CA2347594A1 - Glucose sensor - Google Patents

Glucose sensor Download PDF

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Publication number
CA2347594A1
CA2347594A1 CA002347594A CA2347594A CA2347594A1 CA 2347594 A1 CA2347594 A1 CA 2347594A1 CA 002347594 A CA002347594 A CA 002347594A CA 2347594 A CA2347594 A CA 2347594A CA 2347594 A1 CA2347594 A1 CA 2347594A1
Authority
CA
Canada
Prior art keywords
base plate
reaction layer
glucose sensor
electrode
electrode system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002347594A
Other languages
French (fr)
Other versions
CA2347594C (en
Inventor
Motokazu Watanabe
Keiko Yugawa
Toshihiko Yoshioka
Shiro Nankai
Junko Nakayama
Shoji Miyazaki
Hideyuki Baba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHC Holdings Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2347594A1 publication Critical patent/CA2347594A1/en
Application granted granted Critical
Publication of CA2347594C publication Critical patent/CA2347594C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006Enzyme electrodes involving specific analytes or enzymes for glucose

Abstract

The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises:
an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.
CA002347594A 1999-10-05 2000-10-02 Glucose sensor Expired - Lifetime CA2347594C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28487199 1999-10-05
JP11/284871 1999-10-05
PCT/JP2000/006853 WO2001025776A1 (en) 1999-10-05 2000-10-02 Glucose sensor

Publications (2)

Publication Number Publication Date
CA2347594A1 true CA2347594A1 (en) 2001-04-12
CA2347594C CA2347594C (en) 2006-11-28

Family

ID=17684126

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002347594A Expired - Lifetime CA2347594C (en) 1999-10-05 2000-10-02 Glucose sensor

Country Status (8)

Country Link
US (1) US7005048B1 (en)
EP (1) EP1146332B8 (en)
JP (1) JP3867959B2 (en)
CN (1) CN1184472C (en)
AT (1) ATE313790T1 (en)
CA (1) CA2347594C (en)
DE (1) DE60024965T2 (en)
WO (1) WO2001025776A1 (en)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US20050103624A1 (en) 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
US6911131B2 (en) * 2000-03-29 2005-06-28 Matsushita Electric Industrial Co., Ltd. Biosensor
JP4627911B2 (en) * 2000-03-29 2011-02-09 パナソニック株式会社 Biosensor
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60234598D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
EP1404234B1 (en) 2001-06-12 2011-02-09 Pelikan Technologies Inc. Apparatus for improving success rate of blood yield from a fingerstick
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291256B2 (en) 2002-09-12 2007-11-06 Lifescan, Inc. Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
US7501053B2 (en) * 2002-10-23 2009-03-10 Abbott Laboratories Biosensor having improved hematocrit and oxygen biases
EP1584675B1 (en) * 2002-12-24 2010-02-24 Ikeda Food Research Co. Ltd. Coenzyme-binding glucose dehydrogenase
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DK1633235T3 (en) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparatus for sampling body fluid and detecting analyte
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
PT1639352T (en) 2003-06-20 2018-07-09 Hoffmann La Roche Method and reagent for producing narrow, homogenous reagent strips
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1712907A1 (en) 2004-02-04 2006-10-18 Matsushita Electric Industrial Co Ltd Biosensor and biosensor measuring device and method
WO2005088288A1 (en) * 2004-03-10 2005-09-22 National Institute Of Advanced Industrial Science And Technology Carbon nanotube biosensor
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
CA2600132C (en) * 2005-03-04 2014-09-09 Bayer Healthcare Llc Stabilizing enzyme activity in electrochemical biosensors
EP1862543B1 (en) 2005-03-25 2013-04-03 Ikeda Food Research Co. Ltd. Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
JP2007121060A (en) * 2005-10-27 2007-05-17 Sumitomo Electric Ind Ltd Sensor chip and sensor system
TW200718785A (en) 2005-11-10 2007-05-16 Toyo Boseki A process for improving the thermal stability of a composition containing a soluble coenzyme conjugated glucose dehydrogenase (GDH)
US7955484B2 (en) 2005-12-14 2011-06-07 Nova Biomedical Corporation Glucose biosensor and method
DE102006014714B3 (en) * 2006-03-30 2007-05-16 Draegerwerk Ag Electrochemical sensor for gas detection has aromatic or alphatic acid carbonic acids in alkali electrolyte solution
DE102006014715B3 (en) * 2006-03-30 2007-06-06 Drägerwerk AG Electrochemical gas sensor for detecting analyte, has mediator that is dissolved in saturated form in electrolytes and is available as precipitate in electrolyte space, and protection electrode arranged at rear of measuring electrode
ES2392628T3 (en) * 2006-04-19 2012-12-12 Panasonic Corporation Biosensor
MX2009002830A (en) * 2006-09-22 2009-05-28 Bayer Healthcare Llc Biosensor system having enhanced stability and hematocrit performance.
WO2009087929A1 (en) * 2008-01-07 2009-07-16 Toyo Boseki Kabushiki Kaisha Novel glucose dehydrogenase
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
DE102008030435A1 (en) 2008-06-26 2010-01-07 Bayer Technology Services Gmbh Novel variants of PQQ-dependent glucose hydrogenase with improved substrate specificity
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
JP5627858B2 (en) * 2009-03-31 2014-11-19 シーシーアイ株式会社 Biosensor
WO2011087033A1 (en) * 2010-01-14 2011-07-21 グンゼ株式会社 Biosensor
RU2569753C2 (en) * 2010-01-22 2015-11-27 БАЙЕР ХЕЛТКЭА ЭлЭлСи Accuracy-improving dehumidifiers
US9233788B2 (en) 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
EP2545853B1 (en) * 2010-03-09 2017-10-25 ARKRAY, Inc. Electrochemical sensor
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP2623974B1 (en) * 2010-09-30 2022-02-16 PHC Holdings Corporation Sensor, sensor system, and sensor manufacture process
JP2012211810A (en) * 2011-03-31 2012-11-01 Cci Corp Biosensor having improved measurement accuracy
TWI565943B (en) * 2011-07-22 2017-01-11 拜耳保健公司 Biosensor desiccant system having enhanced measurement performance
AU2013249126B2 (en) 2012-04-19 2015-10-01 Aytu Bioscience, Inc. Multiple layer gel
CA2847665A1 (en) 2012-10-23 2014-04-23 Raphael Bar-Or Methods and systems for measuring and using the oxidation-reduction potential of a biological sample
JP6402887B2 (en) * 2014-01-27 2018-10-10 東洋紡株式会社 Glucose dehydrogenase composition
US10317359B2 (en) 2016-01-05 2019-06-11 Ravi Kumar Meruva Differential carbon dioxide sensor
US10213144B2 (en) 2016-01-25 2019-02-26 International Business Machines Corporation Nanopatterned biosensor electrode for enhanced sensor signal and sensitivity
US10376193B2 (en) 2016-07-25 2019-08-13 International Business Machines Corporation Embedded sacrificial layer to enhance biosensor stability and lifetime for nanopatterned electrodes
US10161898B2 (en) 2017-01-30 2018-12-25 International Business Machines Corporation Nanopatterned biosensor electrode for enhanced sensor signal and sensitivity
US10548530B2 (en) 2017-03-01 2020-02-04 International Business Machines Corporation Biosensor calibration structure containing different sensing surface area
US11562907B2 (en) 2018-11-29 2023-01-24 International Business Machines Corporation Nanostructure featuring nano-topography with optimized electrical and biochemical properties
CN110806437B (en) * 2019-11-15 2020-08-04 中南大学 Black phosphorus nanosheet/maltose- β -cyclodextrin modified glassy carbon electrode and application thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1077197A (en) 1975-03-24 1980-05-06 Kazuhiko Kurimoto Method for bulk polymerization of vinyl chloride
DE3278334D1 (en) 1981-10-23 1988-05-19 Genetics Int Inc Sensor for components of a liquid mixture
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
US5682884A (en) 1983-05-05 1997-11-04 Medisense, Inc. Strip electrode with screen printing
JP2502666B2 (en) 1988-01-29 1996-05-29 松下電器産業株式会社 Biosensor and manufacturing method thereof
DE3826922A1 (en) 1988-08-09 1990-02-22 Boehringer Mannheim Gmbh PROCESS FOR THE COLOR-RIMETRIC DETERMINATION OF AN ANALYTE BY ENZYMATIC OXIDATION
DE68922550D1 (en) 1988-08-30 1995-06-14 New Oji Paper Co Ltd Alcohol oxidase enzyme electrode and method for determining alcohol content.
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
FR2673289B1 (en) 1991-02-21 1994-06-17 Asulab Sa SENSOR FOR MEASURING THE QUANTITY OF A COMPONENT IN SOLUTION.
JP2671693B2 (en) 1991-03-04 1997-10-29 松下電器産業株式会社 Biosensor and manufacturing method thereof
EP0525723B1 (en) * 1991-07-29 1997-05-14 Mochida Pharmaceutical Co., Ltd. Process and device for specific binding assay
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
DE69319771T2 (en) 1992-03-31 1999-04-22 Dainippon Printing Co Ltd Immobilized enzyme electrode, composition for its production and electrically conductive enzymes
US5658443A (en) 1993-07-23 1997-08-19 Matsushita Electric Industrial Co., Ltd. Biosensor and method for producing the same
JP3203108B2 (en) 1993-08-26 2001-08-27 協和メデックス株式会社 Method for stabilizing glucose-6-phosphate dehydrogenase
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
ATE216724T1 (en) 1995-05-12 2002-05-15 Dsm Nv ENZYMATIC PRODUCTION OF GLUCONIC ACID AND ITS SALTS
IT1279043B1 (en) 1995-05-24 1997-12-04 Co Ri Al Scpa METHOD FOR THE DETERMINATION OF LACTIC ACID IN ORGANIC MATERIALS OF FOOD INTEREST AND BIOSENSOR FOR THE EXECUTION OF THIS METHOD
JP3775518B2 (en) 1995-11-22 2006-05-17 東洋紡績株式会社 PQQ-dependent glucose dehydrogenase composition and glucose measurement reagent composition
JPH09262086A (en) * 1996-03-28 1997-10-07 Oji Paper Co Ltd Preservation of immobilized enzyme
DE19629655A1 (en) 1996-07-23 1998-01-29 Boehringer Mannheim Gmbh Diagnostic test carrier and method for determining an analyte with the aid thereof
DE69809391T2 (en) * 1997-02-06 2003-07-10 Therasense Inc SMALL VOLUME SENSOR FOR IN-VITRO DETERMINATION
JPH10227755A (en) * 1997-02-14 1998-08-25 Matsushita Electric Ind Co Ltd Biosensor
US6059946A (en) * 1997-04-14 2000-05-09 Matsushita Electric Industrial Co., Ltd. Biosensor
US5942424A (en) * 1997-06-19 1999-08-24 Lockheed Martin Energy Research Corporation Method for the enzymatic production of hydrogen
US6071391A (en) 1997-09-12 2000-06-06 Nok Corporation Enzyme electrode structure
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JPH11243949A (en) 1998-03-03 1999-09-14 Toyobo Co Ltd Glucose dehydrogenase having pqq as prosthetic group and its production
US6077660A (en) 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
JP3694424B2 (en) * 1998-09-29 2005-09-14 松下電器産業株式会社 Glucose sensor

Also Published As

Publication number Publication date
CA2347594C (en) 2006-11-28
WO2001025776A1 (en) 2001-04-12
DE60024965D1 (en) 2006-01-26
CN1327536A (en) 2001-12-19
EP1146332B8 (en) 2006-06-07
EP1146332A4 (en) 2004-05-12
ATE313790T1 (en) 2006-01-15
CN1184472C (en) 2005-01-12
DE60024965T2 (en) 2006-07-13
EP1146332B1 (en) 2005-12-21
US7005048B1 (en) 2006-02-28
JP3867959B2 (en) 2007-01-17
EP1146332A1 (en) 2001-10-17

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