CA2357881A1 - Polyfluoro copolymer coatings for implantable medical devices - Google Patents

Polyfluoro copolymer coatings for implantable medical devices Download PDF

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Publication number
CA2357881A1
CA2357881A1 CA002357881A CA2357881A CA2357881A1 CA 2357881 A1 CA2357881 A1 CA 2357881A1 CA 002357881 A CA002357881 A CA 002357881A CA 2357881 A CA2357881 A CA 2357881A CA 2357881 A1 CA2357881 A1 CA 2357881A1
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CA
Canada
Prior art keywords
monomer
copolymer
coating
weight percent
prepared
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Granted
Application number
CA002357881A
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French (fr)
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CA2357881C (en
Inventor
Gerard H. Llanos
Mark B. Roller
Angelo Scopelianos
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Ethicon Inc
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Ethicon, Inc.
Gerard H. Llanos
Mark B. Roller
Angelo Scopelianos
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Application filed by Ethicon, Inc., Gerard H. Llanos, Mark B. Roller, Angelo Scopelianos filed Critical Ethicon, Inc.
Publication of CA2357881A1 publication Critical patent/CA2357881A1/en
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Publication of CA2357881C publication Critical patent/CA2357881C/en
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Abstract

The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which coatings/films are present on the device in an amount effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of the device in the mammal, and contain a film-forming polyfluoro copolymer prepared from an amount of a monomer selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and an amount of a second monomer other than the first monomer, wherein the amounts of the first and second monomers are effective to provide the coating and films with properties effective for use in coating implantable medical devices when the coated device is subjected to a maximum temperature of less than about 100°C.

Claims (21)

1. An implantable medical device: comprising, a biocompatible film effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of said device in said mammal, said film comprising a polyfluoro copolymer prepared from an amount of a first monomer selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and an amount of a second monomer other than the first monomer, said second monomer being capable of providing elastomeric properties to the polyfluoro copolymer, wherein the amounts of the first monomer and the second monomer are effective to provide said film with properties sufficient for use in coating implantable medical devices when said coated device is subjected to a maximum temperature of less than about 100°C.
2. The device of claim 1, wherein said copolymer is prepared with from about 50 to about 85 weight percent of the first monomer, and from about 50 to about 15 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
3. The device of claim 1, wherein said copolymer is prepared with from about 55 to about 70 weight percent vinylidenefluoride, and from about 45 to about 30 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
4. The device of claim 1, wherein said copolymer is prepared with from about 55 co about 65 weight percent vinylidenefluoride, and from about 45 to about 35 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
5. The device of claim 1 wherein said second monomer is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro(methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexafluoroisobutylene.
6. The device of claim 4 wherein said second monomer is hexafluoropropylehe.
7. The implantable medical device of claim 1, wherein said-film further comprises a therapeutic and/or pharmaceutical agent.
8. The implantable device of claim 1 wherein said film comprises a polyvinylidenefluoride copolymer effective to provide said film with properties sufficient for use in coating implantable medical devices when said coated device is subjected to a maximum temperature of less than about 65°C.
9. A biocompatible coating for use on implantable medical devices: said coating comprising, a polyfluoro copolymer prepared from an amount of a first monomer selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and an amount of a second monomer other than the first monomer, said second monomer being capable of providing elastomeric properties to the polyfluoro copolymer, wherein the amounts of the first monomer and the second monomer are effective to provide said coating with properties sufficient for use in coating implantable medical devices when said coated medical device is subjected to a maximum temperature of less than about 100°C: and a solvent in which said polyfluoro copolymer is substantially soluble.
10. The coating of claim 9, wherein said copolymer is prepared with from about 50 to about 85 weight percent of the first monomer, and from about 50 to about 15 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
11. The coating of claim 9, wherein said copolymer is prepared with from about 55 to about 70 weight percent vinylidenefluoride, and from about 45 to about 30 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
12. The coating of claim 9, wherein said copolymer is prepared with from about 55 to about 65 weight percent vinylidenefluoride, and from about 45 to about 35 weight percent of the second monomer, based on total monomer weight used to prepare said copolymer.
13. The coating of claim 9 wherein said second monomer is selected from the group consisting of hexafluoropropylene, tetrafluoroethylene, vinylidenefluoride, 1-hydropentafluoropropylene, perfluoro(methyl vinyl ether), chlorotrifluoroethylene, pentafluoropropene, trifluoroethylene, hexafluoroacetone and hexafluoroisobutylene.
14. The coating of claim 12 wherein said second monomer is hexafluoropropylene.
15. The coating of claim 9, further comprising a therapeutic and/or pharmaceutical agent.
16. The coating of claim 9 comprising a polyvinylidenefluoride copolymer effective to provide said coating with properties sufficient for use in coating implantable medical devices when said coated device is subjected to a maximum temperature of less than about 65°C.
17. The coating of claim 9 wherein said solvent is selected from the group consisting of dimethylacetamide, N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahydrofuran, methylethylketone and acetone.
18. A film prepared from the coating of claim 9.
19. A film prepared from the coating of claim 15.
20. A film according to claim 18 wherein the polyfluoro copolymer is crosslinked.
21. A film according to claim 18 wherein the polyfluoro copolymer is crosslinked.
CA2357881A 2000-09-29 2001-09-28 Polyfluoro copolymer coatings for implantable medical devices Expired - Lifetime CA2357881C (en)

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US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
AU1129902A (en) 2000-09-29 2002-04-08 Cordis Corp Coated medical devices

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MXPA01009952A (en) 2005-11-18
ES2348464T3 (en) 2010-12-07
EP1192957B1 (en) 2007-02-14
EP1192957B2 (en) 2016-06-01
ES2281400T3 (en) 2007-10-01
JP4219581B2 (en) 2009-02-04
EP2196226A3 (en) 2010-08-04
EP1764120B1 (en) 2014-12-10
ATE353678T1 (en) 2007-03-15
DK1192957T3 (en) 2007-05-07
EP2848265A2 (en) 2015-03-18
DE60126544T2 (en) 2007-11-22
PT1192957E (en) 2007-03-30
JP2002238994A (en) 2002-08-27
EP2196226A2 (en) 2010-06-16
EP1192957A3 (en) 2004-02-18
EP1764120A1 (en) 2007-03-21
DE60126544T3 (en) 2016-11-03
AU7730201A (en) 2002-04-11
EP2848265A3 (en) 2015-09-02
US20020094440A1 (en) 2002-07-18
EP1192957A2 (en) 2002-04-03
US6746773B2 (en) 2004-06-08
DE60126544D1 (en) 2007-03-29
CA2357881C (en) 2011-03-08

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