CA2355657A1 - Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents - Google Patents

Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents Download PDF

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Publication number
CA2355657A1
CA2355657A1 CA002355657A CA2355657A CA2355657A1 CA 2355657 A1 CA2355657 A1 CA 2355657A1 CA 002355657 A CA002355657 A CA 002355657A CA 2355657 A CA2355657 A CA 2355657A CA 2355657 A1 CA2355657 A1 CA 2355657A1
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CA
Canada
Prior art keywords
biologically active
active agents
block
biodegradable
sustained delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002355657A
Other languages
French (fr)
Other versions
CA2355657C (en
Inventor
Subodh Shah
Weiguo Dai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen, Inc.
Subodh Shah
Weiguo Dai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen, Inc., Subodh Shah, Weiguo Dai filed Critical Amgen, Inc.
Priority claimed from PCT/US1999/029401 external-priority patent/WO2000038651A1/en
Publication of CA2355657A1 publication Critical patent/CA2355657A1/en
Application granted granted Critical
Publication of CA2355657C publication Critical patent/CA2355657C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

The present invention relates generally to the development of pharmaceutical compositions which provide for sustained release of biologically active polypeptides. More specifically, the invention relates to the use of pH/thermosensitive, biodegradable hydrogels, consisting of a A-B di block or A-B-A tri block copolymer of poly(d,1- or 1-lactic acid) (PLA) or poly(lactide-co-glycolide) (PLGA) (block A) and polyethylene glycol (PEG) (block B), with ionizable functional groups on one or both ends of the polymer chains, for the sustained delivery of biologically active agents.
CA002355657A 1998-12-23 1999-12-10 Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents Expired - Fee Related CA2355657C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/221,178 1998-12-23
US09/221,178 US6451346B1 (en) 1998-12-23 1998-12-23 Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
PCT/US1999/029401 WO2000038651A1 (en) 1998-12-23 1999-12-10 BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS

Publications (2)

Publication Number Publication Date
CA2355657A1 true CA2355657A1 (en) 2000-07-06
CA2355657C CA2355657C (en) 2005-05-03

Family

ID=22826693

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002355657A Expired - Fee Related CA2355657C (en) 1998-12-23 1999-12-10 Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents

Country Status (9)

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US (2) US6451346B1 (en)
JP (1) JP2002533377A (en)
AT (1) ATE244556T1 (en)
AU (1) AU769347B2 (en)
CA (1) CA2355657C (en)
DE (1) DE69909519T2 (en)
ES (1) ES2197711T3 (en)
PT (1) PT1143929E (en)
TW (1) TWI250028B (en)

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Publication number Publication date
US20030099709A1 (en) 2003-05-29
PT1143929E (en) 2003-11-28
DE69909519T2 (en) 2003-12-24
ES2197711T3 (en) 2004-01-01
DE69909519D1 (en) 2003-08-14
ATE244556T1 (en) 2003-07-15
US6451346B1 (en) 2002-09-17
AU769347B2 (en) 2004-01-22
JP2002533377A (en) 2002-10-08
CA2355657C (en) 2005-05-03
TWI250028B (en) 2006-03-01
AU2708100A (en) 2000-07-31

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