CA2352296A1 - Collagen hemostatic fibers - Google Patents

Collagen hemostatic fibers Download PDF

Info

Publication number
CA2352296A1
CA2352296A1 CA002352296A CA2352296A CA2352296A1 CA 2352296 A1 CA2352296 A1 CA 2352296A1 CA 002352296 A CA002352296 A CA 002352296A CA 2352296 A CA2352296 A CA 2352296A CA 2352296 A1 CA2352296 A1 CA 2352296A1
Authority
CA
Canada
Prior art keywords
collagen
hemostatic
fiber
fibers
collagen hemostatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002352296A
Other languages
French (fr)
Other versions
CA2352296C (en
Inventor
Robert D. Torgerson
John Uhoch
Francis B. Maddalo
Stephen N. Eldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CR Bard Inc
Original Assignee
C.R. Bard, Inc.
Robert D. Torgerson
John Uhoch
Francis B. Maddalo
Stephen N. Eldridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.R. Bard, Inc., Robert D. Torgerson, John Uhoch, Francis B. Maddalo, Stephen N. Eldridge filed Critical C.R. Bard, Inc.
Publication of CA2352296A1 publication Critical patent/CA2352296A1/en
Application granted granted Critical
Publication of CA2352296C publication Critical patent/CA2352296C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325Collagen
    • DTEXTILES; PAPER
    • D01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01DMECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00Formation of filaments, threads, or the like
    • D01D5/06Wet spinning methods
    • DTEXTILES; PAPER
    • D01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01FCHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

Abstract

A collagen fiber and methods for producing and using the collagen fiber of the inventions to prepare hemostatic fabrics to control bleeding are provided. The collagen particles (e.g., fibrils) of the fiber, preferably, have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the fiber is formed.
The collagen fibers of the invention and hemostatic fabrics formed thereof optionally include hemostatic agents and/or other therapeutic agents, to further promote hemostasis and wound healing.
CA002352296A 1998-12-11 1999-12-06 Collagen hemostatic fibers Expired - Fee Related CA2352296C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/209,723 1998-12-11
US09/209,723 US6361551B1 (en) 1998-12-11 1998-12-11 Collagen hemostatic fibers
PCT/US1999/028854 WO2000034556A1 (en) 1998-12-11 1999-12-06 Collagen hemostatic fibers

Publications (2)

Publication Number Publication Date
CA2352296A1 true CA2352296A1 (en) 2000-06-15
CA2352296C CA2352296C (en) 2005-07-05

Family

ID=22780002

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002352296A Expired - Fee Related CA2352296C (en) 1998-12-11 1999-12-06 Collagen hemostatic fibers

Country Status (9)

Country Link
US (2) US6361551B1 (en)
EP (1) EP1137827B1 (en)
JP (1) JP4903308B2 (en)
KR (1) KR20010090876A (en)
AU (1) AU2042400A (en)
CA (1) CA2352296C (en)
DE (1) DE69926911T2 (en)
ES (1) ES2247850T3 (en)
WO (1) WO2000034556A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US7041657B2 (en) * 2001-02-12 2006-05-09 Marine Polymer Technologies Inc. Compositions and methods for modulation of vascular structure and/or function
ES2271568T3 (en) * 2002-05-08 2007-04-16 Radi Medical Systems Ab SOLUBLE MEDICAL SEALANT DEVICE.
US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
CN100394989C (en) 2002-11-15 2008-06-18 华沙整形外科股份有限公司 Collagen-based materials and methods for augmenting intervertebral discs
EP1587424A4 (en) 2002-12-31 2012-01-25 Marinepolymer Tech Inc Hemostatic compositions and uses therefor
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
EP1638486A4 (en) 2003-06-11 2010-09-29 Osteotech Inc Osteoimplants and methods for their manufacture
US20040260315A1 (en) * 2003-06-17 2004-12-23 Dell Jeffrey R. Expandable tissue support member and method of forming the support member
JP4499719B2 (en) * 2003-07-03 2010-07-07 ラディ・メディカル・システムズ・アクチェボラーグ Wound suture and sealing tool
US20050175659A1 (en) * 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
US20050283256A1 (en) * 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
AU2005237985B2 (en) 2004-04-20 2010-10-21 Genzyme Corporation Surgical mesh-like implant
US20060135946A1 (en) * 2004-12-21 2006-06-22 C. R. Bard, Inc. Hemostasis cuff for catheter securement
US7429241B2 (en) * 2005-09-29 2008-09-30 Codman & Shurtleff, Inc. Dural graft and method of preparing the same
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
US20070190110A1 (en) * 2006-02-10 2007-08-16 Pameijer Cornelis H Agents and devices for providing blood clotting functions to wounds
US20070224251A1 (en) * 2006-03-22 2007-09-27 Masao Tanihara Hemostatic material
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
PL2126167T3 (en) * 2007-03-27 2011-02-28 Dsm Ip Assets Bv Process for removing residual spin solvent from a gel spun filament, the filament, multi-filament yarn and products comprising the filament
JP5569398B2 (en) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー/エス Device for promoting hemostasis and / or wound healing
AU2009201541B2 (en) * 2008-04-23 2014-12-04 Integra Lifesciences Corporation Flowable collagen material for dural closure
NZ591006A (en) * 2008-07-24 2012-12-21 Univ Western Australia A collagen scaffold for cell growth and a method for producing same
CN102905732A (en) 2010-03-15 2013-01-30 弗罗桑医疗设备公司 A method for promotion of hemostasis and/or wound healing
US8940335B2 (en) 2010-06-01 2015-01-27 Baxter International Inc. Process for making dry and stable hemostatic compositions
EP2683864B1 (en) * 2011-03-08 2016-08-17 MiMedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
AU2013275758B2 (en) 2012-06-12 2015-03-12 Ferrosan Medical Devices A/S Dry haemostatic composition
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
GB2518199A (en) 2013-09-13 2015-03-18 Xiros Ltd Method of producing a swellable polymer fibre
JP6489485B2 (en) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ/エス Dry composition containing an extrusion enhancing factor
TW201538163A (en) * 2013-12-25 2015-10-16 Nissan Chemical Ind Ltd Water dispersion solidifying blood serum and blood
US9468654B1 (en) * 2014-04-02 2016-10-18 Ali Razavi Drug delivery compositions and methods
BR112017007466B1 (en) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition
US9801983B2 (en) * 2014-12-18 2017-10-31 Cook Medical Technologies Llc Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10283015B2 (en) 2015-04-08 2019-05-07 Biom'up Device and method for simulation of surface bleedings
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CA3004524A1 (en) 2015-11-08 2017-05-11 Omrix Biopharmaceuticals Ltd. Hemostatic mixture of cellulose-based short and long fibers
CN106075610B (en) * 2016-08-12 2022-02-01 陈旭东 Hemostatic particles for interventional puncture and preparation method thereof
EP3512529A4 (en) * 2016-09-16 2020-05-06 Ali Razavi Drug delivery compositions and methods
KR101876196B1 (en) 2017-11-03 2018-07-09 세원셀론텍(주) Medical materials produced using collagen and method for manufacturing the same
AU2019266529A1 (en) 2018-05-09 2020-12-03 Ethicon Inc. Method for preparing a haemostatic composition
KR102232767B1 (en) * 2020-01-14 2021-03-26 주식회사 제네웰 Method for preparing adm collagen fiber, adm collagen fiber prepared therefrom, and device for manufacturing the same
CN112795995A (en) * 2021-02-03 2021-05-14 常州市武进人民医院 Dry spinning method for medical hemostatic fiber and manufacturing method thereof
WO2022178005A1 (en) 2021-02-17 2022-08-25 Oxion Dental, Llc Stabilized active oxygen-generating antiseptic compositions, irrigation solutions, and articles

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US505148A (en) 1893-09-19 Process of preparing surgical sutures
US2637321A (en) 1944-03-20 1953-05-05 American Cyanamid Co Shaped article and method of producing it
US2598608A (en) 1946-06-11 1952-05-27 Research Corp Preparation of collagenous materials
US2654752A (en) 1952-02-13 1953-10-06 Lilly Co Eli Beta-4-morpholinoethyl-benzoate salt of penicillin
GB831124A (en) 1955-05-18 1960-03-23 Alfred Bloch Purification of collagen
US2920000A (en) 1955-11-07 1960-01-05 Ethicon Inc Ethicon Inc Removable valve Collagen article and the manufacture thereof
US2919999A (en) 1958-10-22 1960-01-05 Ethicon Inc Collagen article and the manufacture thereof
US3114235A (en) 1959-04-13 1963-12-17 Ethicon Inc Method of forming a round collagen strand
US3157524A (en) 1960-10-25 1964-11-17 Ethicon Inc Preparation of collagen sponge
US3114593A (en) 1961-04-12 1963-12-17 Ethicon Inc Method of producing a collagen strand
US3114591A (en) 1961-04-12 1963-12-17 Ethicon Inc Process for the manufacture of suture material from animal tendons
US3502534A (en) 1962-08-10 1970-03-24 Ethicon Inc Method of separating adhering collagen monofilaments
US3293237A (en) 1962-11-30 1966-12-20 Charles J W Wiegand Process of solubilizing native collagen by reacting said collagen with a stoichiometric amount of a mineral acid
US3366440A (en) 1964-11-03 1968-01-30 Ethicon Inc Process for manufacturing a collagen fabric-film laminate
US3520402A (en) 1967-08-30 1970-07-14 Ethicon Inc Purified collagen fibrils
US3625811A (en) 1968-01-19 1971-12-07 Sato Hisao Method of preparing yarn and the like from animal hide
US3587586A (en) 1968-03-15 1971-06-28 Ethicon Inc Porous collagen anastomotic cuff
US3823212A (en) 1968-11-27 1974-07-09 Freudenberg C Fa Process for the production of collagen fiber fabrics in the form of felt-like membranes or sponge-like layers
US3742955A (en) 1970-09-29 1973-07-03 Fmc Corp Fibrous collagen derived product having hemostatic and wound binding properties
US3810472A (en) 1972-10-10 1974-05-14 Kimberly Clark Co Fastening tab arrangement for disposable diapers
US3896814A (en) 1972-10-31 1975-07-29 Daniel Vivien Collagen based threads
US4233360A (en) 1975-10-22 1980-11-11 Collagen Corporation Non-antigenic collagen and articles of manufacture
CA1073360A (en) 1975-10-22 1980-03-11 John R. Daniels Non-antigenic collagen and articles of manufacture
US4016877A (en) 1976-02-23 1977-04-12 Avicon, Inc. Fibrous collagen derived web having hemostatic and wound sealing properties
US4148664A (en) * 1976-05-10 1979-04-10 Avicon, Inc. Preparation of fibrous collagen product having hemostatic and wound sealing properties
US4066083A (en) 1976-06-03 1978-01-03 Pentapharm A.G. Sterile surgical collagen product
US4193813A (en) 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
US4097234A (en) 1976-12-10 1978-06-27 Nippi, Incorporated Method for preparing dispersion of collagen fiber
US4238480A (en) 1978-05-19 1980-12-09 Sawyer Philip Nicholas Method for preparing an improved hemostatic agent and method of employing the same
US4390519A (en) 1978-05-19 1983-06-28 Sawyer Philip Nicholas Bandage with hemostatic agent and methods for preparing and employing the same
AU516741B2 (en) 1978-05-23 1981-06-18 Bio Nova Neo Technics Pty. Ltd. Vascular prostheses
JPS6052129B2 (en) 1979-10-04 1985-11-18 呉羽化学工業株式会社 Manufacturing method of medical collagen fiber
US4271070A (en) 1980-05-05 1981-06-02 Cornell Research Foundation, Inc. Chemically-modified fiber collagen hemostatic agents
DE3020611C2 (en) 1980-05-30 1983-01-05 Chemokol Gesellschaft zur Entwicklung von Kollagenprodukten, 5190 Stolberg Process for the production of collagen material for surgical purposes
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4515637A (en) 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
US4591456A (en) 1984-04-03 1986-05-27 Bioetica, S.A. Process for obtaining homogeneous layers of native collagen, its application in covering or encapsulating various supports and the supports thus covered
USRE35748E (en) 1984-05-29 1998-03-17 Matrix Pharmaceutical, Inc. Treatments employing drug containing matrices for introduction into cellular lesion areas
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
JPS62138532A (en) * 1985-12-12 1987-06-22 Nippi:Kk Production of molded article of collagen
EP0250571B1 (en) 1986-01-06 1991-05-22 The University Of Melbourne Precipitation of collagen in tactoid form
US4760131A (en) 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
IT1214505B (en) 1987-03-12 1990-01-18 Gentili Ist Spa PROCEDURE FOR THE PREPARATION OF COLLAGEN AND PRODUCTS SO OBTAINED.
FR2612938B1 (en) 1987-03-26 1989-06-23 Cird METHOD FOR OBTAINING A SKIN EQUIVALENT AND CORRESPONDING SKIN EQUIVALENT
FR2612939B1 (en) 1987-03-26 1989-06-23 Cird SKIN EQUIVALENT
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
FR2623277B1 (en) 1987-11-17 1990-04-27 Bioetica Sa LYOPHILIZATION METHOD AND APPARATUS COMPRISING THERMAL SHIELDING MEANS BETWEEN LYOPHILIZATION SHELVES
US4863732A (en) 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
ES2060614T3 (en) 1988-03-11 1994-12-01 Chemokol G B R Ing Buro Fur Ko PROCEDURE FOR THE MANUFACTURE OF COLLAGEN MEMBRANES FOR HEMOSTASIS, WOUND TREATMENT AND IMPLANTS.
US5219576A (en) 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4891359A (en) 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
DE3903362A1 (en) 1989-02-04 1990-08-09 Basf Ag CHEMICALLY MODIFIED PROTEINS
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
CA2022480C (en) * 1989-08-02 2001-02-27 Gerald L. Mechanic Process for cross-linking collagenous materials and resulting product
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5378469A (en) 1990-04-06 1995-01-03 Organogenesis, Inc. Collagen threads
JPH0783759B2 (en) 1990-06-29 1995-09-13 株式会社高研 Collagen fiber hemostatic material and method for producing the same
AU641784B2 (en) 1990-08-08 1993-09-30 Showa Denko Kabushiki Kaisha Process for producing collagen powder
US5219895A (en) 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
FR2686612B1 (en) 1992-01-24 1994-04-08 Fournier Sca Laboratoires PROCESS FOR THE PREPARATION OF COLLAGEN FIBERS.
US5331092A (en) 1992-11-06 1994-07-19 Coletica Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby
US5422264A (en) 1993-11-12 1995-06-06 Desmos, Inc. Soluble factor stimulation of attachment and hemidesmosome assembly in epithelial cells
JPH0797715A (en) * 1993-05-06 1995-04-11 Mitsubishi Rayon Co Ltd Production of collagen fiber
JPH09510639A (en) 1994-03-22 1997-10-28 オーガノジェネシス インコーポレイテッド Remodeling collagen three-dimensional fabric
WO1995025550A1 (en) 1994-03-22 1995-09-28 Organogenesis Inc. Biocompatible prosthetic devices
US5562946A (en) 1994-11-02 1996-10-08 Tissue Engineering, Inc. Apparatus and method for spinning and processing collagen fiber
US5660854A (en) * 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
DE69633444T2 (en) * 1995-06-07 2006-02-16 Organogenesis, Inc., Canton COMPOSITIONS OF RECONSTITUTED COLLAGEN FIBER SEGMENTS AND METHOD FOR THE PRODUCTION THEREOF
US5800372A (en) 1996-01-09 1998-09-01 Aerojet-General Corporation Field dressing for control of exsanguination
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix

Also Published As

Publication number Publication date
AU2042400A (en) 2000-06-26
DE69926911D1 (en) 2005-09-29
US20020103503A1 (en) 2002-08-01
EP1137827A1 (en) 2001-10-04
JP4903308B2 (en) 2012-03-28
US6361551B1 (en) 2002-03-26
JP2002531723A (en) 2002-09-24
CA2352296C (en) 2005-07-05
ES2247850T3 (en) 2006-03-01
WO2000034556A1 (en) 2000-06-15
DE69926911T2 (en) 2006-06-14
EP1137827B1 (en) 2005-08-24
KR20010090876A (en) 2001-10-19

Similar Documents

Publication Publication Date Title
CA2352296A1 (en) Collagen hemostatic fibers
CA2351341A1 (en) Collagen hemostatic foam
WO2003057072A3 (en) Hemostatic compositions and methods for controlling bleeding
DE59908453D1 (en) Flexible fibrin-based wound dressing and process for its manufacture
EP1430911A3 (en) Hemostatic wound dressing and fabric containing aldehyde-modified polysaccharide
CA2307954A1 (en) Enzyme-medicated modification of fibrin for tissue engineering
DE69834596D1 (en) Ectroscopic surgical, hemostatic stapler
ATE222781T1 (en) FIBRIN ADHESIVE GRANULES AND METHOD FOR THE PRODUCTION THEREOF
MX9606386A (en) Agents affecting thrombosis hemostasis.
AU5882090A (en) Braided surgical sutures
WO2002058749A8 (en) Carrier with solid fibrinogen and solid thrombin
WO1999015209A3 (en) Fibrin sponge
ATE292481T1 (en) IMPROVED WOUND DRESSINGS
HK1041268B (en) Connective tissue growth factor (ctgf) fragment
DE69821655D1 (en) USE OF PHOSPHOLIPIDES FOR PRODUCING A MEDICINAL PRODUCT FOR PREVENTING ADHESIONS
WO2000015248A3 (en) Growth factor-containing composition for healing tissue damage
EP0651655A4 (en) Blockade of protein c activation reduces microvascular surgical blood loss.
WO2002020729A3 (en) In vitro human angiogenesis model
GB9901504D0 (en) Accelrrated whole blood clotting time (A.W.B.C.T.)
TR199501020A2 (en) Fireproof cellulosic fiber, process for producing fireproof cellulosic textile material, and process to reduce the fibrillation tendency of lyocell textile material.
ATE222501T1 (en) TISSUE FACTOR INFLUENCING VASCULAR FORMATION
AU1100101A (en) Bone hemostasis method and materials
ES2156731A1 (en) Use of tranexamic acid for the preparation of a human fibrinogen composition
JPH06296673A (en) Fiber for hemostatic material
DE69617379T2 (en) Process for the preparation of optically pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its derivatives

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20181206