CA2323211A1 - Topical anesthetic formulation - Google Patents

Topical anesthetic formulation Download PDF

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Publication number
CA2323211A1
CA2323211A1 CA002323211A CA2323211A CA2323211A1 CA 2323211 A1 CA2323211 A1 CA 2323211A1 CA 002323211 A CA002323211 A CA 002323211A CA 2323211 A CA2323211 A CA 2323211A CA 2323211 A1 CA2323211 A1 CA 2323211A1
Authority
CA
Canada
Prior art keywords
formulation
transdermal
prilocaine
anesthetic formulation
topical anesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002323211A
Other languages
French (fr)
Other versions
CA2323211C (en
Inventor
James Castillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2323211A1 publication Critical patent/CA2323211A1/en
Application granted granted Critical
Publication of CA2323211C publication Critical patent/CA2323211C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A topical, transdermal anesthetic formulation comprising a eutectic mixture of, preferably, lidocaine and prilocaine in a ratio of about 3:1 by weight, incorporated within a lipophilic base. In addition to the property of rapid-onset, the formulation of the present invention has high storage stability and is less restricted by dosage limitations of other prilocaine-containing transdermal anesthetics and is, advantageously, not dependent upon occlusive dressing for optimal transdermal absorption.
CA002323211A 1998-04-28 1999-04-27 Topical anesthetic formulation Expired - Lifetime CA2323211C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/067,948 US5993836A (en) 1998-04-28 1998-04-28 Topical anesthetic formulation
US09/067,948 1998-04-28
PCT/US1999/009069 WO1999055287A1 (en) 1998-04-28 1999-04-27 Topical anesthetic formulation

Publications (2)

Publication Number Publication Date
CA2323211A1 true CA2323211A1 (en) 1999-11-04
CA2323211C CA2323211C (en) 2003-12-23

Family

ID=22079486

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002323211A Expired - Lifetime CA2323211C (en) 1998-04-28 1999-04-27 Topical anesthetic formulation

Country Status (8)

Country Link
US (1) US5993836A (en)
EP (1) EP1073401A4 (en)
AU (1) AU743516B2 (en)
BR (1) BR9909948A (en)
CA (1) CA2323211C (en)
IL (1) IL138509A0 (en)
TR (1) TR200003180T2 (en)
WO (1) WO1999055287A1 (en)

Families Citing this family (50)

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US6329398B1 (en) * 1999-09-07 2001-12-11 Stephen M. Zappala Preemptive analgesic agent and methods of use
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6673363B2 (en) * 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
ATE438418T1 (en) 2001-05-01 2009-08-15 Av Topchiev Inst Petrochemical HYDROGEL COMPOSITIONS
US6803420B2 (en) 2001-05-01 2004-10-12 Corium International Two-phase, water-absorbent bioadhesive composition
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20030027833A1 (en) * 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent
US20030049283A1 (en) * 2001-08-31 2003-03-13 Vandell Victor E. Scalp desensitizing formulation
US6894078B2 (en) * 2001-09-17 2005-05-17 James G. Castillo Alcohol based topical anesthetic formulation and method
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
CN1300095C (en) * 2002-10-28 2007-02-14 吉万奥丹股份有限公司 Coolant solutions and compositions comprising the sameitle
BR0301968A (en) * 2003-05-22 2005-06-28 Cristalia Prod Quimicos Farm Ternary and quaternary eutectic mixtures composed of local anesthetic substances, their use in the preparation of pharmaceutical compositions and their use in anesthesia and topical analgesia
ES2223277B1 (en) * 2003-06-19 2006-03-01 Fernando Bouffard Fita ANESTHETIC COMPOSITION FOR TOPICAL ADMINISTRATION.
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
US7482378B2 (en) * 2004-05-28 2009-01-27 Millenium Specialty Chemicals, Inc. Physiological cooling compositions
EP1763370B1 (en) * 2004-06-02 2015-04-29 NeurogesX Inc. Formulations comprising capsaicin, a local anesthetic and/or an antipruritic agent for the treatment of pain
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
CN103497713B (en) 2004-08-05 2018-07-17 考里安国际公司 Adhesive composition
WO2006065870A2 (en) * 2004-12-13 2006-06-22 Prodermrx, Inc. Topical numbing composition for laser therapy
NZ552862A (en) 2005-03-15 2009-03-31 Animal Ethics Pty Ltd A topical analgesic composition
US20060222687A1 (en) * 2005-04-01 2006-10-05 Carter Stephen G Topical anesthetic
US8263047B2 (en) * 2005-09-29 2012-09-11 Wickenhauser Alan J Topical anesthetic for dental procedures
US8623334B1 (en) 2005-09-29 2014-01-07 Alan J. Wickenhauser Topical anesthetic
US20080146672A1 (en) * 2006-12-08 2008-06-19 Denton Marcia Marye Topical Eutectic Anesthetic Composition for Oral or Dermal Tissue
BRPI0700832B8 (en) * 2007-03-16 2021-05-25 Biolab Sanus Farmaceutica Ltda topical anesthetic composition comprising suspension of polymeric nanocapsules of lidocaine and prilocaine
US7883487B2 (en) * 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
US20110238021A1 (en) * 2008-09-26 2011-09-29 Suzana Hillhouse Transdermal delivery device and method
US9012477B2 (en) * 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
EP2413837A4 (en) * 2009-04-01 2013-10-23 Jie Zhang Methods for treating myofascial, muscle, and/or back pain
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
CN102427792A (en) * 2009-05-04 2012-04-25 扎斯制药公司 Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
US9693976B2 (en) 2010-01-14 2017-07-04 Crescita Therapeutics Inc. Solid-forming local anesthetic formulations for pain control
US8535692B2 (en) 2010-04-21 2013-09-17 Teikoku Pharma Usa, Inc. Local anesthetic emulsion compositions and methods of making and using the same
US20120070507A1 (en) * 2010-09-17 2012-03-22 Matrilinex Llc Compositions and Methods for the Treatment of Soft Tissue Injury
FR2977493B1 (en) * 2011-07-05 2014-02-14 Galderma Res & Dev NOVEL STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS
GB201113662D0 (en) 2011-08-08 2011-09-21 Prosonix Ltd Pharmaceutical compositions
US10813897B2 (en) 2011-12-27 2020-10-27 Cmpd Licensing, Llc Composition and method for compounded therapy
US11213501B2 (en) 2011-12-27 2022-01-04 Cmpd Licensing, Llc Composition and method for compounded therapy
US9962391B2 (en) 2011-12-27 2018-05-08 Cmpd Licensing, Llc Composition and method for compounded therapy
US9468599B2 (en) * 2011-12-27 2016-10-18 Cmpd Licensing, Llc Composition and method for compounded therapy
US11213500B2 (en) 2011-12-27 2022-01-04 Cmpd Licensing, Llc Composition and method for compounded therapy
US10653738B2 (en) * 2014-07-22 2020-05-19 Meridian Research and Development Inc. Topical medications for bruises and burns
US10039830B2 (en) 2016-03-04 2018-08-07 Cetylite Industries, Inc. Topical anesthetic composition
CA3038870A1 (en) 2016-10-13 2018-04-19 Trilogic Pharma Llc Lidocaine formulations for use in chronic open wounds

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* Cited by examiner, † Cited by third party
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SE7713618L (en) * 1977-12-01 1979-06-02 Astra Laekemedel Ab LOCAL ANESTHETIC MIXTURE
EP0103911A1 (en) * 1982-06-30 1984-03-28 THE PROCTER & GAMBLE COMPANY Emollient-containing topical pharmaceutical compositions
US5002974A (en) * 1988-04-04 1991-03-26 Warner-Lambert Co. Anesthetic/skin moisturizing composition and method of preparing same
SE8802040D0 (en) * 1988-06-01 1988-06-01 Astra Ab NEW USE
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
SE9200762D0 (en) * 1992-03-12 1992-03-12 Astra Ab NEW TOPICAL USE
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
AU5578096A (en) * 1995-04-28 1996-11-18 Pharmetrix, Inc. Compositions and methods for inducing dermal analgesia
GB9610359D0 (en) * 1996-05-17 1996-07-24 Edko Trading Representation Pharmaceutical compositions
JPH101441A (en) * 1996-06-14 1998-01-06 Tendou Seiyaku Kk Local anesthetic composition

Also Published As

Publication number Publication date
CA2323211C (en) 2003-12-23
BR9909948A (en) 2000-12-26
IL138509A0 (en) 2001-10-31
EP1073401A1 (en) 2001-02-07
TR200003180T2 (en) 2001-04-20
AU3868399A (en) 1999-11-16
WO1999055287A1 (en) 1999-11-04
AU743516B2 (en) 2002-01-24
EP1073401A4 (en) 2006-09-13
US5993836A (en) 1999-11-30

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EEER Examination request
MKEX Expiry

Effective date: 20190429