CA2309730A1 - Sliding reconstitution device for a diluent container - Google Patents

Sliding reconstitution device for a diluent container Download PDF

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Publication number
CA2309730A1
CA2309730A1 CA 2309730 CA2309730A CA2309730A1 CA 2309730 A1 CA2309730 A1 CA 2309730A1 CA 2309730 CA2309730 CA 2309730 CA 2309730 A CA2309730 A CA 2309730A CA 2309730 A1 CA2309730 A1 CA 2309730A1
Authority
CA
Canada
Prior art keywords
sleeve
container
piercing member
section
piercing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2309730
Other languages
French (fr)
Other versions
CA2309730C (en
Inventor
Thomas A. Fowles
Robert J. Weinberg
Thomas J. Progar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA 2646408 priority Critical patent/CA2646408A1/en
Publication of CA2309730A1 publication Critical patent/CA2309730A1/en
Application granted granted Critical
Publication of CA2309730C publication Critical patent/CA2309730C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Abstract

A connector device (10) is disclosed for establishing fluid communication between a diluent container (12) having sidewalls and a drug vial (14). The connector (10) has a piercing member (51) having a first end (52) and a second end (53) and a central fluid pathway (54).
The piercing member (51) is mounted to the liquid container (12) and has fluid accessing portions hermetically sealed from an outside environment.
A vial receiving chamber is associated with the piercing member (51) and is dimensioned to connect to the vial (14). The vial (14) may be selectively attached to the device (10) without piercing the closure (22) of the vial (14) and without breaching the hermetic seal of the fluid accessing portions of the piercing member (51). Means are provided for connecting the vial receiving chamber to the liquid container (12). The device (10) is movable from an inactivated position, where the piercing member (51) is outside the sidewalls and no fluid flows between the liquid container (12) and the drug vial (14), to an activated position, where fluid flows through the fluid pathway (54) between the liquid container (12) and the drug vial (14). The device (10) is movable from the inactivated position to the activated position by a force applied to the device (10) outside the liquid container (12).

Claims (85)

1. A connector device for establishing fluid communication between a liquid container having sidewalls and a drug vial having a neck with a closure therein, the connector comprising:
a piercing member having a first end and a second end and a central fluid pathway, the piercing member being mounted to the liquid container and having fluid accessing portions hermetically sealed from an outside environment;
a vial receiving chamber associated with the piercing member and being dimensioned to connect to the vial and wherein a vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the fluid accessing portions of the piercing member;
means for connecting the vial receiving chamber to the liquid container; and wherein the device is movable from an inactivated position where the piercing member is outside the sidewalls and no fluid flows between the liquid container and the drug vial, to an activated position wherein fluid flows through the fluid pathway between the liquid container and the drug vial, the device being movable from the inactivated position to the activated position by a force applied to the device outside the liquid container.
2. The device of claim 1 wherein the means for connecting the vial receiving chamber to the liquid container comprises:
a first sleeve and a second sleeve mounted for translational motion with respect to one another, the first sleeve being connected to the liquid container and the second sleeve being connected to the vial receiving chamber.
3. The device of claim 2 wherein the first sleeve is mounted within the second sleeve.
4. The device of claim 3 wherein the second sleeve slidably mounts the piercing member for translational motion.
5. The device of claim 4 wherein the second sleeve has an inner surface and the piercing member is capable of sliding on the inner surface.
6. The device of claim 5 wherein a hub mounts the piercing member inside the second sleeve.
7. The device of claim 2 further comprising means disposed between the first sleeve member and the second sleeve member for sealing the first sleeve member and the second sleeve member.
8. The device of claim 1 wherein the means for connecting the vial receiving chamber to the liquid container comprises:
a flexible sleeve having a first end and a second end and defining a central passageway;
the piercing member being positioned within the passageway; and the sleeve being slidable with respect to the piercing member from the inactivated position to the activated position wherein the sleeve slides along the piercing member and folds upon itself, the piercing member piercing a closure of the vial establishing fluid communication between the liquid container and the vial.
9. The device of claim 8 wherein the sleeve has a first section and a second section, the first section having a greater diameter than the second section, wherein when the sleeve moves from the inactivated position to the activated position, the second section slides along the piercing member and the first section folds upon the second section.
10. The device of claim 8 wherein the vial receiving chamber comprises a base connected to a wall portion, the wall portion having a plurality of fingers inwardly spaced from the wall portion and adapted to cooperatively receive the vial, the base being connected to the sleeve.
11. The device of claim 10 further comprising a sealing member positioned between a bottom portion of each finger and the base.
12. The device of claim 11 wherein the sealing member is a pierceable septum.
13. The device of claim 12 wherein the septum comprises a disk, the piercing member passes through the disk when the sleeve is moved from the inactivated position to the activated position.
14. The device of claim 13 wherein the disk further has a generally centrally disposed annular ring extending axially from the disk, the annular ring being dimensioned to fit over a closure of the second container.
15. The device of claim 12 wherein the septum is capable of deforming to accommodate dimensional variations in a height of the closure of the vial.
16. The device of claim 8 wherein the piercing member has a radial slot spaced from the fluid flow passage allowing contents of the liquid container to pass through the radial slot and into contact with an inner surface of the sleeve.
17. A connector device for establishing fluid communication between a liquid container and a vial container comprising:
a first sleeve and a second sleeve mounted for translational movement with respect to one another and define a central channel therein, the first sleeve and the second sleeve each having an inner surface, the first sleeve is adapted to attach to the liquid container;
a piercing member having opposed piercing ends, the piercing member being mounted in the central channel;
means for hermetically sealing the piercing ends when the device is connected to the first container and the second container;
a vial receiving chamber on the second sleeve and being dimensioned to connect to the vial and wherein the vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the piercing ends; and the first sleeve and the second sleeve are capable of being moved from an inactivated position where fluid cannot flow through the device to an activated position where fluid can flow through the device, the device is capable of being moved from the inactivated position to the activated position by applying a force to the device outside the first container and the second container.
18. The device of claim 17 wherein the means for hermetically sealing comprises a sealing member disposed between the first sleeve and the second sleeve.
19. The device of claim 18 wherein the first sleeve is mounted within the second sleeve and the sealing member is mounted on the first member and slides along the inner surface of the second sleeve.
20. The device of claim 19 wherein the means for sealing further comprises a septum mounted within the vial receiving chamber to seal the second sleeve.
21. The device of claim 20 further comprising means for venting the device when the device is moved from the inactivated position to the activated position.
22. The device of claim 21 wherein the means for venting comprises an increased inner diameter portion of the second sleeve proximate a distal end of the second sleeve and upon which the sealing member does not seal.
23. The device of claim 19 further comprising means for supporting the piercing member within the central channel.
24. The device of claim 23 wherein the means for supporting comprises a hub mounting the piercing member, a portion of the hub slides on the inner surface of the second sleeve.
25. The device of claim 24 wherein the hub mounts the piercing member along a generally central portion of the piercing member.
26. The device of claim 24 wherein the means for mounting the piercing member further comprises a guide within the first sleeve that supports a portion of the piercing member.
27. The device of claim 26 wherein the guide is positioned adjacent the liquid container.
28. The device of claim 26 further comprising a disk positioned between the liquid container and the guide.
29. The device of claim 28 wherein when the device is in the activated position the piercing member punctures the septum.
30. The device of claim 29 wherein the device is capable of being positioned between an activated position and a deactivated position wherein in the deactivated position the first end of the piercing member is pulled out of the disk and guide.
31. The device of claim 17 wherein the means for hermetically sealing comprises a first means for sealing the first sleeve and a second means for sealing the second sleeve.
32. The device of claim 31 wherein the first sealing means comprises an annular gasket positioned in the first sleeve.
33. The device of claim 32 wherein the annular gasket supports a portion of the piercing member.
34. The device of claim 33 wherein the piercing member travels a distance when the device is moved from the inactivated position to the activated position and wherein the annular gasket has a length that is greater than the distance.
35. The device of claim 34 wherein the annular gasket has an X-shaped cross section.
36. The device of claim 33 wherein the means for sealing the second sleeve comprises a septum.
37. The device of claim 36 wherein the septum is positioned within the vial receiving chamber.
38. The device of claim 37 wherein the septum has a generally disk shaped portion.
39. The device of claim 38 wherein the septum further comprises a sheath extending axially away from the septum and is dimensioned to fit over one of the piercing ends of the piercing member.
40. The device of claim 39 wherein the sheath has an enlarged distal end that is dimensioned to fit over a portion of a hub that mounts the piercing member.
41. A connector device for establishing fluid communication between a first container and a second container comprising:
a sleeve having a first end and a second end;
a piercing member connected to the first end of the sleeve and adapted to be connected to the first container, the piercing member positioned within the sleeve and providing a fluid flow passage from the first container to the second container;
a cup assembly connected to the second end of the sleeve, the cup assembly adapted to be attached to the second container; and the sleeve being slidable with respect to the piercing member from an inactivated position to an activated position wherein the sleeve slides along the piercing member and folds upon itself, the piercing member piercing a closure of the second container establishing fluid communication between the first container and the second container.
42. The device of claim 41 wherein the sleeve has a first section and a second section, the first section having a greater diameter than the second section, wherein when the sleeve moves from the inactivated position to the activated position, the second section slides along the piercing member and the first section folds upon the second section.
43. The device of claim 41 wherein the cup assembly comprises a base connected to a wall portion, the wall portion having a plurality of fingers inwardly spaced from the wall portion and adapted to cooperatively receive the second container, the base being connected to the sleeve.
44. The device of claim 43 further comprising a sealing member positioned between a bottom portion of each finger and the base.
45. The device of claim 44 wherein the sealing member is a pierceable septum.
46. The device of claim 45 wherein the septum comprises a disk, the piercing member passes through the disk when the sleeve is moved from the inactivated position to the activated position.
47. The device of claim 46 wherein the disk further has a generally centrally disposed annular ring extending axially from the disk, the annular ring being dimensioned to fit over a closure of the second container.
48. The device of claim 45 wherein the septum is capable of deforming to accommodate dimensional variations in a height of a closure of the second container.
49. The device of claim 41 wherein the piercing member has a radial slot spaced from the fluid flow passage allowing contents of the first container to pass through the radial slot and into contact with an inner surface of the sleeve.
50. The device of claim 41 wherein the sleeve has a first section and a second section, the first section having a greater diameter than the second section, and wherein the contents of the first container pass through the radial slot and into contact with an inner surface of the sleeve at the first section.
51. The device of claim 41 wherein the sleeve has a first end having an annular slot, the piercing member including a collar having an annular ridge, the collar connected to the sleeve wherein the annular slot receives the annular ridge, the collar adapted to be attached to the first container.
52. The device of claim 41 wherein the sleeve has a second end sealed by a membrane, the membrane positioned between the piercing member and the cup assembly and being pierced by the piercing member when the sleeve is moved from the inactivated position to the activated position.
53. The device of claim 41 further comprising a seal material releasably secured to the cup assembly.
54. The device of claim 53 wherein the seal material is selected from the group consisting of a foil, a polymeric material and a paper.
55. A connector device for establishing fluid communication between a first container and a second container comprising:
a sleeve having a first end and a second end;

a piercing member connected to the first end of the sleeve and adapted to be connected to the first container, the piercing member positioned within the sleeve and providing a fluid flow passage from the first container to the second container, the piercing member further having a radial slot allowing contents of the first container to pass through the radial slot and into contact with an inner surface of the sleeve;
a cup assembly connected to the second end of the sleeve, the cup assembly adapted to be attached to the second container; and the sleeve being slidable with respect to the piercing member from an inactivated position to an activated position wherein the sleeve slides along the piercing member and folds upon itself, the piercing member piercing a closure of the second container establishing fluid communication between the first container and the second container.
56. The device of claim 55 wherein the sleeve has a first section and a second section, the first section having a greater diameter that the second section wherein a pocket is maintained between the piercing member and the first section, and wherein the contents of the first container pass through the radial slot and into the pocket.
57. A connector device for establishing fluid communication between a first container and a second container comprising:
a sleeve having a first end and a second end;
a piercing member connected to the first end of the sleeve and adapted to be connected to the first container, the piercing member positioned within the sleeve and providing a fluid flow passage from the first container to the second container;
a cup assembly having a base connected to a wall portion, the wall portion having a plurality of fingers inwardly spaced from the wall portion and adapted to cooperatively receive the second container, the base being connected to the second end of the sleeve; and the sleeve being slidable with respect to the piercing member from an inactivated position to an activated position wherein the sleeve slides along the piercing member and folds upon itself, the piercing member piercing a closure of the second container establishing fluid communication between the first container and the second container.
58. The device of claim 57 further comprising a sealing member positioned between a bottom portion of each finger and the base.
59. The device of claim 58 wherein the sealing member is a pierceable septum.
60. The device of claim 59 wherein the septum comprises a disk having a central opening that receives the piercing member when the sleeve is moved from the inactivated position to the activated position.
61. The device of claim 60 wherein the disk further has a centrally disposed annular ring extending axially from the disk, the annular ring being dimensioned to fit over a closure of the second container.
62. The device of claim 59 wherein the septum is capable of deforming to accommodate dimensional variations in a height of a closure of the second container.
63. A connector device for establishing fluid communication between a first container and a second container comprising:
a sleeve having a first end and a second end, the first end having an annular slot, the second end sealed by a membrane;
a collar having an annular ridge, the collar connected to the sleeve wherein the annular slot receives the annular ridge, the collar adapted to be attached to the first container;
a piercing member supported by the collar and positioned within the sleeve and the collar, the piercing member providing a fluid flow passage from the first container to the second container;
a cup assembly connected to the second end of the sleeve, the cup assembly supporting a pierceable septum, the cup assembly adapted to be attached to the second container; and the piercing member being slideable with respect to the sleeve from an inactivated position to an activated position wherein the sleeve moves along the piercing member folding upon itself, the piercing member piercing the membrane, septum and closure of a second container establishing fluid communication between the first container and the second container.
64. A connector device for establishing fluid communication between a flexible solution container and a drug vial comprising:
a sleeve having a first section and a second section, the first section having a greater diameter than the second section, the second section being sealed by a membrane and the first section having an annular slot;

a collar having an opening and an annular ridge around the opening, the collar being connected to the sleeve wherein the annular slot receives the annular ridge, the collar attached to the flexible solution container;
a piercing member having a blunt end and another end having a sharp point, the piercing member positioned within the sleeve wherein the blunt end is positioned in the collar opening and the sharp point is positioned adjacent the membrane, the second section being in surface-to-surface contact with the piercing member, the piercing member providing a fluid flow path from the flexible container to the drug vial;
a cup assembly having a base connected to a wall portion, the base connected to the second section of the sleeve, the wall portion having a plurality of segmented fingers inwardly spaced from the wall portion and adapted to attach to the drug vial;
a pierceable septum supported between a bottom portion of the fingers and the base, the septum having a central opening; and the sleeve movable from an inactivated position to an activated position by applying a force to move the drug vial toward the piercing member wherein the second section of the sleeve moves along the piercing member and the first section folds over the second section, the piercing member piercing the membrane, passing through the central opening of the septum and piercing a closure of the drug vial thereby establishing fluid communication between the first container and the second container.
65. A connector device for establishing fluid communication between a first container and a second container comprising:
a bellows assembly having a first end and a second end, the bellows assembly having a first bellows portion and a second bellows portion and an intermediate section therebetween;
a port connector having one end connected to the first end of the bellows assembly and another end adapted to be attached to the first container, the port connector having a membrane;
an attaching member attached to the second end of the bellows assembly, the attaching member adapted to be attached to the second container;
a piercing assembly positioned within the bellows assembly, the piercing assembly having a hub supporting a first piercing member and a second piercing member, the hub being fixedly attached to the intermediate portion, the piercing assembly providing a fluid flow passage between the first container and the second container; and the bellows assembly being deformable from an inactivated position to an activated position wherein the second piercing member is adapted to pierce the second container and the first piercing member is adapted to pierce the membrane to establish fluid communication between the first container and the second container.
66. The device of claim 65 wherein the second container is capable of being pierced by the second piercing member independently of the first piercing member piercing the membrane.
67. The device of claim 1 wherein the liquid container is a syringe.
68. A device for connecting to a vial having a closure comprising:
a connecting base;
a plurality of segmented fingers circumferentially spaced and axially extending from the base, the segmented fingers defining a receiving chamber dimensioned to accommodate the closure of the vial, wherein the fingers have a proximal end and a distal end; and an annular wall circumjacent the segmented fingers.
69. The device of claim 68 wherein the segmented forgers are spaced a distance therefrom to define an annular space therebetween
70. The device of claim 68 wherein at least one of the fingers has a standing rib.
71. The device of claim 68 wherein a plurality of the fingers have standing ribs.
72. The device of claim 70 wherein the standing rib tapers radially inwardly proximate the distal end of the finger.
73. The device of claim 68 wherein at least one of the fingers has a lead-in section.
74. The device of claim 73 wherein a radially-inwardly tapering tab extends from the lead-in section.
75. The device of claim 68 wherein a plurality of the fingers have radially inwardly tapering tabs extending from a lead-in section.
76. The device of claim 68 wherein a plurality of fingers have standing ribs and a plurality of fingers have radially inwardly tapering tabs extending from a lead-in section wherein the fingers with the tabs and the fingers with the ribs are disposed in alternating order about the receiving chamber.
77. The device of claim 68 wherein the distance between the annular wall and the fingers is dimensioned to allow the fingers to flex when receiving a vial.
78. The device of claim 68 wherein the annular wall is continuous and solid.
79. The device of claim 78 further comprising a seal material releasably secured to the annular wall.
80. The device of claim 79 wherein the seal material is selected from the group consisting of a foil, a polymeric material and a paper.
81. A device for connecting to a vial having a closure comprising:
a base;
an annular wall connected to the base; and a plurality of segmented forgers circumjacent the annular wall and extending therefrom, the segmented fingers defining a receiving chamber dimensioned to accommodate the closure of the vial, wherein the forgers have a proximal end and a distal end.
82. The device of claim 81 wherein the segmented fingers are spaced a distance from the annular wall to define an annular space therebetween.
83. The device of claim 81 wherein the annular wall is solid and continuous.
84. The device of claim 81 further comprising a sealing member positioned between a bottom portion of each finger and the base.
85. The device of claim 84 wherein the sealing member is a pierceable septum.
CA 2309730 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container Expired - Fee Related CA2309730C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2646408 CA2646408A1 (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/153,569 US6022339A (en) 1998-09-15 1998-09-15 Sliding reconstitution device for a diluent container
US09/153,569 1998-09-15
US09/153,816 1998-09-15
US09/153,816 US6113583A (en) 1998-09-15 1998-09-15 Vial connecting device for a sliding reconstitution device for a diluent container
PCT/US1999/020400 WO2000015292A2 (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA 2646408 Division CA2646408A1 (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container

Publications (2)

Publication Number Publication Date
CA2309730A1 true CA2309730A1 (en) 2000-03-23
CA2309730C CA2309730C (en) 2011-03-29

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA 2309730 Expired - Fee Related CA2309730C (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container
CA 2646408 Abandoned CA2646408A1 (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA 2646408 Abandoned CA2646408A1 (en) 1998-09-15 1999-09-07 Sliding reconstitution device for a diluent container

Country Status (11)

Country Link
US (3) US6022339A (en)
EP (4) EP1415635B1 (en)
JP (4) JP2002524217A (en)
AT (4) ATE424799T1 (en)
AU (1) AU762850B2 (en)
BR (1) BR9906945B1 (en)
CA (2) CA2309730C (en)
CO (1) CO5060504A1 (en)
DE (4) DE69940569D1 (en)
DK (2) DK1030711T3 (en)
WO (1) WO2000015292A2 (en)

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EP1030711A1 (en) 2000-08-30
DE69942644D1 (en) 2010-09-09
DE69940569D1 (en) 2009-04-23
JP2002524217A (en) 2002-08-06
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JP2004313808A (en) 2004-11-11
WO2000015292A2 (en) 2000-03-23
ATE283091T1 (en) 2004-12-15
CO5060504A1 (en) 2001-07-30
EP1415635A3 (en) 2005-07-27
CA2646408A1 (en) 2000-03-23
ATE493962T1 (en) 2011-01-15
BR9906945A (en) 2000-10-03
EP1415636B1 (en) 2009-03-11
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US6022339A (en) 2000-02-08
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US6113583A (en) 2000-09-05
EP1415635A2 (en) 2004-05-06
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US6890328B2 (en) 2005-05-10
EP1415636A3 (en) 2005-07-27
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DK1415636T3 (en) 2009-06-08
EP2047836A3 (en) 2009-10-07
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US20030199846A1 (en) 2003-10-23
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ATE475397T1 (en) 2010-08-15
EP1030711B1 (en) 2004-11-24

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