CA2338909A1 - Methods, instruments and materials for chondrocyte cell transplantation - Google Patents
Methods, instruments and materials for chondrocyte cell transplantation Download PDFInfo
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- CA2338909A1 CA2338909A1 CA002338909A CA2338909A CA2338909A1 CA 2338909 A1 CA2338909 A1 CA 2338909A1 CA 002338909 A CA002338909 A CA 002338909A CA 2338909 A CA2338909 A CA 2338909A CA 2338909 A1 CA2338909 A1 CA 2338909A1
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- support matrix
- collagen
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Abstract
The present invention provides a method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. The present invention is also directed to an instrument for placing and manipulating the implantable article at the site of implantation, and a retention device for securing the implantable article to the site of implantation. The present invention is also directed to an implantable article for cartilage repair in an animal, the implantable article including chondrocyte cells retained on an absorbable support matrix, and a method of making same. This invention also encompasses, in general, an article comprising an absorbable flexible support matrix for living cells grown and adhered thereto.
Claims (49)
1. A method for the treatment of a cartilage defect site in an animal, by transplantation of an implantable article at the site of cartilage defect, the method comprising the steps of:
(a) providing an implantable article comprising chondrocyte cells retained on a support matrix, the support matrix being absorbable by said animal; and (b) securing the implantable article at the site of cartilage defect.
(a) providing an implantable article comprising chondrocyte cells retained on a support matrix, the support matrix being absorbable by said animal; and (b) securing the implantable article at the site of cartilage defect.
2. A method according to claim 1, further comprising before said step (b), removing defective cartilage from the cartilage defect site but leaving sufficient cartilage material to prevent bleeding from the cartilage at the cartilage defect site.
3. A method according to claim 1, further comprising placing a hemostatic barrier adjacent the site of defect before said step (b).
4. A method according to claim 1 wherein the support matrix is a sheet-like member capable of supporting growth of the chondrocyte cells and of providing physical integrity to the implantable article to facilitate manipulation thereof.
5. A method according to claim 1, wherein the support matrix comprises polypeptides or proteins.
6. A method according to claim 1 wherein the support matrix is collagen.
7. A method according to claim 6, wherein the collagen is selected from the group consisting essentially of equine, porcine, bovine ovine, and chicken collagen.
8. A method according to claim 6, wherein the collagen is porcine collagen.
9. A method according to claim 6, wherein the collagen is collagen Type I.
10. A method according to claim 6, wherein the collagen is collagen Type II.
11. A method according to claim 1, wherein the support matrix is solid member.
12. A method according to claim 1, wherein the support matrix is gel-like.
13. A method according to claim 1 wherein in said step (b) the implantable article is secured to the site of defect with an adhesive.
14. A method according to claim 13, wherein the adhesive is a fibrin glue.
15. A method according to claim 1, wherein in said step (b) the implantable article is secured to the site of defect with absorbable mechanical retention means.
16. A method according to claim 15, wherein said mechanical retention means is a pin.
17. A method according to claim 1, wherein the animal is human.
18. An instrument for introducing an implantable article comprising chondrocyte cells on a support matrix, to a site of cartilage defect in an animal, the instrument comprising:
(a} a tubular outer sheath, said sheath having a proximal end adapted to be disposed at a user end of the instrument, and a distal end adapted to be disposed at the site of cartilage defect;
(b) a handle and telescoping element disposed at least partially within said proximal end of said sheath;
(c) an injection channel partially disposed within said handle and extending from said proximal end to said distal end of said sheath; and (d) gripping elements attached to said telescoping element and adapted to grip and release the implantable article upon telescopic movement of said handle in said sheath.
(a} a tubular outer sheath, said sheath having a proximal end adapted to be disposed at a user end of the instrument, and a distal end adapted to be disposed at the site of cartilage defect;
(b) a handle and telescoping element disposed at least partially within said proximal end of said sheath;
(c) an injection channel partially disposed within said handle and extending from said proximal end to said distal end of said sheath; and (d) gripping elements attached to said telescoping element and adapted to grip and release the implantable article upon telescopic movement of said handle in said sheath.
19. An instrument according to claim 18, the instrument further comprising a cap slideably attached to said proximal end of said sheath and adapted to exclude fluids from the site of cartilage defect.
20. An implantable article for cartilage repair by implantation in an animal, comprising a support matrix and chondrocyte cells retained on said support matrix, wherein said support matrix is absorbable by the animal.
21. An implantable article according to claim 20, wherein said support matrix is a sheet-like member capable of supporting growth of the chondrocyte cells and of providing physical integrity to the implantable article to facilitate manipulation thereof.
22. An implantable article according to claim 20, wherein said support matrix comprises polypeptides or proteins.
23. An implantable article according to claim 20, wherein said support matrix is collagen.
24. An implantable article according to claim 23, wherein said collagen is selected from the group consisting essentially of equine, porcine, bovine, ovine, and chicken collagen.
25. An implantable article according to claim 23, wherein said collagen is porcine collagen.
26. An implantable article according to claim 20, wherein said support matrix is solid.
27. An implantable article according to claim 20, wherein said support matrix is gel-like.
28. An implantable article according to claim 23, wherein said collagen is collagen Type I.
29. An implantable article according to claim 23, wherein said collagen is collagen Type II.
30. An implantable article according to claim 20, wherein said implantable article is reversibly deformable.
31. An implantable article according to claim 20, wherein said support matrix has a rough side.
32. An implantable article according to claim 31, wherein said rough side is porous.
33. An implantable article according to claim 20, wherein said support matrix has a smooth side.
34. An implantable article according to claim 20, wherein said support matrix has a rough side and a smooth side.
35. A method of making an implantable article comprising chondrocyte cells retained on a support matrix, the method comprising the steps of:
(a) harvesting cartilage chondrocyte cells from a host;
(b) culturing the chondrocyte cells in a media;
(c) providing a support matrix comprising a solid or semi-solid member capable of supporting growth of the chondrocyte cells thereon; and (d) adding the cultured chondrocyte cells to the support matrix to allow further culturing of the chondrocyte cells on the support matrix and retention of the chondrocyte cells on the support matrix.
(a) harvesting cartilage chondrocyte cells from a host;
(b) culturing the chondrocyte cells in a media;
(c) providing a support matrix comprising a solid or semi-solid member capable of supporting growth of the chondrocyte cells thereon; and (d) adding the cultured chondrocyte cells to the support matrix to allow further culturing of the chondrocyte cells on the support matrix and retention of the chondrocyte cells on the support matrix.
36. A method according to claim 35, wherein the support matrix is a sheet-like article.
37. A method according to claim 35, wherein the support matrix comprises polypeptides or proteins.
38. A method according to claim 35, wherein the support matrix is collagen.
39. A method according to claim 38, wherein the collagen is selected from the group consisting essentially of equine, porcine, bovine, ovine, and chicken collagen.
40. A method according to claim 38, wherein the collagen is porcine collagen.
41. A method according to claim 38, wherein the collagen is collagen type I.
42. A method according to claim 38, wherein the collagen is collagen type II.
43. A method according to claim 35, wherein the support matrix is solid.
44. A method according to claim 35, wherein the support matrix is gel-like.
45. A method according to claim 35, wherein the support matrix is absorbable.
46. An article of manufacture comprising living cells disposed on and adhered to a flexible support matrix capable of supporting growth of said cells, said growth penetrating the surface of said matrix whereby, upon said growth, said cells are adhered to said matrix.
47. An article according to claim 46, wherein said support matrix is adapted, when disposed in an animal body, to be absorbed into said animal body by natural biological processes.
48. An element for mechanically securing an implantable article to a site of implantation in an animal body, and being absorbable by the animal, said element comprising:
(a) a longitudinal tubular shaft having a proximal end and a distal end;
(b) a head attached to said proximal end of said shaft and adapted to cover said implantable article; and (c) at least one retention ring disposed on said shaft between said proximal end and said distal end, and adapted to anchor said implantable article and said element to the site of implantation.
(a) a longitudinal tubular shaft having a proximal end and a distal end;
(b) a head attached to said proximal end of said shaft and adapted to cover said implantable article; and (c) at least one retention ring disposed on said shaft between said proximal end and said distal end, and adapted to anchor said implantable article and said element to the site of implantation.
49. An element according to claim 48, wherein said element is formed from polylactide.
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US60/146,683 | 1999-08-02 | ||
PCT/EP1999/005993 WO2000009179A2 (en) | 1998-08-14 | 1999-08-16 | Methods, instruments and materials for chondrocyte cell transplantation |
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CA2338909C CA2338909C (en) | 2011-06-28 |
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EP (1) | EP1104313A2 (en) |
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US7618451B2 (en) * | 2001-05-25 | 2009-11-17 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty |
US7239908B1 (en) | 1998-09-14 | 2007-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
ATE439806T1 (en) | 1998-09-14 | 2009-09-15 | Univ Leland Stanford Junior | DETERMINING THE CONDITION OF A JOINT AND PREVENTING DAMAGE |
US9289153B2 (en) * | 1998-09-14 | 2016-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Joint and cartilage diagnosis, assessment and modeling |
CA2391819A1 (en) * | 1999-08-02 | 2001-02-08 | Verigen Transplantation Service International Ag | Kit for chondrocyte cell transplantation |
WO2002022014A1 (en) * | 2000-09-14 | 2002-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
AU9088701A (en) | 2000-09-14 | 2002-03-26 | Univ Leland Stanford Junior | Assessing condition of a joint and cartilage loss |
JP2002233567A (en) * | 2000-12-06 | 2002-08-20 | Mitsuo Ochi | Tissue equivalent for transplantation and its method of manufacture |
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- 1999-08-16 CN CN99812041A patent/CN1323228A/en active Pending
- 1999-08-16 KR KR10-2004-7012696A patent/KR20040081798A/en not_active Application Discontinuation
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- 1999-08-16 EP EP99942872A patent/EP1104313A2/en not_active Withdrawn
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