CA2319433A1 - Targeted delivery of biologically active media - Google Patents

Targeted delivery of biologically active media Download PDF

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Publication number
CA2319433A1
CA2319433A1 CA002319433A CA2319433A CA2319433A1 CA 2319433 A1 CA2319433 A1 CA 2319433A1 CA 002319433 A CA002319433 A CA 002319433A CA 2319433 A CA2319433 A CA 2319433A CA 2319433 A1 CA2319433 A1 CA 2319433A1
Authority
CA
Canada
Prior art keywords
gas
filled
formulations
site
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002319433A
Other languages
French (fr)
Other versions
CA2319433C (en
Inventor
Michel Schneider
Feng Yan
Agnes Hiver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Research S.A.
Michel Schneider
Feng Yan
Agnes Hiver
Bracco Suisse S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research S.A., Michel Schneider, Feng Yan, Agnes Hiver, Bracco Suisse S.A. filed Critical Bracco Research S.A.
Publication of CA2319433A1 publication Critical patent/CA2319433A1/en
Application granted granted Critical
Publication of CA2319433C publication Critical patent/CA2319433C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Abstract

The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site.
Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active substances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.
CA002319433A 1998-02-09 1999-02-02 Targeted delivery of biologically active media Expired - Fee Related CA2319433C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98810095.4 1998-02-09
EP98810095 1998-02-09
PCT/IB1999/000182 WO1999039738A1 (en) 1998-02-09 1999-02-02 Targeted delivery of biologically active media

Publications (2)

Publication Number Publication Date
CA2319433A1 true CA2319433A1 (en) 1999-08-12
CA2319433C CA2319433C (en) 2008-04-22

Family

ID=8235927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002319433A Expired - Fee Related CA2319433C (en) 1998-02-09 1999-02-02 Targeted delivery of biologically active media

Country Status (11)

Country Link
US (1) US6258378B1 (en)
EP (1) EP1056473B8 (en)
JP (1) JP4772958B2 (en)
AT (1) ATE296113T1 (en)
AU (1) AU753196B2 (en)
CA (1) CA2319433C (en)
DE (1) DE69925461T2 (en)
ES (1) ES2244169T3 (en)
NZ (1) NZ506051A (en)
WO (1) WO1999039738A1 (en)
ZA (1) ZA99987B (en)

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Also Published As

Publication number Publication date
WO1999039738A1 (en) 1999-08-12
US6258378B1 (en) 2001-07-10
AU1980999A (en) 1999-08-23
EP1056473B8 (en) 2005-07-20
EP1056473B1 (en) 2005-05-25
ES2244169T3 (en) 2005-12-01
ZA99987B (en) 1999-08-06
JP4772958B2 (en) 2011-09-14
CA2319433C (en) 2008-04-22
DE69925461D1 (en) 2005-06-30
JP2002502829A (en) 2002-01-29
ATE296113T1 (en) 2005-06-15
NZ506051A (en) 2003-08-29
EP1056473A1 (en) 2000-12-06
DE69925461T2 (en) 2006-04-27
AU753196B2 (en) 2002-10-10

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