CA2307837A1 - Optical array system and reader for micro titer plates - Google Patents
Optical array system and reader for micro titer plates Download PDFInfo
- Publication number
- CA2307837A1 CA2307837A1 CA002307837A CA2307837A CA2307837A1 CA 2307837 A1 CA2307837 A1 CA 2307837A1 CA 002307837 A CA002307837 A CA 002307837A CA 2307837 A CA2307837 A CA 2307837A CA 2307837 A1 CA2307837 A1 CA 2307837A1
- Authority
- CA
- Canada
- Prior art keywords
- array
- lens
- reader according
- detector array
- reader
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
Abstract
An optical system made up of lens arrays (2i, 7) and normal lenses (41, 5, 42) is particularly suitable for use as a massive parallel reader (approx. 102 channels) for micro titer plates (1) and the like in absorption, fluorescence and luminescence.
Claims (10)
1. Reader for microtiter plates or substance chips, with a lens array [21-23], the grid pattern dimensions of which corresponds to the grid pattern dimensions of a microtiter plate or of a substance clop, a detector array [61-63], a telescope which is provided between the lens array and the detector array and which effects a reduction to match the beam diameter defined by the lens array to the dimensions of the detector array, and with a field lens [5], a reduced image of the microtiter plate or the substance clop being formed on the detector array by the system of lens array, telescope, and field lens, so that on the detector array a strict channel separation results between the measurement signals arising from individual sample volumes of the microtiter plate or of the substance chip.
2. Reader according to claim 1, characterized in that a respective lens (41, 42) of a telescope is arranged between the lens array [21-23] and field lens [5], and between the latter and the detector array [61-63].
3. Reader according to at least one of claims 1-2, characterized in that a microlens array [7] is arranged in front of the detector array [6].
4. Reader according to at least one of claim 1-3, characterized in that a reflected light illumination [9, 91, 92] is integrated.
5. Reader according to at least one of claims 1-4, characterized in that an aperture array [3] is arranged between the lens array [21-23] and the field lens [5].
6. Reader according to at least one of claims 1-5, characterized in that the lens array is achromatized, in that each individual lens consists of a lens group with achromatic properties.
7. Reader according to at least one of claims 1-6, characterized in that the detector array [6] is a CCD array or a photodiode array.
8. Reader according to at least one of claims 1-7, characterized by a modular construction with an interchangeable lens array.
9. Reader according to one of claims 1-9, characterized in that the lens array has individual lenses which are arranged with respect to each other in the formal 8 * 12.
10. Reader according to at least one of claims 4-9, characterized in that a dichroic mirror [8] is provided for the coupling-in of the illumination device [9].
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19748211.2 | 1997-10-31 | ||
DE19748211A DE19748211A1 (en) | 1997-10-31 | 1997-10-31 | Optical array system and reader for microtiter plates |
PCT/EP1998/006468 WO1999023474A1 (en) | 1997-10-31 | 1998-10-12 | Optical array system and reader for micro titer plates |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2307837A1 true CA2307837A1 (en) | 1999-05-14 |
CA2307837C CA2307837C (en) | 2010-04-13 |
Family
ID=7847261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2307837A Expired - Fee Related CA2307837C (en) | 1997-10-31 | 1998-10-12 | Optical array system and reader for micro titer plates |
Country Status (7)
Country | Link |
---|---|
US (1) | US6686582B1 (en) |
EP (2) | EP1027591B1 (en) |
JP (1) | JP4227730B2 (en) |
AU (1) | AU9749898A (en) |
CA (1) | CA2307837C (en) |
DE (2) | DE19748211A1 (en) |
WO (1) | WO1999023474A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10823612B2 (en) | 2015-01-30 | 2020-11-03 | Japan Science And Technology Agency | Multifocal spectrometric measurement device, and optical system for multifocal spectrometric measurement device |
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KR950704670A (en) * | 1993-09-30 | 1995-11-20 | 가따다 데쯔야 | Confocal Optics |
FI98765C (en) * | 1995-01-16 | 1997-08-11 | Erkki Soini | Flow cytometric method and apparatus |
DE19624421B4 (en) * | 1995-06-30 | 2008-07-10 | Carl Zeiss Ag | Device and method for the spatially resolved measurement of wavefront deformations |
JP3350918B2 (en) * | 1996-03-26 | 2002-11-25 | 株式会社高岳製作所 | Two-dimensional array confocal optical device |
JP3152140B2 (en) * | 1995-12-18 | 2001-04-03 | 横河電機株式会社 | Optical scanner for confocal |
US6133986A (en) * | 1996-02-28 | 2000-10-17 | Johnson; Kenneth C. | Microlens scanner for microlithography and wide-field confocal microscopy |
DE19651667C2 (en) * | 1996-12-12 | 2003-07-03 | Rudolf Groskopf | Device for three-dimensional examination of an object |
-
1997
- 1997-10-31 DE DE19748211A patent/DE19748211A1/en not_active Withdrawn
-
1998
- 1998-10-12 DE DE59810420T patent/DE59810420D1/en not_active Expired - Lifetime
- 1998-10-12 AU AU97498/98A patent/AU9749898A/en not_active Abandoned
- 1998-10-12 US US09/530,612 patent/US6686582B1/en not_active Expired - Fee Related
- 1998-10-12 WO PCT/EP1998/006468 patent/WO1999023474A1/en active IP Right Grant
- 1998-10-12 JP JP2000519289A patent/JP4227730B2/en not_active Expired - Fee Related
- 1998-10-12 EP EP98951515A patent/EP1027591B1/en not_active Expired - Lifetime
- 1998-10-12 EP EP03021981A patent/EP1384987A3/en not_active Withdrawn
- 1998-10-12 CA CA2307837A patent/CA2307837C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10823612B2 (en) | 2015-01-30 | 2020-11-03 | Japan Science And Technology Agency | Multifocal spectrometric measurement device, and optical system for multifocal spectrometric measurement device |
Also Published As
Publication number | Publication date |
---|---|
US6686582B1 (en) | 2004-02-03 |
DE59810420D1 (en) | 2004-01-22 |
JP4227730B2 (en) | 2009-02-18 |
EP1027591A1 (en) | 2000-08-16 |
WO1999023474A1 (en) | 1999-05-14 |
CA2307837C (en) | 2010-04-13 |
JP2002514739A (en) | 2002-05-21 |
EP1384987A3 (en) | 2012-10-03 |
AU9749898A (en) | 1999-05-24 |
DE19748211A1 (en) | 1999-05-06 |
EP1027591B1 (en) | 2003-12-10 |
EP1384987A2 (en) | 2004-01-28 |
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