CA2349142A1 - Compositions and methods for stimulating gastrointestinal motility - Google Patents
Compositions and methods for stimulating gastrointestinal motility Download PDFInfo
- Publication number
- CA2349142A1 CA2349142A1 CA002349142A CA2349142A CA2349142A1 CA 2349142 A1 CA2349142 A1 CA 2349142A1 CA 002349142 A CA002349142 A CA 002349142A CA 2349142 A CA2349142 A CA 2349142A CA 2349142 A1 CA2349142 A1 CA 2349142A1
- Authority
- CA
- Canada
- Prior art keywords
- methods
- compositions
- prodrug
- gastrointestinal motility
- stimulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Abstract
The present invention is directed to methods for stimulating the motility of the gastrointestinal system in a patient which comprises administering a growth hormone secretagogue, a prodrug thereof or a pharmaceutically acceptable salt of said secretagogue or said prodrug. More particularly, the present invention provides methods for stimulating the motility of the gastrointestinal system in a patient which comprises administering a compound of Formula I:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20823400P | 2000-05-31 | 2000-05-31 | |
US60/208,234 | 2000-05-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2349142A1 true CA2349142A1 (en) | 2001-11-30 |
CA2349142C CA2349142C (en) | 2005-07-12 |
Family
ID=22773794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002349142A Expired - Lifetime CA2349142C (en) | 2000-05-31 | 2001-05-29 | Compositions and methods for stimulating gastrointestinal motility |
Country Status (14)
Country | Link |
---|---|
US (2) | US6548501B2 (en) |
EP (1) | EP1159964B1 (en) |
JP (4) | JP3842987B2 (en) |
KR (1) | KR20010109139A (en) |
AT (1) | ATE446758T1 (en) |
AU (1) | AU4811401A (en) |
CA (1) | CA2349142C (en) |
DE (1) | DE60140285D1 (en) |
ES (1) | ES2333097T3 (en) |
HU (1) | HUP0102272A3 (en) |
IL (1) | IL143388A0 (en) |
MY (1) | MY134190A (en) |
NZ (1) | NZ512072A (en) |
ZA (1) | ZA200104396B (en) |
Families Citing this family (60)
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AU6747498A (en) | 1997-04-11 | 1998-11-11 | Sumitomo Pharmaceuticals Company, Limited | Benzene derivatives |
WO1998051687A1 (en) | 1997-05-14 | 1998-11-19 | Fujisawa Pharmaceutical Co., Ltd. | Piperidino derivatives which promote growth hormone release |
JP4116097B2 (en) | 1997-06-20 | 2008-07-09 | ノボ ノルディスク アクティーゼルスカブ | Compounds with growth hormone releasing properties |
UA53716C2 (en) * | 1997-06-25 | 2003-02-17 | Пфайзер Продактс Інк. | A substituted dipeptide tartaric salt as an agent stimulating the growth hormone secretion |
WO1998058947A1 (en) * | 1997-06-25 | 1998-12-30 | Pfizer Inc. | Dipeptide derivatives as growth hormone secretagogues |
UA64751C2 (en) | 1997-06-25 | 2004-03-15 | Пфайзер Продактс Інк. | Treatment of insulin tolerance using substances increasing growth hormone secretion |
ZA987383B (en) | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
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US6211174B1 (en) * | 1997-10-31 | 2001-04-03 | Merck & Co., Inc. | Naphtho-fused lactams promote release of growth hormone |
US6358951B1 (en) * | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
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JP2003503055A (en) * | 1999-06-30 | 2003-01-28 | ザイモジェネティクス,インコーポレイティド | SGIP peptide |
AU2001264977B2 (en) * | 2000-05-30 | 2005-04-14 | Merck & Co., Inc. | Melanocortin receptor agonists |
ATE446758T1 (en) * | 2000-05-31 | 2009-11-15 | Pfizer Prod Inc | USE OF GROWTH HORMONE SECRETAGOGENES TO PROMOTE DIGESTIVE MOTILITY |
-
2001
- 2001-05-16 AT AT01304334T patent/ATE446758T1/en not_active IP Right Cessation
- 2001-05-16 ES ES01304334T patent/ES2333097T3/en not_active Expired - Lifetime
- 2001-05-16 EP EP01304334A patent/EP1159964B1/en not_active Expired - Lifetime
- 2001-05-16 DE DE60140285T patent/DE60140285D1/en not_active Expired - Lifetime
- 2001-05-24 IL IL14338801A patent/IL143388A0/en unknown
- 2001-05-29 CA CA002349142A patent/CA2349142C/en not_active Expired - Lifetime
- 2001-05-29 KR KR1020010029620A patent/KR20010109139A/en active Search and Examination
- 2001-05-29 ZA ZA200104396A patent/ZA200104396B/en unknown
- 2001-05-29 MY MYPI20012552 patent/MY134190A/en unknown
- 2001-05-30 AU AU48114/01A patent/AU4811401A/en not_active Abandoned
- 2001-05-30 US US09/870,105 patent/US6548501B2/en not_active Expired - Lifetime
- 2001-05-30 HU HU0102272A patent/HUP0102272A3/en unknown
- 2001-05-30 NZ NZ512072A patent/NZ512072A/en unknown
- 2001-05-31 JP JP2001164877A patent/JP3842987B2/en not_active Expired - Lifetime
-
2003
- 2003-04-11 US US10/411,756 patent/US6852722B2/en not_active Expired - Lifetime
-
2006
- 2006-07-03 JP JP2006183577A patent/JP2006265270A/en not_active Withdrawn
-
2013
- 2013-04-19 JP JP2013088135A patent/JP2013139482A/en not_active Withdrawn
-
2015
- 2015-04-06 JP JP2015077334A patent/JP2015127344A/en active Pending
Also Published As
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HUP0102272A3 (en) | 2003-09-29 |
ZA200104396B (en) | 2002-11-29 |
DE60140285D1 (en) | 2009-12-10 |
US20030225096A1 (en) | 2003-12-04 |
HUP0102272A2 (en) | 2002-02-28 |
MY134190A (en) | 2007-11-30 |
JP2015127344A (en) | 2015-07-09 |
US6548501B2 (en) | 2003-04-15 |
CA2349142C (en) | 2005-07-12 |
ES2333097T3 (en) | 2010-02-17 |
JP2013139482A (en) | 2013-07-18 |
HU0102272D0 (en) | 2001-08-28 |
JP3842987B2 (en) | 2006-11-08 |
ATE446758T1 (en) | 2009-11-15 |
AU4811401A (en) | 2001-12-06 |
JP2006265270A (en) | 2006-10-05 |
US6852722B2 (en) | 2005-02-08 |
NZ512072A (en) | 2002-10-25 |
EP1159964A3 (en) | 2003-10-01 |
IL143388A0 (en) | 2002-04-21 |
EP1159964B1 (en) | 2009-10-28 |
EP1159964A2 (en) | 2001-12-05 |
KR20010109139A (en) | 2001-12-08 |
US20020042419A1 (en) | 2002-04-11 |
JP2002012556A (en) | 2002-01-15 |
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