CA2339244A1 - Methods of ophthalmic administration - Google Patents

Methods of ophthalmic administration Download PDF

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Publication number
CA2339244A1
CA2339244A1 CA002339244A CA2339244A CA2339244A1 CA 2339244 A1 CA2339244 A1 CA 2339244A1 CA 002339244 A CA002339244 A CA 002339244A CA 2339244 A CA2339244 A CA 2339244A CA 2339244 A1 CA2339244 A1 CA 2339244A1
Authority
CA
Canada
Prior art keywords
eye
sclera
posterior segment
methods
ophthalmic administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002339244A
Other languages
French (fr)
Other versions
CA2339244C (en
Inventor
Lyle M. Bowman
James F. Pfeiffer
Leslie A. Clark
Karl I. Hecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Inc
Original Assignee
Lyle M. Bowman
James F. Pfeiffer
Leslie A. Clark
Karl I. Hecker
Insite Vision, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyle M. Bowman, James F. Pfeiffer, Leslie A. Clark, Karl I. Hecker, Insite Vision, Incorporated filed Critical Lyle M. Bowman
Publication of CA2339244A1 publication Critical patent/CA2339244A1/en
Application granted granted Critical
Publication of CA2339244C publication Critical patent/CA2339244C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/908—Mechanical repair performed/surgical

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy. The sclera can be used to hold a depot of the material such as for sustained released or as a conduit for propelling material through whereby the material is delivered immediately to the underlying tissues but without physically penetrating the sclera with an instrument or otherwise unreasonably traumatizing the eye.
CA002339244A 1998-08-03 1999-08-02 Methods of ophthalmic administration Expired - Fee Related CA2339244C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/127,920 1998-08-03
US09/127,920 US6378526B1 (en) 1998-08-03 1998-08-03 Methods of ophthalmic administration
PCT/US1999/017543 WO2000007565A2 (en) 1998-08-03 1999-08-02 Methods of ophthalmic administration

Publications (2)

Publication Number Publication Date
CA2339244A1 true CA2339244A1 (en) 2000-02-17
CA2339244C CA2339244C (en) 2008-10-14

Family

ID=22432636

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339244A Expired - Fee Related CA2339244C (en) 1998-08-03 1999-08-02 Methods of ophthalmic administration

Country Status (7)

Country Link
US (2) US6378526B1 (en)
EP (1) EP1100462A2 (en)
JP (1) JP2002522373A (en)
AU (1) AU761830B2 (en)
CA (1) CA2339244C (en)
NO (1) NO20010556L (en)
WO (1) WO2000007565A2 (en)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2358296A1 (en) * 1999-01-05 2000-07-13 Anthony P. Adamis Targeted transscleral controlled release drug delivery to the retina and choroid
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6699492B2 (en) * 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6685958B2 (en) 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
CA2383572C (en) 1999-10-21 2007-12-11 Alcon Universal Ltd. Sub-tenon drug delivery
KR100748297B1 (en) * 2000-02-29 2007-08-09 알콘, 인코퍼레이티드 Diagnostics and therapeutics for glaucoma
JP2003529567A (en) * 2000-03-10 2003-10-07 インサイト・ビジョン・インコーポレイテッド Methods and compositions for treating and preventing posterior segment eye diseases
US7141607B1 (en) * 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
AU2006211555A1 (en) * 2000-03-11 2006-10-05 Johns Hopkins University Sutureless ocular surgical methods and instruments for use in such methods
US7077848B1 (en) * 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
ATE547080T1 (en) * 2000-08-30 2012-03-15 Univ Johns Hopkins DEVICES FOR INTRAOCULAR DRUG DELIVERY
CA2427334C (en) 2000-11-01 2013-06-11 Merck Patent Gesellschaft Mit Beschraenkter Haftung Methods and compositions for the treatment of diseases of the eye
US20040029788A1 (en) * 2000-11-01 2004-02-12 Hans-Markus Bender Methods and compositions for the treatment of diseases of the eye
US6875165B2 (en) * 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP1418868B1 (en) 2001-04-07 2008-03-26 Glaukos Corporation Glaucoma stent for glaucoma treatment
US7795218B2 (en) 2001-04-12 2010-09-14 Bioaxone Therapeutique Inc. ADP-ribosyl transferase fusion variant proteins
US7678065B2 (en) * 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
MXPA03011631A (en) * 2001-06-15 2007-01-30 Univ Houston System Thin film optical detectors for retinal implantation and methods for making and using same.
US7485113B2 (en) * 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
AU2002319606B2 (en) * 2001-07-23 2006-09-14 Alcon, Inc. Ophthalmic drug delivery device
EP1409065B1 (en) 2001-07-23 2007-01-17 Alcon, Inc. Ophthalmic drug delivery device
US20040198644A1 (en) * 2001-08-01 2004-10-07 Hans-Markus Bender Integrin inhibitors for the treatment of eye diseases
US7179798B2 (en) * 2001-11-16 2007-02-20 Russell R. Roby Methods and compositions for the treatment of pain and other hormone-allergy-related symptoms using dilute hormone solutions
WO2003061519A2 (en) * 2002-01-18 2003-07-31 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
SI1484054T1 (en) * 2002-02-22 2012-12-31 Santen Pharmaceutical Co. Ltd. Drug delivery system for the subconjunctival administration of fine grains
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US20060094643A1 (en) * 2002-07-03 2006-05-04 Yuri Svirkin Compositions of hyaluronic acid and methods of use
EP1539066B1 (en) * 2002-09-17 2012-11-07 Iscience Surgical Corporation Apparatus surgical bypass of aqueous humor
US20050143363A1 (en) * 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US20050282814A1 (en) * 2002-10-03 2005-12-22 Targegen, Inc. Vasculostatic agents and methods of use thereof
JP2004196787A (en) * 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd Drug delivery system with subconjunctival depot
GB0228409D0 (en) * 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US20040253293A1 (en) * 2003-06-16 2004-12-16 Afshin Shafiee Rate controlled release of a pharmaceutical agent in a biodegradable device
ZA200508654B (en) * 2003-07-10 2007-01-31 Alcon Inc Ophthalmic drug delivery device
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
US20050065136A1 (en) * 2003-08-13 2005-03-24 Roby Russell R. Methods and compositions for the treatment of infertility using dilute hormone solutions
EP1666025A4 (en) * 2003-08-20 2011-08-31 Santen Pharmaceutical Co Ltd Drug delivery system by administrating fine particles to sub-tenon
AU2004274026A1 (en) * 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
BRPI0507690A (en) * 2004-02-12 2007-07-24 Neovista Inc methods and apparatus for intraocular brachytherapy
WO2005097210A1 (en) * 2004-03-26 2005-10-20 The University Of Utah Research Foundation Bioresponsive polymer system for delivery of microbicides
AU2005231507B2 (en) * 2004-04-08 2012-03-01 Targegen, Inc. Benzotriazine inhibitors of kinases
US20050239757A1 (en) * 2004-04-21 2005-10-27 Roby Russell R Hormone treatment of macular degeneration
WO2005105107A2 (en) * 2004-04-21 2005-11-10 Roby Russell R Hormone treatment of multiple sclerosis
US9549895B2 (en) * 2004-04-23 2017-01-24 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
US20080058704A1 (en) * 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
CA2564806A1 (en) * 2004-04-29 2005-11-17 Iscience Surgical Corporation Apparatus and method for surgical enhancement of aqueous humor drainage
AU2005240073A1 (en) * 2004-04-29 2005-11-17 Iscience Surgical Corporation Apparatus and method for ocular treatment
SE0401182D0 (en) * 2004-05-05 2004-05-05 Q Med Ab Novel use of a viscoelastic composition
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US20060025390A1 (en) * 2004-07-28 2006-02-02 Roby Russell R Treatment of hormone allergy and related symptoms and disorders
JP5275628B2 (en) 2004-08-25 2013-08-28 ターゲジェン インコーポレーティッド Heterocyclic compounds and methods of use
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
ES2347340T3 (en) 2004-09-13 2010-10-28 Genzyme Corporation MULTIMERICAL CONSTRUCTIONS.
US7553496B2 (en) * 2004-12-21 2009-06-30 University Of Kentucky Research Foundation VEGF-A as an inhibitor of angiogenesis and methods of using same
KR101387456B1 (en) 2005-02-09 2014-04-21 산텐 세이야꾸 가부시키가이샤 Liquid formulations for treatment of diseases or conditions
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
US7803375B2 (en) * 2005-02-23 2010-09-28 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
WO2006110487A1 (en) * 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants for subretinal delivery
MX2007013327A (en) * 2005-04-25 2008-04-21 Teva Pharma Extended release formulations.
NZ563984A (en) * 2005-06-08 2011-11-25 Targegen Inc Methods and compositions for the treatment of ocular disorders
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN105582523B (en) 2005-10-08 2022-04-15 阿佩利斯制药公司 Compstatin and analogs thereof for ocular disorders
US8604042B2 (en) * 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) * 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
DK1951684T3 (en) 2005-11-01 2016-10-24 Targegen Inc BIARYLMETAPYRIMIDIN kinase inhibitors
WO2007059208A2 (en) * 2005-11-15 2007-05-24 Neovista Inc. Methods and apparatus for intraocular brachytherapy
EP2001438A2 (en) 2006-02-09 2008-12-17 Macusight, Inc. Stable formulations, and methods of their preparation and use
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
DK2001466T3 (en) 2006-03-23 2016-02-29 Santen Pharmaceutical Co Ltd LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8030487B2 (en) 2006-07-07 2011-10-04 Targegen, Inc. 2-amino—5-substituted pyrimidine inhibitors
US8506515B2 (en) 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US7553486B2 (en) * 2006-11-13 2009-06-30 Paul Theodore Finger Anti-VEGF treatment for radiation-induced vasculopathy
US20100034808A1 (en) * 2006-11-21 2010-02-11 Toru Nakazawa Compositions and methods for preserving cells of the eye
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
US11078262B2 (en) * 2007-04-30 2021-08-03 Allergan, Inc. High viscosity macromolecular compositions for treating ocular conditions
US8231892B2 (en) * 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US20090036827A1 (en) * 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US20100081707A1 (en) * 2008-02-21 2010-04-01 Ali Robin R Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea
US20100152646A1 (en) * 2008-02-29 2010-06-17 Reshma Girijavallabhan Intravitreal injection device and method
AU2009256236A1 (en) 2008-06-04 2009-12-10 Neovista, Inc. Handheld radiation delivery system for advancing a radiation source wire
US7585291B1 (en) * 2008-07-03 2009-09-08 Michael Campion Eye coloring systems
US10138485B2 (en) 2008-09-22 2018-11-27 Rxi Pharmaceuticals Corporation Neutral nanotransporters
US20100121441A1 (en) * 2008-11-10 2010-05-13 Nabil Jabbour Surgical implant and method
US20110125090A1 (en) * 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) * 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US9314421B2 (en) * 2009-03-06 2016-04-19 The Hong Kong University Of Science And Technology Ultrasound-enhanced intrascleral delivery of macromolecules
US8287494B2 (en) * 2009-03-23 2012-10-16 Colin Ma Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye
JP5342301B2 (en) * 2009-03-30 2013-11-13 三菱重工業株式会社 Solar concentrator
US8372036B2 (en) * 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US8177747B2 (en) * 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8343106B2 (en) 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
EP2515774B1 (en) 2009-12-23 2014-03-19 Alcon Research, Ltd. Ophthalmic valved trocar cannula
RU2615143C2 (en) 2010-03-24 2017-04-04 Адвирна Self-delivered rnai compounds of reduced size
US9095504B2 (en) 2010-03-24 2015-08-04 Rxi Pharmaceuticals Corporation RNA interference in ocular indications
SI2601214T1 (en) 2010-08-06 2018-03-30 Genzyme Corporation Vegf antagonist compositions and uses thereof
US8217163B2 (en) * 2010-09-20 2012-07-10 Biomics Biotechnologies Co., Ltd. Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas
CN103327939B (en) 2010-10-15 2017-05-24 科尼尔赛德生物医学公司 Device for ocular access
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US10285852B2 (en) * 2010-12-02 2019-05-14 Tel Hashomer Medical Research Infrastructure And Services Ltd., The Chaim Sheba Medical Center Subretinal delivery of therapeutic compositions
US8349005B2 (en) * 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US9682144B2 (en) 2011-06-30 2017-06-20 Gene Signal International, Sa Composition comprising inhibitors of IRS-1 and of VEGF
GB201112145D0 (en) 2011-07-15 2011-08-31 Vib Vzw Means and methods for the treatment of pathological angiogenesis
EP3659495B1 (en) 2011-09-13 2022-12-14 Dose Medical Corporation Intraocular physiological sensor
JP6465490B2 (en) 2012-03-26 2019-02-06 グローコス コーポレーション Implant delivery device
WO2013167299A1 (en) 2012-05-11 2013-11-14 Kael-Gemvax Co., Ltd. Anti-inflammatory peptides and composition comprising the same
WO2014010971A1 (en) 2012-07-11 2014-01-16 주식회사 카엘젬백스 Cell-penetrating peptide, conjugate comprising same and composition comprising same
KR20150083117A (en) 2012-11-08 2015-07-16 클리어사이드 바이오메디컬, 인코포레이드 Methods and devices for the treatment of ocular disease in human subjects
DK2920201T3 (en) 2012-11-15 2020-04-14 Apellis Pharmaceuticals Inc Long-acting compstatin analogs and related compositions and methods
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US10308687B2 (en) 2013-03-15 2019-06-04 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US9044508B2 (en) 2013-03-15 2015-06-02 Insite Vision Corporation Concentrated aqueous azalide formulations
CN110302004B (en) 2013-05-03 2023-04-28 科尼尔赛德生物医学公司 Apparatus and method for ocular injection
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US10383926B2 (en) 2013-06-07 2019-08-20 Gemvax & Kael Co., Ltd. Biological markers useful in cancer immunotherapy
ES2808076T3 (en) 2013-06-21 2021-02-25 Gemvax & Kael Co Ltd Regulator of hormonal secretion, composition that contains it and procedure to control hormonal secretion through its use
JP2016525544A (en) * 2013-07-22 2016-08-25 インプリミス・ファーマシューティカルズ・インコーポレイテッドＩｍｐｒｉｍｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Pharmaceutical composition for intraocular administration comprising an antibacterial agent and an anti-inflammatory agent
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
ES2818921T3 (en) 2013-11-22 2021-04-14 Gemvax & Kael Co Ltd Peptide having angiogenesis inhibitory activity and composition containing the same
JP6367950B2 (en) 2013-12-17 2018-08-01 ジェムバックス アンド カエル カンパニー，リミティド Prostate cancer treatment composition
US10010447B2 (en) 2013-12-18 2018-07-03 Novartis Ag Systems and methods for subretinal delivery of therapeutic agents
ES2908096T3 (en) 2014-04-11 2022-04-27 Gemvax & Kael Co Ltd Peptide with inhibitory activity of fibrosis and composition containing it
EP3137119B1 (en) 2014-04-28 2020-07-01 Phio Pharmaceuticals Corp. Methods for treating cancer using a nucleic acid targeting mdm2
CN106659149B (en) 2014-04-30 2020-05-19 珍白斯凯尔有限公司 Compositions, kits and methods for organ, tissue or cell transplantation
AU2015266850B2 (en) 2014-05-29 2019-12-05 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
MX2016017028A (en) 2014-06-20 2017-08-07 Clearside Biomedical Inc Variable diameter cannula and methods for controlling insertion depth for medicament delivery.
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
KR102413243B1 (en) * 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 Peptides for treating ophthalmopathy and the Composition Comprising the Same
WO2016137162A1 (en) 2015-02-27 2016-09-01 주식회사 젬백스앤카엘 Peptide for preventing hearing loss, and composition comprising same
ES2886946T3 (en) 2015-07-02 2021-12-21 Gemvax & Kael Co Ltd Peptide with antiviral effect and composition containing it
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN117503905A (en) 2015-10-07 2024-02-06 阿佩利斯制药有限公司 dosing regimen
EP3413851B1 (en) 2016-02-10 2023-09-27 Clearside Biomedical, Inc. Packaging
US10898540B2 (en) 2016-04-07 2021-01-26 Gem Vax & KAEL Co., Ltd. Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same
AU2017252294B2 (en) 2016-04-20 2021-12-02 Dose Medical Corporation Bioresorbable ocular drug delivery device
CA3062845A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
MX2019012033A (en) 2017-04-07 2019-12-05 Apellis Pharmaceuticals Inc Dosing regimens and related compositions and methods.
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
CN113893085A (en) 2017-10-06 2022-01-07 格劳科斯公司 Systems and methods for delivering multiple ocular implants
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
JP7423070B2 (en) 2018-04-06 2024-01-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Compstatin analogs with increased solubility and improved pharmacokinetic properties
CN111249034B (en) * 2020-03-31 2021-11-16 许寅聪 Posterior sclera reinforcing structure capable of developing under nuclear magnetic resonance

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2033397A (en) 1935-05-25 1936-03-10 Richman Frances Method of and apparatus for the intracapsular extraction of the crystalline lens of an eye
US2591457A (en) 1948-09-15 1952-04-01 Emma C Maynes Syringe operating device
US2760483A (en) 1953-10-29 1956-08-28 Tassicker Graham Edward Retinal stimulator
US3626940A (en) 1969-05-02 1971-12-14 Alza Corp Ocular insert
US3890970A (en) 1974-01-21 1975-06-24 Robert L Gullen Retention cannula or catheter and applicator
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US4186448A (en) 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
DE2929425A1 (en) 1979-07-20 1981-02-12 Lothar Kling DEVICE FOR INJECTION SYRINGES FOR INTRAMUSCULAR AND SUBENTANE INJECTION
US4578061A (en) 1980-10-28 1986-03-25 Lemelson Jerome H Injection catheter and method
US4688570A (en) 1981-03-09 1987-08-25 The Regents Of The University Of California Ophthalmologic surgical instrument
SU1016882A1 (en) 1982-01-12 1984-12-30 Московский научно-исследовательский институт микрохирургии глаза Device for ophthalmologic operations
US4454151A (en) 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4552146A (en) 1982-05-18 1985-11-12 Myocur, Inc. Disposable ophthalmic instrument for performing radial keratotomy on the cornea
US4499898A (en) 1982-08-23 1985-02-19 Koi Associates Surgical knife with controllably extendable blade and gauge therefor
US4580561A (en) 1984-05-04 1986-04-08 Williamson Theodore J Interstitial implant system
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4549529A (en) 1985-10-11 1985-10-29 White Thomas C Myopia alleviation prosthesis
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4759746A (en) 1987-05-14 1988-07-26 Straus Jeffrey G Retro-bulbar needle
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4957117A (en) 1988-11-03 1990-09-18 Ramsey Foundation One-handed percutaneous transluminal angioplasty steering device and method
US4990135A (en) 1989-08-29 1991-02-05 Truesdale Jr R Grant Inoculator and needle therefor
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5294604A (en) 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
US4968296A (en) 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5454796A (en) 1991-04-09 1995-10-03 Hood Laboratories Device and method for controlling intraocular fluid pressure
US5207660A (en) 1991-04-26 1993-05-04 Cornell Research Foundation, Inc. Method for the delivery of compositions to the ocular tissues
US5176643A (en) 1991-04-29 1993-01-05 George C. Kramer System and method for rapid vascular drug delivery
US5167641A (en) 1991-05-29 1992-12-01 Arnis, Inc. Auto-retracting needle injector system
US5279265A (en) 1991-07-26 1994-01-18 Nissan Motor Co., Ltd. V-type internal combustion engine with improved water pump arrangement
US5152769A (en) 1991-11-04 1992-10-06 Will Baber Apparatus for laparoscopic suturing with improved suture needle
US5391174A (en) 1991-11-29 1995-02-21 Weston; Peter V. Endoscopic needle holders
US5284476A (en) 1992-03-20 1994-02-08 Koch Paul S Nuclear hydrolysis cannula
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
US5538504A (en) 1992-07-14 1996-07-23 Scimed Life Systems, Inc. Intra-extravascular drug delivery catheter and method
US5370607A (en) 1992-10-28 1994-12-06 Annuit Coeptis, Inc. Glaucoma implant device and method for implanting same
US5314419A (en) 1992-10-30 1994-05-24 Pelling George E Method for dispensing ophthalmic drugs to the eye
US5336178A (en) 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US5342377A (en) 1992-12-18 1994-08-30 Lazerson Howard E Rotating blade capsulotomy instrument and method of performing a capsulotomy
US5487730A (en) 1992-12-30 1996-01-30 Medtronic, Inc. Balloon catheter with balloon surface retention means
US5279565A (en) 1993-02-03 1994-01-18 Localmed, Inc. Intravascular treatment apparatus and method
US5674240A (en) 1993-02-04 1997-10-07 Peter M. Bonutti Expandable cannula
US5707643A (en) 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
DE4306120C1 (en) 1993-02-27 1994-07-28 Orthmann & Herbst Beverage filler for transparent containers
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5770589A (en) 1993-07-27 1998-06-23 The University Of Sydney Treatment of macular degeneration
US5496329A (en) 1993-09-08 1996-03-05 Alpha Surgical, Inc. Method and apparatus for implanting a medical ventilation tube
CA2171563A1 (en) 1993-09-14 1995-03-23 Eric Le Cheminant Injection device
JPH0795999A (en) 1993-09-30 1995-04-11 Nidek Co Ltd Ophthalmic operation device
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5437640A (en) 1994-01-31 1995-08-01 Schwab; Louis Apparatus and method for inserting hypodermic, tuberculin and other needles and for administering Mantoux tuberculin tests
DE4408108A1 (en) 1994-03-10 1995-09-14 Bavaria Med Tech Catheter for injecting a fluid or a drug
AU3584895A (en) 1994-09-28 1996-04-19 Celtrix Pharmaceuticals, Inc. Method of treating macular degeneration using tgf-beta
US5499991A (en) 1994-12-19 1996-03-19 Linvatec Corporation Endoscopic needle with suture retriever
US5643292A (en) 1995-01-10 1997-07-01 Applied Medical Resources Corporation Percutaneous suturing device
CN1283324C (en) 1995-05-14 2006-11-08 奥普通诺尔有限公司 Intraocular implant, delivery device, and method of implantation
US5630827A (en) 1995-06-19 1997-05-20 Dutch Ophthalmic Research Center International Bv Vitreous removing apparatus
US5746716A (en) 1995-07-10 1998-05-05 Interventional Technologies Inc. Catheter for injecting fluid medication into an arterial wall
US5562693A (en) 1995-08-11 1996-10-08 Alcon Laboratories, Inc. Cutting blade assembly for a surgical scissors
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
WO1997041844A1 (en) 1996-05-09 1997-11-13 Alcon Laboratories, Inc. Combinations of angiostatic compounds
US5911707A (en) 1997-04-09 1999-06-15 Datascope Investment Corp. Needle guide

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US6397849B1 (en) 2002-06-04
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