CA2322954A1 - Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles - Google Patents

Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles Download PDF

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Publication number
CA2322954A1
CA2322954A1 CA002322954A CA2322954A CA2322954A1 CA 2322954 A1 CA2322954 A1 CA 2322954A1 CA 002322954 A CA002322954 A CA 002322954A CA 2322954 A CA2322954 A CA 2322954A CA 2322954 A1 CA2322954 A1 CA 2322954A1
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Prior art keywords
microparticles
microspheres
cell adhesion
hydrophilic
adhesion promoter
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Granted
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CA002322954A
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French (fr)
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CA2322954C (en
Inventor
Jean Marie Vogel
Richard Thomas
Egisto Boschetti
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Biosphere Medical Inc
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Individual
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Publication of CA2322954C publication Critical patent/CA2322954C/en
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Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/048—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.

Claims (42)

1. A method for treating gastroesophageal reflux disease which comprises administering to a mammal in need of such treatment a therapeutically effective tissue bulking amount of biocompatible cationic hydrophilic microparticles comprising a positive charge on their surface and a cell adhesion promoter, said administration into the lower esophageal sphincter or the diaphragm.
2. The method of claim 1 wherein said mammal is a human.
3. The method of claim 1 wherein the microparticles are pre-treated with, administered with or coated with autologous cells.
4. The method of claim 1 or 3 wherein the microspheres or cell coated microspheres are washed with serum or whole blood prior to administration.
5. The method of claim 3 wherein the autologous cells are mucosal cells, muscle cells, fat cells, or combinations thereof.
6. The method of claim 1 wherein the microparticles are coated with or linked to at least one collagen or a derivative thereof, glucosaminoglycans, or a mixture thereof.
7. The method of claim 1 wherein the microparticles are administered in a sterile and pyrogen-free injectable solution.
8. The method of claim 1 wherein said microparticles are hydrophilic microspheres comprising a cationic charge and a cell adhesion promoter.
9. The method of claim 8 wherein said microparticles are microspheres comprising a hydrophilic copolymer which comprises in copolymerized form about 25 to about 99% by weight of neutral hydrophilic acrylic monomer, about 2 to about 50% by weight of one or more monomers having a cationic charge, and about 1 to about 30% by weight of a functionalized monomer; and a cell adhesion promoter.
10. The method of claim 9 wherein said microspheres have a diameter ranging between about l0 to about 1000 µm.
11. A method for treating urinary incontinence which comprises administering to a mammal in need of such treatment a therapeutically effective amount of biocompatible cationic hydrophilic microparticles comprising a positive charge on their surface and a cell adhesion promoter, said administration into the bladder sphincter.
12. The method of claim 1 wherein said mammal is a human.
13. The method of claim 11 wherein the microparticles are pre-treated with, administered with or coated with autologous cells.
14. The method of claim 11 or 13 wherein the microparticles or cell coated microspheres are washed with serum or whole blood prior to administration.
15. The method of claim 13 wherein the autologous cells are bladder cells, muscle cells, fat cells or combinations thereof.
16. The method of claim 11 wherein the microparticles are coated with or covalently linked to at least one of collagen or a derivative thereof, glucosaminoglycan, or a mixture thereof.
17. The method of claim 11 wherein the microparticles are administered in a sterile and pyrogen-free injectable solution.
18. The method of claim 11 wherein said administration is made via syringe.
19. The method of claim 11 wherein said microparticles are hydrophilic microspheres comprising a cationic charge and a cell adhesion promoter.
20. The method of claim 19 wherein said microparticles are microspheres comprising a hydrophilic copolymer which comprises in copolymerized form about 25 to about 99% by weight of neutral hydrophilic acrylic monomer, about 2 to about 50% by weight of one or more monomers having a cationic charge, and about 1 to about 30% by weight of a functionalized monomer; and a cell adhesion promoter.
21. The method of claim 11 wherein said microparticles are loaded with or administered with one or more anti-inflammatory agents.
22. The method of claim 20 wherein said microspheres have a diameter ranging between about 10 to about 1000 µm.
23. A method for ameliorating skin wrinkles which comprises administering, to a mammal in need of thereof, biocompatible cationic hydrophilic microparticles comprising a positive charge on their surface and a cell adhesion promoter, said administration at or surrounding the site of said skin wrinkles.
24. The method of claim 23 wherein said mammal is a human.
25. The method of claim 23 wherein said site of said skin wrinkle is found on the face, neck, torso, arms, hands, stomach, hips, legs or feet of a human.
26. The method of claim 25 wherein said site of said skin wrinkles is in the area of the eye, lips, cheeks, ears or nose of a human.
27. The methods of claims 23 wherein said microparticles are pre-treated with or administered with or coated with autologous cells.
28. The method of claim 27 wherein said autologous cells are pre-adipocytes.
29. The method of claims 23 or 27 wherein the microparticles or cell coated microspheres are washed with serum or whole blood prior to administration.
30. The method of claim 23 wherein said microparticles are coated with or linked to at least one of collagen or a derivative thereof, glucosaminoglycan, or a mixture thereof.
31. The method of claim 23 wherein the microparticles are administered in a sterile and pyrogen-free injectable solution.
32. The method of claim 23 wherein said microparticles are hydrophilic microspheres comprising a cationic charge and a cell adhesion promoter.
33. The method of claim 32 wherein said microparticles are microspheres comprising a hydrophilic copolymer which comprises in copolymerized form about 25 to about 98% by weighted neutral hydrophilic acrylic monomer, about 2 to about 50% by weight by one or more monomers having a cationic charge, and about 1 to about 30% by weight of a functionalized monomer; and a cell adhesion promoter.
34. The method of claim 23 wherein said microparticles are loaded with or administered with one or more anti-inflammatory agents.
35. The method of claims 33 wherein said microspheres have a diameter ranging between about 10 to about 1000 µm.
36. The method of claim 23 wherein said administration is repeated multiple times over a period of days.
37. The method of claims 1, 11 or 23 wherein said cell adhesion promoters selected from the group consisting of fibronectin, laminin, chondronectin, entacin, epibolin, liver cell adhesion molecule, serum spreading factor, collagen, heparin sulfates, dermatan sulfates, chonodroctin sulfates, glucosaminoglycans, and mixtures thereof.
38. A sterile injectable solution suitable for tissue bulking which comprises:
(a) hydrophilic, cationic microspheres, having a diameter of l0 to 1000 µm, said microspheres comprising a neutral hydrophilic monomer, one or more cationic monomers, one or more functionalized monomers and a cell adhesion promoter; and (b) autologous cells.
39. A method for tissue bulking comprising:
(a) preparing cationic microparticles which comprise hydrophilic polymers and a cell adhesion promoter;
(b) administering the resulting microparticles to a mammal at a site where said tissue bulking is desired.
40. A method for ameliorating skin wrinkles comprising:
(a) preparing cationic microparticles which comprise hydrophilic polymers and a cell adhesion promoter;
(b) administering the resulting microparticles to a mammal at the site of said skin wrinkles.
41. A method for treating gastroesophageal reflux disease comprising:
(-a.) preparing cationic microparticles which comprise hydrophilic polymers and a cell adhesion promoter;
(b) administering the resulting microparticles to a mammal by injection into walls of a sphincter located where the esophagus meets the stomach.
42. A method for treating urinary incontinence disease comprising:
(a) preparing cationic microparticles which comprises hydrophilic polymers and a cell adhesion promoter;
(b) administering the resulting microparticle to a mammal through the urethra and injecting the microparticles into walls of the bladder sphincter.
CA2322954A 1998-03-06 1999-03-04 Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles Expired - Fee Related CA2322954C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7716698P 1998-03-06 1998-03-06
US60/077,166 1998-03-06
PCT/US1999/004689 WO1999044643A1 (en) 1998-03-06 1999-03-04 Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles

Publications (2)

Publication Number Publication Date
CA2322954A1 true CA2322954A1 (en) 1999-09-10
CA2322954C CA2322954C (en) 2011-06-07

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CA2322954A Expired - Fee Related CA2322954C (en) 1998-03-06 1999-03-04 Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles

Country Status (10)

Country Link
US (2) US6335028B1 (en)
EP (1) EP1059943B1 (en)
JP (2) JP5095049B2 (en)
CN (2) CN100457188C (en)
AT (1) ATE283709T1 (en)
AU (1) AU742786B2 (en)
CA (1) CA2322954C (en)
DE (1) DE69922352T2 (en)
HK (1) HK1035318A1 (en)
WO (1) WO1999044643A1 (en)

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