CA2321376A1 - Parallel high-performance liquid chromatography with serial injection - Google Patents

Parallel high-performance liquid chromatography with serial injection Download PDF

Info

Publication number
CA2321376A1
CA2321376A1 CA002321376A CA2321376A CA2321376A1 CA 2321376 A1 CA2321376 A1 CA 2321376A1 CA 002321376 A CA002321376 A CA 002321376A CA 2321376 A CA2321376 A CA 2321376A CA 2321376 A1 CA2321376 A1 CA 2321376A1
Authority
CA
Canada
Prior art keywords
liquid chromatography
performance liquid
samples
injection
parallel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002321376A
Other languages
French (fr)
Other versions
CA2321376C (en
Inventor
Miroslav Petro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symyx Technologies Inc
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Publication of CA2321376A1 publication Critical patent/CA2321376A1/en
Application granted granted Critical
Publication of CA2321376C publication Critical patent/CA2321376C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1885—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00759—Purification of compounds synthesised
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G01N2030/885—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8859—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample inorganic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44—Resins; rubber; leather
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44—Resins; rubber; leather
    • G01N33/442—Resins, plastics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of samples into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected.
Because injection of samples is relatively fast as compared to separation, substantial efficiencies are gained with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials
CA002321376A 1999-10-01 2000-09-28 Parallel high-performance liquid chromatography with serial injection Expired - Fee Related CA2321376C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/410,546 US6296771B1 (en) 1999-04-02 1999-10-01 Parallel high-performance liquid chromatography with serial injection
US09/410,546 1999-10-01

Publications (2)

Publication Number Publication Date
CA2321376A1 true CA2321376A1 (en) 2001-04-01
CA2321376C CA2321376C (en) 2004-11-09

Family

ID=23625202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321376A Expired - Fee Related CA2321376C (en) 1999-10-01 2000-09-28 Parallel high-performance liquid chromatography with serial injection

Country Status (3)

Country Link
US (2) US6296771B1 (en)
EP (1) EP1089074A1 (en)
CA (1) CA2321376C (en)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6866786B2 (en) * 1998-04-03 2005-03-15 Symyx Technologies, Inc. Rapid characterization of polymers
US6406632B1 (en) * 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
US6535284B1 (en) * 1998-10-19 2003-03-18 Symyx Technologies, Inc. Rheo-optical indexer and method of screening and characterizing arrays of materials
US6436292B1 (en) * 1999-04-02 2002-08-20 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with post-separation treatment
US6855258B2 (en) * 1999-04-02 2005-02-15 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
US6502448B1 (en) * 1999-09-07 2003-01-07 Edward Rapkin Chromatography detection system and method
US7216113B1 (en) * 2000-03-24 2007-05-08 Symyx Technologies, Inc. Remote Execution of Materials Library Designs
US6537613B1 (en) * 2000-04-10 2003-03-25 Air Products And Chemicals, Inc. Process for metal metalloid oxides and nitrides with compositional gradients
US6460420B1 (en) * 2000-04-13 2002-10-08 Sandia National Laboratories Flowmeter for pressure-driven chromatography systems
US6393898B1 (en) 2000-05-25 2002-05-28 Symyx Technologies, Inc. High throughput viscometer and method of using same
US6664067B1 (en) * 2000-05-26 2003-12-16 Symyx Technologies, Inc. Instrument for high throughput measurement of material physical properties and method of using same
US6868715B1 (en) * 2000-09-20 2005-03-22 General Electric Company Method and apparatus for rapid determination of polymer molecular weight
US6544795B1 (en) * 2000-09-20 2003-04-08 General Electric Company Method and apparatus for rapid determination of fries rearrangement products in aromatic polycarbonate resins
US6541264B1 (en) * 2000-10-19 2003-04-01 General Electric Company Aromatic polycarbonate characterization
US6456955B1 (en) * 2000-12-05 2002-09-24 Waters Investments Limited Automated test protocol
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US6755074B2 (en) * 2001-02-27 2004-06-29 Isco, Inc. Liquid chromatographic method and system
US6904784B2 (en) 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US6427526B1 (en) * 2001-02-27 2002-08-06 Isco, Inc. Liquid chromatographic method and system
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US6812030B2 (en) * 2001-04-25 2004-11-02 Biotrove, Inc. System and method for high throughput sample preparation and analysis using column chromatography
US7066011B2 (en) * 2001-06-07 2006-06-27 Nano Solution, Inc. Liquid chromatograph and analysis system
DE60221984T2 (en) 2001-06-13 2008-05-15 Kenneth F. Los Gatos Uffenheimer AUTOMATIC LIQUID TREATMENT SYSTEM AND METHOD
AU2002316372A1 (en) * 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
US6838052B2 (en) 2001-06-29 2005-01-04 Symyx Technologies, Inc. In-situ injection and materials screening device
US6923939B1 (en) * 2001-07-05 2005-08-02 Uop Llc Heat activated membrane introduction apparatus and method for screening materials
US6690179B2 (en) 2001-08-24 2004-02-10 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using capacitance
US6837115B2 (en) * 2001-08-24 2005-01-04 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6650102B2 (en) * 2001-08-24 2003-11-18 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using a piezoelectric
US6769292B2 (en) * 2001-08-24 2004-08-03 Symyx Technologies, Inc High throughput rheological testing of materials
US6772642B2 (en) 2001-08-24 2004-08-10 Damian A. Hajduk High throughput mechanical property and bulge testing of materials libraries
US6736017B2 (en) 2001-08-24 2004-05-18 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6730228B2 (en) * 2001-08-28 2004-05-04 Symyx Technologies, Inc. Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
JP3868267B2 (en) * 2001-10-31 2007-01-17 株式会社荏原製作所 Multi-column affinity detection system
AU2002352771A1 (en) * 2001-11-16 2003-06-10 Waters Investments Limited Parallel concentration, desalting and deposition onto maldi targets
JP3870367B2 (en) * 2001-11-19 2007-01-17 ▲たけ▼徳 谷村 Preparative chromatography apparatus and separation / purification method using the same
AU2002363961A1 (en) * 2001-12-05 2003-06-23 Kentucky Bioprocessing, Llc Flexible method and apparatus for high throughput production and purification of multiple proteins
US20030141253A1 (en) * 2001-12-07 2003-07-31 Bihan Thierry Le Apparatus for efficient liquid chromatography/mass spectrometry processing
US6881363B2 (en) * 2001-12-07 2005-04-19 Symyx Technologies, Inc. High throughput preparation and analysis of materials
WO2003054514A2 (en) * 2001-12-19 2003-07-03 Rett Corporation Novel parallel throughput system
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
AU2003213071A1 (en) * 2002-02-13 2003-09-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US6667376B2 (en) * 2002-03-22 2003-12-23 Symyx Technologies, Inc. Control agents for living-type free radical polymerization and methods of polymerizing
US6794514B2 (en) 2002-04-12 2004-09-21 Symyx Technologies, Inc. Ethylene-styrene copolymers and phenol-triazole type complexes, catalysts, and processes for polymerizing
US20030196896A1 (en) * 2002-04-17 2003-10-23 Mcwaid Thomas Harding Method and apparatus for screening flowable separation media for electrophoresis and related applications
US6841502B2 (en) * 2002-04-24 2005-01-11 Symyx Technologies, Inc. Bridged bi-aromatic ligands, catalysts, processes for polymerizing and polymers therefrom
US7060848B2 (en) * 2002-04-24 2006-06-13 Symyx Technologies, Inc. Bridged bi-aromatic catalysts, complexes, and methods of using the same
US7091292B2 (en) * 2002-04-24 2006-08-15 Symyx Technologies, Inc. Bridged bi-aromatic catalysts, complexes, and methods of using the same
US20030203500A1 (en) * 2002-04-26 2003-10-30 Symyx Technologies, Inc. High throughput testing of fluid samples using an electric field
US20050059779A1 (en) * 2002-10-21 2005-03-17 Symyx Technologies, Inc. Olefin-hydrophilic block copolymers of controlled sizes and methods of making and using the same
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
US7010964B2 (en) * 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US6976384B2 (en) * 2002-10-31 2005-12-20 Nanostream, Inc. Parallel detection chromatography systems
US6818134B2 (en) * 2002-11-04 2004-11-16 General Electric Company Systems and methods for screening and optimization of solid oxide fuel cell materials
US20040086633A1 (en) * 2002-11-04 2004-05-06 Lemmon John P. Systems and methods for the fabrication of solid oxide fuel cell components using liquid spraying
US6780315B2 (en) 2002-12-09 2004-08-24 Waters Investments Limited Backflow prevention for high pressure gradient systems
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US7160513B2 (en) * 2002-12-20 2007-01-09 Symyx Technologies, Inc. Batch reactor with injection system
GB0229696D0 (en) * 2002-12-20 2003-01-29 Amersham Biosciences Ab Separation medium
US20050042772A1 (en) * 2003-02-07 2005-02-24 Beyond Genomics Removal of proteins from a sample
US7024955B2 (en) * 2003-03-01 2006-04-11 Symyx Technologies, Inc. Methods and systems for dissolution testing
US7721590B2 (en) 2003-03-21 2010-05-25 MEAS France Resonator sensor assembly
US7178386B1 (en) 2003-04-10 2007-02-20 Nanostream, Inc. Parallel fluid processing systems and methods
US7074327B2 (en) * 2003-05-08 2006-07-11 Nanostream, Inc. Sample preparation for parallel chromatography
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US7579192B2 (en) * 2003-10-31 2009-08-25 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US20050095717A1 (en) * 2003-10-31 2005-05-05 Wollenberg Robert H. High throughput screening methods for lubricating oil compositions
US7462490B2 (en) 2003-10-31 2008-12-09 Chevron Oronite Company Llc Combinatorial lubricating oil composition libraries
US7150182B2 (en) * 2003-10-31 2006-12-19 Chevron Oronite Company, Llc High throughput screening methods for lubricating oil compositions
US7069203B2 (en) * 2003-10-31 2006-06-27 Chevron Oronite Company Llc Method and system of product development process for chemical compositions using high volume modeling
US20050095714A1 (en) 2003-10-31 2005-05-05 Wollenberg Robert H. High throughput preparation of lubricating oil compositions for combinatorial libraries
US8249816B2 (en) * 2004-02-13 2012-08-21 Chevron Oronite Company, Llc High throughput screening methods for fuel compositions
US7306948B2 (en) * 2004-02-13 2007-12-11 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US7137289B2 (en) 2004-02-13 2006-11-21 Chevron Oronite Company, Llc High throughput screening methods for lubricating oil compositions
US7985592B2 (en) * 2004-02-13 2011-07-26 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US6968729B1 (en) * 2004-02-27 2005-11-29 Uop Llc Method and apparatus for expediting analysis of samples
WO2005116614A1 (en) * 2004-05-24 2005-12-08 Nanostream, Inc. Capillary multi-channel optical flow cell
WO2006029017A1 (en) * 2004-09-03 2006-03-16 Symyx Technologies, Inc. System and method for rapid chromatography with fluid temperature and mobile phase composition control
US7256296B2 (en) * 2004-09-22 2007-08-14 Symyx Technologies, Inc. Heterocycle-amine ligands, compositions, complexes, and catalysts
EP1794196A2 (en) * 2004-09-22 2007-06-13 Symyx Technologies, Inc. Heterocycle-amine ligands, compositions, complexes, and catalysts, and methods of making and using the same
WO2006042365A1 (en) * 2004-10-18 2006-04-27 Varian Australia Pty Ltd Liquid chromatography apparatus
WO2006066126A2 (en) * 2004-12-16 2006-06-22 Symyx Technologies, Inc. Phenol-heterocyclic ligands, metal complexes, and their uses as catalysts
WO2006089103A1 (en) * 2005-02-18 2006-08-24 Kalypsys, Inc. Automated evaluation of target samples in a high performance analysis system
JP2006242720A (en) * 2005-03-02 2006-09-14 Shimadzu Corp Automatic sample introducing apparatus
JP4622602B2 (en) * 2005-03-17 2011-02-02 株式会社島津製作所 Glycan analyzer
US8802035B2 (en) * 2005-06-21 2014-08-12 Waters Technologies Corporation Apparatus and methods for performing steps of a multi-step process in parallel
US8920645B2 (en) * 2005-12-07 2014-12-30 Tarpon Biosystems Inc. Disposable chromatography valves and system
AU2006329980A1 (en) 2005-12-16 2007-07-05 Dow Global Technologies Inc. Polydentate heteroatom ligand containing metal complexes, catalysts and methods of making and using the same
US8281332B2 (en) * 2007-05-02 2012-10-02 Google Inc. Animated video overlays
JP2011503548A (en) * 2007-11-02 2011-01-27 バイオトローブ， インコーポレイテッド Apparatus and method for coupling a mass spectrometer to a chromatography system
US7823439B2 (en) * 2007-11-15 2010-11-02 Midwest Research Institute Method for identifying the composition of a sample
EP2112173A1 (en) 2008-04-16 2009-10-28 ExxonMobil Chemical Patents Inc. Catalyst compounds and use thereof
EP2103634A1 (en) 2008-03-20 2009-09-23 ExxonMobil Chemical Patents Inc. Production of propylene-based polymers
US20090286944A1 (en) * 2008-05-15 2009-11-19 Symyx Technologies, Inc. Select phenol-heterocycle ligands, metal complexes formed therefrom, and their uses as catalysts
US8322189B2 (en) * 2008-08-29 2012-12-04 Exxonmobil Research And Engineering Company Comprehensive two-dimensional gas chromatography method with one switching valve as the modulator
JPWO2010026742A1 (en) * 2008-09-02 2012-06-14 ジーエルサイエンス株式会社 Liquid chromatograph
WO2010068274A1 (en) * 2008-12-10 2010-06-17 Alltech Associates Inc. Automated sample injection apparatus, multiport valve, and methods of making and using the same
WO2010072546A1 (en) * 2008-12-04 2010-07-01 Vrije Universiteit Brussel A chromatographic separation device with variable length and a method for its use
US20110281763A1 (en) * 2008-12-23 2011-11-17 Microvast, Inc. Apparatus and methods for high-throughput analysis
EP2319874A1 (en) 2009-11-06 2011-05-11 DSM IP Assets B.V. Catalyst component for the polymerization of olefins having a guanidinate ligand
US8733152B2 (en) * 2010-01-19 2014-05-27 Bio-Rad Laboratories, Inc. Automated analyzer with low-pressure in-line filtration
US8058461B2 (en) 2010-03-01 2011-11-15 Exxonmobil Chemical Patents Inc. Mono-indenyl transition metal compounds and polymerization therewith
CA2793723A1 (en) * 2010-03-31 2011-10-06 Ge Healthcare Bio-Sciences Ab A parallel separation system
JP5843516B2 (en) * 2010-08-25 2016-01-13 アークレイ株式会社 Analysis apparatus and analysis method
CN103189119B (en) 2010-10-29 2015-05-27 赛默菲尼根有限责任公司 Method and system for liquid chromatograph with compressibility and viscosity monitoring to identify fluids
US11262334B2 (en) 2010-10-29 2022-03-01 Thermo Finnigan Llc Methods for liquid chromatography fluidic monitoring
US8607869B2 (en) * 2011-05-20 2013-12-17 Global Environmental Solutions, Inc. Linear pressure reducer for regulating injection pressure in an enhanced oil recovery system
US8658556B2 (en) 2011-06-08 2014-02-25 Exxonmobil Chemical Patents Inc. Catalyst systems comprising multiple non-coordinating anion activators and methods for polymerization therewith
EP2760895A4 (en) 2011-09-30 2015-07-22 Exxonmobil Chem Patents Inc Dynamic modulation of metallocene catalysts
US9074236B2 (en) 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry
US9694301B2 (en) * 2012-05-10 2017-07-04 Agilent Technologies, Inc. Two-dimensional fluid separation with controlled pressure
US9102773B2 (en) 2013-02-06 2015-08-11 Exxonmobil Chemical Patents Inc. Process for controlling molecular weight of polyolefins prepared using pyridyl diamide catalyst systems
CN105188871B (en) 2013-03-14 2018-01-12 生物辐射实验室股份有限公司 Bottle pressure-flow system
ES2644669T3 (en) 2013-03-15 2017-11-29 Univation Technologies, Llc Ligands for catalysts
US9644053B2 (en) 2013-03-15 2017-05-09 Univation Technologies, Llc Tridentate nitrogen based ligands for olefin polymerisation catalysts
CN105263969B (en) 2013-04-11 2017-04-05 埃克森美孚化学专利公司 Using metallocene polymerization catalyst preparation polyolefin and the method for copolymer
CN105377904B (en) 2013-07-17 2018-07-10 埃克森美孚化学专利公司 Metallocene and by its derivative carbon monoxide-olefin polymeric
WO2015009473A1 (en) 2013-07-17 2015-01-22 Exxonmobil Chemical Patents Inc. Cyclopropyl substituted metallocene catalysts
JP2016530360A (en) 2013-07-17 2016-09-29 エクソンモービル ケミカル パテンツ インコーポレイテッド Process using substituted metallocene catalysts and products derived therefrom
WO2015011522A1 (en) 2013-07-23 2015-01-29 Tubitak Ume Multi-task sample preparation system with reconfigurable modules for on-line dilution, enzymatic digestion and fractionation
US20170010243A1 (en) * 2014-02-11 2017-01-12 Büchi Labortechnik AG Multiple column chromatographic system and methods of use
US9315526B2 (en) 2014-03-03 2016-04-19 Exxonmobil Chemical Patents Inc. Pyridyldiamido transition metal complexes, production and use thereof
US20150298025A1 (en) * 2014-04-17 2015-10-22 Munson Technology LLC Focused sample delivery and eluent selection for chromatography
US9796795B2 (en) 2015-01-14 2017-10-24 Exxonmobil Chemical Patents Inc. Tetrahydroindacenyl catalyst composition, catalyst system, and processes for use thereof
WO2016171808A1 (en) 2015-04-20 2016-10-27 Exxonmobil Chemical Patents Inc. Catalyst composition comprising fluorided support and processes for use thereof
EP3274353B1 (en) 2015-03-24 2021-03-31 ExxonMobil Chemical Patents Inc. Bisphenolate transition metal complexes, production and use thereof
JP6875997B2 (en) * 2015-03-31 2021-05-26 ウオーターズ・テクノロジーズ・コーポレイシヨン Multi-injection mode valve module
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US9632066B2 (en) * 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
EP3274380B1 (en) 2015-04-20 2020-08-19 ExxonMobil Chemical Patents Inc. Catalyst composition comprising fluorided support and processes for use thereof
US9879104B2 (en) 2015-04-28 2018-01-30 Exxonmobil Chemical Patents Inc. Process to produce ethylene conjugated diene copolymers and copolymers therefrom
US9598444B2 (en) 2015-06-30 2017-03-21 Exxonmobil Chemical Patents Inc. Transition metal complexes of tridentate dianionic CNN ligands, production and use thereof
US10618988B2 (en) 2015-08-31 2020-04-14 Exxonmobil Chemical Patents Inc. Branched propylene polymers produced via use of vinyl transfer agents and processes for production thereof
CN107922528B (en) 2015-08-31 2020-11-03 埃克森美孚化学专利公司 Polymers produced by using vinyl transfer agents
EP3344385A4 (en) 2015-08-31 2019-08-14 ExxonMobil Chemical Patents Inc. Aluminum alkyls with pendant olefins on clays
EP3356038A4 (en) 2015-10-02 2018-11-14 ExxonMobil Chemical Patents Inc. Asymmetric fluorenyl-substituted salan catalysts
US9988471B2 (en) 2015-12-16 2018-06-05 Exxonmobil Chemical Patents Inc Catalysts for producing polymers with enhanced properties
CN108291896B (en) * 2015-12-18 2020-11-20 豪夫迈·罗氏有限公司 Automated clinical diagnostic system and method
EP3452521B1 (en) 2016-05-03 2023-07-12 ExxonMobil Chemical Patents Inc. Tetrahydroindacenyl catalyst composition, catalyst system, and processes for use thereof
US9803037B1 (en) 2016-05-03 2017-10-31 Exxonmobil Chemical Patents Inc. Tetrahydro-as-indacenyl catalyst composition, catalyst system, and processes for use thereof
US10208140B2 (en) 2016-06-30 2019-02-19 Exxonmobil Chemical Patents Inc. Quinolinyldiamido transition metal complexes, production and use thereof
WO2018022249A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Heterocyclic amido transition metal complexes, production and use thereof
US10150821B2 (en) 2016-07-29 2018-12-11 Exxonmobil Chemical Patents Inc. Heterocyclic amido transition metal complexes, production and use thereof
WO2018067686A2 (en) * 2016-10-04 2018-04-12 The Regents Of The University Of Michigan Multi-channel multi-dimensional comprehensive gas chromatography
US20190360978A1 (en) * 2016-11-15 2019-11-28 Shiseido Company, Ltd. Multidimensional chromatographic analysis method and analysis system
US10626200B2 (en) 2017-02-28 2020-04-21 Exxonmobil Chemical Patents Inc. Branched EPDM polymers produced via use of vinyl transfer agents and processes for production thereof
JP6790963B2 (en) * 2017-03-30 2020-11-25 株式会社島津製作所 Liquid chromatograph
JP6990902B2 (en) * 2017-03-31 2022-01-12 株式会社日立ハイテクサイエンス Liquid chromatograph device
US10703838B2 (en) 2017-10-31 2020-07-07 Exxonmobil Chemical Patents Inc. Mixed catalyst systems with four metallocenes on a single support
WO2019156968A1 (en) 2018-02-07 2019-08-15 Exxonmobil Chemical Patents Inc. Supported catalysts systems and polymerization processes for using the same
WO2019160710A1 (en) 2018-02-19 2019-08-22 Exxonmobil Chemical Patents Inc. Catalysts, catalyst systems, and methods for using the same
WO2019182982A1 (en) 2018-03-19 2019-09-26 Exxonmobil Chemical Patents Inc. Multiple non-coordinating anion activators for propylene-ethylene-diene monomer polymerization reactions
US11053329B2 (en) 2018-03-19 2021-07-06 Exxonmobil Chemical Patents Inc. Multiple non-coordinating anion activators for propylene-ethylene-diene monomer polymerization reactions
CN112236218B (en) 2018-04-02 2022-04-26 滴管公司 System and method for continuous flow emulsion processing
CN112135863A (en) 2018-04-06 2020-12-25 埃克森美孚化学专利公司 Thermoplastic vulcanizate composition
US11414436B2 (en) 2018-04-26 2022-08-16 Exxonmobil Chemical Patents Inc. Non-coordinating anion type activators containing cation having large alkyl groups
JP7216184B2 (en) 2018-07-23 2023-01-31 エクソンモービル・ケミカル・パテンツ・インク Preparation of bimodal rubber, thermoplastic vulcanizates and articles made therefrom
EP3870970A1 (en) * 2018-10-26 2021-09-01 Agilent Technologies, Inc. Injector serving multiple sample separation apparatuses
US11180580B2 (en) 2019-03-29 2021-11-23 Exxonmobil Chemical Patents Inc. Benzazole and pseudoindole diamido transition metal complexes and use thereof in olefin polymerization
US11091567B2 (en) 2019-04-15 2021-08-17 Exxonmobil Chemical Patents Inc. Amido-benzoquinone catalyst systems and processes thereof
CN114867758A (en) 2019-08-02 2022-08-05 埃克森美孚化学专利公司 Metallocenes and methods thereof
US11649256B2 (en) 2019-10-11 2023-05-16 Exxonmobil Chemical Patents Inc. Catalysts for olefin polymerization
WO2021126692A1 (en) 2019-12-16 2021-06-24 Exxonmobil Chemical Patents Inc. Iron bis(imino) aryl catalysts and methods thereof
WO2021133646A1 (en) 2019-12-23 2021-07-01 Waters Technologies Corporation Sample metering and injection for liquid chromatography
CN115427464A (en) 2020-02-24 2022-12-02 埃克森美孚化学专利公司 Lewis base catalyst and process therefor
CN115485311A (en) 2020-02-24 2022-12-16 埃克森美孚化学专利公司 Ansa-bis (inden-2-yl) catalysts for the production of vinylidene-terminated polyalphaolefins
US11760814B2 (en) 2020-03-03 2023-09-19 Exxonmobil Chemical Patents Inc. 1,5 diazabicyclooctane ligand systems and methods therewith
US11739169B2 (en) 2020-04-24 2023-08-29 Exxonmobil Chemical Patents Inc. Solubility improvement of non-metallocene transition metal complexes in aliphatic hydrocarbon solvents
WO2021222018A1 (en) 2020-05-01 2021-11-04 Exxonmobil Chemical Patents Inc. Transition metal-complex catalysts having appended group 13 lewis acids and related polymerization methods
WO2021262842A1 (en) 2020-06-26 2021-12-30 Exxonmobil Chemical Patents Inc. COPOLYMERS OF ETHYLENE, α-OLEFIN, NON-CONJUGATED DIENE, AND ARYL-SUBSTITUTED CYCLOALKENE, METHODS TO PRODUCE, BLENDS, AND ARTICLES THEREFROM
US11766669B2 (en) 2020-06-26 2023-09-26 Exxonmobil Chemical Patents Inc. Hexahydrocyclopenta[e]-as-indacen-1-yl and octahydrobenzo[e]-as-indacen-1-yl based catalyst complexes and process for use thereof
CN116490528A (en) 2020-08-13 2023-07-25 埃克森美孚化学专利公司 Polymer compositions containing cyclics obtained using transition metal bis (phenoxide) catalyst complexes and process for their preparation
WO2022072180A1 (en) 2020-09-30 2022-04-07 Exxonmobil Chemical Patents Inc. Bis(heterocyclic-olate) lewis base catalysts and methods thereof
US11814460B2 (en) 2020-10-22 2023-11-14 Exxonmobil Chemical Patents Inc. Pyridyl hydroxyl amine catalyst compounds and systems for Olefin Polymerization
US20230312772A1 (en) 2020-10-22 2023-10-05 Exxonmobil Chemical Patents Inc. Multidentate Lewis Base Catalysts and Methods for use Thereof
US11919981B2 (en) 2020-10-22 2024-03-05 Exxonmobil Chemical Patents Inc. Monocyclopentadienyl pyridyl hydroxyl amine catalyst compounds and systems for olefin polymerization
WO2022093814A1 (en) 2020-10-28 2022-05-05 Exxonmobil Chemical Patents Inc. Non-aromatic hydrocarbon soluble olefin polymerization catalysts and use thereof
US11746163B2 (en) 2021-01-05 2023-09-05 Exxonmobil Chemical Patents Inc. Isohexane-soluble unsaturated alkyl anilinium tetrakis(perfluoroaryl)borate activators
US20240124618A1 (en) 2021-01-12 2024-04-18 Exxonmobil Chemical Patents Inc. Asymmetric Constrained Geometry Catalysts
CN113189212B (en) * 2021-03-24 2022-09-27 上海星猫仪器设备有限公司 Chromatograph all-in-one machine
US11802170B2 (en) 2021-04-29 2023-10-31 Exxonmobil Chemical Patents Inc. Polyolefins prepared with binuclear metallocene catalysts
WO2023034889A1 (en) 2021-09-02 2023-03-09 Exxonmobil Chemical Patents Inc. C1 symmetric metallocene catalysts tailored for production of vinyl-terminated polypropylene oligomers and macromonomers
WO2023150480A1 (en) 2022-02-07 2023-08-10 Exxonmobil Chemical Patents Inc. C1 symmetric 5-ome-6-alkyl substituted metallocenes
CN114380478B (en) * 2022-03-24 2022-05-20 昌邑市畜牧业发展中心 Automatic dehydration treatment equipment for livestock manure
WO2023215695A1 (en) 2022-05-04 2023-11-09 Exxonmobil Chemical Patents Inc. Substituted pyridine-2,6-bis (phenylenephenolate) complexes with enhanced solubility that are useful as catalyst components for olefin polymerization
WO2023215696A1 (en) 2022-05-04 2023-11-09 Exxonmobil Chemical Patents Inc. Modified pyridine-2,6-bis(phenylenephenolate) complexes with enhanced solubility that are useful as catalyst components for olefin polymerization
WO2023215694A1 (en) 2022-05-04 2023-11-09 Exxonmobil Chemical Patents Inc. Substituted pyridine-2,6-bis(phenylenephenolate) complexes with enhanced solubility that are useful as catalyst components for olefin polymerization
WO2023215693A1 (en) 2022-05-04 2023-11-09 Exxonmobil Chemical Patents Inc. Substituted pyridine-2,6-bis(phenylenephenolate) complexes with enhanced solubility that are useful as catalyst components for olefin polymerization
WO2023250268A1 (en) 2022-06-24 2023-12-28 Exxonmobil Chemical Patents Inc. Constrained geometry metal-ligand complexes and use thereof in olefin polymerization
WO2024036052A1 (en) 2022-08-09 2024-02-15 Exxonmobil Chemical Patents Inc. Methods for preparing diphenylsilane bridged c1 symmetric catalysts and polymers made therefrom

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458437A (en) 1966-05-27 1969-07-29 Dart Ind Inc Method and apparatus for chromatographic analysis
FR2308932A1 (en) 1975-04-24 1976-11-19 Aquitaine Petrole DEVICE FOR INTRODUCING SAMPLES INTO A CHROMATOGRAPH
GB1542518A (en) 1976-07-06 1979-03-21 Euratom Vacuum shut-off valves
DE2731652A1 (en) * 1977-07-13 1979-01-25 Siemens Ag Multiple sample liq. chromatography system - has three separating columns switched in succession and has injection device
US4444066A (en) 1981-06-29 1984-04-24 Beckman Instruments, Inc. High pressure sample injector valve
US4711764A (en) 1982-10-08 1987-12-08 Analytichem International, Inc. Automatic sample injector and disposable sample cassette
US4631687A (en) 1983-11-03 1986-12-23 Rohrback Technology Corporation Method and apparatus for analysis employing multiple separation processes
JPS60115854A (en) 1983-11-28 1985-06-22 Shimadzu Corp Liquid chromatograph for multi-term analysis
US5106756A (en) 1984-03-02 1992-04-21 The United States Of America As Represented By The United States Department Of Energy Method and system for gathering a library of response patterns for sensor arrays
DE3687484D1 (en) 1985-06-28 1993-02-25 Shell Int Research CHROMATOGRAPHIC ANALYSIS.
US4980130A (en) 1986-12-16 1990-12-25 Ciba-Geigy Corporation System for preparation of samples for analysis
US4926702A (en) 1987-09-18 1990-05-22 Beckman Instruments, Inc. Sample presence detector for automatic sample injector
US4816226A (en) 1987-12-30 1989-03-28 Shell Oil Company Apparatus for continuous flow injection solvent extraction analysis
US5240604A (en) 1988-09-13 1993-08-31 The Dow Chemical Company Multidimensional chromatographic system
JP2834224B2 (en) 1989-10-18 1998-12-09 株式会社日立製作所 Sample analyzer by liquid chromatography
US5277871A (en) 1989-10-20 1994-01-11 Hitachi, Ltd. Liquid chromatographic analyzer, sample feeder and prelabeling reaction treating method
US5108928A (en) 1989-11-13 1992-04-28 General Dynamics Corporation Method and apparatus for delivering a sample to multiple analytical instruments
US4999439A (en) 1990-03-22 1991-03-12 International Flavors & Fragrances Inc. Alkyl-substituted tetra- or hexahydrobenzopyran derivatives, organoleptic uses thereof and process for preparing same
US5071547A (en) 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
ATE154981T1 (en) 1990-04-06 1997-07-15 Perkin Elmer Corp AUTOMATED MOLECULAR BIOLOGY LABORATORY
US5205845A (en) 1990-09-28 1993-04-27 The Regents Of The University Of Michigan Mechanical gas chromatography injection valves and column multiplexing techniques
CA2132270A1 (en) 1993-10-28 1995-04-29 Erich Lerch Automatic pipetting apparatus having a cleaning device
JPH07210842A (en) 1994-01-24 1995-08-11 Sony Corp Centering method for rotary drum and centering device for rotary drum
DE19509275A1 (en) 1994-06-16 1995-12-21 Hewlett Packard Co High speed rotary injection valve
WO1996001994A1 (en) 1994-07-11 1996-01-25 Tekmar Company Modular vial autosampler
US5492831A (en) 1994-11-15 1996-02-20 Lachat Instruments Shared peripheral analytical system
AU5438796A (en) 1995-04-06 1996-10-23 Arqule, Inc. Method for rapid purification, analysis and characterization of collections of chemical compounds
US5603899A (en) 1995-04-12 1997-02-18 Pharmacia Biotech, Inc. Multiple column chromatography assembly
WO1997005249A2 (en) 1995-07-31 1997-02-13 The Government Of The United States Of America, Represented By The Secretary, Department Of Healt H And Human Services Extension of a protein-protein interaction surface to inactivate the function of a cellular protein
US5711786A (en) 1995-10-23 1998-01-27 The Perkin-Elmer Corporation Gas chromatographic system with controlled sample transfer
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
AU2275097A (en) 1996-02-20 1997-09-02 Waters Investments Limited Capillary chromatography detector apparatus
US5670054A (en) * 1996-04-04 1997-09-23 Warner Lambert Company Method and system for identification, purification, and quantitation of reaction components
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
DE19641210A1 (en) 1996-09-25 1998-04-02 Analyticon Ag Biotechnologie P Separation of complex mixtures, e.g. of natural products
WO1998013118A1 (en) 1996-09-25 1998-04-02 Analyticon Ag Biotechnologie Pharmazie Hplc-based device and method for separating high complex substance mixtures
US5814742A (en) 1996-10-11 1998-09-29 L C Packings, Nederland B.V. Fully automated micro-autosampler for micro, capillary and nano high performance liquid chromatography
DE19704477A1 (en) 1997-02-06 1998-08-13 Solvay Pharm Gmbh Device and method for parallel chromatography
US5938932A (en) 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
US6054047A (en) 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6077438A (en) * 1998-12-22 2000-06-20 Combichem, Inc. Automated on-line evaporation light scattering detection to quantify isolated fluid sample compounds in microtiter plate format

Also Published As

Publication number Publication date
US20020020670A1 (en) 2002-02-21
CA2321376C (en) 2004-11-09
US6296771B1 (en) 2001-10-02
EP1089074A1 (en) 2001-04-04
US6491816B2 (en) 2002-12-10

Similar Documents

Publication Publication Date Title
CA2321376A1 (en) Parallel high-performance liquid chromatography with serial injection
NZ501836A (en) Retentate chromatography and protein chip arrays with applications in biology and medicine
AU4450900A (en) High-throughput parallel liquid chromatography system
Zeng et al. Automated analytical/preparative high-performance liquid chromatography–mass spectrometry system for the rapid characterization and purification of compound libraries
Kimura et al. Simple 2D‐HPLC using a monolithic silica column for peptide separation
AU5905300A (en) Microfabricated injector and capillary array assembly for high-resolution and high throughput separations
EP2053406A3 (en) Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
WO1999030154A3 (en) Continuous format high throughput screening
EP1287882A3 (en) Method for screening a catalyst library
ID27796A (en) NEW INULIN FRACTIONS, PROCESSES FOR PREPARING THE INULIN FRACTION, AND FOOD RESULTS CONTAINING THE INULIN FACTIONS
AU6167598A (en) Chromatographic purification of chlorinated sucrose
CA2413156A1 (en) Expression vectors
WO1999045374A3 (en) Purification and detection processes using reversible affinity electrophoresis
CA2472038A1 (en) An apparatus for separating material
EP2322154A3 (en) Methods for detecting and clearing cross beta structure comprising proteins with crossbeta structure binding compounds.
HUP9801797A3 (en) Immunostimulant and metastasis-inhibiting fermented dried material, pharmaceutical compositions containing same, process for its production and its uses
Ren et al. Contributions of commercial sorbents to the selectivity in immobilized metal affinity chromatography with Cu (II)
DE4493391D2 (en) Mixers, especially high-performance mixers for refining pre-shredded substances
Dong A Universal Reversed‑Phase HPLC Method for Pharmaceutical Analysis
US6245238B1 (en) Purification of peptides and oligonucleotides by sample displacement chromatography process and apparatus
WO2005048126A3 (en) High throughput autosampler
FR2603056A1 (en) Arrangement for partitioning spaces, particularly for setting up divisions by means of panels or the like
ATE376183T1 (en) PROTEOME DEGRADATION
EP1310791A3 (en) Rapid characterization of polymers with a high-aspect ratio column
Matysik et al. Stepwise gradient development in thin-layer chromatography: II. Two-dimensional gradients for complex mixtures

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed