CA2316887A1 - Osmotic drug delivery monitoring system and method - Google Patents

Osmotic drug delivery monitoring system and method Download PDF

Info

Publication number
CA2316887A1
CA2316887A1 CA002316887A CA2316887A CA2316887A1 CA 2316887 A1 CA2316887 A1 CA 2316887A1 CA 002316887 A CA002316887 A CA 002316887A CA 2316887 A CA2316887 A CA 2316887A CA 2316887 A1 CA2316887 A1 CA 2316887A1
Authority
CA
Canada
Prior art keywords
monitoring
beneficial agent
performance
delivery device
monitoring system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002316887A
Other languages
French (fr)
Other versions
CA2316887C (en
Inventor
Rupal Ayer
James B. Eckenhoff (Deceased)
Stephen Berry
Gregory Robert Stewart
Scott Darwin Jordan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corporation
Rupal Ayer
James B. Eckenhoff (Deceased)
Stephen Berry
Gregory Robert Stewart
Scott Darwin Jordan
Eckenhoff, Bonnie J.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, Rupal Ayer, James B. Eckenhoff (Deceased), Stephen Berry, Gregory Robert Stewart, Scott Darwin Jordan, Eckenhoff, Bonnie J. filed Critical Alza Corporation
Publication of CA2316887A1 publication Critical patent/CA2316887A1/en
Application granted granted Critical
Publication of CA2316887C publication Critical patent/CA2316887C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/1424—Manually operated pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/1684—Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion

Abstract

Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
CA002316887A 1997-12-31 1998-12-21 Osmotic drug delivery monitoring system and method Expired - Lifetime CA2316887C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7017897P 1997-12-31 1997-12-31
US60/070,178 1997-12-31
PCT/US1998/027208 WO1999033513A1 (en) 1997-12-31 1998-12-21 Osmotic drug delivery monitoring system and method

Publications (2)

Publication Number Publication Date
CA2316887A1 true CA2316887A1 (en) 1999-07-08
CA2316887C CA2316887C (en) 2008-04-08

Family

ID=22093633

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002316887A Expired - Lifetime CA2316887C (en) 1997-12-31 1998-12-21 Osmotic drug delivery monitoring system and method

Country Status (14)

Country Link
US (1) US6283953B1 (en)
EP (1) EP1051217B8 (en)
AR (1) AR014231A1 (en)
AT (2) ATE248002T1 (en)
AU (1) AU1937099A (en)
CA (1) CA2316887C (en)
DE (2) DE69834213T2 (en)
DK (1) DK1051217T3 (en)
ES (1) ES2205595T3 (en)
HK (1) HK1032363A1 (en)
PT (1) PT1051217E (en)
TW (1) TW381974B (en)
WO (1) WO1999033513A1 (en)
ZA (1) ZA9811879B (en)

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Also Published As

Publication number Publication date
EP1051217B1 (en) 2003-08-27
DK1051217T3 (en) 2003-12-08
EP1051217B8 (en) 2004-07-21
AR014231A1 (en) 2001-02-07
CA2316887C (en) 2008-04-08
AU1937099A (en) 1999-07-19
US6283953B1 (en) 2001-09-04
HK1032363A1 (en) 2001-07-20
ZA9811879B (en) 1999-09-02
PT1051217E (en) 2003-12-31
TW381974B (en) 2000-02-11
DE69834213T2 (en) 2007-01-25
ATE248002T1 (en) 2003-09-15
DE69817621T2 (en) 2004-03-25
EP1051217A1 (en) 2000-11-15
ES2205595T3 (en) 2004-05-01
DE69834213D1 (en) 2006-05-24
WO1999033513A1 (en) 1999-07-08
DE69817621D1 (en) 2003-10-02
ATE322928T1 (en) 2006-04-15

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Effective date: 20181221