CA2307837A1 - Optical array system and reader for micro titer plates - Google Patents

Optical array system and reader for micro titer plates Download PDF

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Publication number
CA2307837A1
CA2307837A1 CA002307837A CA2307837A CA2307837A1 CA 2307837 A1 CA2307837 A1 CA 2307837A1 CA 002307837 A CA002307837 A CA 002307837A CA 2307837 A CA2307837 A CA 2307837A CA 2307837 A1 CA2307837 A1 CA 2307837A1
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CA
Canada
Prior art keywords
array
lens
reader according
detector array
reader
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002307837A
Other languages
French (fr)
Other versions
CA2307837C (en
Inventor
Martin Volcker
Jurgen Liegel
Martin Gluch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss AG
Original Assignee
Carl-Zeiss-Stiftung Trading As Carl Zeiss
Martin Volcker
Jurgen Liegel
Martin Gluch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl-Zeiss-Stiftung Trading As Carl Zeiss, Martin Volcker, Jurgen Liegel, Martin Gluch filed Critical Carl-Zeiss-Stiftung Trading As Carl Zeiss
Publication of CA2307837A1 publication Critical patent/CA2307837A1/en
Application granted granted Critical
Publication of CA2307837C publication Critical patent/CA2307837C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
    • G01N21/253Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/02Mechanical
    • G01N2201/024Modular construction

Abstract

An optical system made up of lens arrays (2i, 7) and normal lenses (41, 5, 42) is particularly suitable for use as a massive parallel reader (approx. 102 channels) for micro titer plates (1) and the like in absorption, fluorescence and luminescence.

Claims (10)

1. Reader for microtiter plates or substance chips, with a lens array [21-23], the grid pattern dimensions of which corresponds to the grid pattern dimensions of a microtiter plate or of a substance clop, a detector array [61-63], a telescope which is provided between the lens array and the detector array and which effects a reduction to match the beam diameter defined by the lens array to the dimensions of the detector array, and with a field lens [5], a reduced image of the microtiter plate or the substance clop being formed on the detector array by the system of lens array, telescope, and field lens, so that on the detector array a strict channel separation results between the measurement signals arising from individual sample volumes of the microtiter plate or of the substance chip.
2. Reader according to claim 1, characterized in that a respective lens (41, 42) of a telescope is arranged between the lens array [21-23] and field lens [5], and between the latter and the detector array [61-63].
3. Reader according to at least one of claims 1-2, characterized in that a microlens array [7] is arranged in front of the detector array [6].
4. Reader according to at least one of claim 1-3, characterized in that a reflected light illumination [9, 91, 92] is integrated.
5. Reader according to at least one of claims 1-4, characterized in that an aperture array [3] is arranged between the lens array [21-23] and the field lens [5].
6. Reader according to at least one of claims 1-5, characterized in that the lens array is achromatized, in that each individual lens consists of a lens group with achromatic properties.
7. Reader according to at least one of claims 1-6, characterized in that the detector array [6] is a CCD array or a photodiode array.
8. Reader according to at least one of claims 1-7, characterized by a modular construction with an interchangeable lens array.
9. Reader according to one of claims 1-9, characterized in that the lens array has individual lenses which are arranged with respect to each other in the formal 8 * 12.
10. Reader according to at least one of claims 4-9, characterized in that a dichroic mirror [8] is provided for the coupling-in of the illumination device [9].
CA2307837A 1997-10-31 1998-10-12 Optical array system and reader for micro titer plates Expired - Fee Related CA2307837C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19748211.2 1997-10-31
DE19748211A DE19748211A1 (en) 1997-10-31 1997-10-31 Optical array system and reader for microtiter plates
PCT/EP1998/006468 WO1999023474A1 (en) 1997-10-31 1998-10-12 Optical array system and reader for micro titer plates

Publications (2)

Publication Number Publication Date
CA2307837A1 true CA2307837A1 (en) 1999-05-14
CA2307837C CA2307837C (en) 2010-04-13

Family

ID=7847261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2307837A Expired - Fee Related CA2307837C (en) 1997-10-31 1998-10-12 Optical array system and reader for micro titer plates

Country Status (7)

Country Link
US (1) US6686582B1 (en)
EP (2) EP1027591B1 (en)
JP (1) JP4227730B2 (en)
AU (1) AU9749898A (en)
CA (1) CA2307837C (en)
DE (2) DE19748211A1 (en)
WO (1) WO1999023474A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10823612B2 (en) 2015-01-30 2020-11-03 Japan Science And Technology Agency Multifocal spectrometric measurement device, and optical system for multifocal spectrometric measurement device

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
AU759974B2 (en) 1998-05-16 2003-05-01 Applied Biosystems, Llc Instrument for monitoring polymerase chain reaction of DNA
DE19825716A1 (en) 1998-06-09 1999-12-16 Zeiss Carl Fa Optical element and socket assembly
DE19846928A1 (en) 1998-10-12 2000-04-13 Zeiss Carl Fa Imaging system, especially in a high throughput automatic analyzer useful for drug development or medical diagnosis, has a cylindrical lens array combined with or preceded by a prism array
ES2251244T3 (en) * 1998-11-20 2006-04-16 Graffinity Pharmaceutical Design Gmbh MEASUREMENT DEVICE AND MEASUREMENT METHOD FOR PARALLEL READING OF SPR SENSORS.
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
DE19919092A1 (en) * 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Arrangement for the optical evaluation of an array of objects
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
DE19924259C2 (en) * 1999-05-27 2002-11-21 Fraunhofer Ges Forschung Device and method for detecting the fill level of a liquid container
EP1055925B1 (en) * 1999-05-28 2010-09-08 Yokogawa Electric Corporation Biochip reader
GB2394544B (en) * 1999-06-26 2004-06-30 Packard Instrument Co Inc Improved assay analysis
US7170597B1 (en) 1999-06-26 2007-01-30 Packard Instrument Company, Inc. Microplate reader
DE19930607C2 (en) * 1999-07-02 2002-08-01 Max Planck Gesellschaft Method for obtaining data which provide information about the kinetics of the reactions of reactants in a large number of samples and device for carrying out the method
EP1617207A3 (en) * 1999-07-21 2006-05-31 Applera Corporation Luminescence detection workstation
EP1221038A4 (en) * 1999-07-21 2004-09-08 Applera Corp Luminescence detection workstation
DE19936999C2 (en) * 1999-08-02 2002-03-14 Jena Optronik Gmbh Arrangement for detecting the fluorescence radiation from matrix-shaped sample carriers
JP3729043B2 (en) * 2000-08-09 2005-12-21 株式会社日立製作所 Fluorescence image detection method, DNA inspection method and apparatus
US7217573B1 (en) * 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
EP1369699A1 (en) * 1999-10-15 2003-12-10 PE Corporation (NY) System and method for filling a substrate with a liquid sample
US6272939B1 (en) * 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US6320174B1 (en) * 1999-11-16 2001-11-20 Ikonisys Inc. Composing microscope
US6597522B2 (en) 2000-01-28 2003-07-22 Werner Freber Optical system
DE10003789C1 (en) * 2000-01-28 2001-08-02 Werner Freber microscope
DE10017824B4 (en) * 2000-04-10 2004-03-18 Till I.D. Gmbh Device for parallel photometric fluorescence or luminescence analysis of several separate sample areas on an object
WO2002001194A1 (en) * 2000-06-25 2002-01-03 Affymetrix, Inc. Optically active substrates
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
DE10038185C2 (en) 2000-08-04 2003-05-28 Siemens Ag Device for detecting different fluorescence signals of a sample holder illuminated over the entire area with different excitation wavelengths
DE10153663B4 (en) * 2000-11-03 2005-05-25 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Microanalytical device for detecting molecules emitting near-infrared radiation
JP3824135B2 (en) * 2001-01-10 2006-09-20 横河電機株式会社 Biochip reader
JP2004527742A (en) * 2001-03-09 2004-09-09 グノーティス ホールディング ソシエテ アノニム Analyte determination by fluorescence-correlation spectroscopy
DE10111420A1 (en) * 2001-03-09 2002-09-12 Gnothis Holding Sa Ecublens To detect an analyte by fluorescence correlation spectroscopy, a set gap is established between the light focusing unit and the volume of the sample, and the sample carrier is thermally insulated from the light source
US20060291048A1 (en) * 2001-03-19 2006-12-28 Dmetrix, Inc. Multi-axis imaging system with single-axis relay
US20040004759A1 (en) * 2002-07-08 2004-01-08 Olszak Artur G. Microscope array for simultaneously imaging multiple objects
US20050088735A1 (en) * 2003-10-22 2005-04-28 Olszak Artur G. Multi-axis imaging system with single-axis relay
WO2002082064A1 (en) * 2001-04-06 2002-10-17 Kla-Tencor Corporation Improved defect detection system
DE10121064A1 (en) 2001-04-28 2002-10-31 Evotec Ag Device and method for the optical measurement of chemical and / or biological samples
DE10126083A1 (en) * 2001-05-29 2002-12-05 Gnothis Holding Sa Ecublens Use of optical diffraction elements in detection methods
US7348587B2 (en) 2001-06-28 2008-03-25 Fujifilm Corporation Method for producing biochemical analysis data and apparatus used therefor
JP2003057557A (en) * 2001-08-09 2003-02-26 Yokogawa Electric Corp Biochip reader
DE10145221A1 (en) * 2001-09-13 2003-04-10 Lavision Biotec Gmbh Apparatus for detecting luminescence from micro-arrays, comprises directing white light at the micro-array through an optical system and optically gathering the emitted fluorescence at a detector to be digitized for processing
DE10200499A1 (en) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Method and / or arrangement for the identification of fluorescent, luminescent and / or absorbent substances on and / or in sample carriers
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
US7312432B2 (en) * 2002-07-08 2007-12-25 Dmetrix, Inc. Single axis illumination for multi-axis imaging system
JP3747890B2 (en) * 2002-07-08 2006-02-22 オムロン株式会社 OPTICAL COMPONENT, OPTICAL DETECTOR USING THE OPTICAL COMPONENT, OPTICAL DETECTING METHOD, AND ANALYSIS METHOD
US20040051030A1 (en) * 2002-09-17 2004-03-18 Artur Olszak Method and apparatus for acquiring images from a multiple axis imaging system
JP4495083B2 (en) * 2003-02-13 2010-06-30 浜松ホトニクス株式会社 Fluorescence correlation spectroscopy analyzer
US7292333B2 (en) * 2003-06-24 2007-11-06 Corning Incorporated Optical interrogation system and method for 2-D sensor arrays
US7057720B2 (en) * 2003-06-24 2006-06-06 Corning Incorporated Optical interrogation system and method for using same
JP2005167824A (en) * 2003-12-04 2005-06-23 Canon Inc Photodetector and optical transmission apparatus
EP1568986A1 (en) * 2004-02-27 2005-08-31 DR. Chip Biotechnology Incorporation Microarray image detection and recognition apparatus
US7177023B2 (en) * 2004-03-19 2007-02-13 Applera Corporation Fluorescent light detection
JP2006058044A (en) * 2004-08-18 2006-03-02 Yokogawa Electric Corp Cartridge for biochip and biochip reading apparatus
WO2006059727A1 (en) * 2004-12-03 2006-06-08 National Institute Of Advanced Industrial Science And Technology Detection and analysis system for protein array
US20060133080A1 (en) * 2004-12-17 2006-06-22 Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware Multiple light source orientation system for multi-well reaction plate
ATE359500T1 (en) 2005-01-18 2007-05-15 Hoffmann La Roche FLUORESCENCE IMAGING USING TELECENTRICITY
ATE357653T1 (en) 2005-01-18 2007-04-15 Hoffmann La Roche FLUORESCENT IMAGING USING TELECENTRIC EXCITATION AND IMAGING OPTICS
FI20055043A0 (en) * 2005-01-31 2005-01-31 Wallac Oy Arrangements at an imaging device for microtiter wells
US20070132831A1 (en) * 2005-12-13 2007-06-14 Bio-Rad Laboratories, Inc. Masking to prevent overexposure and light spillage in microarray scanning
MX338460B (en) 2005-12-21 2016-04-15 Meso Scale Technologies Llc Assay apparatuses, methods and reagents.
CN105115949B (en) * 2005-12-21 2018-06-22 梅索斯卡莱科技公司 Analytical equipment, method and reagent
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
CN101674887B (en) * 2006-11-09 2013-01-02 Asmag控股有限公司 Titer plate with thin-film-light sensor
JP2008175712A (en) * 2007-01-19 2008-07-31 Casio Comput Co Ltd Biopolymer analysis chip
DE102007011877A1 (en) * 2007-03-13 2008-09-18 Eppendorf Ag Optical sensor system on a device for the treatment of liquids
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
FI20085062A0 (en) * 2008-01-25 2008-01-25 Wallac Oy Improved measurement system and method
US20090262332A1 (en) * 2008-04-18 2009-10-22 Microvast, Inc. High-throughput spectral imaging and spectroscopy apparatus and methods
EP2291643B1 (en) * 2008-06-24 2016-11-23 Koninklijke Philips N.V. Microarray characterization system and method
EP2163885A1 (en) * 2008-06-24 2010-03-17 Koninklijke Philips Electronics N.V. Microarray characterization system and method
EP2148187A1 (en) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Stimulation and optical display system for fluorescence detection
WO2010110096A1 (en) * 2009-03-26 2010-09-30 ユニバーサル・バイオ・リサーチ株式会社 Reaction optical measurement device and method for measurement therefor
WO2010122547A1 (en) 2009-04-20 2010-10-28 Bio-Rad Laboratories Inc. Non-scanning surface plasmon resonance ( spr) system
CN101581829B (en) * 2009-06-19 2011-11-09 宁波永新光学股份有限公司 Microscope imaging method of CMOS sensor based on microlens array and system therefor
JP2011158419A (en) * 2010-02-03 2011-08-18 Sony Corp Optical detector
DE102010001714A1 (en) 2010-02-09 2011-08-11 Robert Bosch GmbH, 70469 Apparatus and method for the optical parallel analysis of a sample arrangement and corresponding production method
JP5609611B2 (en) * 2010-03-11 2014-10-22 株式会社リコー Spectral characteristic acquisition device, image evaluation device, and image forming device
DE102010016382B4 (en) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluorescence microscope and method for carrying out multi-positioning in a screening application
WO2011156764A1 (en) 2010-06-10 2011-12-15 Spaario Inc. Optical system providing magnification
DE102010023486A1 (en) * 2010-06-11 2011-12-15 B. Braun Avitum Ag Detection device and method
JP5644296B2 (en) * 2010-09-13 2014-12-24 株式会社リコー Spectral characteristic acquisition device, image evaluation device, and image forming device
DE102010049212A1 (en) * 2010-10-21 2012-04-26 Rudolf Grosskopf Arrangement for arranging fluorescence correlation spectroscopy in multiple locations, comprises lighting grid having light emitting areas for illuminating object, and lens assembly, which indicates lighting grid in focal plane
MX2014002578A (en) * 2011-09-06 2014-06-05 Koninkl Philips Nv Optical biosensor with a plurality of sensors regions.
DE202012104237U1 (en) * 2011-11-04 2013-05-22 Dynex Technologies Inc. Multiplexed optical arrangement
WO2013186780A1 (en) 2012-06-13 2013-12-19 Hadasit Medical Research Services And Development Ltd. Devices and methods for detection of internal bleeding and hematoma
TW201400607A (en) * 2012-06-22 2014-01-01 Maestrogen Inc Assistant pipetting device for microtiter plate
US20150018646A1 (en) * 2013-07-12 2015-01-15 Sandeep Gulati Dynamic sample mapping noninvasive analyzer apparatus and method of use thereof
EP2693252B1 (en) * 2012-08-02 2016-05-18 F. Hoffmann-La Roche AG Array optics
US8790599B2 (en) 2012-08-13 2014-07-29 David Childs Microtiter plate system and method
CN102818886A (en) * 2012-08-28 2012-12-12 天津市先石光学技术有限公司 Low-dose homogenous excitation light immunoassay instrument
DE102012018303A1 (en) * 2012-09-14 2014-03-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Measuring device for luminescence measurement
US10036877B2 (en) 2013-02-05 2018-07-31 Vanderbilt University Microlens array for enhanced imaging of multiregion targets
KR101568573B1 (en) * 2013-03-13 2015-11-20 고려대학교 산학협력단 Apparatus and method for detection and enumeration of rare cells in whole blood
WO2016022998A2 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device for temporal binning of received photons
DE102014115564A1 (en) 2014-10-27 2016-04-28 Christian-Albrechts-Universität Zu Kiel Mobile photometric measuring device and method for the mobile photometric measurement of microtiter plates
US9475149B1 (en) 2015-04-24 2016-10-25 Testrake Aviation, Inc. Optical device and method of making same
US20180371518A1 (en) * 2015-07-28 2018-12-27 Kabushiki Kaisha Dnaform Analysis kit and analysis method using same
JP6345169B2 (en) * 2015-12-24 2018-06-20 株式会社Screenホールディングス Lens unit, well plate, image acquisition device
JP2019512090A (en) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドTesseract Health,Inc. Sensors and Devices for Lifetime Imaging and Detection Applications
MX2019007530A (en) 2016-12-22 2019-08-16 Quantum Si Inc Integrated photodetector with direct binning pixel.
EP3568677A4 (en) * 2017-01-10 2020-10-21 Photoswitch Biosciences, Inc. Systems and methods for detection
JP6439810B2 (en) 2017-02-06 2018-12-19 横河電機株式会社 Biochip, biochip unit, biochip reader, and biochip manufacturing method
JP6731901B2 (en) * 2017-09-29 2020-07-29 株式会社日立ハイテク Analysis equipment
AU2019288394A1 (en) 2018-06-22 2021-01-07 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
AU2019330042A1 (en) * 2018-08-29 2021-03-11 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors
US11333748B2 (en) 2018-09-17 2022-05-17 Waymo Llc Array of light detectors with corresponding array of optical elements
KR102292599B1 (en) 2019-11-06 2021-08-23 주식회사 뷰웍스 Optical analysis device and optical analysis method
US11869917B2 (en) 2020-01-14 2024-01-09 Quantum-Si Incorporated Integrated sensor for lifetime characterization
AU2021208557A1 (en) 2020-01-14 2022-09-01 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
TW202147591A (en) 2020-03-02 2021-12-16 美商寬騰矽公司 Integrated sensor for multi-dimensional signal analysis
DE102020108432A1 (en) 2020-03-25 2021-09-30 Jenoptik Optical Systems Gmbh Device and method for luminescence analysis of several samples
US11573180B2 (en) 2020-04-08 2023-02-07 Quantum-Si Incorporated Integrated sensor with reduced skew
US11619588B2 (en) * 2020-10-26 2023-04-04 K2R2 Llc Portable analyzer
WO2024020021A1 (en) * 2022-07-19 2024-01-25 Trustees Of Boston University High throughput screening system for engineered cardiac tissues

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2718896B2 (en) * 1977-04-28 1980-02-14 Fa. Carl Zeiss, 7920 Heidenheim Achromatic microscope objective made of three lens sections
US4710031A (en) * 1985-07-31 1987-12-01 Lancraft, Inc. Microtiter plate reader
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
EP0706686B1 (en) * 1993-07-01 1998-10-14 Legent Corporation System and method for distributed storage management on networked computer systems
EP0706646B1 (en) * 1993-07-02 1998-03-25 Institut Für Molekulare Biologie E.V. Sample holder and its use
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
JP3404607B2 (en) * 1993-09-30 2003-05-12 株式会社小松製作所 Confocal optics
KR950704670A (en) * 1993-09-30 1995-11-20 가따다 데쯔야 Confocal Optics
FI98765C (en) * 1995-01-16 1997-08-11 Erkki Soini Flow cytometric method and apparatus
DE19624421B4 (en) * 1995-06-30 2008-07-10 Carl Zeiss Ag Device and method for the spatially resolved measurement of wavefront deformations
JP3350918B2 (en) * 1996-03-26 2002-11-25 株式会社高岳製作所 Two-dimensional array confocal optical device
JP3152140B2 (en) * 1995-12-18 2001-04-03 横河電機株式会社 Optical scanner for confocal
US6133986A (en) * 1996-02-28 2000-10-17 Johnson; Kenneth C. Microlens scanner for microlithography and wide-field confocal microscopy
DE19651667C2 (en) * 1996-12-12 2003-07-03 Rudolf Groskopf Device for three-dimensional examination of an object

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10823612B2 (en) 2015-01-30 2020-11-03 Japan Science And Technology Agency Multifocal spectrometric measurement device, and optical system for multifocal spectrometric measurement device

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US6686582B1 (en) 2004-02-03
DE59810420D1 (en) 2004-01-22
JP4227730B2 (en) 2009-02-18
EP1027591A1 (en) 2000-08-16
WO1999023474A1 (en) 1999-05-14
CA2307837C (en) 2010-04-13
JP2002514739A (en) 2002-05-21
EP1384987A3 (en) 2012-10-03
AU9749898A (en) 1999-05-24
DE19748211A1 (en) 1999-05-06
EP1027591B1 (en) 2003-12-10
EP1384987A2 (en) 2004-01-28

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