CA2328950A1 - Piperidinopyrimidine derivatives for topical application - Google Patents

Piperidinopyrimidine derivatives for topical application Download PDF

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Publication number
CA2328950A1
CA2328950A1 CA002328950A CA2328950A CA2328950A1 CA 2328950 A1 CA2328950 A1 CA 2328950A1 CA 002328950 A CA002328950 A CA 002328950A CA 2328950 A CA2328950 A CA 2328950A CA 2328950 A1 CA2328950 A1 CA 2328950A1
Authority
CA
Canada
Prior art keywords
weight
piperidinopyrimidine
topical application
solvent
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002328950A
Other languages
French (fr)
Other versions
CA2328950C (en
Inventor
Tony Wai-Chiu So
Peter Paul Deo
Russell John Tait
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stiefel Research Australia Pty Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3807366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2328950(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2328950A1 publication Critical patent/CA2328950A1/en
Application granted granted Critical
Publication of CA2328950C publication Critical patent/CA2328950C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Abstract

A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5 % by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10 %
by weight.
CA002328950A 1998-04-22 1999-04-20 Piperidinopyrimidine derivatives for topical application Expired - Lifetime CA2328950C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP3107A AUPP310798A0 (en) 1998-04-22 1998-04-22 Vehicle system for a composition comprising a piperidinopyrimidine derivative
AUPP3107 1998-04-22
PCT/AU1999/000294 WO1999053923A1 (en) 1998-04-22 1999-04-20 Pharmaceutical composition

Publications (2)

Publication Number Publication Date
CA2328950A1 true CA2328950A1 (en) 1999-10-28
CA2328950C CA2328950C (en) 2008-07-29

Family

ID=3807366

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328950A Expired - Lifetime CA2328950C (en) 1998-04-22 1999-04-20 Piperidinopyrimidine derivatives for topical application

Country Status (13)

Country Link
US (2) US6946120B2 (en)
EP (2) EP1073439B1 (en)
JP (3) JP3710380B2 (en)
AT (1) ATE331517T1 (en)
AU (1) AUPP310798A0 (en)
BR (1) BR9909796B1 (en)
CA (1) CA2328950C (en)
CY (1) CY1120513T1 (en)
DE (1) DE69932158T2 (en)
DK (2) DK1695708T3 (en)
ES (2) ES2268856T3 (en)
PT (2) PT1695708T (en)
WO (1) WO1999053923A1 (en)

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US6946120B2 (en) 2005-09-20
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DK1073439T3 (en) 2006-10-23
EP1695708B1 (en) 2018-02-28
US20050037060A1 (en) 2005-02-17
JP2002512192A (en) 2002-04-23
CA2328950C (en) 2008-07-29
DE69932158D1 (en) 2006-08-10
ATE331517T1 (en) 2006-07-15
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PT1073439E (en) 2006-11-30
BR9909796A (en) 2000-12-26
US20020172649A1 (en) 2002-11-21
JP2004059587A (en) 2004-02-26
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EP1073439A4 (en) 2003-07-02
PT1695708T (en) 2018-05-18
EP1695708A2 (en) 2006-08-30
BR9909796B1 (en) 2013-10-29
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EP1073439A1 (en) 2001-02-07

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