CA2347826A1 - Novel amine and quaternary ammonium compounds made from ketones and aldehydes, and compositions containing them - Google Patents

Abstract

A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile; (c) reducing the ether nitril to a tertiary amine ketal or a tertiary amine acetal; (d) hydrolyzing the tertiary amine ketal or the tertiary amine acetal to a tertiary amine diol; and (e) esterifying the tertiary amine diol to the tertiary amine ester of formula (I), wherein R1 and R2 are each independently a hydrogen atom or a linear, branched, or cyclic alkyl, alkylene, alkaryl, or aryl-containing group containing 1 to 18 carbon atoms; and each R3 are each independently of one another fatty acid radicals having 6-22 carbon atoms. The process may optionally include the further step of: (f) protonating or quaternizing the tertiary amine ester of formula (I) to a protonated or quaternary amine ester of formula (II) wherein A- is an inorganic or organic anion.

Description

5 NOVEL AMINE AND QUATERNARY AI~VIONIUM COMPOUNDS
M_ ADE FROM KETONES AND AI~DEHYDES AND
COMpn~f'1'1~ONS CONTAINING THEM
The present invention relates to a quaternary ammonium compounds and formulations thereof useful as, for instance, cleaning compositions, antistatic compounds, fabric softeners, hair conditioners, skin conditioners, paper deinking and ink floatation agents, asphalt emulsion agents, corrosion inhibitor agents, ore floatation agents, pesticide emulsion agents, car drying aid sprays, drilling fluid additives, and the like.
Heretofore quaternary ammonium compounds and a very few dialkyl ammonium compounds ("conventional quats") have found widespread use in many applications. For example, a variety of conventional quats have been proposed for many uses, for example, 20 in fabric softeners for home use or for industrial and institutional use. In general, such compounds exhibit properties which present some di~culty in the manufacture, formulation use, aesthetic properties, biodegradability, and environmental compatibility of these compositions. For example, many of the conventional 25 compositions used for these functions, even if completely biodegradable with time, do not biodegrade as rapidly as could be desired and are thus not considered readily biodegradable. In addition, several of the commercial readily biodegradable softeners, conditioners, and debonders do not function as effectively as the 30 conventional products that are less biodegradable. Thus, to maintain effective levels of performance, increased amounts of such less effective, more readily biodegradable products (such as softeners) must be employed and, as will be readily apparent, this factor decreases the cost-effectiveness of the product.

SUBSTITUTE SHEET (RULE 26) The relatively poor solubility of conventional gusts also contributes to certain difficulties that will vary, depending on the application. For example, when such conventional gusts are used in fabric softeners, their poor solubility inhibits the dispersibility of the S fabric softener actives into water and the dispersibility of the formulated fabric softener product into the washing machine. In washing of textiles, the rinse softeners are often used in the last washing stage. In this way, coarsening of the fabric is lessened which otherwise could be realized upon drying. The feel of textiles treated in this way such as hand and bath towels as well as clothes and bed linens is pleasantly improved.
Cationic compounds are customarily used as rinse softeners, for example, quaternary ammonium compounds which can contain long-chain alkyl groups as well as ester groups or amide groups, such as are described in U.S. Patents Nos. 3,349,043 3,644,203 3,946,115 3,997,453 4,073,735 and 4,119,545. These quaternary ammonium compounds are added to the rinse water by themselves or in mixtures with other cationic or neutral compounds in the form of aqueous dispersions.
In addition, quaternary ammonium compounds which contain ester linkages are frequently used, such as are described in EP-A-023910, U.S. Patent No. 3,915,867 U.S. Patent No. 4,137,180 and U.S. Patent No. 4,830,771. Particularly widely used are ester compounds based on triethanolamine such as Nmethyl, N,N
bis( ~ - C 14-ls-acyloxyethyl), N - /3 -hydroxyethyl ammonium methylsulfate, which are available from Kao Corporation under tradename TETRANYL~ AT 75, from Stepan Corporation under the tradename STEPANTEX~ ZRH 90, and from Witco Surfactants GmbH under the tradename REWOQUAT~ WE 18. While these cationic compounds exhibit effective softening when used in the last rinse stage, they exhibit some disadvantages during use. For SUBSTITUTE SHEET (RULE 26) example, one disadvantage is that a relatively large amount of softening agents is required to simultaneously obtain good rewettability and soft feel of textiles, although the softness is still unsatisfactory. R,ewetting power or rewettability is generally taken 5 to mean the absorption of moisture by the fiber. Inadequate rewetting power is, however, disadvantageous wherever relatively large amounts of moisture are to be absorbed from the surface of the skin, for example, in the case of hand or bath towels and in the case of underwear or bed linen. However, batch or continuous processes 10 are known that can be used to prepare stable fabric softener dispersions using these products.
Thus, there remains a need for identification of new amine and ammonium derivatives, and particular quaternary derivatives, which are useful as fabric softeners and which are also biodegradable, 15 highly effective in softening, debonding, conditioning, and the like, and yet avoid these problems upon manufacture, formulation and use. It is also desirable for the active agents used in hair and skin conditioners, textile softeners, and the like, to be readily biodegradable and to exhibit a satisfactorily high activity.
20 Conventional products have to date not been able to exhibit both properties to a high degree, thus necessitating acceptance of reduced biodegradability or reduced activity. There is thus still a need for compounds exhibiting levels of activity as conditioners, and so on, as the case may be, which are comparable or superior to conventionally 25 employed actives, such as conventional quats, while also exhibiting ready biodegradability.
As can be appreciated, the chemistry of fabric softeners, hair conditioners, skin conditioners, textile softeners, car wax sprays, and the like is challenging. Each of these applications presents its own 30 complications, because the interactions between the various components of the compositions must be considered in addition to the SUBSTITUTE SHEET (RULE 26) individual chemistry of each component. For example, considering the fabric softening application, the detergent compounds with the widest range of cleaning properties are generally anionic (negatively charged) surfactants. Such anionic surfactants, for example, may S include the alkylbenzene sulfonatea, a - olefin aulfonates, and xylene aulfonates available from Witco Corporation under the WITCONATE~ trademark. In contrast, as exemplified by the amine and ammonium compounds discussed above, fabric softening compounds are generally cationic (positively charged). Thus, when the anionic detergent ingredients and cationic softening ingredients are present in the same aqueous solution, they have a natural tendency to complex together or even precipitate out of solution. This complexation or precipitation reaction interferes with the performance of both the detergent compounds and the softening compounds and is therefore undesirable. It can be readily appreciated that this undesirable complexation or precipitation reaction may occur if both detergent and softener compounds are added together in a wash cycle however, as North American washing machines typically rinse the clothes only once before fabric softener is added to the washload, even if the fabric softener is added during a rinse cycle (as is typically done), residual anionic detergent compounds (including builders) present in the fabric complexes with the cationic softener compounds.
The present invention achieves these objectives and also exhibits the properties and advantages described herein. The present invention relates to a process for making certain novel ester amine compounds and the salts and quaternary ammonium compounds thereof, and the compounds made by the instant process.
The present invention also relates to the compounds made by the instant process and formulations thereof useful as, for instance, cleaning compositions, antistatic compounds, fabric softeners, hair SUBSTITUTE SHEET (RULE 26) conditioners, skin conditioners, paper deinking and ink floatation agents, asphalt emulsion agents, corrosion inhibitor agents, ore floatation agents, pesticide emulsion agents, car drying aid spray~f, drilling fluid additives, and the like.

5 An object of the present invention was to overcome the abovementioned disadvantages of traditional fabric softener formulations and to provide laundry fabric softeners which, in addition to good biodegradability, have a significantly improved level of simultaneously good soft handle and rewetting power.
10 One aspect of the instant invention provides a process for making a tertiary amine ester of the following formula (I):
~CH3 o-CH2-cH2 -~ CHa I
O~C ~=O

(I), the process comprising:
(a) reacting a ketone or an aldehyde having the formula 1 S R' R2 with a glycol to form a ketal or an acetah (b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile~
(c) reducing the ether nitrile to a tertiary amine ketal or a 20 tertiary amine acetah (d) hydrolyzing the tertiary amine ketal or the tertiary amine acetal to a tertiary amine dioh and (e) esterifying the tertiary amine diol to a tertiary amine ester, wherein Ri and RZ are each independently a hydrogen atom or 25 a linear, branched, or cyclic alkyl, alkylene, alkaryl, or aryl containing group containing 1 to 18 carbon atoms, and SUBSTITUTE SHEET (RULE 26) each Rs are each independently of one another fatty acid radicals having 6-22 carbon atoms.
Another aspect of the instant invention provides a process for making a protonated or quaternary amine ester of the following formula:
Q Ae ~~

O O
C C °O

(II), the process comprising:
(a) reacting a ketone or an aldehyde having the formula R~ R2 with a glycol to form a ketal or an acetate (b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile~
(c) reducing the ether nitrite to a tertiary amine ketal or tertiary amine acetate 1 S (d) hydrolyzing the tertiary amine ketal or tertiary amine acetal to a tertiary amine dioh (e) esterifying the tertiary amine diol to a tertiary amine ester and (~ protonating or quaternizing the tertiary amine ester to the protonated or quaternary amine ester, - wherein Rl and RZ are each independently a hydrogen atom or a linear, branched, or cyclic alkyl, alkylene, alkaryl, or aryl-containing group containing 1 to 18 carbon atoms each R3 are each independently of one another fatty acid radicals having 6-22 carbon atoms SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 fa is -H, -CHs or -CZHs~ and A- is an inorganic or organic anion. In general, A-, whether shown or understood, may be selected, without limitation, from the group consisting of fluoride, chloride, bromide, iodide, chlorite, 5 chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and salicylate, and the like.
Preferred examples of the anions are chloride, bromide, methyl sulfate, ethyl sulfate, and salicylate.
10 In preferred embodiments of the invention, the composition includes water in the formulation. In other preferred embodiments of the invention, the composition comprises a mixture of two or more different compounds of formulas (I) and/or (II). The invention also provides compositions comprising compounds of the general formula 15 (I) and/or (II)~ in preferred embodiments of such compositions the amount of compounds of the general formula (I) andlor (II) generally ranges from about 2 wt.% to about 80 wt.%, preferably 5 wt.% to 30 wt.%, and more preferably 6 wt.°/ to 25 wt.%, of the total composition. The invention additionally provides compositions 20 comprising compounds of the general formula (I) and/or (II) in combination with conventional quaternary ammonium compounds that comprise from about 10% to about 90% by weight of the total amount of quaternary ammonium compounds, which is the compounds of the general formula (I) and/or (II) and the conventional 25 quaternary ammonium compounds, in the composition. Other preferred embodiment of the instant invention comprises compounds of the general formula (I) and/or (II) in combination with water.
The invention further provides compositions comprising at least one of the compounds of the general formula (I) and/or (II), 30 useful for many applications, for example, as fabric softeners. In the fabric softener application, the composition is contemplated to be SUBSTITUTE SHEET (RULE 26) applied in any of the many conventional ways fabric softeners are applied to fabrics. For example, the compositions of the instant invention may be applied or used at any time in the wash cycle of a washing machine, for example, in a prewash cycle, wash cycle, or 5 postwash (rinse) cycle by adding such composition to the wash or rinse water or spraying directly on the clothes. In addition, the compositions of the instant invention may be applied or used at any time previous or subsequent to the fabric being placed in a washing machine, for example, in a clothes dryer by use of a fabric softener 10 dryer sheet impregnated with one of the compounds of the general formula (I) and/or (II), or by spraying a formulation comprising one of the compounds of the general formula (I) and/or (II) on the fabric at any time before or after washing.
The invention also provides compositions comprising 15 compounds of the general formula (I) and/or (II), which may optionally include from about 1% to about 20% by weight of a secondary surfactant selected from the group consisting of nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, and ionic surfactants. In preferred embodiments, the secondary 20 surfactant is selected from the group consisting of ammonium lauryl sulfate, sodium lauryl sulfate, any a - olefin sulfonate, ammonium laureth sulfate (2 or 3 moles), sodium laureth sulfate (2 or 3 moles), sodium myristyl sulfate, sodium myristeth sulfate (1-4 moles), ammonium xylene sulfonate, sodium xylene sulfonate, TEA
25 dodecylbenzene sulfonate, TEA lauryl sulfate, ammonium pareth sulfate, sodium pareth sulfate, sodium oleth sulfate, derivatives thereof, and mixtures thereof. In other preferred embodiments, the secondary surfactant is selected from the group consisting of:
betaines, sulfosuccinates, mono- and diglycerides, glycinates, sugars 30 and derivatives thereof, hydroxysultaines, mono- and diacetates, ethoxylated derivatives thereof, and mixtures thereof. In yet other s SUBSTITUTE SHEET (RULE 26) preferred embodiments, the secondary surfactant is selected from the group consisting of alkanolamides~ amine oxides nonylphenol ethoxylates~ Cs-C2o linear or branched alcoxylates using EO, PO, BO, or mixtures thereof amine ethoxylates~ fatty amide ethoxylates~ fatty 5 acid ethoxylates~ carboxylated nonionics~ (-polyglucosides~ and mixtures thereof. In still other preferred embodiments, the formulation further comprises water and/or about 0.1% to 10% by weight of thickeners, perfumes, preservatives, dyes, plant extracts and other additives and auxiliaries.
10 The invention further provides for the use of compounds of the general formulas (I) and/or (II) in amounts of 1-5% by weight for the preparation of hair or skin conditioner compositions with use of auxiliaries and additives customary in this field. Hair or skin conditioner compositions are taken to mean applications such as hair 15 treatments, hair rinses, hair balsam, hair mousses, spray lotions for improving combability, conditioning shampoos, shower gels, and liquid soaps having a smoothing effect on the skin.
The invention further provides for the use of 5-20% by weight of the compounds of the general formula (I) and/or (II) for the 20 preparation of detergents and rinses and drying auxiliaries for motor vehicles with use of the additives and auxiliaries customary in this field, such as solvents, viscosity regulators, fatty acid esters, and additional surfactants.
The compounds of the general formulas (I) and/or (II) can, in 25 combination with other surfactants and/or silicone compounds, be used as hydrophilic handle modifiers for yarns, fabrics and other textiles made from synthetic and mixed fibers and, preferably, from natural fibers, in which case they impart excellent antistatic properties, good handle, and hydrophilicity to the textiles without 30 causing yellowing. The handle modifiers are used as 1-10% strength dispersions, coverage being 1-15%. The invention thus further SUBSTITUTE SHEET (RULE 26) provides for the use of the compounds of the general formulas (I) and/or (II) for the preparation of hydrophilic handle modifiers for yarns, fabrics and other textiles, comprising 15% to 25% by weight of alkyl fatty acid polyglycol ester having 6 to 25 moles of E0, 45% to 5 65% by weight of compounds of the general formula (I) and/or (II), 10 20% by weight of partial glyceride esters having 5 to 80 moles of EO, and 5% to 10% by weight of alkyl ether citrates (monoesters, diesters, and triesters having a degree of ethoxylation of 5 to 15), with the proviso that the components total 100°/ by weight. In preferred embodiment, the hydrophilic handle modifier compositions further comprise 0.001% to 10% by weight of silicone compounds most preferably from about 0.01% to about 5% by weight of silicone compounds. In another preferred embodiment of the invention, the silicone compounds comprise silicone compounds of the polydimethylsiloxane and cationically-modified polydimethylailoxane type.
The compounds of the general formula (I) and/or (II) can be used as such or in combination with other surfactants and/or silicone compounds as preparations for the permanent hydrophilization of polyolefin or polyester fibers and filaments and the nonwovens prepared therefrom. The permanent hydrophilization compositions are used as 1% to 10% strength dispersions, coverage being 1% to 15%. The surface-active constituents which are also used are preferably based on vegetable raw materials. The invention thus further provides for the use of the compounds of the general formula (I) and/or (II) for the preparation of permanent hydrophilization compositions comprising: 15% to 30°/ by weight of alkyl fatty acid polyglycol esters having 6 to 25 moles of EO~ 45% to 65% by weight of compounds of the general formula (I) and/or (II)~ and 5% to 10% by weight of alkyl ether citrates (monoesters, diesters, and triesters having a degree of ethoxylation of 5 to 15), with the proviso that the to SUBSTITUTE SHEET (RULE 26) components total 100% by weight. In preferred embodiment, the permanent hydrophilization compositions further comprise 0.001% to 10% by weight of silicone compounds, most preferably from about 0.01% to about 5°/ by weight of silicone compounds. In another preferred embodiment, the silicone compounds comprise silicone compounds of the polydimethylsiloxane and cationically-modified polydimethylsiloxane type.
The invention also provides a detergent, rinse, or drying auxiliary formulation for cars, comprising: (a) from about 5°/ to about 10 20% by weight of at least one quaternary ammonium compound selected from the group consisting of compounds of the general formula (I) and the general formula (II)~ and (b) from about 1% to about 20°/ by weight of a secondary surfactant selected from the group consisting of nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, and ionic surfactants, and blends thereof.
In preferred embodiments, the secondary surfactant is selected from the group consisting of alkylbenzene sulfonates, a - olefin sulfonates, and xylene sulfonates.
The present invention also provides a composition comprising:
(a) at least one compound selected from the group consisting of compounds of the general formula (I) and the general formula (II)~ (b) a solvatrope or coupling agent or blends thereof and (c) an oil or hydrophobic organic component and blends thereof. In a preferred embodiment of the invention, the composition further comprises 25 water. In yet another preferred embodiment of the invention, the amount of the compound of formula (I) and/or (II) is about 0.1 wt.% to about 65 wt.% of the formulation the amount of solvatrope or coupling agent is about 0.1 wt.% to about 65 wt.°/ of the formulation, the amount of oil or hydrophobic organic component is about 0.1 wt.%
to 65 wt.°/ of the formulation, and the amount of water is about 20 to 99.? wt.% of the formulation, preferably about 35 wt.% to about 99.?

SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 wt.%. In still other preferred embodiments of the invention, the composition comprises a mixture of two or more different solvents or coupling agents or the solvatrope or coupling agent is selected from the group consisting of hydroxypivalyl hydroxypivalate and its alkoxylated derivatives, TMPD, TMPD alkoxylates, ethanol, isopropanol, butanol, 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, HPHP glycol, isopentyldiol, I,2-hexanediol, ethylene glycol butyl ether, hexylene glycol, isoprene glycol, sorbitan ethoxylates, 2-butoxyethanol, Cs-Ciz diols/triols and ester diols/triols and their alkoxylated derivatives, glycol ethers, and mixtures thereof. In another preferred embodiment of the invention, the oil or hydrophobic organic component is selected from the group consisting of fatty acids fatty amides fatty alcohols~ fatty oils fatty esters made from a Cs-Cz2 fatty acid and a Ci-Cs alcohoh dialkyl esters ,15 mineral oih mineral seal oils silicone oils petrolatums~
monoglycerides~ diglycerides~ triglycerides~ aliphatic, paraffinic, and naphthalinic hydrocarbons oils and spirits and mixtures thereof. In yet another preferred embodiment of the invention, the composition comprises a personal care emollient, which may be selected from the group consisting of acetylated lanolin, aminopropyl dimethicone, ammonium hydrolyzed collagen, ammonium lauroyl sarcoainate, amodimethicone, amodimethicone/dimethicone copolyol, amodimethicone hydroxystearate, capryloyl hydrolyzed collagen, cetyl alcohol, cetyl esters, cetyl laurate, cocamidopropyl dimethylamine dihydroxymethylpropionate, cocoyl hydrolyzed soy protein, collagen, disodium cocoamphodiacetate, disodium cocoamphodipropionate, dioctyl dimerate, ditridecyl adipate, glycerine, glyceryl oleate, glyceryl stearate, hydrogenated soybean oil, hydrogenated tallow glycerides, isocetyl stearate, jojoba (Buxus chinensis) oil, keratin, lanolin, milk protein, mineral oil, oat (Avena sativa) protein, octyl cocoate, oleyl myristate, oleyl stearate, palm SUBSTITUTE SHEET (RULE 26) alcohol, palm glycerides, panthenol, PEG-10, PEG-32, PEG-100, PEG-200, petrolatum, PPG-6-sorbeth-245, stearyl citrate, tridecyl stearate, urea, vegetable oil, wheat amino acids, and mixtures thereof. In another preferred embodiment of the invention, the S composition further comprises a personal care emulsifier, which may be selected from the group consisting of beheneth-5, beheneth-10, beheneth-20, butylglucoside caprate, ceteareth-2, ceteareth-10, ceteareth-18, ceteth-10, ceteth-16, corn oil PEG-8 esters, Cs-ii pareth-3, Cm-is pareth-5, Cii-is pareth-12, Cia-is pareth-2, Ci2-is pareth-10, lO C12-13 pareth-15, deceth-4, deceth-5, deceth-6, cli-Ci2-is pareth-6 phosphate, dl-C12-15 pareth-8 phosphate, glyceryl cocoate, glyceryl laurate, glyceryl oleate, isoceteth-10, isodeceth-6, isosteareth-10, laureth-4, laureth-5, laureth-10, octyldodeceth-10, octyldodeceth-20, oleoyl ethyl glucoside, oleth-2, oleth-4, PEG-8 caprate, PEG-8 castor 15 oil, PEG-7 cocamide, PEG-11 cocamide, PEG-15 cocoate, PEG-20 dilaurate, PEG-32 dilaurate, PEG-8 dioleate, PEG-2 distearate, PEG-8 distearate, PEG-8 glyceryl laurate, PEG-15 glyceryl laurate, PEG-4 isostearate, PEG-4 laurate, PEG-5 octanoate, PEG-9 oleamide, PEG-S oleate, PEG-20 palmitate, PEG-6 stearate, PEG-16 tallate, 20 polysorbate 20, polysorbate 80, steareth-10, trideceth-5, undeceth-9, and mixtures thereof. In yet other preferred embodiments, the composition is emulsified into a microemulsion or is clear. In a preferred embodiment of the invention, the amount of the compound of formula (I) and/or (II) is about 5 wt.% to about 50 wt.% of the 25 formulation, the amount of solvatrope or coupling agent is about 2 wt.% to about 15 wt.% of the formulation, and the amount of oil or hydrophobic organic component is about 5 wt.% to 50 wt.% of the formulation.
For individual applications, the surfactants, viscosity 30 regulators, preservatives, corrosion inhibitors, dyes, perfumes, plant extracts or other additives customary in the respective fields can be SUBSTITUTE SHEET (RULE 26) used. These agents are sufficiently known to the person skilled in the art from current practice and the corresponding specialist literature and require no further explanation. Many other optional additives are set forth below.
5 It can be seen from the above, that ranges in amounts given for each ingredient or component of a composition or formulation set forth herein in certain circumstances may be theoretically capable of adding up to a sum of greater than 100%. As would be appreciated by those of skill in the art, it is understood that such impossible formulations (that is, those formulations whose component amounts add to a sum greater than 100%) are excluded from the claims and disclosure. For example, a formulation having components A and B, where the amount of A is said to range from 25% to 75°/ and the amount of B is said to range from 25% to 55%, if containing 65% of A, is understood to have 35% or less of B in that formulation, so that the sum of A and B does not exceed 100%. Thus, all formulations or compositions presented herein whose component amounts add to a sum less than or equal to 100% are understood as being part of the claims and disclosure.
The instant invention relates to a process of making novel tertiary amine esters of general formula (I) and the corresponding protonated or quaternized derivative thereof of general formula (II), the compounds themselves, formulations of the compounds, and their many applications. The invention is described in more detail below.
A. SYNTHESIS
The process of the instant invention involves the following steps:
(a) reacting a ketone or aldehyde having the formula R' RZ with a glycol to form a ketal or acetah SUBSTITUTE SHEET (RULE 26) (b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile~
(c) reducing the ether nitrile to a tertiary amine ketal or tertiary amine acetah 5 (d) hydrolyzing the tertiary amine ketal or the tertiary amine acetal to a tertiary amine diol~
(e) esterifying the tertiary amine diol to a tertiary amine ester of general formula (I)~ and, optionally quaternizing the tertiary amine ester of the general formula (I) to the quaternary amine ester of general formula (II).
Although detailed synthesis procedures for each of these steps are set forth below in detail, it should be understood that all of these procedures are exemplary and the invention is not limited to the examples set f rth below. As would be appreciated by those of skill 15 in the art, many different synthesis, separation, and analysis methods and different apparatus and equipment are known to those of skill in the art which would produce similar or the same results are the exemplary procedures and methods used below. It is therefore, expected that the exemplary procedures set forth below 20 may be modified, supplemented, or substituted with other methods known to those of skill in the art without departing from the spirit of the invention or the disclosure herein. All such procedures and methods are intended to be covered by the appended claims.
25 (a~ Formation of the .Ketal or the Acetal from the .I~etone or the Aldehyde and Glycol The general reaction (1) for forming the ketal or the acetal from a ketone or aldehyde of formula Rl(CO)R2 and glycol is shown 30 below.
SUBSTITUTE SHEET (RULE 26) .,.", ,, ." . _ . ;
~H ~H-C02 CH2 CH -CH2 + C -~ ~~ + HZO
OH OH OH R R
2 2 R' R2 (1) The ketal formation reaction from ketones is similar to the more familiar esterification reaction of aldehydes, although the reaction is more di~cult with ketones, see, for example, J. March, 5 Advanced Org~Bnic Chemistry: Reactions, Mechanisms and Structure, (McGraw-Hill: 1968) pp. 661-662. Therefore, the ketal reaction is preferably performed as a reflux reaction and/or the by-product water is removed during reaction to drive the equilibrium to the products.
Hypophosphorous acid (HPPA) is preferably added to maintain the 10 color during the reaction. Catalysts such as oxalic acid and sulfuric acid are also used. Although glycerol is used here, glycerol is only exemplary, and any triol where the hydroxyls are either 1,2 or 1,3 may be substituted therefor. The ketone or the aldehyde Ri(CO)R2 is preferably used in stoichiometric excess of the amount of glycerol or 15 triol used, as before, to drive the equilibrium to the products. In the reaction, water is produced as a by-product that comes over during the reaction along with unreacted ketone or is otherwise removed.
Preferably, the ketone or the aldehyde is then recycled back into the reactor. In general, the reaction is performed under atmospheric 20 conditions with a nitrogen sparge. Under such conditions, a cold trap condenser is necessary to keep the ketone or the aldehyde from becoming volatile.
Although any ketone or aldehyde of formula Rl(CO)R2, where Rl and R2 are each independently is hydrogen or a linear, branched, 25 or cyclic alkyl, alkylene, alkaryl, or aryl-containing group containing 1 to 18 carbon atoms, may be used, preferred ketones include acetone, cyclohexanone, 2-pentanone, methyl ethyl ketone, 2-hexanone, and the most preferred ketone is methyl isobutyl ketone (MIBI~, and preferred aldehydes are butraldehdye (butanal), SUBSTITUTE SHEET (RULE 26) isobutraldehyde (2-methylpropanal), n-valeraldehyde, caproaldehyde (hexanal), octanal, decanal, dodecanal, 2-ethylexanal, and benzaldenyde. MIBK has a boiling point of 117°C-118°C at atmospheric conditions. Typical charges for a batch might be as follows MIBK (55.6 wt.°/)~ glycerol (44.4 wt.%)~ oxalic acid (0.2 wt.%)~
sulfuric acid (0.05 wt.%)~ and 50% HPPA (0.10 wt.°/). The glycerol ketal of acetone (commonly called "solketal") has been known for many years and is commercially available.
A typical and preferred reaction procedure for this step is as follows. To a clean reactor, charge all raw materials start agitation and a nitrogen sparge and agitate without heat for 20 minutes to purge the air out of the reactor. After a 20 minute sparge, start the heat, setting the temperature to 170°C. Initially, the reaction temperature will be about 115°C-120°C~ however, as the amount of ketone declines and the amount of ketal rises, the reactor temperature will rise. In general, constant heating is necessary in order to keep the reaction going. Generally, the reaction is followed using analytical procedures known by those of skill in the art, for example, gas chromatography (GC). If GC is used, a representative sample is withdrawn from the reactor and the sample is derivatized with trimethylchlorosilane (TMCS) and bis(trimethylsilyl)trifluoroacetamide (BSTFA) before being injected into the GC. Samples after would typically be taken after four hours, then every hour thereafter. The reaction is considered complete when a desired endpoint is reached, for example, when there is less than 2% free glycerin.
Once the reaction is completed, the excess ketone is removed.
A preferred procedure would be to cool the reactor to below 100°C
while continuing the nitrogen sparge~ when the temperature reaches 100°C, a vacuum is applied to the reactor until a pressure of about 150 mmHg (1.98 kPa) is reached at this point the reactor is heated SUBSTITUTE SHEET (RULE 26) slowly to 130°C and the vacuum is increased to about 100 mmHg (1.33 kPa), which should be sufficient to remove the ketone or the aldehyde from the reactor. As noted previously, a cold condenser is needed to trap the ketone or the aldehyde, otherwise, the ketone or the aldehyde will volatilize and cannot be reused. A distillation column with the appropriate number of plates may also be required to separate the ketone or the aldehyde from the ketal or the acetal product. Using such a distillation column, the first 80% of the ketone or the aldehyde removed will contain very little ketal product, 10 however, the last 20% is being removed, the ketal or the acetal product will be found in the ketone or the aldehyde. Once the ketone or the aldehyde has been removed, the reactor is cooled down under vacuum and the vacuum is then broken with a nitrogen sparge.
Before the next step, the acids in the ketal or the acetal product will 15 have to be neutralized with an equivalent molar quantity of dry sodium hydroxide or potassium hydroxide (no water is to be used).
This step provides about 84% of the theoretical yield of ketal.
(b) Formation of the Ether Nitrite from the Ketal or the Acetal 20 and Acrylonitrile The general reaction (2) for forming the ether nitrite from the ketal or the acetal and acrylonitrile is shown below.
iH2 CH -CH2 O--CH2 CH2 CN
OH ~ ~- H~ C~H ---~ CHz CH-CHz / i ~ I
H~ ~~N \ /O
R' R2 /
R~ R2 25 (2) In this step, the ketal or the acetal obtained from the prior step is reacted with acrylonitrile with, a strong base catalyst to form the ether nitrite. Subsequently, the catalyst is neutralized with a is SUBSTITUTE SHEET (RULE 26) slight excess of sulfuric acid to prevent the reverse reaction and the excess acid is neutralized with triethanolamine (TEA) to minimize polymerization of the ether nitrite product. Preferably, the crude ether nitrite product is then fractionally distilled under vacuum to make the final purified ether nitrite product.
A typical and preferred reaction procedure is as follows. The reactor to be used and all charge lines to the reactor should be clean and dry. Charge the reactor with the ketal or the acetal, powdered potassium hydroxide, and 25% tetramethylammonium hydroxide in IO methanol, heating the reactor to 50°C while stirring the reactants with a slow nitrogen sparge. Once the reactor reaches 50°C, the nitrogen sparge is shut off and a high vacuum (2 mmHg to 5 mmHg (266 Pa to 666 Pa)) is gradually applied to the reactor to distill off the methanol from the catalyst. The high vacuum is maintained until at I5 least 75% of the theoretical methanol has distilled off, at which point the vacuum is broken with a light nitrogen sparge which is maintained. The acrylonitrile is metered in over a 3-6 hour period with the addition rate slowing down as the addition proceeds. This reaction will be exothermic and the temperature should not be 20 allowed to exceed 65°C. After the acrylonitrile addition, the reactor temperature is maintained at 65°C and samples are taken every hour or two for GC analysis. The reaction is considered complete when a desired endpoint is reached, for example, when the amount of free ketal is below 5 wt.% of the reaction mixture. Once the free ketal 25 content is acceptable, sulfuric acid is added to neutralize the base catalyst, after which the stirring of the reaction mixture is maintained for 30 minutes and TEA is added to neutralize any excess sulfuric acid. The stirring of the reaction mixture is maintained for another 30 minutes and then a fractional vacuum distillation of the 30 crude product mixture is prepared.

SUBSTITUTE SHEET (RULE 26) During fractional vacuum distillation, a vacuum of about 2 mmHg to about 5 mmHg (266 Pa to 666 Pa) is gradually applied to the reactor and the reactor temperature is then raised. For MIBK-derivatives, depending upon the vacuum, the bulk of the forecut will come off between about 65°C and 120°C. It should amount to 3-6 wt.% of the crude product and can be recycled into the next batch since it consists mostly of the ketal or the acetal starting material.
The main fraction will come off between 120°C and 175°C and should amount to 85-95% of the crude product. The residue should amount to 3-10°/. Generally, typical charges (assuming the use of MIBK
ketal derivative) would be as follows: ketal (76.6 wt.%)~ acrylonitrile (22.9 wt.°/)~ tetramethylammonium hydroxide (25 wt.% in methanol) (0.4 wt.%)~ potassium hydroxide (0.1 wt.%)~ with sulfuric acid and triethanolamine used as needed.
(c~ Formation of the Tertiary Amine Ketal or the Tertiary Amine Acetal from the Ether Nitrite The general reaction (3) for forming the tertiary amine ketal or the tertiary amine acetal from the ether nitrite is shown below.
~Hs ~H2 CH2 CN ~-CH2 CH2 'CH2 N\
CH2 CH-CH2 -.,. CH2 CIH--CHz CH3 R/ Rz ~\
R Rz (3) In this step, the ether nitrite is reacted with ammonia and hydrogen in the presence of a catalyst to form the primary amine.
The primary amine is then converted into the dimethyl tertiary amine ketal or the dimethyl tertiary amine acetal by adding formaldehyde along with hydrogen. Generally, typical charges (assuming the user of MIBK ether nitrite derivative) would be as SUBSTITUTE SHEET (RULE 26) follows: MIBK ether nitrile (59.1 wt.%)~ nickel catalyst available from Activated Metals of Tennessee under the tradename AMCAT 5343 (1.2 wt.%)~ formaldehyde (37% cone) (39.7 wt.%)> with hydrogen and ammonia used as needed.
The formaldehyde charge is calculated based on the molecular weight of the primary amine, that is, the total amine value (TAV), as follows (56108/TAV). The addition of a greater formaldehyde charge will tend to make the color of the product dark. The full calculation is as follows:
grams of 37% formaldehyde = [grams of ethernitrile x TAV/56108] x [30 x 2/0.37]
A typical and preferred reaction procedure is as follows. To a clean reactor, charge the ether nitrile and the catalyst, for example, AMCAT 5343 Ni catalyst. The reactants are agitated and a vacuum is applied to 100 mmHg or below while heating is applied to raise the temperature to 40°C. When the reactor reaches 40°C, the reactor is sealed and ammonia is added to achieve a pressure of 90 psig. The reactor is then heated to 120°C, at which point the ammonia pressure is adjusted to 150 psig, and hydrogen gas is subsequently added to achieve a pressure- of 600 psig. During this time, the temperature is maintained at 120°C and the pressure is maintained at 600 psig with the further addition of hydrogen gas. After 2 hours, sample for TAV.
For the MIBK ether nitrile, the theoretical TAV for the primary amine is 242.6. The reaction should be continued until a selected endpoint is reached for example, for the MIBK ether nitrile a TAV
of 230.5 or higher (95.0% of theoretical) may be considered an appropriate endpoint. If TAV is lower than the selected endpoint (for example, 230.5 for the MIBK ether nitrite), the reaction is continued for 30 minutes and rechecked until the selected TAV
endpoint is reached. When the TAV endpoint is reached, the hydrogen and ammonia is vented to atmospheric and a vacuum to 100 mmHg or below is applied. The reactor is then sealed and SUBSTITUTE SHEET (RULE 26) pressurized to 600 psig with hydrogen. The formaldehyde (37%
solution) is then added at a constant rate that will allow complete addition of the entire amount over 5 hours. At the conclusion of the formaldehyde addition, the temperature is maintained at 120°C and 600 prig for 30 minutes, at which point the reactor is cooled to about 75°C and vented to atmospheric pressure. The reactor contents are then filtered and the recovered crude product, at this point, will be two layers. The layers are allowed to separate and TAV and 3AV
(teriary amine value) are measured for the top layer. The tertiary AV (3AV) should be about 90% or more of the TAV. Typical results would be around 174 TAV and 164 3AV. Preferably the bottom layer is retained and used in the hydrolysis step. Lab batches for forming the MIBK tertiary amine ketal have given about 85.1°/ of the theoretical yield. The major losses of products are likely due to the 15 filtration and vacuum procedures.
(d~ Hydrolysis of the Tertiary Amine Ketal or the Tertiary Amine Acetal to the TertiaryAmine Diol The general reaction (4) for forming the tertiary amine ketal or the tertiary amine acetal from the ether nitrile is shown below.

O~H2 CH2 CH2 N
I -CH-CH CHa O-CH2 CH2 CH2 N~H3 O +HZO -~ CHZ CH-CHZ CH3 / \
\ ~ I R~ R2 ~C\ OH OH
R~ Rz (4) In this step, the tertiary amine ketal or the tertiary amine 25 acetal is hydrolyzed to obtain the tertiary amine diol (hydrolyzed amine). The hydrolysis reaction generally takes place under high temperatures (for example, 175°C) and acidic conditions. It has been discovered that the acid that yields the highest hydrolysis rate is formic acid and is therefore preferred. Other weak or strong acids, SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iTS00/23071 whether organic acids or mineral acids, such as sulfuric, methane sulfonic, and oxalic, may also be used but do not give as high a yield as formic acid. A system of removing and separating the ketone (aldehyde)/water-IPA mixture is necessary to optimize this step.
As noted in the previous step of preparing the tertiary amine ketal or the tertiary amine acetal, water is left in the product. This water, which is not removed, is a large fraction of reaction product mixture of the previous step, typically ranging from 35 wt.% to 50 wt.°/ of the total reaction product mixture. In this step, the water is 10 used to hydrolyze the tertiary amine ketal or the tertiary amine acetal to the tertiary amine diol. The TAV should be calculated in order to determine the neutralization equivalent (NE). Typically, the number of moles of formic acid added is one-fourth that of the number of moles of tertiary amine ketal or tertiary amine acetal.
1 S Generally, typical charges (assuming the use of MIBK ether nitrile derivative) would be as follows: tertiary amine ketal (37.3 wt.%)~
isopropyl alcohol (IPA) (30.6 wt.%)~ water (30.6 wt.%)~ and formic acid (~1.5 wt.%).
A typical and preferred reaction procedure is as follows. To a 20 clean reactor, charge all raw materials. The reactants are agitated and a nitrogen purge performed twice. Nitrogen is then added to 50 psig and the absence of leaks confirmed. Such purging of the reactor with nitrogen is necessary to keep the hydrolyzed amine in good color and air must be kept out of the reactor. The nitrogen is vented until 25 a pressure of 20 psig is reached and the reactor is heated to 175°C.
Generally, the reaction is followed using analytical procedures known by those of skill in the art, for example, gas chromatography (GC). If GC is used, a representative sample is withdrawn from the reactor and the sample is derivatized with trimethylchlorosilane (TMCS) and 30 bis(trimethylsilyl)trifluoroacetamide (BSTFA) before being injected into the GC. Samples would typically be taken after four hours, then SUBSTITUTE SHEET (RULE 26) every hour thereafter. The reaction is considered complete when a desired endpoint is reached, for example, when the percent of hydrolyzed material is greater than 98%.
Once the reaction is finished, the water and ketone are removed by cooling the reactor to 80°C and then applying a vacuum to the reactor until it reaches about 150 mmHg~ at this point the reactor is slowly heated to 130°C and the vacuum is increase to about 85 mmHg. This procedure should be sufficient to remove the ketone or the aldehyde and water from the reactor. It should be noted that a 10 cold condenser is generally needed to trap the MIBK or ketone, which will otherwise volatilize and cannot be reused. A distillation column with the appropriate number of plates may be used to separate the ketone or the aldehyde from the water.
Once the ketone or the aldehyde and water have been removed from the reactor, the reactor is cooled down under vacuum and the vacuum is then broken with a nitrogen sparge. Before the tertiary amine diol can be esterified, it needs to be further purified, for example, by distillation. The MIBK derivative will distill at about 160°C at 5 mmHg vacuum.
(e~ Esterification ofthe TertiaryAmineDiol to the TertiaryAmine Ester The general reaction (5) for the esterification of the tertiary amine diol to the tertiary amine ester is shown below.
o-~ + 2 Fi~000H ~ ~z +2 O= i ~O
F~

SUBSTITUTE SHEET (RULE 26) The esterification process can be done under nitrogen sparge at atmospheric conditions or nitrogen sparge under vacuum. Water is the by-product of this reaction and hypophosphorous acid (HPPA) is used as the esterification catalyst. Fatty acids used for the esterification steps are monobasic fatty acids, which may be used in the form of their glycerides, methyl or ethyl esters or as free acids.
The extent of unsaturation in these fatty acids or fatty acid esters is, as far as desired, adjusted to a desired iodine value by known catalytic hydrogenation processes, or achieved by mixing fatty components which are completely hydrogenated with fatty components which are not completely hydrogenated. The iodine value (LV.), a measure of the mean degree of saturation of a fatty acid, is the amount of iodine which is absorbed by 100 grams of the compound to saturate the double bonds. Preferred according to the present invention are tallow fatty acids and palm fatty acids with iodine values between 15 and 50. These are commercially available products and can be obtained from various firms under the respective trade names for these products. According to the invention, preference is given to tallow fatty acids and palm fatty acids having iodine values between 1-50 and rapeseed oil fatty acids having iodine values between 80-120. They are commercially available products and are supplied by various companies under their respective tradenames. A typical charge is as follows: tertiary amine diol (26.2 wt.%)~ tallow fatty acid (DISTAL 51) (73.6 wt.%)~ and 50% HPPA (0.2 wt.°/). The TAV needs to be determined in order to find the neutralization equivalent, which is needed to charge the proper quantity of amine and fatty acid into the reactor. In addition, the Acid Value (AV) for the desired fatty acid should be determined to ensure accurate charging.
A typical and preferred reaction procedure is as follows. To a clean reactor, charge all raw materials. The reactants are agitated SUBSTITUTE SHEET (RULE 26) a uc~JU I~JN~ ~ ~ ~r ~ a and a nitrogen sparge applied while the reactor is heated and maintained at 185°C. Generally, the reaction is followed using analytical procedures known by those of skill in the art, for example, acid value analysis. Samples would typically be taken after four hours, then every hour thereafter. The reaction is considered complete when a desired endpoint is reached, for example, when the acid value is below ten. If acid value is remaining constant over two samplings, the TAV is measured to determine if enough amine is present. If the TAV is low, additional tertiary amine diol is added if the TAV is normal, a vacuum may be needed to finish the reaction.
Once the acid value is acceptable, the esterification is considered complete and the reactor is cooled to room temperature under a nitrogen sparge.
Protonation or Quaternization of the Tertiary Amine Ester to 1 S the Amine Ester Salt or the Quaternary Amine Ester The general reaction (6) for the quaternization of the tertiary amine ester to the quaternary amine ester is shown below.

i -CHZ CHZ-CHs N~ O
(~
CHZ CIH'CIH2 ~H9 Q-'CH2 CH2 CH2 i -CH3 + QA --~" CIHz CH-CH2 CH3 O=C C=O O O

O I i -O
R' R3 (6) In this step, which is optional, the tertiary amine ester is protonized (using an acid) or quaternized (using a quaternizing agent) to the respective amine salt or quaternary ammonium compound, respectively. The quaternization is carried out by known processes, generally involving the addition of a slight excess of the quaternizing agent, with stirring and optionally under pressure, to SUBSTITUTE SHEET (RULE 26) the ester amine, optionally with use of ~a solvent, preferably isopropanol, ethanol, 1,2-propylene glycol and/or .dipropylene glycol, and monitoring completion of the reaction by checking the TAV.
Examples of quaternizing agents which can be used are short-chain 5 dialkyl phosphates and sulfates, such as, in particular, dimethyl sulfate (DMS), diethyl sulfate (DES), dimethyl phosphate, diethyl phosphate, and short-chain halogenated hydrocarbons, in particular methyl chloride or dimethyl sulfate. If quaternization is desired, laA
represents the quaternizing agent, which may be any quaternizing 10 agent known to those of skill in the art. If protonization is desired, QA may alternatively represent any organic or inorganic acid, that is, Q may be H. In either case, A- is an inorganic or organic anion. In general, A-, whether shown or understood, may be selected, without limitation, from the group consisting of fluoride, chloride, bromide, 15 iodide, chlorite, chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and salicylate, and the like. Preferred examples of the anions are chloride, bromide, methyl sulfate, ethyl sulfate, and salicylate.
20 A typical and preferred quaternization reaction procedure is as follows. The reactor and all charge lines to the reactor are made clean and dry and the reactor is charged with the required amount of tertiary amine ester and solvent, for example, isopropanol. The reactants are stirred with a slow nitrogen sparge and heated to 50°C, 25 at which point the nitrogen sparge is discontinued and a vacuum is applied to the reactor until the pressure reaches 100 mmHg to 200 mmHg. The molecular weight of the tertiary amine ester should be determined to calculate the proper quantity of quaternizing agent to be used, generally a slight excess. The required amount of 30 quaternizing agent, for example, methyl chloride, is then added.
Because the quaternizing reaction is exothermic, the reactor is cooled SUBSTITUTE SHEET {RULE 26) so that the temperature does not exceed 88°C-96°C. After the quaternizing agent addition is complete, the reactor is maintained at 90°C and take a sample every half hour for free amine analysis. The reaction is considered complete when a desired endpoint is reached, for example, when the amount of free amine is below 3 wt.°/ of reaction mixture. Once the free amine content is acceptable, the reactor is cooled to 60°C, at which point a slow nitrogen purge is used to remove excess quaternizing agent, until a desired level is reached.
The solvent should be retained until this point is reached and the 10 material must be blanketed with nitrogen as long as it is molten.
Generally, typical charges (assuming the use of MIBK tertiary amine ester derivative) would be as follows: MIBK tertiary amine ester (78.6 wt.%)~ isopropyl alcohol (15.0 wt.%)~ and methyl chloride (6.4 wt.%).
B. APPLICATIONS
The present disclosure shows that the compounds and formulations of the present invention may be used for many purposes and suitable additives may be incorporated therein based on the 20 ultimate application. Such ingredients, for example, may contribute significantly to the ease of formulation, stability, dispersibility, fluidity, and the performance properties of the compositions.
In one aspect, the present invention provides compounds and formulations that have the ability to impart to fabric (that is, articles 25 of clothing, textiles, and so forth), properties including softness to the touch, ease of handling, increased lubricity, and a reduced tendency to carry or pick up static electricity. One form in the compounds and formulations of the present invention are provided is as a liquid, for instance, as an emulsion or as a solution/suspension of the desired 30 components. During use, an appropriate controlled amount of the liquid formulation is employed, for example, by pouring the SUBSTITUTE SHEET (RULE 26) formulation directly into the washing machine. Typically, the formulation is dispensed during the rinse cycle of the washing machine, either poured in by hand or metered in by an appropriate automatic metering device with which the washing machine is equipped.
In addition, the present invention also provides compounds and formulations that may find use as textile treatments to add lubricity and finishing to the fabric prior to shipping the textile to market, particularly when used in conjunction with a resin bath. In 10 such an application, the textile mill would typically apply the formulation in dilute emulsions and rapidly dry the excess water from the fabric to lubricate the fibers and give it a surface finish.
The present invention also provides compounds and formulations that are useful in personal care products such as hair or 1 S skin conditioners. In this application, the present invention provides formulations that impart softness, lubricity, and improve the surface appearance of the skin or hair. The hair conditioners additionally reduce the tendency for tangling, improve the manageability, and impart a soft feel to the hair strands. Such hair conditioners are 20 applied as dilute emulsions to the hair following its wash or may be incorporated into a combined conditioner and shampoo composition, also known as a conditioning shampoo, two-in-one shampoo, or two-in-one. Such hair and skin conditioning formulations typically incorporate effective amounts, for example, 0.1 wt.% to 10 wt.°/ or 25 more, of emollients, humectants, and/or slip and conditioning agents, such as organopolysiloxanes and the like, to create formulations that are monophasic and can be made to be translucent or even clear.
Compounds suitable for use as emollients, humectants and conditioners in formulations for skin care or hair care can be found in 30 the CTFA Cosmetic Ingredient Dictionary, 3d Editioa, and in the SUBSTITUTE SHEET (RULE 26) CTFA Cosmetic Ingredient Handbook, which are hereby incorporated by reference in their entireties.
The compositions of the present invention are particularly useful in applications that take advantage of their ability to disperse hydrophobic material, to stabilize foam, and to enhance the penetration and wetting exhibited by the compositions. Examples of such compositions and applications are set forth below, each revealing an additional aspect of the present invention.
The compounds and formulations of the present invention may 10 be used as oil dispersants and oil slick dispersant formulations for application onto oil, for example, onto a film of oil, to disperse the oil.
The compounds and formulations of the present invention may also be used as oil well stimulation and oil recovery aids for injection into oil wells in order to penetrate into the surface of the borehole and assist liberation of crude oil from the matrix material into the borehole, from which it can be brought to the surface.
In addition, the compounds and formulations of the present invention may be used as vehicles for hydrophobic sheeting agents such as mineral oil and silicone oil. Such oils can readily be 20 dispersed in compositions, according to the present invention, and the resulting formulations are highly satisfactory when sprayed or otherwise applied to a surface, such as a freshly washed automobile surface, to impart a lustrous, water-repellent film to the surface.
The compounds and formulations of the present invention may also be used as rinse aids, such as used in automatic dishwashers, wherein application of the composition of the present invention disperses residual hydrophobic matter, including cleaner residues and films.
Furthermore, the compounds and formulations of the present 30 invention may be used as paper deinking and ink flotation agents for treating waste inked paper by addition to the pulp slurry such that SUBSTITUTE SHEET (RULE 26) the ink is liberated from the paper and prevented from redepositing onto the paper. In this application, the ink is typically dispersed or even fully solubilized in the resulting solution when the ink particles are floated from the fibers.
5 The compounds and formulations of the present invention may also be used as asphalt emulsion agents for emulsifying finely divided asphalt (at loadings of typically 1-20 wt.%), with or without particulate filler such as sand, in an aqueous phase which comprises the composition according to the present invention.
Moreover, the compounds and formulations of the present invention may be used as corrosion inhibitor agents for application to any surface to which one desires to apply a film that protects against corrosion. The composition would typically contain an effective amount of a hydrophobic corrosion inhibiting material, such as liquid or waxy-solid fatty ester, paraffinic hydrocarbon, silicone, or the like, dispersed in a composition according to the present invention.
In addition, the compounds and formulations of the present invention may be used with ore flotation agents for separating ore from rock. Such floatation agents might include, for example, the 20 agent available from Witco Corporation under the tradename WITCAMINE~ AL42-12. Typically, the ore floatation agent (a collector or frother, depending on the characteristics of the particular separation desired in the flotation cell) or mixture thereof, which is a relatively hydrophobic material, is dispersed in a composition according to the invention and an effective amount is added (on a batch or continuous basis) to the ore separation cell. This permits the formulator to improve the dispersibility of the hydrophobic ore floatation agent, which often improves the performance of the mineral separation by improving the efficiency of the floatation 30 agent's dispersibility. This can enable the operator to use smaller amounts of the ore floatation agent to achieve the desired purpose SUBSTITUTE SHEET (RULE 26) because there is a higher concentration of active ingredients available.
In addition, the compounds and formulations of the present invention may be used as suspension concentrates and emulsifiable 5 concentrates of herbicides, pesticides, miticides, fungicides, or bactericides, wherein one or more liquid or solid, generally hydrophobic, active ingredients are dispersed in a composition according to the present invention. The resulting concentrate can be applied as a concentrate on or around desired vegetation, but is more 10 often mixed with water (for example, at the point of use) to form a final dilute formulation having the desired concentration of active ingredient(s). This application takes advantage of the noteworthy property of this invention that addition of the water does not disrupt the monophasic state, nor the fluidity, of the formulation.
15 As noted above, the compositions and formulations of the present invention can also optionally contain other components, depending on the additional properties one may wish to provide in the finished composition. Such additional components include, but are not limited to, additional coupling agents and solvents, additional 20 quaternary ammonium compounds, additional surfactants, hydrocarbon actives, perfumes, preservatives including bacteriocides and fungicides, insect and moth repelling agents, polymeric soil release agents, antistatic agents, dyes and colorants, especially bluing agents, viscosity control agents, antioxidants, silicones, 25 defoaming agents, antifoaming agents, emulsifiers, brighteners, opacifiers, freeze-thaw control agents, shrinkage control agents, aloe, humectants, skin protectants, feel modifiers, and mixtures thereof.
Each of the foregoing reactions can be carried out in solvent or in solvent-free conditions, in each case employing conditions well 30 established for the respective reactions in this field.

SUBSTITUTE SHEET (RULE 26) C. FORMULATIONS AND PROPERTIES
The products as described herein exhibit a number of desirable properties making them particularly suitable for formulation into commercial products such as fabric softeners and other commercial products, as mentioned above.
Most notably, the compounds of formulas (I) and (II) can' readily be formulated into useful compositions such as aqueous compositions, which achieve the desired functionality and which are clear, that is, transparent or translucent. This property can be 10 realized at a variety of concentrations of active ingredient, with or even without special solvents or coupling agents. In addition, microemulsion formulations can be made that improve the ease of application and effectiveness of the resulting formulation.
In particular, the compounds of formulas (I) and (II) and their 15 ability to make clear and biodegradable formulation, for example, fabric softeners or personal care formulations, is highly unusual. The compounds of formulas (I) and (II) are most often clear when the iodine value (IV) of the fatty acids used in the esterification is high (about 50 to about 120), for example, canola or oleic fatty acids. The 20 resulting concentrated, clear, and biodegradable formulations have many advantageous properties, depending on the application, for example, such fabric softeners would improve softening, reduce staining, and improve water absorbency over other types of formulations. These new products give good clarity and dispersibility 25 in formulations with solvents selected from a class of C2 to C10 diols, mono-ols, glycol ethers, and esters and/or ester diols. These ester quats can be easily formulated into clear softeners using solvents such as but not limited to: mono-ols C2 to C6 such as IPA, ethanol and propyl alcohol etc., diols of C2 to C10 such as TMPD, and its 30 alkoxylates, hexylene glycol, 2-ethyl-1,3-hexanediol, etc. and ester diols such as hydroxy pivalyl hydroxyl pivalerate (C12 ester diol.

SUBSTITUTE SHEET (RULE 26) Other solvents can include but are not limited to glycol ethers such as propylene glycol n-butyl ether, diethylene glycol n-butyl ether etc.
These solvents are added to these unsaturated ester quats (these ester quats are present in the formulation at about 10 to 50°/ active) S at levels between 4 and 50% with the optimum about 8 to 20%. To little solvent and the formulation become thick and opaque and does remain stable. Nonionic and cationic surfactants such as amine ethoxylates, alcohol ethoxylates, and monoalkyl ethoxylated amine quats can be added to improve stability, fluidity and improve dispersibility. Calcium chloride or other salts can be added to thin formulation viscosity and improve stability cost effectively. Salts, both inorganic and organic salts, can be added between 0 to 2% active level. A typical formulation might be:
_ EXAMPLE A: Fabric Softener Com onent Amount (wei ht ~6) Canola/oleic-based soketal ester uat 40.0 TMPD ethox late (1 mole) 11.0 K 205 (Coconut Amine 5 Mole Ethoxylate)1.0 1%

Fra ante 1.5 Calcium chloride 0.10 Water, 90 German Hardness to I00 Emulsion or microemulsion formulations according to the present invention have many applications, for example, as car "cheater" wax spray technology to improve beading and act as a drying aid, as fabric softeners, and as personal care products, for 20 example, as a moisturizer/conditioner if the compound of formulas (I) and/or (II) is not skin irritating. In addition, such emulsions or microemulsions may find uses as emulsifiers for silicone oils and pesticides, and as emulsifiers/softeners for textile finishing.
Generally such formulations include three components: (a) compound 25 of formulas (I) and/or (II), (b) a solvatrope or coupling agent and blends thereof, and (c) an oil or hydrophobic organic component and SUBSTITUTE SHEET (RULE 26) blends thereof, which are blended in water. These microemulsion formulations give stable, clear (translucent) products that do not go through thick or viscous gel phases but disperse readily and quickly into very fine particle size microemulsions when diluted or dispersed 5 in water. These microemulsions have many additional advantages over conventional microemulsions, such as the products sold by Witco Corporation under the tradename CA.RSPR,AYTM: reduced particle size, improved beading and sheeting over, and improved biodegradability, especially when used with methyl ester oils.
If the resulting formulation is intended to be used as a personal care formulation, the amount of the compound of formulas (I) and/or (II) is about 0.1 wt.% to about 65 wt.% of the formulation, preferably about 0.1 wt.% to about 25 wt.°/, and most preferably about 0.1 wt.% to about 5 wt.%~ the amount of solvatrope or coupling 15 agent is about 0.1 wt.% to about 65 wt.% of the formulation, preferably about 0.1 wt.% about 25 wt.°/, and most preferably about 0.1 wt.% to about 0.5 wt.°/ ~ the amount of oil or hydrophobic organic component is about 0.1 wt.°/ to 65 wt.°/ of the formulation, preferably about 0.1 wt.°/ to about 25 wt.%, and most preferably about 0.1 wt.% to about 5 wt.°/ ~ and the amount of water is about 20 to 99.? wt.% of the formulation, preferably about 35 wt.°/ to about 99.7 wt.%, and most preferably about 65 wt.% to about 99.? wt.%.
If the resulting formulation is intended to be used in a car drying aid formulation or other application, the amount of the 25 compound of formulas (I) and/or (II) is about 5 wt.% to about 50 wt.%
of the formulation, preferably about 10 wt.% to about 30 wt.°/, and most preferably about 15 wt.% to about 25 wt.°/~ the amount of solvatrope or coupling agent is about 2 wt.°/ to about 15 wt.% of the formulation, preferably about 3 wt.% about 10 wt.%, and most 30 preferably about 6 wt.% to about 10 wt.%~ the amount of oil or hydrophobic organic component is about 5 wt.% to 50 wt.°/ of the SUBSTITUTE SHEET (RULE 26) formulation, preferably about 10 wt.°/ to about 30 wt.°/, and most preferably about 15 wt.% to about 20 wt.%~ and the amount of water is about 10 to 70 wt.% of the formulation, preferably about 20 wt.% to about 60 wt.%, and most preferably about 30 wt.°/ to about 50 wt.%.
Although the compounds of formulas (I) and/or (II) have many potential uses, in particular, they exhibit highly satisfactory fabric softening capabilities. Thus, the compounds of formulas (I) and/or (II), as well as mixtures of such compounds, can be advantageously formulated appropriately into products useable as fabric softeners.
Preferred emulsions useful as fabric softener compositions can contain about 2 wt.% to about 80 wt.%, preferably 5 wt.% to 30 wt.%, and more preferably 6 wt.°/ to 25 wt.%, of one or more compounds corresponding to formulas (I) and/or (II). In general, higher solids contents can be provided more easily with lower degrees of 15 quaternization. On the other hand, higher degrees of quaternization (such as a degree of quaternization approaching 2.0 for a diamine), lead to aqueous formulations wherein the maximum acceptable solids content without excessive solubility problems is lower.
The compounds of formulas (I) and/or (II) can be formulated into compositions, including clear fabric softener compositions. Such fabric softening composition would typically include water and one or more of the solvents which are conventionally used in formulating fabric softeners. Examples of such solvents include ethanol, isopropanol, hexylene glycol, propylene glycol, diethylene glycol, or 25 similar solvent of mixture thereof, as a concentrate or more dilute form, depending on the application. Selection of a suitable solvent for a particular application is well-known to those of skill in the art.
Such formulations generally comprise about 10 wt.% up to about 50 wt.% of one compound of formulas (I) and/or (II) or a mixture thereof.
30 The compounds of formulas (I) and/or (II) can be formulated with greater ease than is encountered with conventional quaternary SUBSTITUTE SHEET (RULE 26) ammonium fabric softener actives. Most conventional quaternary ammonium compounds exhibit a tendency to form a gel during dilution with water when formulated in clear formulations. When formulated in clear formulations, however, the compounds of 5 formulas (I) and/or (II) show very little gelation, or no gelation at all, during dilution with water, even cold water, which would be expected to provoke gelation. This freedom from a tendency to gel means that compositions including compounds of formulas (I) and/or (II) can be prepared at active concentrations of 40 wt.% or higher, for example, 10 even 50 wt.% or higher. The preparation itself of such formulations is much simpler: the freedom from gelation means that when a formulator chooses to manufacture a more concentrated product for resale to the consumer, there is no need for special treatment to deal with gel formation. Also, the freedom from gel formation means that 15 the consumer can use the more concentrated product directly without concern that a gelled byproduct would form. For example, the consumer could add a concentrated fabric softener composition according to the present invention directly into the wash water in the wash or rinse cycle, without any apprehension that a gel will form 20 that that would reduce softening efficiency or leave a deposit on. the clothes.
It should be noted that the ability of the compounds of formulas (I) and/or (II) to form a clear formulation, at lower and at higher concentrations, extends also to formulations which also 25 contain one or more other quaternary ammonium compounds as fabric softener co~actives, as well as other additives as disclosed herein.
D. ADDITIONAL CONVENTIONAL QUATERNARY AMMONIUM

Additional conventional quaternary ammonium compounds or salts may be present with the compound or compounds of formulas (I) SUBSTITUTE SHEET (RULE 26) and/or (II) in accordance with the present invention. The compounds presented below are only examples of conventional quaternary compounds that are suitable for use in the formulations of the present invention. As with the compounds of formulas (I) and/or (II), 5 these conventional quaternary ammonium compounds (quats or salts) may have an anion to provide electrical neutrality and, in general, such anion may be any anion which is not deleterious to the properties of the overall compound. Thus, in the structural formulas (i) to (xxiii) below, the counteranion, whether designated as A- or not 10 shown but understood, may be selected, without limitation, from the group consisting of fluoride, chloride, bromide, iodide, chlorite, chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and salicylate, and the like.
15 Preferred examples of the anions are chloride, bromide, methyl sulfate, ethyl sulfate, and salicylate. If the anion is monovalent (has a charge of -1), A- represents the anion group, if the anion is divalent (has a charge of -2), A- represents half of the anion group, if the anion is trivalent (has a charge of -3), A- represents a third of the anion 20 group, and so on.
The conventional quats that may be formulated with the compounds of formulas (I) and/or (II) in accordance with the present invention include, but are not limited to, nitrogenous compounds selected from the group consisting of quaternized or acid salt 25 derivatives of () alkylene diamines, diamides, or amidoamines, includrng compounds of the formula Z
R~ N ~ R
\R /

of o_, of o_, SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 wherein each Ri is an acyclic alkyl or alkylene Ci2-Czi hydrocarbon group, each Z is -(Rz0)o-4H, or -RzH, and R2 and R3 are 5 divalent Cl-Cs alkylene groups substituted imidazoline compounds having the formula:
V
R~
R' HO'~
(lid reaction products of higher fatty acids with alkylenetriamines in, for example, a molecular ratio of about 2:1, the reaction products containing compounds of the formula:
H H H
O N I N
~R~

R~ R, wherein Ri, RZ and Rs are defined as above and v) substituted imidazoline compounds having the formula:
R

G~
wherein G is -0- or -NH- and Ri and R2 are defined as above and mixtures thereof.
25 Preferred examples of compounds of structural formula (i) are those derived from hydrogenated tallow fatty acids and the SUBSTITUTE SHEET (RULE 26) hydroxyalkylalkylenediaminE is N - 2 - hydroxyethylethylenediamine, such that Ri is an aliphatic Cis-Czi hydrocarbon group, and Rz and Rs are divalent ethylene groups.
5 A preferred example of a compound of structural formula (iii) is stearic hydroxyethyl imidazoline, wherein Ri is an aliphatic Czi hydrocarbon group and Rz is a divalent ethylene group.
A preferred example of compounds of structural formula (iii) is N, N" -ditallowalkanoyldiethylenetriamine where Rl is an aliphatic Cis-Czi hydrocarbon group and Rz and Rs are divalent ethylene groups.
A preferred example of compounds of structural formula (iv) is 1-tallowamidoethyl-2-tallowimidazoline wherein Ri is an aliphatic C15'C21 hydrocarbon group and Rz is a divalent ethylene group.
Both N, N"- ditallowalkanoyldiethylenetriamine and 1-tallowethylamido-2-tallowimidazoline are reaction products of tallow fatty acids and diethylenetriamine, and are precursors of the cationic fabric softening agent methyl-1-tallowamidoethyl-2-tallowimidazolinium methylsulfate (see "Cationic Surface Active 20 Agents as Fabric Softeners," R.R. Egan, ~Tournal of the American Oil & Chemicals Society, January 1978, pages 118-121).
N, N"- ditallowalkanoyldiethylenetriamine and 1-tallowamidoethyl-2-tallowimidazoline can be obtained from Witco Corporation. Methyl-1-tallowamidoethyl-2-tallowimidazolinium methylsulfate is available from Witco Corporation under the tradename VARISOFT~ 475.
Other suitable quats are those containing one long chain acyclic aliphatic Cs-Czz hydrocarbon group, selected from the group consisting of SUBSTITUTE SHEET (RULE 26) (v~ acyclic quaternary ammonium salts having the formula:
Rs A
Ra N- R5 Rs wherein R4 is an acyclic aliphatic Cs-Czz hydrocarbon group, alkyl, benzyl or (C4-Cig alkyl)'(OCH2CH~2-3', Rs and Rs are Ci-C4 saturated alkyl or hydroxyalkyl groups, and A- is an anion as defined above (v~ substituted imidazolinium salts having the formula:
N
~ a Ri ~\ ~ A
/N
H
R~
wherein Ri is an acyclic alkyl or alkylene Ciz-Czi hydrocarbon group, R~ is hydrogen or a CuC4 saturated alkyl or hydroxyalkyl group, and A- is an anion as defined above (viii substituted imidazolinium salts having the formula:
R~ N Ae ~ N

1$
wherein Ri, Rz, Rs, and A- are as defined above (viii alkylpyridli~ium salts having the formula:
Ae 20 wherein R4 is an acyclic aliphatic C8'C22 hydrocarbon group and A- is an anion as defined above and SUBSTITUTE SHEET (RULE 26) ~'a~ alkanamide alkylene pyridinium salts ha wing the formula:
Ae N
1 ~H
wherein Ri is an acyclic aliphatic C12-C21 hydrocarbon group, R2 is a divalent Ci-Cs alkylene group, and A- is an anion as defined above and mixtures thereof.
Examples of compounds of structural formula (v) are the monoalkyltrimethylammonium salts including monotallowtrimethylammonium chloride, mono(hydrogenated tallow)-trimethylammonium chloride, palmityltrimethylammonium 10 chloride and soyatrimethylammonium chloride, available from Witco Corporation under the tradenames ADOGEN~ 471, ADOGEN~ 441, ADOGEN~ 444, and ADOGEN~ 415, respectively. In these compounds, R4 is an acyclic aliphatic Cis-Cis hydrocarbon group, and Rs and Rs are methyl groups. In this application, mono(hydrogenated tallow)trimethylammonium chloride and monotallowtrimethylammonium chloride are preferred. Other examples of compounds of structural formula (v) are behenyltrimethylammonium chloride wherein R4 is a Cza hydrocarbon group, which is available from the Humko Chemical Division of Witco Corporation under the tradename KEMAMINE~
fa2803-C~ soyadimethylethylammonium ethylsulfate wherein R4 is a Cis-Cis hydrocarbon group, Rs is a methyl group, Rs is an ethyl group, and A- is an ethylsulfate anion and methyl bis(2-hydroxyethyl)octadecylammonium chloride wherein R4 is a Cis hydrocarbon group, Rs is a 2-hydroxyethyl group and Rs is a methyl group.
An example of a compound of structural formula (vii) is 1-ethyl-1-(2-hydroxyethyl)-2-isoheptadecylimidazolinium ethylsulfate SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 wherein Ri is a C1~ hydrocarbon group, R2 is an ethylene group, Rs is an ethyl group, and A- is an ethylsulfate anion.
Other quats useful in the present invention include cationic nitrogenous salts having two or more long chain acyclic aliphatic Cs-S C22 hydrocarbon groups or one long chain acyclic aliphatic Ca-C22 hydrocarbon group and an arylalkyl group. Examples include:
(ark acyclic quaternary ammonium salts having the formul8:
I a Ae R4 ~ -R5 10 wherein each R4 is an acyclic aliphatic Cs-C22 hydrocarbon group, Ra is a C1-C~ saturated alkyl or hydroxyalkyl group, Rs is selected from the group consisting of R4 and Rs groups, and A- is an anion as defined above 1 S (~~ dlsmido quaternary ammonium salts having the formula:
Ae -N\ ~ ~Re R1 R2 N\
Rs R2 N
wherein each Ri is an acyclic alkyl or alkylene Ciz-Czi hydrocarbon group, each Rz is a divalent alkylene group having 1 to 3 carbon atoms, Rs and Rs are C1-C4 saturated alkyl or hydroxyalkyl 20 groups, and A- is an anion as defined above SUBSTITUTE SHEET (RULE 26) (xii~ alkoxylated diamido quaternary ammonium salts having the formula:
Ae --N ~ / (CH2CH20)nH
R' _ \R2/N\
Rs R2 N
O
fi'~
wherein n is equal to 1 to about 5, and Ri, R2, Rs, and A- are as defined above (xiii~ quaternary ammonium compounds having the formula:
Ae R4 ~ s R5 \
wherein R4 is an acyclic aliphatic Cg-C22 hydrocarbon carbon group, each Rs is a Ci-C4 saturated alkyl or hydroxyalkyl group, and A- is an anion as defined above (xiv) amide substituted imidazolinium salts having the formula:
R-~~
a A

R N~
H
U
wherein each Ri is an acyclic aliphatic Ci2-C2i hydrocarbon group, Rz is a divalent alkylene group having 1 to 3 carbon atoms, and Rs and A- are as defined above, or Rs is -H~ and SUBSTITUTE SHEET (RULE 26) (xv~ ester-substituted imidazolinium salts having the formula:
R
Ae Rs R O
U
wherein Ri, Rz, Rs, and A- are as defined above> and mixtures thereof.
5 Examples of compounds of structural formula (x) are the well-known dialkyldimethylammonium salts including ditallowdimethylammonium chloride, ditallowdimethylammonium methylsulfate, distearyldimethylammonium chloride, di(hydrogenated tallow)dimethylammonium chloride, 10 dibehenyldimethylammonium chloride. Di(hydrogenated tallow)dimethylammonium chloride and ditallowdimethylammonium chloride are preferred. Examples of commercially available dialkyldimethylammonium salts usable in the present invention are di(hydrogenated tallow)dimethylammonium chloride (available from 15 Witco Corporation under the tradename ADOGEN~ 442) ditallowdimethylammonium chloride (available from Witco Corporation under the tradename ADOGEN~ 4?0)~
distearyldimethylammonium chloride (available from Witco Corporation under the tradename AROSURF~ TA-100)~
20 dicocodimethyl ammonium chloride (available from Witco Corporation under the tradename ADOGEN~ 462), and dibehenyldimethylammonium chloride, wherein R4 is an acyclic aliphatic Caz hydrocarbon group (available from the Humko Chemical Division of Witco Corporation under the tradename KEMAMINE~
25 Q-2802C).
SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/i1S00/23071 Examples of compounds of structural formula (xi) are methylbis(tallowamidoethyl)(2-hydroxyethyl)ammonium methylsulfate and methylbis(hydrogenated tallowamidoethyl)(2-hydroxyethyl)ammonium methylsulfate, wherein Ri is an acyclic 5 aliphatic Cis-C1~ hydrocarbon group, RZ is an ethylene group, Rs is a methyl group, Rs is a hydroxyalkyl group and A- is a methylsulfate anion both of these materials are available from Witco Corporation under the tradenames VARISOFT~ 222 and VARISOFT~ 110, respectively.
10 An example of a compound of structural formula (xiii) is dimethylstearylbenzylammonium chloride, wherein R4 is an acyclic aliphatic Cis hydrocarbon group, Rs is a methyl group and A- is chloride, which is available from Witco Corporation under the tradename VARISOFT~ SDC.
15 Examples of compounds of structural formula (xiv) are 1-methyl-1-tallowamidoethyl-2-tallowimidazolinium methylsulfate and 1-methyl-1-(hydrogenated tallowamidoethyl)-2-(hydrogenated tallow)imidazolinium methylsulfate wherein Ri is an acyclic aliphatic Cls-C1~ hydrocarbon group, R2 is an ethylene group, Rs is a methyl 20 group and A- is a chloride anion available from Witco Corporation under the tradenames VARISOFT~ 475 and VARISOFT~ 445, respectively.
Additional examples of quaternary ammonium compounds useful in the present invention include:
(xv.,i~ compounds having the formula:

_~I
R
ZmR~2 wherein Rii is selected from the group consisting of: (a) -CHs, -CH2CHs, -CHzCHzOH, or straight chain aliphatic hydrocarbon SUBSTITUTE SHEET (RULE 26) groups each of which contains from 12 through 24 carbon atoms, (b) ether groups each of which has the structure: R13~(CH2O)y', (c) amide groups each of which has the structure:
R~
\(CHp)Y
and (d) ester groups each of which has the structure:
R~
O (CH2)Y
Ri2 is a straight chain aliphatic hydrocarbon group containing from 8 to 32 carbon atoms, Ris is a straight chain aliphatic hydrocarbon group containing from 8 to 21 carbon atoms, Ri4 is a straight chain aliphatic hydrocarbon group containing from 7 to 17 carbon atoms, Z is an alkoxy group containing one oxygen atom and either two or three carbon atoms, A- is an anion as defined above, m is an integer from 1 through 12, and y is an integer which is either 2 or 3.
Yet additional examples of fabric softening compounds useful in the present invention include:

SUBSTITUTE SHEET (RULE 26) (xvii~ compounds having the formula:
t5 Ris i -(CH2)rt ~ Rm x (Riyy H
wherein Ris is hydrogen or Ci-C4 alkyl, Ris i -(CH2)n (Ri8)y S each Ris is Ci'C4 alkyl or, each Rm is a Cs-Cza alkyl or alkenyl group, Ris is hydrogen or Ci-C4 alkyl, each y is 0 or 1, x is 0 or 1, and each n is from 1 to 6~
(xvii~ amides represented by the structural formula:
R'~
N
R2o R2t wherein Ris and Rao are selected independently from the group consisting of Ci-zz alk(en)yl aryl or alkyl aryl groups, R2i is hydrogen or a Ci-2z alk(en)yl, aryl or alkyl-aryl group or is O-Rz2, wherein RZZ is 15 a Ci'22 alk(en)yl, aryl or alkyl-aryl group, and Rzi and Rzz optionally contain 1 to 10 alkylene oxide units or functional groups selected from hydroxy, amine, amide, ester, and ether groups the aryl groups being possibly derived from heterocyclic compounds at least one of the Ris and Rzo groups contains 10 or more carbon atoms and where the sum of carbon atoms in Ris+Rzo+R2i is equal to or greater than 14. Preferably, the sum of carbon atoms in Ris+Rzo is equal to or greater than 16. Examples of compounds of structural formula (xviii) include IV,Nditallow acetamide, N,~dicoconut acetamide, N,N

SUBSTITUTE SHEET (RULE 26) dioctadecyl propanamide, Ndodecyl-Noctadecyl acetamide, l1~
hexadecyl-Ndodecyl butanamide, N,Nditallow benzamide, N,N
dicoconut benzamide, and N,Nditallow 2-phenyl acetamide.
Additional fabric softening compounds useful in the present invention include all ester quaternaries, including but not limited to:
(xix~ compounds of the following structural formulas:
a A
O
O
AIk21 ~O
O ~O
1_4 1_4 and ~ a R2~ o-CH H2 . i -Q2~
0-3 Q2~
R2~ CH2 wherein each Rzi is independently a saturated or unsaturated alkyl or alkylene radical containing 12 to 22 carbon atoms each fa2i is independently an alkyl group containing 1 to 4 carbon atoms, benzyl, -CH2CHzOH, -CHzCH(OH)CHs, or R2i-C(O)-(O-(Alkzl)) i-4-~
each A1k21 is independently C2H4, CsHs or C4Hs~ and A- is an anion as defined above SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 (xx~ compounds ofthe formula:
/ +(i+j) A - I ~CH ~N~ p,I ~ nAe wherein each A22 is the same or different and each is alkyl containing up to 3 carbon atoms, benzyl, or H-(A1k22-O) i-s-Alk2z-wherein each A1k22 signifies -CH2CHa-, -CH(CH~CH2-, or -CHaCH(CHa)-, provided further that one of the A22 can be hydrogen D is methyl, ethyl, propyl, -(CH~1-sC00-, benzyl or hydrogen i is 0 or 1 and j is 0 or 1, provided that the sum of (i + j) is 1 or 2~
each X2z is a straight or branched saturated or unsaturated aliphatic group containing up to 3 carbon-carbon double bonds and containing 11 to 23 carbon atoms n is two minus the number of -(CH~1-3C00-substituents present and A- is an anion as defined above (xxi~ compounds of the formula:
R23' (C(O)O(CH~J l6~ 0-1-C(O)NH(CH~2-6-N(R23~~2Sb) (CH2)2~B-OC(O)R2SA
wherein each RZS is independently straight or branched alkyl or alkenyl containing 8 to 22 carbon atoms R23a is straight or branched alkyl or hydroxyalkyl containing 1 to 3 carbon atoms, benzyl, or -C2H40C(O)Rzs, wherein Ras is straight or branched alkyl or alkenyl containing 8 to 22 carbon atoms so SUBSTITUTE SHEET (RULE 26) R23b is -H, -CH3, -C2H5 or benzyh and A- is an anion as defined above and (xxii~ compounds of the following structural formulas:
Ae 1824)4-m N~ ~CH2)n Y 825 m and a A

~R24)3 N-CH2 ;H
CH2YR~
wherein 10 each Ra4 is independently straight or branched alkyl or alkenyl containing 1 to 8 carbon atoms and 0 to 3 hydroxyl groups each R2s is straight or branched alkyl or alkenyl containing 10 to 22 carbon atoms and 0 to 3 hydroxyl groups each Y is -O-C(O)- or -C(O)-O-~
each m is 1 to 3~
each n is from 1 to 8~ and A- is an anion as defined above.
Preferred examples of compounds of structural formulas (xxii) include methyl diethanolamine ~MDEA) ester quats, triethanolamine 20 (TEA) ester quats, for example, di-(tallow carboxyethyl) hydroxyethyl methylammonium methosulfate, available from Witco Corporation under the tradename REWOfaUATTM WE 16, or epichlorohydrin-based ester quats, all of which are used and accepted as fabric softeners worldwide because of their favorable biodegradation profiles, but usually lack the optimum softening performance of other quats.

SUBSTITUTE SHEET (RULE 26) Additional compounds useful in the present invention include polyester polyquaternary compounds, including but not limited to=
(arrxiii~ compounds of the following structural formula:
+m R1 Rs Ra p IS 2 13 x R2~0-A2~N-R~Iw-R'" f ~A4~R4 ~nAe i ~ ~)k \Q2)j wherein each of R* and R** is independently a linear, branched or cyclic alkylene group containing 2 to 12 carbon atoms, wherein no two nitrogen atoms are separated by fewer than 2 carbon atoms each of Al, Az, A3, A4, and A~ is independently a straight or branched alkylene containing 2 to 4 carbon atoms each of Rl, Rz, R3, R4, and R~ is independently -H or RAC(O)-wherein RA is straight or branched alkyl or alkenyl containing 7 to 21 carbon atoms and 0 to 4 carbon-carbon double bonds provided that at least one of Rl, Rz, Rg, R4, or Rb is RAC(O)-each of Q1, Qz and Q3 is independently -H, -CHs, -CzHs, -C3H7, -C4Hs, benzyl, -CH2COOH, or -CHzCOOA-~ or, if R* is a -CH2CHz-group, Q1 and Q3 together or Q1 and Qz together may be a -CH2CHz-group to form a six-membered piperazine ring or, if R** is a -CH2CHz- group, Q3 and Qg together may be a -CH2CHz- group to form a six-membered piperazine ring misOto4~
risOto2~
each of v, w, x, y, and z is independently 1 to 8~

SUBSTITUTE SHEET (RULE 26) i is 0 to 1, j is 0 to 1, and each k is 0 to 1, and the sum of (i+j+k) is 0 to 4~
each A- is independently an anion that may be selected, without limitation, from the group consisting of fluoride, chloride, S bromide, iodide, chlorite, chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and salicylate, and the like and n is the number of moles of A- needed to give the compound of 10 structural formula (xxiii) a zero net charge. Compounds of structural formula (xxiii), formulations thereof, and uses thereof, form the subject matter of pending U.S. application No. 09!170,623, filed on October 13, 1998, which is incorporated by reference in its entirety and 15 ~XXIYJ compoundsofthefollowingstructuralformulas:
C\ /CH2 CH2 ORS
A / N
R CH2 ~H---OR

and ~H2 CH2 OR3 A /N\
R CHZ C~H-OH

wherein R is -H, -CHs or -CzHa~
Rl, Rz, and R3 are each independently of one another fatty acid radicals having 6-22 carbon atoms and SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/iJS00/23071 A- is an inorganic or organic anion that may be selected, without limitation, from the group consisting of fluoride, chloride, bromide, iodide, chlorite, chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and sa:icylate, and the like. Compounds of structural formula (xxiv), formulations thereof, and uses thereof, form the subject matter of pending PCT application No. PCTIUS99/00213, filed on January 6, 1999 and pending PCT application No. PCTlUS99/00295, filed on 10 January 7, 1999, both of which are incorporated by reference in their entireties.
E. DIOL AND DIOL ALKOXYLATE COUPLING AGENT
ADDITIVES

In a preferred embodiment of this invention, fabric softener formulations and other formulations which may be clear (translucent or transparent) and easily dispersed in water can be provided by including an appropriate amount of one or more straight or branched 20 alkyl diols containing 4 to 12 carbon atoms, and/or alkoxylates of such diols with up to 40 alkoxy units per diol moiety, wherein the alkoxylate chains are composed of alkoxy units which are ethoxy, propoxy or butoxy or mixtures thereof, and preferably ethoxy or propoxy. These diol and diol alkoxylate hydrotropes or coupling 25 agents are added to the formulations to increase the amount of the relatively water-insoluble surfactants that can be solubilized into the system. In most cases, they do not act as surfactants to lower surface tension but they often allow surfactants in the presence of salts or electrolytes to be added and subsequently dispersed into water at 30 higher concentrations or at lower viscosities of the formulation than is otherwise achieved using only surfactant and water. These coupling agents assist surfactants by increasing the surfactant's SUBSTITUTE SHEET (RULE 26) solubility in water and its stability in the formulation, especially in the presence of salts, electrolytes and/or pH agents.
These diols and alkoxylates correspond to structural formula (T) HO-(X-O)X-RT-(O-Y)Y-OH (T) wherein each X and each Y is ethylene (that is, -C2H4-), propylene (that is, -CsHs-), or butylene (that is, -C4Hs-)~ x is 0-40 y is 0-40 the sum (x+y) is 0-40 and RT is straight, branched or cyclic alkyl containing 4 to 12 carbon atoms. Preferably, RT contains 7-12 or even 7-9 carbon atoms.
The alkylene residue RT in structural formula (T) represents a saturated, straight-chain, branched-chain, or cyclic moiety containing 4 to 12 carbon atoms. It is preferred that RT is branched, wherein the term "branched" is intended to encompass structures having one side alkyl chain, more than one side alkyl chain, or one or more side alkyl chains, one or more of which is itself branched. Branched structures include cyclic structures substituted with one or more alkyl groups, the alkyl groups being straight or branched. Examples of suitable RT groups include such groups as CH2CH(CHs)CH2-,' (CH~s-,-CH2CHzCH2-,-C(CHs)zCHz-, CHzCH(CHzCHs)CHzCH2CHzCHz-,-CHZC(CHs)zCH2-CHZC(CH~zCH(CH(CH~~J-, -CH2CH(CHaCH2CH2CHs)-, and -CH(CH2)2CH(CH2)2 In the alkoxylated diols, the number of repeating units in each poly(alkoxy) chain can be up to 40 but it is preferred that each chain contains 1 to 10 repeating alkoxy units or more preferably 1 to 5 alkoxy units. The preferred alkoxy chains are poly(ethoxy), or are composed of 1 to 2 ethoxy units capped with a chain of 1 to 5 propoxy units.
SUBSTITUTE SHEET (RULE 26) Compounds of structural formula (T) defined above are in many instances commercially available. Compounds of structural formula (T) can be prepared in straightforward manner familiar to those of ordinary skill in this art by obtaining or preparing the 5 corresponding precursor diol of structural formula HO-RT-OH, and then alkoxylating the precursor diol with a stoichiometrically appropriate number of moles of the desired corresponding alkylene oxide, such as ethylene oxide, propylene oxide, and/or butylene oxide.
In those cases where it is desired to alkoxylate only one of the 10 hydroxyl groups on the precursor diol, in some embodiments the alkoxylation will preferentially occur at only one of the hydroxyl groups, particularly where one of them is a primary hydroxyl and the other is a secondary hydroxyl. However, in those cases where both hydroxyl groups on the precursor diol might tend to alkoxylate but 15 alkoxylation at only one of the hydroxyl groups is desired, the hydroxyl group at which alkoxylation is desired not to occur can be protected by preliminarily reacting it with a suitable protecting group such as a lower alkyl moiety or an esterifying substituent.
Thereafter, following the alkoxylation, the protecting group is 20 removed in a known manner.
Preferred examples of compounds of the foregoing structural formula (T) include any one, or mixtures, of 2,2,4-trimethyl-1,3-pentanediol (TMPD) and/or 2-ethylhexane-1,3-diol, and/or the reaction product of TMPD and/or 2-ethylhexane-1,3-diol with 1 to 10 25 moles of ethylene oxide, and preferably with 1 to 5 moles of ethylene oxide, as well as analogs alkoxylated with other Cs or C4 alkyl oxides or mixtures of any of C2, Cs and/or C4 alkyl oxides. Since the diol which is alkoxylated includes ane primary hydroxyl group and one secondary hydroxyl group, the alkoxylation proceeds predominantly 30 at the primary hydroxyl group.

SUBSTITUTE SHEET (RULE 26) The compositions which contain one or more compounds of formulas (I) and/or (II) can also contain one or a mixture of compounds of structural formula (E) S RE1-C(O)O-RE2-(OC(O)RE3)0-1 (E) wherein RE1 is straight, cyclic or branched alkyl containing 1-15 carbon atoms, and REl is substituted with 0 to 3 hydroxyl groups and wherein RE2 is straight, cyclic or branched alkyl containing 1 to 10 carbon atoms, and RE2 is substituted with 0 to 3 hydroxyl groups, and 10 RE2 can optionally be substituted with a group of the structure OC(O)-REg wherein RE3 is straight, cyclic or branched alkyl containing 1 to 15 carbon atoms and is optionally substituted with a hydroxyl group.
Preferred compounds of structural formula (E) include those 15 wherein REZ contains 2 or 3 carbon atoms, for example, glycol and glyceryl derivative, or REZ contains about $ carbon atoms,. for example, derivatives of 2,2,4-trimethylpentanediol or of 2-ethylhexanediol. Preferred compounds of structural formula (E) include 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 20 hydroxypivalyl hydroxypivalate, and the monoester of TMPD with hydroxypivalic acid.
Formulations can also contain what may be termed aesthetic additives to provide properties such as fragrance, preservative, viscosity control, and color. Such additives are discussed below. The 25 formulations according to the present invention generally exhibit highly satisfactory viscosities, generally as pourable and even sprayable fluids.
F. ADDITIONAL SURFACTANTS
30 Other suitable non-quaternary compound surfactants, whether anionic, cationic, zwitterionic, nonionic, or amphoteric, may be used SUBSTITUTE SHEET (RULE 26) WO 01!14313 PCT/US00/23071 in combination with the compounds and formulations of the invention, depending on the application.
1. General Surfactants 5 For example, in a fabric softening application, suitable anionic surfactants may include, without limitation, the alkylbenzene sulfonates, a - olefin sulfonates, and xylene sulfonates available from Witco Corporation under the WITCONATE~ trademark. While these surfactants may be unsuitable for personal care applications 10 because they may cause skin and eye irritation, surfactants suitable for personal care applications may be used in other non-personal care applications.
2. Personal Care Surfactanis 15 For personal care applications, suitable anionic surfactants would include, without limitation, ammonium lauryl sulfate, sodium lauryl sulfate, any a - olefin sulfonate, ammonium laureth sulfate (2 or 3 moles), sodium laureth sulfate (2 or 3 moles), sodium myristyl sulfate, sodium myristeth sulfate (1-4 moles), ammonium xylene 20 sulfonate, sodium xylene sulfonate, TEA dodecylbenzene sulfonate, TEA lauryl sulfate, ammonium pareth sulfate, sodium pareth sulfate, sodium oleth sulfate, derivatives of any of the forgoing, and similar compounds known to those of skill in the art, and mixtures thereof.
For personal care applications, suitable amphoteric surfactants or 25 non-ionic surfactants include betaines, sulfosuccinates, mono- and diglycerides, glycinates, sugars and derivatives thereof, hydroxysultaines, mono- and diacetates, ethoxylated derivatives of any of the forgoing, and similar compounds known to those of skill in the art, and mixtures thereof. Preferred surfactants include 30 cocamidopropyl betaine, lauramidopropyl betaine, ricinoleamidopropyl betaine, myristamidopropyl betaine, SUBSTITUTE SHEET (RULE 26j palmamidopropyl betaine, stearamidopropyl betaine, behenamidopropyl betaine, erucamidopropyl betaine, cocamidopropyl hydroxysultaine, myristamidopropyl hydroxysultaine, palmamidopropyl hydroxysultaine, stearamidopropyl hydroxysultaine, behenamidopropyl hydroxysultaine, erucamidopropyl hydroxysultaine, disodium lauroamphodiacetate, disodium cocamphodiacetate, disodium myristamphodiacetate, disodium palmamphodiacetate, disodium stearamphodiacetate, disodium behenamphodiacetate, disodium erucamphodiacetate, sodium lauryl amphoacetate, sodium cocamphoacetate, sodium cocoamphopropionate, sodium laurylamphopropionate, disodium lauroamphodipropionate, sodium lauryl sulfosuccinate, disodium laureth sulfosuccinate, cocobetaine, laurylbetaine, myristylbetaine, stearylbetaine, behenylbetaine, PEG 1-300 glyceryl cocoate, PEG 1-300 glyceryl tallowate, PEG 1-500 hydrogenated glyceryl palmitate, coco-glucoside, lauryl glucoside, decyl glucoside, and mixtures thereof.
Other surfactants that may be added to these systems include, but are not limited to, alkanolamides such as almondamide diethanolamine (DEA), behenamide DEA, cocamide DEA, hydrogenated tallowamide DEA, isostearamide DEA, lactamide DEA, lauramide DEA, linoleamide DEA, myristamide DEA, oleamide DEA, palmamide DEA, palmitamide DEA, ricinoleamide DEA, soyamide DEA, stearamide DEA, tallamide DEA, and tallowamide DEA.
Preferred alkanolamides include acetamide monoethanolamine (MEA), behenamide MEA, cocamide MEA, hydroxystearamide MEA, isostearamide MEA, lactamide MEA, lauramide MEA, linoleamide MEA, myristamide MEA, oleamide MEA, palmamide MEA, palmitamide MEA, ricinoleamide MEA, stearamide MEA, tallowamide MEA, undecylenamide MEA, cocamide monoisopropylamine (MIPA), hydroxyethyl stearamide MIPA, SUBSTITUTE SHEET (RULE 26) isostearamide MIPA, lauramide MIPA, linoleamide MIPA, myristamide MIPA, oleamide MIPA, palmamide MIPA, ricinoleamide MIPA, and stearamide MIPA. Some of these alkanolamides are available from Witco Corporation under the WITCAMIDE~
tradename.
In addition, various amine oxides may be used in these systems. Preferred amine oxides include, but are not limited to, behenamine oxide, cocamidopropylamine oxide, cocamine oxide, decylamine oxide, dihydroxyethylcocamine oxide, 10 dihydroxyethyllauramine oxide, dihydroxyethyltallowamine oxide, hydrogenated palm kernel amine oxide, hydrogenated tallowamine oxide, isostearamidopropylamine oxide, lauramidopropylamine oxide, lauramine oxide, myristamidopropylamine oxide, myristamine oxide, oleamidopropylamine oxide, oleamine oxide, 15 palmitamidopropylamine oxide, palmitamine oxide, soyamidopropylamine oxide, stearamidopropylamine oxide, stearamine oxide, tallowamidopropylamine oxide, tallowamine oxide, and undecylenamidopropylamine oxide. Several of these materials are available from Witco Corporation under the VAROX~ tradename.
G. PERSONAL CARE EMOLLIENTS AND EMULSIFIERS
Emollients and emulsifiers are also typically used in personal care formulations in combination with the polyester amine 25 compounds and polyquaternary compounds of the invention, depending on the application.
1. Personal Care Emollients The preferred embodiment of this invention may also be used in emulsions that can be used as skin or hair conditioners which can take the form of lotions, creams, leave-on products, and rinse-off products. These systems may also include additional products that may improve the feel and conditioning, or the emolliency of skin and SUBSTITUTE SHEET (RULE 26) hair. In addition to some of the materials mentioned above that can also function as conditioning agents, preferred additives for this use include, but are not restricted to, acetylated lanolin, aminopropyl dimethicone, ammonium hydrolyzed collagen, ammonium lauroyl 5 sarcosinate, amodimethicone, amodimethicone/dimethicone copolyol, amodimethicone hydroxystearate, capryloyl hydrolyzed collagen, cetyl alcohol, cetyl esters, cetyl laurate, cocamidopropyl dimethylamine dihydroxymethylpropionate, cocoyl hydrolyzed soy protein, collagen, disodium cocoamphodiacetate, disodium 10 cocoamphodipropionate, dioctyl dimerate, ditridecyl adipate, glycerine, glyceryl oleate, glyceryl stearate, hydrogenated soybean oil, hydrogenated tallow glycerides, isocetyl stearate, jojoba (Buxus chinensis) oil, keratin, lanolin, milk protein, mineral oil, oat (Avena sativa) protein, octyl cocoate, oleyl myristate, oleyl stearate, palm 15 alcohol, palm glycerides, panthenol, PEG-10, PEG-32, PEG-100, PEG-200, petrolatum, PPG-6-sorbeth-245, stearyl citrate, tridecyl stearate, urea, vegetable oil, and wheat amino acids. Some of these products are available from Witco Corporation under the KEMSTRENE~, WITCONOLTM, STARFOL~, and KEMESTER~
20 tradenames.
2. Personal Care Emulsifiers Such emulsions usually include emulsifiers to form and 25 preserve the emulsion. In addition to some of the materials previously mentioned that also act as emulsifiers, some preferred emulsifiers for this use include, but are not restricted to beheneth-5, beheneth-10, beheneth-20, butylglucoside caprate, ceteareth-2, ceteareth-10, ceteareth-18, ceteth-10, ceteth-16, corn oil PEG-8 30 esters, Cs-ii pareth-3, Cm-is pareth-5, Cii-is pareth-12, Ciz-is pareth-2, C~z-~s pareth-10, Ciz-~s pareth-15, deceth-4, deceth-5, deceth-6, di-Ciz-is pareth-6 phosphate, dl-C12-15 pareth-8 phosphate, glyceryl cocoate, glyceryl laurate, glyceryl oleate, isoceteth-10, isodeceth-6, SUBSTITUTE SHEET (RULE 26) isosteareth-10, laureth-4, laureth-5, laureth-10, octyldodeceth-10, octyldodeceth-20, oleoyl ethyl glucoside, oleth-2, oleth-4, PEG-8 caprate, PEG-8 castor oil, PEG-7 cocamide, PEG-11 cocamide, PEG-15 cocoate, PEG-20 dilaurate, PEG-32 dilaurate, PEG-8 dioleate, 5 PEG-2 distearate, PEG-8 distearate, PEG-8 glyceryl laurate, PEG-15 glyceryl laurate, PEG-4 isostearate, PEG-4 laurate, PEG-5 octanoate, PEG-9 oleamide, PEG-5 oleate, PEG-20 palmitate, PEG-6 stearate, PEG-16 tallate, polysorbate 20, polysorbate 80, steareth-10, trideceth-5, and undeceth-9.
H. OTHER ADDITIVES
Other additives and adjuvants can be optionally added to the compounds and formulations of the present invention for their known purposes. Such additives and adjuvants include, but are not limited to, perfumes, preservatives including bacteriocides and fungicides, insect and moth repelling agents, polymeric soil release agents, antistatic agents, dyes and colorants, especially bluing agents, viscosity control agents, antioxidants, silicones, defoaming agents, antifoaming agents, emulsifiers, brighteners, opacifiers, freeze-thaw control agents, shrinkage control agents, aloe, humectants, skin protectants, feel modifiers, waxes, glycerine, vitamins and extracts, and mixtures thereof. The identity and amounts of the additives and adjuvants used would depend on the application of the formulation and its desired properties. The additives and adjuvants are well-known to those of skill in the art and the additives and adjuvants listed below are not meant to be an exhaustive list but merely a guide to the types of additives that would typically be used.

SUBSTITUTE SHEET (RULE 26) 1. Perfumes As noted above, perfumes or fragrance materials may be added to the compositions and formulations of the present invention. The selection of the perfume or perfumes is based upon the application, the desired effect on the consumer, and preferences of the formulator.
The perfume selected for use in the compositions and formulations of the present invention contains ingredients with odor characteristics which are preferred in order to provide a fresh impression on the surface to which the composition is directed, for example, those which provide a fresh impression for fabrics if a fabric softener treatment formulation is prepared. Such perfume is preferably present at a level of from about 0.01% to about 5%, preferably from about 0.05%
to about 3°/, more preferably from about 0.1% to about 2%, by weight of the total composition.
1 S Preferably, the perfume is composed of fragrance materials selected from the group consisting of aromatic and aliphatic esters having molecular weights from about 130 to about 250 aliphatic and aromatic alcohols having molecular weights from about 90 to about 240 aliphatic ketones having molecular weights from about 150 to about 260 aromatic ketones having molecular weights from about 150 to about 270 aromatic and aliphatic lactones having molecular weights from about 130 to about 290 aliphatic aldehydes having molecular weights from about 140 to about 200 aromatic aldehydes having molecular weights from about 90 to about 230 aliphatic and aromatic ethers having molecular weights from about 150 to about 270 and condensation products of aldehydes and amines having molecular weights from about 180 to about 320 and mixtures thereof. The selection of such perfumes and fragrance materials are well-known to those of skill in the art, both for desired scent and appropriate scent impact. For example, when high initial perfume odor impact on fabrics is desired, it is preferable to select a perfume SUBSTITUTE SHEET (RULE 26) WO 01/14313 PCT/i1S00/23071 containing perfume ingredients which are not too hydrophobic. The degree of hydrophobicity of a perfume ingredient can be correlated with its octanol/water partitioning coefficient P, the ratio between its equilibrium concentration in octanol and in water. Thus, a perfume 5 ingredient with a greater partitioning coefficient P is more hydrophobic and a perfume ingredient with a smaller partitioning coefficient P is more hydrophilic a selection based on the application and intended effect may be made accordingly. For example, in a fabric application, the preferred perfume ingredients would have an octanol/water partitioning coefficient P of about 1,000 or smaller.
2. Preservatives Optionally, solubilized, water-soluble preservatives can be added to the present invention. Preservatives are especially preferred when organic compounds that are subject to microorganisms are added to the compositions of the present invention, especially when they are used in aqueous compositions.
When such compounds are present, long term and even short term storage stability of the compositions and formulations becomes an 20 important issue since contamination by certain microorganisms with subsequent microbial growth often results in an unsightly and/or malodorous solution. Therefore, because microbial growth in these compositions and formulations is highly objectionable when it occurs, it is preferable to include a solubilized water-soluble, antimicrobial preservative, which is effective for inhibiting and/or regulating microbial growth in order to increase storage stability of the preferably clear and often aqueous compositions and formulations of the present invention.
Typical microorganisms that can be found personal care products include bacteria, for example, Bacillus thuringiensis (cereus group) and Bacillus sphaericus, and fungi, for example, Aspergillus ustus. Bacillus sphaericus is one of the most numerous members of SUBSTITUTE SHEET (RULE 26) Bacillus species in soils. In addition, microorganisms such as Escherichia coli and Pseudomonas aerupinosa are found in some water sources, and can be introduced during the preparation of aqueous solutions of the present invention.
5 It is preferable to use a broad spectrum preservative, for example, one that is effective on both bacteria (both gram positive and gram negative) and fungi. A limited spectrum preservative, for example, one that is only effective on a single group of microorganisms, for example, fungi, can be used in combination with 10 a broad spectrum preservative or other limited spectrum preservatives with complimentary and/or supplementary activity. A
mixture of broad spectrum preservatives can also be used.
Antimicrobial preservatives useful in the present invention can be biocidal compounds, that is, substances that kill 15 microorganisms, or biostatic compounds, that is, substances that inhibit and/or regulate the growth of microorganisms. Preferred antimicrobial preservatives are those that are water-soluble and are effective at low levels. In general, the water-soluble preservatives that may be used include organic sulfur compounds, halogenated 20 compounds, cyclic organic nitrogen compounds, low molecular weight aldehydes, quaternary compounds, dehydroacetic acid, phenyl and phenoxy compounds, and mixtures thereof. Examples of preservatives useful in the present invention include, but are not limited to, the short chain alkyl esters of p-hydroxybenzoic acid 25 (commonly known as parabens)~ N(4-chlorophenyl)-N(3,4-dichlorophenyl) urea (also known as 3,4,4'-trichlorocarbanilide or triclocarban)~ 2,4,4'-trichloro-2'-hydroxydiphenyl ether, commonly known as triclosan)~ a mixture of about 77% 5-chloro-2-methyl-4-isothiazolin-3-one and about 23% 2-methyl-4-isothiazolin-3-one, a 30 broad spectrum preservative available from the Rohm and Haas Company as a 1.5% aqueous solution under the tradename SUBSTITUTE SHEET (RULE 26) KATHON~ CG~ 5-bromo-5-nitro-1,3-dioxane, available from Henkel Corporation under the tradename BRONIDOX~ L~ 2-bromo-2-nitropropane-1,3-diol, available from Inolex Chemical Company under the tradename BRONOPOLTM~ 1,1'-hexamethylenebis(5-(p-5 chloraphenyl)biguanide) (commonly known as chlorhexidine) and its salts, for example, with acetic and digluconic acids a 95:5 mixture of 1,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione and 3-butyl-2-iodopropynyl carbamate, available from Lonza Inc. under the tradename GLYDANT~ Plus N[1,3-bis(hydroxymethyl)2,5-dioxo-4-10 imidazolidinyl]-N,N'-bis(hydroxy-methyl) urea, commonly known as diazolidinyl urea, available from Sutton Laboratories, Inc. under the tradename GERMALL~ Ih N,N"-methylenebis[N'-[1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea] (commonly known as imidazolidinyl urea), available, for example, from 3V-Sigma under 15 the tradename ABIOLTM, from Induchem under the tradename UNICIDE~ U-13, and from Sutton Laboratories, Inc. under the tradename GERMALL~ 115 polymethoxy bicyclic oxazolidine, available from Hills America Inc. under the tradename NUOSEPT~~
formaldehyde glutaraldehyde~ polyaminopropyl biguanide, available 20 from ICI Americas, Inc. under the tradename COSMOCIL~ CQ or from Brooks Industries Inc. under the tradename MIKR,OKILLT"'~
dehydroacetic acid and mixtures thereof. In general, however, the preservative can be any organic preservative material which is appropriate for the application, for example, in a fabric softening 25 application such preservative will preferably not cause damage to fabric appearance, for example, discoloration, coloration, or bleaching of the fabric.
If the antimicrobial preservative is included in the compositions and formulations of the present invention, it is 30 preferably present in an effective amount, wherein an "effective amount" means a level sufficient to prevent spoilage or prevent SUBSTITUTE SHEET (RULE 26) growth of inadvertently added microorganisms for a specific period of time. Preferred levels of preservative are from about 0.0001% to about 0.5°/, more preferably from about 0.0002% to about 0.2%, most preferably from about 0.0003°/ to about 0.1%, by weight of the 5 composition.
Bacteriostatic effects can sometimes be obtained for aqueous compositions by adjusting the composition pH to an acid pH, for example, less than about pH 4, preferably less than about pH 3. Low pH for microbial control is not a preferred approach in the present invention because the low pH can cause chemical degradation of the cyclodextrins. Therefore, aqueous compositions of the present invention should have a pH greater than about 3.0, preferably greater than about 4.0, more preferably greater than about 4.5. As stated above, it is preferable to use the preservative at an effective amount, as defined hereinabove. Optionally, however, the preservative can be used at a level which provides an antimicrobial effect on the treated fabrics.
3. AntistaticAgents 20 The composition of the present invention can optionally contain an effective amount of antistatic agent to provide the treated clothes with in-wear static. Preferred antistatic agents are those that are water soluble in at least effective amount, such that the composition remains a clear solution. Examples of these antistatic 25 agents include monoalkyl cationic quaternary ammonium compounds, for example, mono(Cio-Ci4 alkyl)trimethyl ammonium halide, such as monolauryl trimethyl ammonium chloride, hydroxycetyl hydroxyethyl dimethyl ammonium chloride (available from Henkel Corporation under the tradename DEHYQUARTTM E), 30 and ethyl bis(polyethoxyethanol) alkylammonium ethylsulfate (available from Witco Corporation under the tradename SUBSTITUTE SHEET (RULE 26) VARIfaUAT~ , 66), polyethylene glycols, polymeric quaternary ammonium salts (such as those available from Rhone-Poulenc Corporation under the MIRAPOL~ tradename), quaternized polyethyleneimines, 5 vinylpyrrolidone/methacrylamidopropyltrimethylammonium chloride copolymer (available from GAF Corporation under the tradename GAFQUAT~ HS-100), triethonium hydrolyzed collagen ethosulfate (available from Maybrook Inc. under the tradename QUAT-PRO~ E), and mixtures thereof.
10 It is preferred that a no foaming, or low foaming, agent is used, to avoid foam formation during fabric treatment. It is also preferred that polyethoxylated agents such as polyethylene glycol or VARIQUAT~ 66 are not used when a - cyclodextrin is used. When an antistatic agent is used it is typically present at a level of from 15 about 0.05°/ to about 10%, preferably from about 0.1% to about 5°/, more preferably from about 0.3% to about 3°/, by weight of the composition.
4. Dyes and Colorants 20 Colorants and dyes, especially bluing agents, can be optionally added to the compositions of the present invention for visual appeal and performance impression. When colorants are used, they are used at extremely low levels to avoid fabric staining. Preferred colorants for use in the present compositions are highly water-soluble dyes, for 25 example, LIfaUITINT~ dyes available from Milliken Chemical Company. Non-limiting examples of suitable dyes are, LIQUITINT~
Blue HP, LIQUITINT~ Blue 65, LIQUITINT~ Patent Blue, LIfIUITINT~ Royal Blue, LIfaUITINT~ Experimental Yellow 8949-43, LIIaUITINT~ Green HMC, LIQUITINT~ Yellow II, and mixtures 30 thereof. Any dye can be used in the compositions of the present invention, but nonionic dyes are preferred to decrease interaction SUBSTITUTE SHEET (RULE 26) with dye transfer inhibitor. Useful acid dyes include: Polar Brilliant Blue, and D&C Yellow #10, both supplied by Hilton Davis Chemical Company. Nonionic LIQUITINT~ dyes supplied by Milliken Chemical Company are also useful.
5 For many personal care products using the present invention, colorants are also added at extremely low levels. Color additives for products to be marketed in the United States are named in compliance with Title 21 of the U.S. Code of Federal Regulations.
Suitable colors include, but are not limited to, Acid Black 1, Acid 10 Blue 3, Acid Blue 9 Aluminum Lake, Acid Blue 74, Acid Green 1, Acid Orange 6, Acid Red 14 Aluminum Lake, Acid Red 27, Acid Red 27 Aluminum Lake, Acid Red 51, Acid Violet 9, Acid Yellow 3, Acid Yellow 3 Aluminum Lake, Acid Yellow 73, Aluminum Powder, Basic Blue 6, Basic Yellow 11, ~l3 - Carotene, Brilliant Black 1, Bromocresol 15 Green, Chromium Oxide Greens, CI 12010, CI 12120, CI 28440, CI
71105, Curry Red, D&C Blue No. 1 Aluminum Lake, D&C Blue No.
4, D&C Brown No. 1, D&C Green No. 3 Aluminum Lake, D&C Green No. 5, D&C Orange No. 4 Aluminum Lake, D&C Red No. 6, D&C Red No. 6 Aluminum Lake, D&C Violet No. 2, D&C Yellow No. 7, D&C
20 Yellow No. 11, D&C Blue No. 1, FD&C Yellow No. 5 Aluminum Lake, iron oxides, Pigment Orange 5, Pigment Red 83, Pigment Yellow 73, Solvent Orange 1, Solvent Yellow 18, ultramarines, and zinc stearate.
25 5. Insect and Moth RepellingAgents The composition of the present invention can optionally contain an effective amount of insect or moth repelling agents.
Typical insect and moth repelling agents are pheromones, such as anti-aggregation pheromones, and other natural and/or synthetic 30 ingredients. Preferred insect and moth repellent agents useful in the composition of the present invention are perfume ingredients, such as citronellol, citranellal, citral, linalool, cedar extract, geranium oil, SUBSTITUTE SHEET (RULE 26) sandalwood oil, 2-(diethylphenoxy)ethanol, 1-dodecene, and the like.
Other examples of insect and/or moth repellents useful in the composition of the present invention are disclosed in U.S. Patent Nos. 4,449,987 4,693,890 4,696,676 4,933,371 5,030,660 and 5 5,196,200 and in B. D. Mookherjee et al., "Semio Activity of Flavor and Fragrance Molecules on Various Insect Species", published in Bioactive Volatile Compounds from Plants, ASC Symposium Series 525, R. Teranishi, R.G. Buttery, and H. Sugisawa (eds.), 1993, pp. 35-48. A11 of these patents and publications are herein incorporated by 10 reference in their entireties. When an insect and/or moth repellent is used it is typically present at a level of from about 0.005 wt.% to about 3 wt.°/ of the composition.
6. Polymeric Soil Release Agents 15 Soil release agents, usually polymers, are especially desirable additives at levels of from about 0.05 wt.% to about 5 wt.%, preferably from about 0.1 wt.% to about 4 wt.%, more preferably from about 0.2 wt.% to about 3 wt.%. Suitable soil release agents are disclosed in U.S. Patent Nos. 4,702,857 4,711,730 4,713,194 20 4,877,896 4,956,447 and 4,749,596, all of these patents being herein incorporated by reference in their entireties.
Especially desirable optional ingredients are polymeric soil release agents comprising block copolymers of polyalkylene terephthalate and polyoxyethylene terephthalate, and block 25 copolymers of polyalkylene terephthalate and polyethylene glycol.
The polyalkylene terephthalate blocks preferably comprise ethylene and/or propylene groups. Many such soil release polymers are nonionic, for example, the nonionic soil release polymer is described in U.S. Patent No. 4,849,257, which patent is herein incorporated by 30 reference in its entirety.
The polymeric soil release agents useful in the present invention can include anionic and cationic polymeric soil release SUBSTITUTE SHEET (RULE 26) agents. Suitable anionic polymeric or oligomeric soil release agents are disclosed in U.S. Patent No. 4,018,569, which patent is herein incorporated by reference in its entirety. Other suitable polymers are disclosed in U.S. Patent No. 4,808,086, which patent is herein 5 incorporated by reference in its entirety. Suitable cationic soil release polymers are described in U.S. Patent No. 4,956,447, which patent has already been herein incorporated by reference.
7. Viscosity Control Agents 10 Viscosity control agents can be organic or inorganic in nature and may either lower or raise the viscosity of the formulation.
Examples of organic viscosity modifiers (lowering) are aryl carboxylates and sulfonates (for example, benzoate, 2-hydroxybenzoate, 2-aminobenzoate, benzenesulfonate, 2-15 hydroxybenzenesulfonate, 2-aminobenzenesulfonate, etc.), fatty acids and esters, fatty alcohols, and water-miscible solvents such as short chain alcohols. Examples of inorganic viscosity control agents are water-soluble ionizable salts. A wide variety of ionizable salts can be used. Examples of suitable salts are the halides and acetates of 20 ammonium ion and the group IA and IIA metals of the Periodic Table of the Elements, for example, calcium chloride, lithium chloride, sodium chloride, potassium chloride, magnesium chloride, ammonium chloride, sodium bromide, potassium bromide, calcium bromide, magnesium bromide, ammonium bromide, sodium iodide, 25 potassium iodide, calcium iodide, magnesium iodide, ammonium iodide, sodium acetate, potassium acetate, or mixtures thereof.
Calcium chloride is preferred. The ionizable salts are particularly useful during the . process of mixing the ingredients to make the compositions herein, and later to obtain the desired viscosity. The 30 amount of ionizable salts used depends on the amount of active ingredients used in the compositions and can be adjusted according to the desire of the formulator. Typical levels of salts used to control SUBSTITUTE SHEET (RULE 26) the composition viscosity are from 0 to about 10 wt.%, preferably from about 0.01 wt.% to about 6 wt.%, and most preferably from about 0.02 wt.% to about 3 wt.% of the composition.
Viscosity modifiers (raising) or thickening agents can be added S to increase the ability of the compositions to stably suspend water-insoluble articles, for example, perfume microcapsules. Such materials include hydroxypropyl substituted guar gum (such as that available from Rhone-Poulenc Corporation under the tradename JAGUAR~ HP200), polyethylene glycol (such as that available from 10 Union Carbide Corporation under the tradename CARBOWAX~
20M), hydrophobic modified hydroxyethylcellulose (such as that available from the Aqualon Company under the tradename NATROSOL~ Plus), and/or organophilic clays (for example, hectorite and/or bentonite clays such as those available from the Rheox 15 Company under the tradename BENTONE'''M 27, 34 and 38 or from Southern Clay Products under the tradename BENTOLITETM L~ and those described in U.S. Patent No. 4,103,04?, which is herein incorporated by reference in its entirety). These viscosity raisers (thickeners) are typically used at levels from about 0.5 wt.°/ to about 20 30 wt.°/, preferably from about 1 wt.% to about 5 wt.%, more preferably from about 1.5 wt.% to about 3.5 wt.°/, and most preferably from about 2 wt.°/ to about 3 wt.%, of the composition.
8. Pearlizing and OpacifylngAgents 25 Examples of pearlizing or opacifying agents that can be added to the compositions of this invention include, but are not restricted to, glycol distearate, propylene glycol distearate, and glycol stearate.
Some of these products are available from Witco Corporation under the KEMESTER~ tradename.

SUBSTITUTE SHEET (RULE 26) 9. Vitamins and Extracts In personal care applications, vitamins and extracts are often used in the formulations thereof. Examples of vitamins that can be added to the compositions of this invention include, but are not 5 restricted to, vitamins Al, Az, Bi, Bz, B6, Biz, C, D, E, H, and K, the provitamins, salts, derivatives, and complexes thereof, and mixtures thereof. Examples of extracts that can be added to the compositions of this invention include, but are not restricted to, rosemary extract, carrot extract, Camelina sativa, camomile extract, egg yolk extract, 10 elm extract, acacia extract, rose extract, lilac extract, licorice extract, lemon extract, orange extract, lime extract, linden extract, melon extract, peach extract, orchid extract, orris extract, and the like, and mixtures thereof.
1S 10. Antioxidanis Examples of antioxidants that can be added to the compositions of this invention are progyl gallate, available from Eastman Chemical Products, Inc. under the tradenames TENOX~
PG and TENOX~ S-1, and dibutylated hydroxytoluene, available 20 from UOP Inc. under the tradename SUSTANE~ BHT.

11. Silicones The present compositions can contain silicones to provide additional benefits, for example, in a fabric application they may 25 provide ease of ironing and improved fabric absorbency. As used herein, the term "silicones" comprises cationic and amphoteric silicones, polysiloxanes, and polysiloxanes having hydrogen-bonding functional groups consisting of amino, carboxyl, hydroxyl, ether, polyether, aldehyde, ketone, amide, ester, and thiol groups. Such 30 polysiloxanes include, but are not limited to, polyether-modified polysiloxanes, amino-modified polysiloxanes, epoxy-modified polysiloxanes, polyhydrido-modified polysiloxanes, phenol-derivative-SUBSTITUTE SHEET (RULE 26) modified polysiloxanes, ABA-type polysiloxanes, [AB]N-type polysiloxanes, amino (CAB]rr-type polysiloxanes, including those available from OSi Specialties, Inc. (a division of Witco Corporation), under the SILWET~, NUWET~, NUDRYTM, NUSOFTTM
MAGNASOFT~ tradenames.
Suitable silicones may include polydimethylsiloxanes ~ of viscosity of from about 100 centistokes (cs) to about 100,000 cs, preferably from about 200 cs to about 60,000 cs and/or silicone gums.
These silicones can be used in emulsified form, which can be 10 conveniently obtained directly from the suppliers. Examples of these preemulsified silicones are the 60% emulsion of polydimethylsiloxane (350 cs) sold by Dow Corning Corporation under the tradename DOW
CORNING~ 1157 Fluid and the 50% emulsion of polydimethylsiloxane (10,000 cs) sold by General Electric Company under the tradename GENERAL ELECTRIC~ SM 2140 silicones.
The optional silicone component can be used in an amount of from about 0.1 wt.% to about 6 wt.% of the composition.
Silicone foam suppressants can also be used. These are usually not emulsified and typically have viscosities of from about 100 cs to about 10,000 cs, preferably from about 200 cs to about 5;000 cs. Very low levels are used, typically from about 0.01°/ to about 1%, preferably from about 0.02°/ to about 0.5%. Another preferred foam suppressant is a silicone/silicate mixture, for example, Dow Corning's ANTIFOAM''M A.
The pH (10% solution) of the compositions of this invention is generally adjusted to be in the range of from about 2 to about 7, preferably from about 2.4 to about 6.5, more preferably from about 2.6 to about 4. Adjustment of pH is normally carried out by including a small quantity of free acid in the formulation. Because no strong 30 pH buffers are present, only small amounts of acid are required. Any acidic material can be used its selection can be made by anyone SUBSTITUTE SHEET (RULE 26) skilled in the softener arts on the basis of cost, availability, safety, etc. Among the acids that can be used are methyl sulfonic, hydrochloric, sulfuric, phosphoric, citric, malefic, and succinic. For the purposes of this invention, pH is measured by a glass electrode in a 10°/ solution in water of the softening composition in comparison with a standard calomel reference electrode.

12. Lubrication and Slip Additives Compositions and formulations of the present invention can contain additives such as water, insoluble organics such as fatty acid's, fatty esters, triglycerides, oils, alcohols, fatty alcohols, fatty amines and derivatives, amides, hydrocarbons, mineral oils, waxes, and the like, and mixtures thereof, as lubrication and slip agents.
1 S 13. Dye Transfer Inhibitors Compositions and formulations of the present invention can contain ethoxylated amines, amphoterics, betaines, polymers such as polyvinylpyrrolidone, and other ingredients that inhibit dye transfer.
I. EXAMPLES
The above examples are but a few examples of more particular formulations embodying the compositions of the present invention.
The following examples are provided for purposes of further description of the present invention and are not intended to limit the scope of that which is regarded as the invention.
Testing of WE-18 and V3626 Under U.S. Conditions A Pairwise Ranking method was used for this testing, which is different from our normal method of Forced Ranking. The method is 30 described by Meilgaard, Civille, and Carr, Sensory Evaluation Techniques, (pp. 88-91, 254, and 268) and is being looked at by a SUBSTITUTE SHEET (RULE 26) CSMA committee. Hard tallow solketal esterquat (SEQ) softens as well as HEQ while the soft tallow an canola were worse.
Example 1 is softening testing done for Lever's Kuschelweich (HEQ), "improved" WE-18 (lot GS58101) and V3626 (lot GS58141).
5 The method is explained as follows: 15% dispersions were made of WE-18 and V3626 (pH=3, about 850 ppm calcium chloride (100°/
bases) added for viscosity control. Solids on Kuschelweich 15.2%~ the standard AATCC detergent was used in the wash cycle 0.1% loading of softener was used on the bundle weight and all towels dried in a electric dryer.
Three towel study «< paired set»>
WE-18 towel V3626 towel WE-18 towel V36236 towel WE-18 towel HE towel 3 WE-18 towel HE towel 1 V3626 towel HE towel 2 V3626 towel HE towel 4 15 Analysis results: The table below shows the number of times ( out of 10) each "column" sample was chosen as being softer than each "row"
sample. For example, when towel WE-18 was presented with towel HEQ it (WE-18) was perceived softer 9 out of the 10 times.

Comparison of towel samples The first step in the Friedman analysis is to compute the rank sum for each sample as follows:
WE-28: 2(8+9) + (2+1) = 37 V3626: 2(2+10) + ($+0) = 48 HEQ: 2(1+0) + (9+10) = 21 The Honestly significant difference at 95°/ (HSD95) is a standard statistical measure calculated as follows: HSD95=

SUBSTITUTE SHEET (RULE 26) q°.os(pt~4)li2 where: q°~°g is a constant for a particular number of samples (3.31 for 3 samples) ~ p = # of judgments (10 for this test) ~ t is the number of treatments of samples tested (3 for this test). For this evaluation, HSD95 was calculated as 9.06. Taking the difference between the rank sums of V3626, WE-18, and HEQ, the differences are greater than 9.06. Consequently, V3626 and WE-18 are "significantly" softer than HEQ.
Softening testing was done on WE-18, V3626 and Kuschelweich (HEQ). The following points need to be outlined 10 concerning this test: softening evaluations were done on both line dried and dryer dried towels no detergent was used in the wash cycle sample WE-18 (lot GS59078) upon dispersing in water resulted in a high viscosity (over 5000 cP) formulations and a high loading of softener was added to the bundle weight (0.28%) Line D Softenin Results Ranked sums: HEla= 47 WE-18=32 V3626 = 47 HSD95 for this test 10.7 Results: HEQ is softer than WE-18. There is no difference in softening between V3626 and HEQ.

Dryer Dry Softening Results SUBSTITUTE SHEET (RULE 26) Ranked sums: HEIa = 50 WE-18 = 32 V3626 = 44 HSD95 for this test 10.7 Results: HEQ is softer than WE-18. There is no difference in softening between V3626 and HEQ.
Solketal Derivative Softening Results Under U.S. Conditions 10 Several derivatives of solketal ester quats were tested for towel softening vs. Kuschelweich (HEQ) and WE-16. The solketal derivatives were canola-based, soft tallow-based, and hard tallow based. These were compared using the normal Forced Ranking method.~~ The following charts summarizes the softening results done 15 on these solketal quat esters.
Chart 1: Soft tallow solketal ._____.___..._ 3.5 ------ - - .-_____....__.........
.__.._-__.__....._._.. . . ... ..._ 2.5 ~--_._ _.._.. __. ...
__ ~ _ .~_..___._.._.......
20 ratin~ _-.._ ._ 0.5 - - _._..._..._ __.
0 -i I I- -sollcetal WE-16 I-IEC~ Marsh softoner Chart 2 25 hardtallow eokletal ester quat ,, _ ~ . - ~_.____-_.._..__.__..__ ......_ _. ..
3.5 .--_.... _.___...._ _-__ _..._.-_.._...__............._..
..__ __ ___. ~-.. _ ._....__...___.._._.._ .. . .
2.5 ._.___ - ~__.-__ _..___....._... .
-_ ___.____.._..__...._.._.. _....
1. _' _ 30 1 __-0.5 ______ -___~. ._.~_- _._....__.._ _..
0 .-- ~ _ _ __ solkelal WE-IG IIEO I~aisf~

SUBSTITUTE SHEET (RULE 26) Chart 3 Canola solketal ester quat _______.____________-~_ - ~_.~_______.
._.. ____.._._....__._.____________...__-~ __..._._____...._.
3 ,, _... _..._.
--_ __~- _-.__.___....
u~ ? !i .. __._..._.._._...___._._._ ~. ~.__.__.._..__...__._..
_._.. _.~___ ~ ._._.._______....._.._..._ _ ~r ____..
I __ 0.~ _- ~_I- r- ~- -.
sollcelal WF-1G IIEC'a harsh 9011C110f There are many unexpected benefits of the above formulations.
Most importantly, there is improved softening performance of the formulation over an equivalent amount of dialkyl ester quat formulation absent compounds of formulae (I) and/or (II). In addition; however, the formulations above disperse readily into water, even cold water, without a viscosity increase as with conventional quats, and provide a finer final particle size when so dispersed, for example, at 100 ppm concentration.
EXAMPLE 1: Fabric Softener Com onent Amount (wei ht %) Component A 20.8 Dye (1% solution of SANDOLAN~ Walkblau0.60 NBL
160 available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, 0.80 available from Haarmann and R,eimer GmbH) Calcium chloride 0.10 Water, 9 German hardness to 100 EXAMPLE 2: Fabric Softener Com onent Amount (wei ht %) Component B 22.0 Dye (1% solution of SANDOLAN~ Walkblau 0.60 NBL

150 available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, available0.80 from Haarmann and Reimer GmbH) SUBSTITUTE SHEET (RULE 26) Calcium chloride 1~ ~ 0.10 Water, 9° German hardness to 100 EXAMPLE 3: Fabric Softener Com onent Amount (wei ht rb) Com onent C 20.5 Dye (I% solution of SANDOLAN~ Walkblau0.60 NBL
150, available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, 0.80 available from Haarmann and R.eimer GmbH) Calcium chloride 0.10 Water, 9 German hardness to 100 EXAMPLE 4: Fabric Softener Com onent Amount (wei ht ~) Component D 21.6 Dye (1% solution of SANDOLAN~ Walkblau0.60 NBL
150, available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, 0.80 available from Haarmann and R.eimer GmbH) Calcium chloride 0.10 Water, 9 German hardness to 100 EXAMPLE 5: Fabric Softener Com onent Amount (wei ht ib) Component F 20.5 Dye (1% solution of SANDOLAN~ Walkblau0.60 NBL
150 available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, 0.80 available from Haarmann and Reimer GmbH) Calcium chloride 0.10 Water, 9 German hardness to 100 EXAMPLE 6: Fabric Softener Com onent Amount (wei ht ~) Component F 21.6 Dye (1% solution of SANDOLAN~ Walkblau0.60 NBL
150 available from Sandoz) Antiform (SAG 220, available from OSi 0.20 Specialties) Fragrance~ perfume oil (D 60515 W, 0.80 available from Haarmann and Reimer GmbH) Calcium chloride 0.10 Water, 9 German hardness to 100 SUBSTITUTE SHEET (RULE 26) EXAMPLE 7: Halt Rinse Com onent Amount (wei ht rb) Component C 2.3 Propoxylated myristyl alcohol (INCI 1.0 name: PPG-3 myristyl ether) (available from Whitco S.A., France under the tradename WITCONOL ~ A PM) Glyceryl stearate SE (available from 1.0 Goldschmidt under the tradename TEGENACID~

Hydroxyethylcellulose (available from 1.0 Aqualon under the tradename NATROSOL~ IIIIG) Citric acid 0.05 Deionized water to 100 FxamnlP 7 shows improved wet and drv compatibility of washed hair.
EXAMPLE 8: Car Rinse .

Com onent Amount (wei ht %) Component G 8.8 PEG-30 glyceryl cocoate (available 7.3 from Witco Surfactants GmbH under the tradename REWODERM~ LI 63) 2-ethylhexyl stearate (available from 7.0 Henkel KGaA

under the tradename RILONIT~ EHS) Methyl ester of a fatty acid having 4.0 8-18 carbon atoms Oleic acid imidazoline ether sulfate 7.3 (available from Witco GmbH under the tradename REWOQUAT~
W

3690) Dipropylene glycol mono-rrbutyl ether 20.0 (available from Dow Chemicals under the tradename DOWANOI~

DPnB) Butyldiglycol 10.0 Deionized water to 100 F,rarnnln R ehr,we ;mnrnved water bed-off behavior on the surfaces of car bodies.
EXAMPLE 9: Car Shaml 00 Com oaent Amount (wei ht %) Component G 20.0 Dipropylene glycol 15.0 Ethoxylated lauryl alcohol (available 28.0 from Witco Surfactants GmbH under the tradename RE OPAL~ LA 12-80 Cocoamidopropyl l~oxide (available 10.0 from Witco Surfactants GmbH under the tradename REWOMINOX~ B204) Citric acid Trisodium salt of methylglycinediacetic2.0 acid (available from BASF under the tradename Trilon~
M) Deionized water To 100 SUBSTITUTE SHEET (RULE 26) Example 9 shows improved cleaning action with increased gloss of the surface ,a~~.,oa EXAMPLE 10: H dro hilic Handle Modifier Com onent Amount (wei ht rb) Component D 65.0 Coconut fatty acid polyglycol ester 20.0 8 EO (available from Witco Corp. under the tradename WITCONOI~ 2650) Ethoxylated coconut fatty acid partial10.0 glycerides (available from Witco Surfactants GmbH
under the tradename REWODERM~ ES 90/R,EWODERM~

LI 63 in the ratio 1:1) Lauryl ether citrate (available from 5.0 Witco Corp.

under the tradename (WITCONOL~ EC 1127) This 100% strength formulation can be diluted with water as S desired and adjusted to the desired viscosity. The handle and the rewetting power of the formulation in Example 10 were superior to those for a formulation in which Component D was replaced by a conventional esterquat (REWOQUAT~ WE 18).
EXAMPLE 11: Permanent H dro hilizati on Com osition Com onent Amount (wei ht ib) Component G 50.0 Coconut fatty acid polyglycol ester 30.0 8 EO (available from Witco Corp. under the tradename WITCONOL~ 2650) Magnasoft Plus Fluid (Witco Corporatioxi)10.0 Magnasoft TLC (Witco Corporation) 5.0 Lauryl ether citrate (available from 5.0 Witco Corp.
under the tradename (WITCONOL~ EC 1127) This 100% strength formulation can be diluted with water as desired and adjusted to the desired viscosity. The handle and rewetting power of the formulation in Example 11 were superior to those for a formulation in which Component G was replaced by a conventional esterquat (REWOQUAT~ WE 18).
s2 SUBSTITUTE SHEET (RULE 26) EXAMPLE A
This example illustrates formulations of compounds according to the present invention that are formulated into a microemulsion.
As noted above, such formulations generally include three 5 components (a) a compound of formulas (I) and/or (II), (b) a solvatrope or coupling agent and blends thereof, and (c) an oil or hydrophobic organic component and blends thereof, which are blended in water.
Suitable solvatropes or coupling agents may be selected from 10 the diols and alkoxylates corresponding to structural formulas (T) or (E), TMPD, TMPD alkoxylates, ethanol, isopropanol, butanol, 1,2 cyclohexanedimethanol (1,2-CHDM), 1,4-cyclohexanedimethanol (1,4 CHDM), HPHP glycol, isopentyldiol, 1,2-hexanediol, ethylene glycol butyl ether, hexylene glycol, 2-butoxyethanol (sold by Union Carbide 15 under the tradename butyl CELLOSOLVE~), Cs-Ciz diols/triols and ester diols/triols, glycol ethers, and the like. Oils and hydrophobic organic components may be selected from the fatty C8-C22 methyl esters, such as methyl oleate, mineral seal oils, silicone oils, fatty acids, monoglycerides, diglycerides, triglycerides, dialkyl esters, and 20 the like, depending on the application. The methyl esters are the preferred oil based on performance and biodegradability, although mineral seal oil is preferred in car drying aid applications.
EXAMPLE B
25 This example illustrates formulations of compounds according formulas (I) and/or (II) for use as emulsifiers, for example, for agricultural emulsifiers or asphalt emulsifiers. Thus, these compounds are useful as an emulsifier for organic compounds, for example, when formulated with pesticides, other surfactants and 30 dispersants, and water, the resulting formulation would make a useful agricultural pesticide spray, the compounds of formulas (I) SUBSTITUTE SHEET (RULE 26) and/or (II) encouraging the organic components to remain dispersed in the water, allowing efficient transfer and coverage in treating plants.
EXAMPLE C
This example illustrates formulations of compounds according to formulas (I) and/or (II) for use as a herbicide emulsion agent. A
compound according to formulas (I) and/or (II) or mixture thereof is added to a solvent or solvent mixture and water and a herbicide is 10 incorporated therein and an emulsion formed. The amount of the compound of formulas (I) and/or (II) is generally from about 5 wt.°/ to about 50 wt.%, preferably from about 10 wt.% to about 40 wt.%, most preferably from about 15 wt.% to about 30 wt.°/, of the herbicide concentrate composition. In addition, the compound of formulas (I) and/or (II) can be used in a pesticide emulsion agent formulation that does not incorporate the pesticide itself, instead an appropriate amount of pesticide must be added to the pesticide emulsion agent formulation to make a pesticide emulsion concentrate, which is diluted with water by the user and applied in the dilute form. In general, only 10-30 wt.% of the pesticide emulsion agent formulation is used to in the pesticide emulsion concentrate, that is, there is 70-90 wt.°/ pesticide in the pesticide emulsion concentrate, which is the form it will generally be commercialized. The final customer will then dilute the pesticide emulsion concentrate (pesticidelemulsifier package) into water for actual application of pesticide.
EXAMPLE D
As noted above, the compounds of formulas (I) and/or (II) may also be used as an asphalt emulsifier as an additive for asphalt, the 30 possible applications in asphalt products are as a cationic rapid set (CRS) emulsion for chip seal, as a cationic medium set (CMS) for SUBSTITUTE SHEET (RULE 26) mixing grade applications, in a slurry seal or microsurfacing application, in a roofing and driveway sealer, a cationic slow set emulsion, cationic quick set emulsion, tack coat, fog seal, base stabilization, prime coat, slurry seal, microsurfacing, industrial 5 asphalt emulsion, or filled asphalt emulsion. The amount of the compound of formulas (I) and/or (II) in such an application would likely include from about 0.1 wt.% to about 8.0 wt.%, preferably about 0.20 wt.°/ to about 5.0 wt.%, and most preferably about 0.5 wt.% to about 2.0 wt.%, of the asphalt. The pH of the emulsifier 10 solution should be less than about ?.0, and may be adjusted with any strong acid to have a pH of between about 1.0 and about 5.0, preferably between about 2.0 to about 4.0, most preferably between about 2.0 and about 3Ø

This example illustrates formulations of compounds according to formulas (I) and/or (II) for use in corrosion inhibition, for example, for lubricating oil or oil field use. A compound according to formulas (I) and/or (II) or mixture thereof is added to lubricating or other oils 20 as a corrosion inhibitor, alone or in combination with a surfactant and/or coupling agent, which may be incorporated in the formulation or applied separately. When used, an effective amount is applied to the oil or oil mixture that will come in contact with the metal. The term "effective amount" denotes the amount of compound of formulas 25 (I) and/or (II) that would be effective to inhibit corrosion. In general, the amount of the compound of formulas (I) and/or (II) ranges from about 0.001 wt.% to about 5 wt.%, preferably from about 0.01 wt.% to about 1 wt.%, most preferably from about 0.01 wt.% to about 0.5 wt.%, of the oil mixture in which it is used.

SUBSTITUTE SHEET (RULE 26) EXAMPLE F
This example illustrates formulations of compounds according to formulas (I) and/or (II) for use in a lubricant and anti-balling agent for silicate muds and other water-based muds, for example, to 5 lubricate drill strings to prevent stuck pipe, bit-balling, or string balling associated with drilling wells. The apparatus for drilling and general lubrication processes in well-known to those of skill in the art, and are disclosed, for example, in U.S. Patent Nos. 5,586,608 5,593,954 and 5,639,715, all of these patents being herein 10 incorporated by reference in their entireties. In this lubrication process, a compound according to formulas (I) and/or (II) or mixture thereof is added to lubricating or other oils effective to inhibit stuck pipe, bit balling, or string balling. The polyamine may be used alone or in combination with a surfactant and/or coupling agent, for 15 example, propylene glycols or ethoxylated glycols, which may be incorporated with the compound of formulas (I) and/or (II) in a formulation or applied separately. Of particular use are the oilfield products available from Witco Corporation under the tradename WITBREAK~, such as WITBREAK~ DPG-484. When used, an 20 effective amount of polyamine is applied to the lubricant mixture as used in the drilling operation. The term "effective amount" denotes the amount of polyamine compound that would be effective to inhibit stuck pipe, bit balling, or string balling. In general, the amount of the compound of formulas (I) and/or (II) ranges from about 0.001 25 wt.% to about 5 wt.%, preferably from about 0.01 wt.°/ to about 2 wt.%, most preferably from about 0.05 wt.% to about 0.5 wt.%, of the lubricating mixture in which it is used.

SUBSTITUTE SHEET (RULE 26)

Claims (33)

WHAT IS CLAIMED IS:

1. A process for making a tertiary amine ester of the following formula (I):
the process comprising:
(a) reacting a ketone or an aldehyde having the formula with a glycol to form a ketal or an acetal;
(b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile;
(c) reducing the ether nitrile to a tertiary amine ketal or a tertiary amine acetal;
(d) hydrolyzing the tertiary amine ketal or the tertiary amine acetal to a tertiary amine diol; and (e) esterifying the tertiary amine diol to the tertiary amine ester of formula (I), wherein R1 and R2 are each independently a hydrogen atom or a linear, branched, or cyclic alkyl, alkylene, alkaryl, or aryl-containing group containing 1 to 18 carbon atoms; and each R3 are each independently of one another fatty acid radicals having 6-22 carbon atoms.

2. The process according to claim 1, further comprising:

(f) protonating or quaternizing the tertiary amine ester of formula (I) to a protonated or quaternary amine ester of the following formula:
wherein A- is an inorganic or organic anion.

3. The process according to claim 2, wherein A- is selected from the group consisting of fluoride, chloride, bromide, iodide, chlorite, chlorate, hydroxide, hypophosphite, phosphite, phosphate, carbonate, formate, acetate, lactate, and other carboxylates, oxalate, methyl sulfate, ethyl sulfate, benzoate, and salicylate, and the like.

4. The composition produced by the process of claim 1.

5. The composition according to claim 4, further comprising water.

6. The composition according to claim 5, wherein the amount of compounds of the general formula (I) and/or (II) generally ranges from about 2 wt.% to about 80 wt.% of the total composition.

7. The composition according to claim 6, wherein the amount of compounds of the general formula (I) and/or (II) generally ranges from about 5 wt.% to about 30 wt.% of the total composition.

8. The composition according to claim 4, further comprising at least one conventional quaternary ammonium compound.

9. The composition according to claim 8, wherein the compounds of formula (I) comprise from about 10% to about 90% by weight of the total amount of quaternary ammonium compounds.

10. The composition according to claim 4, further comprising a secondary surfactant selected from the group consisting of nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, and ionic surfactants.

11. The composition according to claim 10, wherein the secondary surfactant is selected from the group consisting of:
ammonium lauryl sulfate, sodium lauryl sulfate, any .alpha.-olefin sulfonate, ammonium laureth sulfate (2 or 3 moles), sodium laureth sulfate (2 or 3 moles), sodium myristyl sulfate, sodium myristeth sulfate (1-4 moles), ammonium xylene sulfonate, sodium xylene sulfonate, TEA dodecylbenzene sulfonate, TEA lauryl sulfate, ammonium pareth sulfate, sodium pareth sulfate, sodium oleth sulfate, derivatives thereof, and mixtures thereof.

12. The composition according to claim 10, wherein the secondary surfactant is selected from the group consisting of:
betaines, sulfosuccinates, mono- and diglycerides, glycinates, sugars and derivatives thereof, hydroxysultaines, mono- and diacetates, ethoxylated derivatives thereof, and mixtures thereof.

13. The composition according to claim 10, wherein the secondary surfactant is selected from the group consisting of:

alkanolamides; amine oxides nonylphenol ethoxylates; C5-C20 linear or branched alcoxylates using EO, PO, BO, or mixtures thereof;
amine ethoxylates; fatty amide ethoxylates; fatty acid ethoxylates;
carboxylated nonionics; (-polyglucosides; and mixtures thereof.

14. A hydrophilic handle modifier composition comprising:
(a) 15% to 25% by weight of alkyl fatty acid polyglycol ester having 6 to 25 moles of EO;
(b) 45% to 65% by weight of the compounds according to claim 4;
(c) 10% to 20% by weight of partial glyceride esters having 5 to 80 moles of EO; and (d) 5% to 10% by weight of alkyl ether citrates.

15. The hydrophilic handle modifier composition according to claim 14, further comprising:
(e) 0.001% to 10% by weight of silicone compounds.

16. A composition comprising:
(a) at least one compound according to claim 4;
(b) a solvatrope or coupling agent or blends thereof and (c) an oil or hydrophobic organic component and blends thereof.

17. The composition according to claim 16, wherein the solvatrope or coupling agent is selected from the group consisting of:
hydroxypivalyl hydroxypivalate and its alkoxylated derivatives, TMPD, TMPD alkoxylates, ethanol, isopropanol, butanol, 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, HPHP glycol, isopentyldiol, 1,2-hexanediol, ethylene glycol butyl ether, hexylene glycol, isoprene glycol, sorbitan ethoxylates, 2-butoxyethanol, C6-C12 diols/triols and ester diols/triols and their alkoxylated derivatives, glycol ethers, and mixtures thereof.

18. The composition according to claim 16, wherein the oil or hydrophobic organic component is selected from the group consisting of fatty acids fatty amides fatty alcohols; fatty oils fatty esters made from a C8-C22 fatty acid and a C1-C8 alcohol; dialkyl esters;
mineral oil; mineral seal oils silicone oils petrolatums;
monoglycerides; diglycerides; triglycerides; aliphatic, paraffinic, and naphthalinic hydrocarbons; oils and spirits; and mixtures thereof.

19. The composition produced by the process of claim 2.

20. The composition according to claim 19, further comprising water.

21. The composition according to claim 20, wherein the amount of compounds of the general formula (I) and/or (II) generally ranges from about 2 wt.% to about 80 wt.% of the total composition.

22. The composition according to claim 21, wherein the amount of compounds of the general formula (I) and/or (II) generally ranges from about 5 wt.% to about 30 wt.% of the total composition.

23. The composition according to claim 19, further comprising at least one conventional quaternary ammonium compound.

24. The composition according to claim 23, wherein the compounds of formula (I) comprise from about 10% to about 90% by weight of the total amount of quaternary ammonium compounds.

25. The composition according to claim 19, further comprising a secondary surfactant selected from the group consisting of: nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, and ionic surfactants.

26. The composition according to claim 25, wherein the secondary surfactant is selected from the group consisting of:
ammonium lauryl sulfate, sodium lauryl sulfate, any .alpha.-olefin sulfonate, ammonium laureth sulfate (2 or 3 moles), sodium laureth sulfate (2 or 3 moles), sodium myristyl sulfate, sodium myristeth sulfate (1-4 moles), ammonium xylene sulfonate, sodium xylene sulfonate, TEA dodecylbenzene sulfonate, TEA lauryl sulfate, ammonium pareth sulfate, sodium pareth sulfate, sodium oleth sulfate, derivatives thereof, and mixtures thereof.

27. The composition according to claim 25, wherein the secondary surfactant is selected from the group consisting of betaines, sulfosuccinates, mono- and diglycerides, glycinates, sugars and derivatives thereof, hydroxysultaines, mono- and diacetates, ethoxylated derivatives thereof, and mixtures thereof.

28. The composition according to claim 25, wherein the secondary surfactant is selected from the group consisting of alkanolamides; amine oxides nonylphenol ethoxylates; C5-C20 linear or branched alcoxylates using EO, PO, BO, or mixtures thereof;
amine ethoxylates; fatty amide ethoxylates; fatty acid ethoxylates;
carboxylated nonionics; .alpha.-polyglucosides; and mixtures thereof.

29. A hydrophilic handle modifier composition comprising (a) 15% to 25% by weight of alkyl fatty acid polyglycol ester having 6 to 25 moles of EO:

(b) 45% to 65% by weight of the compounds according to claim 19;
(c) 10% to 20% by weight of partial glyceride esters having 5 to 80 moles of EO; and (d) 5% to 10% by weight of alkyl ether citrates.

30. The hydrophilic handle modifier composition according to claim 29, further comprising:
(e) 0.001% to 10% by weight of silicone compounds.

31. A composition comprising:
(a) at least one compound according to claim 19;
(b) a solvatrope or coupling agent or blends thereof; and (c) an oil or hydrophobic organic component and blends thereof.

32. The composition according to claim 31, wherein the solvatrope or coupling agent is selected from the group consisting of:
hydroxypivalyl hydroxypivalate and its alkoxylated derivatives, TMPD, TMPD alkoxylates, ethanol, isopropanol, butanol, 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, HPHP glycol, isopentyldiol, 1,2-hexanediol, ethylene glycol butyl ether, hexylene glycol, isoprene glycol, sorbitan ethoxylates, 2-butoxyethanol, C6-C12 diols/triols and ester diols/triols and their alkoxylated derivatives, glycol ethers, and mixtures thereof.

33. The composition according to claim 31, wherein the oil or hydrophobic organic component is selected from the group consisting of fatty acids fatty amides fatty alcohols; fatty oils fatty esters made from a C8-C22 fatty acid and a C1-C8 alcohol; dialkyl esters;
mineral oil; mineral seal oils silicone oils; petrolatums;

monoglycerides; diglycerides; triglycerides; aliphatic, paraffinic, and naphthalinic hydrocarbons; oils and spirits and mixtures thereof.