
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co., Ltd., Mitsuyoshi Azuma, Yukuo Yoshida, Mitsunori Waki, Masayoshi Uehata, Welfide Corporation, Mitsubishi Pharma Corporation, Mitsubishi Tanabe Pharma Corporation filed Critical Senju Pharmaceutical Co., Ltd.
Priority to CA2635412A priority Critical patent/CA2635412C/en
Publication of CA2307285A1 publication Critical patent/CA2307285A1/en
Application granted granted Critical
Publication of CA2307285C publication Critical patent/CA2307285C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) (see formula I) wherein each symbol is as defined in the specification, as the compound having a Rho kinase inhibitory activity, is provided. The agent for the prophylaxis and treatment of glaucoma of the present invention is a novel agent for the prophylaxis and treatment of glaucoma and has intraocular pressure lowering action, optic disc blood flow improving action and aqueous humor outflow promoting action.
CA002307285A 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of glaucoma Expired - Fee Related CA2307285C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2635412A CA2635412C (en) 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of asthenopia or pseudomyopia

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24776298 1998-08-17
JP247762/1998 1998-08-17
JP12296099 1999-04-28
JP122960/1999 1999-04-28
PCT/JP1999/004403 WO2000009162A1 (en) 1998-08-17 1999-08-13 Preventives/remedies for glaucoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2635412A Division CA2635412C (en) 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of asthenopia or pseudomyopia

Publications (2)

Publication Number Publication Date
CA2307285A1 true CA2307285A1 (en) 2000-02-24
CA2307285C CA2307285C (en) 2009-03-31

Family

ID=26459997

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002307285A Expired - Fee Related CA2307285C (en) 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of glaucoma
CA2635412A Expired - Fee Related CA2635412C (en) 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of asthenopia or pseudomyopia

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2635412A Expired - Fee Related CA2635412C (en) 1998-08-17 1999-08-13 Agent for prophylaxis and treatment of asthenopia or pseudomyopia

Country Status (12)

Country Link
US (2) US6673812B1 (en)
EP (3) EP1034793B1 (en)
JP (2) JP3720264B2 (en)
KR (1) KR100616466B1 (en)
CN (2) CN1195547C (en)
AT (3) ATE307609T1 (en)
AU (1) AU5198199A (en)
CA (2) CA2307285C (en)
DE (1) DE69927936T2 (en)
ES (3) ES2247822T3 (en)
HK (3) HK1069121A1 (en)
WO (1) WO2000009162A1 (en)

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Also Published As

Publication number Publication date
US6673812B1 (en) 2004-01-06
WO2000009162A1 (en) 2000-02-24
EP1459742B1 (en) 2011-10-12
KR100616466B1 (en) 2006-08-29
DE69927936T2 (en) 2006-06-29
JP3720264B2 (en) 2005-11-24
ES2372572T3 (en) 2012-01-23
EP1459742B9 (en) 2012-05-02
ES2374518T3 (en) 2012-02-17
EP1459743A2 (en) 2004-09-22
EP1459743B1 (en) 2011-10-19
EP1034793A4 (en) 2003-07-09
EP1459743A3 (en) 2007-12-26
HK1030883A1 (en) 2001-05-25
ATE307609T1 (en) 2005-11-15
EP1459743A8 (en) 2005-02-02
US6649625B2 (en) 2003-11-18
EP1034793B1 (en) 2005-10-26
EP1459742A2 (en) 2004-09-22
DE69927936D1 (en) 2005-12-01
CN1195547C (en) 2005-04-06
US20030125351A1 (en) 2003-07-03
CN1287494A (en) 2001-03-14
CN1293878C (en) 2007-01-10
CN1494903A (en) 2004-05-12
AU5198199A (en) 2000-03-06
EP1459743B9 (en) 2012-08-01
HK1069120A1 (en) 2005-05-13
EP1034793A1 (en) 2000-09-13
CA2307285C (en) 2009-03-31
KR20010015761A (en) 2001-02-26
ES2247822T3 (en) 2006-03-01
JP4490748B2 (en) 2010-06-30
CA2635412A1 (en) 2000-02-24
ATE529102T1 (en) 2011-11-15
ATE527993T1 (en) 2011-10-15
EP1459742A3 (en) 2007-12-26
JP2004277432A (en) 2004-10-07
CA2635412C (en) 2011-06-21
HK1069121A1 (en) 2005-05-13

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