CA2344379A1 - Bone repair composite material - Google Patents

Bone repair composite material Download PDF

Info

Publication number
CA2344379A1
CA2344379A1 CA002344379A CA2344379A CA2344379A1 CA 2344379 A1 CA2344379 A1 CA 2344379A1 CA 002344379 A CA002344379 A CA 002344379A CA 2344379 A CA2344379 A CA 2344379A CA 2344379 A1 CA2344379 A1 CA 2344379A1
Authority
CA
Canada
Prior art keywords
admixture
bone
composite material
particles
aggregate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002344379A
Other languages
French (fr)
Other versions
CA2344379C (en
Inventor
Thomas Gilchrist
David Michael Healy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fite Holdings Ltd
Original Assignee
Giltech Limited
Thomas Gilchrist
David Michael Healy
Fite Holdings Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giltech Limited, Thomas Gilchrist, David Michael Healy, Fite Holdings Limited filed Critical Giltech Limited
Publication of CA2344379A1 publication Critical patent/CA2344379A1/en
Application granted granted Critical
Publication of CA2344379C publication Critical patent/CA2344379C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C12/00—Powdered glass; Bead compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0068—Inorganic materials not covered by groups A61L24/0057 or A61L24/0063
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/12—Silica-free oxide glass compositions
    • C03C3/16—Silica-free oxide glass compositions containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • C03C4/0014—Biodegradable glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

There is provided an admixture comprising morsellised bone particles and particles of water-soluble biodegradable glass. The particle size distribution and diameter range is pre-selected to produce an aggregate.
Addition of the glass enables an admixture having aggregate characteristics and thus increased shear strength to be produced whilst simultaneously enabling bone regeneration to occur within the treated defect. The admixture is therefore useful in the repair of bone defects, especially primary joint arthroplasties, such as hip replacement operations.
CA002344379A 1998-09-19 1999-09-15 Bone repair composite material Expired - Fee Related CA2344379C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9820369.8 1998-09-19
GBGB9820369.8A GB9820369D0 (en) 1998-09-19 1998-09-19 Material
PCT/GB1999/003077 WO2000016819A1 (en) 1998-09-19 1999-09-15 Bone repair composite material

Publications (2)

Publication Number Publication Date
CA2344379A1 true CA2344379A1 (en) 2000-03-30
CA2344379C CA2344379C (en) 2008-12-30

Family

ID=10839096

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002344379A Expired - Fee Related CA2344379C (en) 1998-09-19 1999-09-15 Bone repair composite material

Country Status (12)

Country Link
US (1) US6692532B1 (en)
EP (1) EP1113826B1 (en)
JP (1) JP4874462B2 (en)
AT (1) ATE309827T1 (en)
AU (1) AU5877299A (en)
CA (1) CA2344379C (en)
CY (1) CY1106065T1 (en)
DE (1) DE69928412T2 (en)
DK (1) DK1113826T3 (en)
ES (1) ES2253913T3 (en)
GB (1) GB9820369D0 (en)
WO (1) WO2000016819A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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AU2002213351A1 (en) * 2000-10-17 2002-04-29 Maria-Grazia Ascenzi System and method for modeling bone structure
CN1162187C (en) 2001-02-22 2004-08-18 华东理工大学 Inorganic bane adhesive and its application in body's hard tissue repair
US7283940B2 (en) * 2001-10-17 2007-10-16 Maria-Grazia Ascenzi Multidirectional morphology and mechanics of osteonic lamellae
US7353153B2 (en) * 2001-10-17 2008-04-01 Maria-Grazia Ascenzi Method and system for modeling bone structure
US7212958B2 (en) * 2001-10-17 2007-05-01 Maria-Grazia Ascenzi Method and system for modelling bone structure
WO2005032612A2 (en) * 2003-10-02 2005-04-14 Lostec, Inc. A transplantable particulate bone composition and methods for making and using same
CN100581594C (en) * 2006-01-17 2010-01-20 叶南辉 Production method of biological bone having concrete property
US20070173949A1 (en) * 2006-01-25 2007-07-26 Sharps Lewis S Bonding system for orthopedic implants
GB2436067A (en) * 2006-03-17 2007-09-19 Apatech Ltd A flowable biomedical filler resisiting flow at higher shear stress or compressive force
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
US20090131950A1 (en) * 2007-11-16 2009-05-21 Liu Y King Vertebroplasty method with enhanced control
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
US20090182427A1 (en) * 2007-12-06 2009-07-16 Osseon Therapeutics, Inc. Vertebroplasty implant with enhanced interfacial shear strength
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
GB0911365D0 (en) 2009-06-30 2009-08-12 Bioceramic Therapeutics Ltd Multicomponent glasses for use as coatings and in personal care products
US8673018B2 (en) * 2010-02-05 2014-03-18 AMx Tek LLC Methods of using water-soluble inorganic compounds for implants
CN102958456B (en) 2010-04-29 2015-12-16 Dfine有限公司 Be used for the treatment of the system of vertebral fracture
JP6218449B2 (en) * 2013-06-17 2017-10-25 株式会社堀場製作所 Particle size distribution measuring device
PL3485868T3 (en) * 2016-07-15 2022-12-12 Gc Corporation Dental glass and dental composition
CN109862834B (en) 2016-10-27 2022-05-24 Dfine有限公司 Bendable osteotome with cement delivery channel
WO2018098433A1 (en) 2016-11-28 2018-05-31 Dfine, Inc. Tumor ablation devices and related methods
EP3551100B1 (en) 2016-12-09 2021-11-10 Dfine, Inc. Medical devices for treating hard tissues
US10660656B2 (en) 2017-01-06 2020-05-26 Dfine, Inc. Osteotome with a distal portion for simultaneous advancement and articulation
EP3876857A4 (en) 2018-11-08 2022-08-03 Dfine, Inc. Ablation systems with parameter-based modulation and related devices and methods
CN114618013B (en) * 2022-03-10 2023-09-15 苏州卓恰医疗科技有限公司 MnO 2 Modified magnesium-based bone cement powder, bone cement and preparation method thereof

Family Cites Families (16)

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DE2724814C3 (en) * 1977-06-02 1980-03-27 Kulzer & Co Gmbh, 6380 Bad Homburg Preliminary product for the preparation of bone cement
JPS6050744B2 (en) * 1979-04-16 1985-11-09 日本特殊陶業株式会社 High strength calcium phosphate sintered body
GB2099702B (en) * 1981-06-04 1984-08-08 Standard Telephones Cables Ltd Water-soluble prosthesis
GB2161800B (en) * 1984-07-18 1988-08-10 Stc Plc Water soluble compositions for preparing analytical solutions
FR2646084B1 (en) * 1989-04-20 1994-09-16 Fbfc International Sa BIOREACTIVE MATERIAL FOR FILLING BONE CAVITES
GB9022754D0 (en) * 1990-10-19 1990-12-05 Pilkington Controlled Release Improvements in or relating to water dispersible moulds
GB9213774D0 (en) 1992-06-29 1992-08-12 Queen Mary & Westfield College Sintered hydroxyapatite compositions and method for the preparation thereof
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US5817327A (en) * 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
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Also Published As

Publication number Publication date
DE69928412T2 (en) 2006-07-13
JP4874462B2 (en) 2012-02-15
CA2344379C (en) 2008-12-30
JP2002526205A (en) 2002-08-20
CY1106065T1 (en) 2011-06-08
EP1113826B1 (en) 2005-11-16
EP1113826A1 (en) 2001-07-11
GB9820369D0 (en) 1998-11-11
AU5877299A (en) 2000-04-10
ES2253913T3 (en) 2006-06-01
DK1113826T3 (en) 2006-04-03
ATE309827T1 (en) 2005-12-15
WO2000016819A1 (en) 2000-03-30
US6692532B1 (en) 2004-02-17
DE69928412D1 (en) 2005-12-22

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130917