CA2358455A1 - Flexible implant using partially demineralized bone - Google Patents
Flexible implant using partially demineralized bone Download PDFInfo
- Publication number
- CA2358455A1 CA2358455A1 CA002358455A CA2358455A CA2358455A1 CA 2358455 A1 CA2358455 A1 CA 2358455A1 CA 002358455 A CA002358455 A CA 002358455A CA 2358455 A CA2358455 A CA 2358455A CA 2358455 A1 CA2358455 A1 CA 2358455A1
- Authority
- CA
- Canada
- Prior art keywords
- bone
- implant
- flexible
- adjacent
- engaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
- A61L27/3658—Intervertebral discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30724—Spacers for centering an implant in a bone cavity, e.g. in a cement-receiving cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
- A61F2002/2839—Bone plugs or bone graft dowels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30059—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
- A61F2002/30131—Rounded shapes, e.g. with rounded corners horseshoe- or crescent- or C-shaped or U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30153—Convex polygonal shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30154—Convex polygonal shapes square
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30159—Concave polygonal shapes
- A61F2002/30176—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/302—Three-dimensional shapes toroidal, e.g. rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30563—Special structural features of bone or joint prostheses not otherwise provided for having elastic means or damping means, different from springs, e.g. including an elastomeric core or shock absorbers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30565—Special structural features of bone or joint prostheses not otherwise provided for having spring elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30579—Special structural features of bone or joint prostheses not otherwise provided for with mechanically expandable devices, e.g. fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30594—Special structural features of bone or joint prostheses not otherwise provided for slotted, e.g. radial or meridian slot ending in a polar aperture, non-polar slots, horizontal or arcuate slots
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30777—Oblong apertures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30795—Blind bores, e.g. of circular cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
- A61F2002/30845—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes with cutting edges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3085—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30879—Ribs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30894—Plurality of protrusions inclined obliquely with respect to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0021—Angular shapes square
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0065—Three-dimensional shapes toroidal, e.g. ring-shaped, doughnut-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0029—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00359—Bone or bony tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
- Y10S623/919—Bone
Abstract
Implantable devices (10) useful for creating bony fusion particularly in intervertebral spinal fusion. The device (10) is formed of bone and has an at least partially demineralized portion (16) between two rigid bone portions (12 and 14) creating an area of flexibility. In one application, the area of flexibility may be used to move the device between a reduced size insertion configuration (Fig. 2) and an expanded implanted configuration (Fig. 3). In another use, the area of flexibility may be useful to dampen shock applied to the implant (Fig. 8). A method is also disclosed for making the implants and inserting the implants into an intervertebral disc space to promote interbody fusion.
Description
FLEXIBLE IMPLANT USING PARTIALLY
DEMINERALIZED BONE
BACKGROUND OF THE INVENTION
The present invention relates to implantable fusion devices and methods for their use. More particularly, the present invention relates to interbody fusion devices formed of bone that may be utilized in spinal fusions.
A variety of interbody fusion implants are available for spinal fusion procedures. These implants have been manufactured of various materials including steel, titanium, composites, allograft, xenograft or other biocompatible materials.
These implants may be inserted using fixed protective tubes to protect surrounding 2o neurological and vascular structures or through an unprotected open procedure.
One limitation on the size of a device inserted into the disc space is the size of the opening through surrounding tissue that is available to gain access to the disc space. From a posterior approach to the spine, the dura and nerve roots must be mobilized to gain access to the disc space. Similarly, from an anterior approach, the aorta and vena cava must be mobilized to gain access to the disc space.
Such mobilization is often limited by the anatomical structures, thus resulting in a relatively small access site in comparison to the size of the disc space.
Removal of additional ligaments and bone to enlarge an entrance to the disc space may de-stabilize and weaken the joint between two adjacent vertebra. Moreover, excessive 3o retraction of vessels and neural structures to create a large access opening may result in damage to these tissues. Thus, prior procedures have been limited to placing a first device passable through the available opening on one side of the spine and mobilizing the tissue or vessels to place another similar implant on the opposite side of the spine. Each implant being limited in size by the available access site.
In response, expandable implants have been developed from biocompatible materials such as titanium and composites. These devices rely on hinges or selective deformation of the implant material to permit expansion after they are positioned in the disc space. While such devices have a reduced insertion configuration and an expanded spacing configuration, the materials utilized to form the implants are synthetic and will not incorporate into adjacent bony tissues.
While bone offers much improved incorporation, the inherent brittle nature of bone Io resulting from a high mineral content, particularly load-bearing cortical bone, severely limits its potential deformation. Typically, for example, cortical bone consists of approximately 70% mineral content and 30% non-mineral matter. Of this non-mineral matter, approximately 95% is type I collagen, with the balance being cellular matter a.nd non-collagenous proteins.
Bone grafts, in conjunction with other load-bearing implants, have commonly been used in a fixed shape, pulverized, or as pliable demineralized bone. One form of a pliable bone graft is a demineralized bone material typically in the form of a sponge or putty having very little structural integrity.
While a deminerilized bone segment may retain properties suitable to support bone ingrowth, the structural properties of the bone are altered by removal of its mineral content. Thus, such bone sponges and putties may not typically be used in load-bearing applications.
Therefore, there remains a need for a strong bone implant having an area of flexibility.
SUMMARY OF THE INVENTION
In one aspect, the present invention provides a flexible bone implant. The bone implant of the present invention comprises a first bone portion, a second bone portion, and a flexible bone portion joining the first and second bone portions. The intermediate flexible bone portion permits movement of the first bone portion in relation to the second bone portion. In a preferred embodiment, the movement of the first and second bone portions would be between a reduced size insertion configuration and an expanded configuration suitable for maintaining two bony Io structures in a spaced relation and permitting bone ingrowth, if desired.
Optionally, the movement between the first and second bone portions may be utilized as an elastic damper when the device is positioned between adjacent bony structures.
In accordance with another aspect of the invention, the bone implant comprises a bone segment having at least one partially demineralized area creating a flexible segment of the demineralized bone segment. In one embodiment, an opposite portion of the cortical femoral ring segment is severed such that the ring segment may be expanded once it has been inserted into an intervertebral disc space. In yet another embodiment, the device includes at least two partially 2o demineralized bone portions on substantially opposing portions of the bone segment. In this configuration, the substantially rigid portions are placed in contact with the load bearing surfaces between two adjacent bony structures such that the flexible portions perform an elastic function, allowing more normal motion or to better load bone adjacent the disc space.
In yet a further aspect of the present invention, there is provided a method for the preparation of a bone implant. The method includes providing a rigid bone segment and delineating an intermediate portion of that segment. The central portion is then at least partially demineralized to create a flexible segment between two adjacent sections of bone. The method of at least partially demineralizing a segment of bone between two adjacent rigid bone segments may be repeated as often as necessary to create the desired structure for implantation.
The present invention further contemplates a method of inserting a device formed in accordance with the present invention. Specifically, the method includes providing an insertion tube and an implant formed of bone having a first and second portions joined by a flexible central portion. The insertion tube is positioned adjacent a disc space formed by adjoining vertebrae. The first and second portions of the bone implant are then positioned into a reduced size configuration for insertion into the insertion tube. The implant is then inserted into Io the tube and advanced until it is positioned in the disc space. Once the implant is in the desired position, the first and second portions are moved with respect to one another by flexing of the flexible portion into an expanded implantation configuration. In a preferred embodiment of the insertion method, bone ingrowth material is placed between the first and second portions to encourage further bone 15 ingrowth into and around the fusion devices.
These and other objects of the present invention will be apparent to those skilled in the art based on the following descriptions of the preferred embodiment of the present invention.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is perspective view of an implant according to the present invention.
FIG. 2 is a top view of the implant in its insertion configuration.
5 FIG. 3 is a top view of the implant in its expanded implanted condition.
FIG. 4 is a side view of an implant according to the present invention inserted between two adjacent vertebra.
FIG. 5 is a top view of an alternative embodiment of the present invention.
FIG. 6 is an end view of the embodiment of FIG. 5.
to FIG. 7 is a top view of the implant of FIG. 5 in an expanded configuration.
FIG. 8 is a side view of yet a further embodiment according to the present invention disposed between two adjacent vertebra.
FIG. 9 is a top view of a ring-shaped bone segment prepared in accordance with another aspect of the present invention.
i s FIG. 10(a) is a top view of an alternative embodiment according to the present invention.
FIG 10(b) is a modified embodiment of FIG. 10(a).
DESCRPITION OF THE PREFERRED EMBODIMENTS
For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the illustrated devices, and such further applications of the principles of the invention as illustrated therein being contemplated as would normally occur to one skilled in the art to which the invention relates.
Referring now to FIG. 1, there is shown an implant according to a preferred embodiment of the present invention. Although implants according to the present invention may have many uses, the embodiment shown in FIG. 1 is particularly adapted for promoting interbody fusion in the spine. Specifically, FIG. 1 illustrates a bone implant 10 having a first substantially rigid portion 12 and a second substantially rigid portion 14. The first and second rigid portions 12 and 14 are joined by intermediate portion 16. Intermediate portion 16 has been at least partially demineralized to create an area of flexibility in the bone implant.
Preferably, an area of intermediate portion 16 has been completely demineralized 2o to provide maximum flexibility. The flexibility created by demineralization of intermediate portion 16 permits rigid portions 12 and 14 to be moved with respect to each other. The advantages of this feature will be further described herein.
Bone portion 12 includes bone engagement ridges 20 defined on upper bearing surface 17 with an identical set of ridges 21 defined on the bottom-bearing surface (not shown). In a similar manner, bone portion 14 includes bone engaging ridges 18 defined on upper bearing surface 15 and identical ridges 19 defined on the bottom-bearing surface (not shown). It will be understood that while ridges have been shown in a preferred embodiment, it is contemplated that there are a variety of structures, which could provide a surface for effective engagement with the vertebral bodies to limit expulsion from the disc space.
The rigid bone portions 12 and 14 are adapted to provide structural support between the respective upper and lower bearing surfaces. Specifically, the bone implant may be selected from donor bone having sufficient resistance to compression between the upper and lower surfaces to find application in the intended environment. The pair of rigid bone portions cooperate to provide support for spacing between adjacent vertebra. While the preferred embodiments of the implants according to the present invention have been shown with two rigid bone portions, it is contemplated that further rigid bone portions may be interconnected by flexible bone areas to offer further implant shapes.
Referring now to FIGS. 2-4, there is shown a method of inserting a device according to the present invention for interbody fusion between adjacent vertebral bodies. Specifically referring to FIG. 2, implant 10 is shown in its reduced size insertion configuration with first portion 12 positioned substantially adjacent second portion 14. As shown in FIG. 2, it is contemplated that the rigid portions may be positioned in substantially parallel alignment. However, in some applications, this amount of flexibility in intermediate portion 16 may not be necessary. In a preferred embodiment, the implant is constrained in the insertion 2o configuration within insertion tube 30.
Access to the disc space between adjacent vertebra is achieved as known in the art. Although access may be achieved from any direction without deviating from the invention, for the purpose of illustration and without limitation, FIGS. 2 and 3 illustrate access via a posterior approach. Once access is achieved, a protective sleeve may be positioned adjacent the disc space and the disc space distracted if necessary. Implant 10 is moved to the insertion configuration with the longitudinal extent of bone portions 12 and 14 in substantial parallel alignment.
The implant, in the reduced size configuration, is positioned in protective sleeve 30 and advanced toward the disc space D. It will be understood that while implant may have a much greater size after placement, dura 34 need only be retracted within cavity 38 enough to allow passage of protective sleeve 30 and the reduced size implant.
Implant 10 is advanced through protective sleeve 30 by use of a pushing device (not shown) until it exits protective sleeve 30 into the disc space D
(FIGS. 3 and 4). Once in disc space D, the device either expands by release of an elastic deformation formed in the central portion 16 or a separate instrument (not shown) may be inserted between first portion 12 and second portion 14 to urge movement between the respective portions to manipulate the device into the expanded spacing to configuration shown in FIG. 3. Expansion of the device creates an implant having greater stability to the intervertebral space via a broader support area and less tendency to topple over in the disc space. Further cavity 33 between portions and 14 provides an area to receive material to promote bony incorporation and fusion. Once implant 10 has been properly positioned, bone grovvh promoting 15 material 32 may be positioned between first portion 12 and second portion 14 to encourage bone growth into and through implant 10. Although not illustrated, it will be understood that typically a second implant will be placed in disc space D to provide further stability.
As shown more clearly in FIG. 4, implant 10 has a height H which is 2o substantially equal to the height of disc space D formed between vertebra 36 and vertebra 38. It will understood by those skilled in the art that in the preferred embodiment illustrated herein, the height H is substantially constant from the insertion shown in FIG. 3 to the expanded configuration shown in FIG. 4.
Furthermore, while a uniform height implant is shown in FIG. 2, it will be 25 understood that implant 10 may have a tapering height such that the implant could be utilized for establishing or maintaining the proper lordotic curvature in the spine. With reference to rigid bone portion 14, upper bearing surface 25 engages and supports upper vertebral body 38 while lower bearing surface 27 engages and supports the implant on lower vertebral body 36. Rigids 18 and 19 engage the surface of vertebral bodies 38 and 36, respectively, to resist expulsion.
Rigid bone portion 14, in conjunction with rigid bone portion 12 having similar engagement with the vertebrae, has sufficient rigid and structural integrity to substantially maintain height H and to withstand normal forces applied to the spinal column.
Flexible area 16 need not have such structural requirements, although, preferably, it assists in the implant stability by maintaining the connection between the two support walls.
Flexible bone implant 10 provides the desirable features of being formed of a highly successful bone fusion material, i.e. natural bone, with the advantages of Io having a reduced size insertion configuration and an expanded spacing configuration. Thus, while the implant maintains the desired height of disc space distraction, the width of the implant opposite central portion 16 is readily expandable from the insertion configuration of FIG. 2 to the expanded configuration of FIG. 3. This feature permits insertion through a smaller access 15 site and increases implant stability in the disc space.
Referring now to FIGS. 5 through 7, there is shown a further embodiment of an implant according to the present invention. FIG. 5 shows a threaded cortical bone dowel 50 modified in accordance with the present invention. Bone dowel 50 includes a thread 58 for engaging adjacent vertebra to advance the implant in a 2o controlled manner and to resist expulsion. Implant 50 has a recessed slot 64 for engaging a driving tool adapted to rotate the device. In accordance with the invention, threaded bone dowel 50 is divided into a first side wall 52 and second side wall 54 separated by flexible area 56 and slot 62. As described further herein, flexible area 56 is created by at least partial demineralization of the bone in this 25 area of the implant. Each of the first and second side walls 52 and 54 include upper and lower bearing surfaces. Threaded dowel 50 further includes a central opening 60. This opening may be created by the natural medullary canal of a diaphyseal bone or by removal of a cancellous portion of a donor bone, although this depends on the configuration of the donor bone.
In the configuration of FIG. 5, the device may be inserted through an insertion tube or other device into a disc space as previously described. Once positioned with opening 60 adjacent the upper and lower vertebral bodies, first side wall 52 and second side wall 54 are urged away from each other with the implant flexing at flexible portion 56. The implant 50 is shown in its expanded condition in FIG. 7. Once the desired expansion has been created, bone growth promoting material 64 may be inserted into the interior area 60 between first side wall 52 and second side wall 54. The side walls provide structured support to maintain the disc space height. As shown in FIGS. 5 through 7, bone implant SO has a reduced-size 1 o insertion configuration and an expanded spacing configuration.
Referring to FIG.B, in still a further embodiment of the present invention, a threaded, cylindrical bone dowel has been modified in accordance with the present invention. Specifically, bone implant 80 has been modified to include at least two areas 86 and 88 of reduced mineral content, providing a degree of flexibility in the implant. Demineralized sections 86 and 88 are disposed between rigid portions and 84. Thus, sudden changes in forces applied to rigid portions 82 or 84 may be dampened by the intervening flexible areas. Referring to FIG. 8, such a device is implanted in disc space 94 between vertebral body V 1 and vertebral body V2 with rigid portions 92 and 94 positioned adjacent vertebral bodies V 1 and V2, respectively. It will be understood that as force is applied to vertebral bodies V 1 and V2, there will be a tendency for the implant to flex at demineralized areas 86 and 88 to provide a degree of flexibility in the implant and to provide physiologic loading environment. Specifically, compressive forces represented by arrows 102, 103, 104 and 105 may be more normally transferred by flexing of flexible portions 86 and 88 to positions 110 and 112, respectively. Such devices may have application in both fusion (normal loading) and arthroplasty (normal motion).
Refernng to FIG. 9, there is shown yet a further aspect of the present invention. Donor bone 120 is a substantially ring-shaped bone segment having an internal cavity 30, such as a femoral ring. A slot 128 is formed in ring 120.
Opposite slot 128, portion 126 is treated to remove at least a portion of the bone minerals. This creates an area of flexibility at portion 126. Thus, the bone is divided into side walls 122 and 124, separated by slot 128 and flexible portion 126.
As previously described, the bone graft may be expanded after insertion by movement of side wall 124 away from side wall 122.
Referring now to FIG. 10(a), there is shown an alternative embodiment according to the present invention. Spacer 180 is a Smith-Robinson type bone graft that is typically used in the cervical region of the spine. Spacer 180 includes an internal cavity 188 defined by walls 182, 183, 184 and 191. Cavity 188 is to suitable for receiving bone graft material to promote fusion between adjacent vertebrae. To provide for expansion, an opening 186 in wall 183 is created and an opposing flexible hinge area 190 is created in wall 191 by at least partial demineralization. In this manner, walls 182 and 184 may be moved in the direction of arrows 192 and 194, respectively, to expand the implant after insertion between adjacent vertebrae. It will be understood that wall 191 will be at least partially deformed during the expansion process.
FIG. 10(b) shows a modified embodiment of the implant of FIG. 10(a). In FIG. 10(b), spacer 195 has an internal chamber 208 defined by walls 199, 200, 201, and 202. Wall 201 includes an opening 196 formed there through. Flexible areas of bone are created by at least partial demineralization at hinge areas 197 and 198 on walls 200 and 202, respectively, adjacent the connection to wall 199. Walls 200 and 202 may be moved in the direction of arrows 204 and 206 to permit expansion of spacer 195. The use of dual hinge areas on the implant permits precise placement of wall 199 in the disc space and permits the expansion to take place laterally without the location of a portion of wall 199 being altered during expansion.
In addition to the above described embodiments, the present invention may have further uses. Specifically, but without limitation, one such may be to reform donor bone segments to conform more closely to spaces needing implants. In some cases, donor bone segments may have shapes incompatible with the shape of the implantation site. These bone segments may have flexible areas to reform the bone graft to more closely match its intended use. Such segments may have one or more flexible areas such that the overall shape of the donor bone segment may be modified by flexing at the flexible segments. This may preserve much of the load bearing strength of the implants. This use of the present invention may increase the potentially useable portions of the limited supply of donor bone. Full utilization of donor bone and alternative graft shapes is more fully disclosed in U.
S. Patent Application No. 09/181,353 filed October 29, 1998, entitled IMPACTED
1 o BONE IMPLANTS AND INSTRUMENTATION, incorporated herein by reference.
Creation of the demineralized portion of the bone will now be described.
The processing involves the use of donor bone with processing in a clean room environment within a bone processing facility. Such donor bone may include 15 allograft from human sources or xenograft from animal sources. Further, it is contemplated that as technology advances in the area of bone processing, the donor bone may be generated in the manufacturing process, either by bone growth or by a processing of constituent components of bone to create artificial materials having properties very similar to bone. More specifically, while any available allogenic or 2o xenogenic bone stock may be utilized for the procedure, cortical bone is conventionally preferred for spinal fusion for its structural properties, although cortical cancellous or cancellous bone may be used depending upon the particular requirements for the implantable device.
In further processing, the connective tissues are removed and the bone is 25 cleaned, rinsed, and defatted using a solvent such as ethanol or hydrogen peroxide.
The bone is then machined or otherwise shaped using conventional techniques to create its final shape, such as a wedge, dowel, or other shape. An intermediate portion of the bone is delineated as needing an increased degree of flexibility.
Demineralization takes place solely at the location requiring the flexible capability.
Penetration of the demineralization fluid into the bone adjacent the desired area of flexibility may be controlled by hydrostatic pressure thereby limiting the area of demineralization. The amount of mineral removed from the bone may be adjusted to create the desired amount of flexibility. This demineralization conventionally uses an organic acid such as hydrochloric, nitric, or citric acid. Preferably, the demineralization solution comprises 0.1 to 1.0 N HCI, most preferably 0.3 N
HCI.
If a xenograft is used, known techniques on the utilization of organic solvents to inactivate bone proteins and reduce antigenecity may be applied at this point.
Additionally, the use of glutaraldehyde may take place in order to further cross-line 1 o the collagen structure following removal of the mineral portion. Once the device has been machined and partially demineralized, it may be stored prior to insertion.
Although the above-described processing is disclosed herein as a preferred embodiment, it is contemplated that other suitable processes may be used.
While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiments have been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected.
DEMINERALIZED BONE
BACKGROUND OF THE INVENTION
The present invention relates to implantable fusion devices and methods for their use. More particularly, the present invention relates to interbody fusion devices formed of bone that may be utilized in spinal fusions.
A variety of interbody fusion implants are available for spinal fusion procedures. These implants have been manufactured of various materials including steel, titanium, composites, allograft, xenograft or other biocompatible materials.
These implants may be inserted using fixed protective tubes to protect surrounding 2o neurological and vascular structures or through an unprotected open procedure.
One limitation on the size of a device inserted into the disc space is the size of the opening through surrounding tissue that is available to gain access to the disc space. From a posterior approach to the spine, the dura and nerve roots must be mobilized to gain access to the disc space. Similarly, from an anterior approach, the aorta and vena cava must be mobilized to gain access to the disc space.
Such mobilization is often limited by the anatomical structures, thus resulting in a relatively small access site in comparison to the size of the disc space.
Removal of additional ligaments and bone to enlarge an entrance to the disc space may de-stabilize and weaken the joint between two adjacent vertebra. Moreover, excessive 3o retraction of vessels and neural structures to create a large access opening may result in damage to these tissues. Thus, prior procedures have been limited to placing a first device passable through the available opening on one side of the spine and mobilizing the tissue or vessels to place another similar implant on the opposite side of the spine. Each implant being limited in size by the available access site.
In response, expandable implants have been developed from biocompatible materials such as titanium and composites. These devices rely on hinges or selective deformation of the implant material to permit expansion after they are positioned in the disc space. While such devices have a reduced insertion configuration and an expanded spacing configuration, the materials utilized to form the implants are synthetic and will not incorporate into adjacent bony tissues.
While bone offers much improved incorporation, the inherent brittle nature of bone Io resulting from a high mineral content, particularly load-bearing cortical bone, severely limits its potential deformation. Typically, for example, cortical bone consists of approximately 70% mineral content and 30% non-mineral matter. Of this non-mineral matter, approximately 95% is type I collagen, with the balance being cellular matter a.nd non-collagenous proteins.
Bone grafts, in conjunction with other load-bearing implants, have commonly been used in a fixed shape, pulverized, or as pliable demineralized bone. One form of a pliable bone graft is a demineralized bone material typically in the form of a sponge or putty having very little structural integrity.
While a deminerilized bone segment may retain properties suitable to support bone ingrowth, the structural properties of the bone are altered by removal of its mineral content. Thus, such bone sponges and putties may not typically be used in load-bearing applications.
Therefore, there remains a need for a strong bone implant having an area of flexibility.
SUMMARY OF THE INVENTION
In one aspect, the present invention provides a flexible bone implant. The bone implant of the present invention comprises a first bone portion, a second bone portion, and a flexible bone portion joining the first and second bone portions. The intermediate flexible bone portion permits movement of the first bone portion in relation to the second bone portion. In a preferred embodiment, the movement of the first and second bone portions would be between a reduced size insertion configuration and an expanded configuration suitable for maintaining two bony Io structures in a spaced relation and permitting bone ingrowth, if desired.
Optionally, the movement between the first and second bone portions may be utilized as an elastic damper when the device is positioned between adjacent bony structures.
In accordance with another aspect of the invention, the bone implant comprises a bone segment having at least one partially demineralized area creating a flexible segment of the demineralized bone segment. In one embodiment, an opposite portion of the cortical femoral ring segment is severed such that the ring segment may be expanded once it has been inserted into an intervertebral disc space. In yet another embodiment, the device includes at least two partially 2o demineralized bone portions on substantially opposing portions of the bone segment. In this configuration, the substantially rigid portions are placed in contact with the load bearing surfaces between two adjacent bony structures such that the flexible portions perform an elastic function, allowing more normal motion or to better load bone adjacent the disc space.
In yet a further aspect of the present invention, there is provided a method for the preparation of a bone implant. The method includes providing a rigid bone segment and delineating an intermediate portion of that segment. The central portion is then at least partially demineralized to create a flexible segment between two adjacent sections of bone. The method of at least partially demineralizing a segment of bone between two adjacent rigid bone segments may be repeated as often as necessary to create the desired structure for implantation.
The present invention further contemplates a method of inserting a device formed in accordance with the present invention. Specifically, the method includes providing an insertion tube and an implant formed of bone having a first and second portions joined by a flexible central portion. The insertion tube is positioned adjacent a disc space formed by adjoining vertebrae. The first and second portions of the bone implant are then positioned into a reduced size configuration for insertion into the insertion tube. The implant is then inserted into Io the tube and advanced until it is positioned in the disc space. Once the implant is in the desired position, the first and second portions are moved with respect to one another by flexing of the flexible portion into an expanded implantation configuration. In a preferred embodiment of the insertion method, bone ingrowth material is placed between the first and second portions to encourage further bone 15 ingrowth into and around the fusion devices.
These and other objects of the present invention will be apparent to those skilled in the art based on the following descriptions of the preferred embodiment of the present invention.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is perspective view of an implant according to the present invention.
FIG. 2 is a top view of the implant in its insertion configuration.
5 FIG. 3 is a top view of the implant in its expanded implanted condition.
FIG. 4 is a side view of an implant according to the present invention inserted between two adjacent vertebra.
FIG. 5 is a top view of an alternative embodiment of the present invention.
FIG. 6 is an end view of the embodiment of FIG. 5.
to FIG. 7 is a top view of the implant of FIG. 5 in an expanded configuration.
FIG. 8 is a side view of yet a further embodiment according to the present invention disposed between two adjacent vertebra.
FIG. 9 is a top view of a ring-shaped bone segment prepared in accordance with another aspect of the present invention.
i s FIG. 10(a) is a top view of an alternative embodiment according to the present invention.
FIG 10(b) is a modified embodiment of FIG. 10(a).
DESCRPITION OF THE PREFERRED EMBODIMENTS
For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the illustrated devices, and such further applications of the principles of the invention as illustrated therein being contemplated as would normally occur to one skilled in the art to which the invention relates.
Referring now to FIG. 1, there is shown an implant according to a preferred embodiment of the present invention. Although implants according to the present invention may have many uses, the embodiment shown in FIG. 1 is particularly adapted for promoting interbody fusion in the spine. Specifically, FIG. 1 illustrates a bone implant 10 having a first substantially rigid portion 12 and a second substantially rigid portion 14. The first and second rigid portions 12 and 14 are joined by intermediate portion 16. Intermediate portion 16 has been at least partially demineralized to create an area of flexibility in the bone implant.
Preferably, an area of intermediate portion 16 has been completely demineralized 2o to provide maximum flexibility. The flexibility created by demineralization of intermediate portion 16 permits rigid portions 12 and 14 to be moved with respect to each other. The advantages of this feature will be further described herein.
Bone portion 12 includes bone engagement ridges 20 defined on upper bearing surface 17 with an identical set of ridges 21 defined on the bottom-bearing surface (not shown). In a similar manner, bone portion 14 includes bone engaging ridges 18 defined on upper bearing surface 15 and identical ridges 19 defined on the bottom-bearing surface (not shown). It will be understood that while ridges have been shown in a preferred embodiment, it is contemplated that there are a variety of structures, which could provide a surface for effective engagement with the vertebral bodies to limit expulsion from the disc space.
The rigid bone portions 12 and 14 are adapted to provide structural support between the respective upper and lower bearing surfaces. Specifically, the bone implant may be selected from donor bone having sufficient resistance to compression between the upper and lower surfaces to find application in the intended environment. The pair of rigid bone portions cooperate to provide support for spacing between adjacent vertebra. While the preferred embodiments of the implants according to the present invention have been shown with two rigid bone portions, it is contemplated that further rigid bone portions may be interconnected by flexible bone areas to offer further implant shapes.
Referring now to FIGS. 2-4, there is shown a method of inserting a device according to the present invention for interbody fusion between adjacent vertebral bodies. Specifically referring to FIG. 2, implant 10 is shown in its reduced size insertion configuration with first portion 12 positioned substantially adjacent second portion 14. As shown in FIG. 2, it is contemplated that the rigid portions may be positioned in substantially parallel alignment. However, in some applications, this amount of flexibility in intermediate portion 16 may not be necessary. In a preferred embodiment, the implant is constrained in the insertion 2o configuration within insertion tube 30.
Access to the disc space between adjacent vertebra is achieved as known in the art. Although access may be achieved from any direction without deviating from the invention, for the purpose of illustration and without limitation, FIGS. 2 and 3 illustrate access via a posterior approach. Once access is achieved, a protective sleeve may be positioned adjacent the disc space and the disc space distracted if necessary. Implant 10 is moved to the insertion configuration with the longitudinal extent of bone portions 12 and 14 in substantial parallel alignment.
The implant, in the reduced size configuration, is positioned in protective sleeve 30 and advanced toward the disc space D. It will be understood that while implant may have a much greater size after placement, dura 34 need only be retracted within cavity 38 enough to allow passage of protective sleeve 30 and the reduced size implant.
Implant 10 is advanced through protective sleeve 30 by use of a pushing device (not shown) until it exits protective sleeve 30 into the disc space D
(FIGS. 3 and 4). Once in disc space D, the device either expands by release of an elastic deformation formed in the central portion 16 or a separate instrument (not shown) may be inserted between first portion 12 and second portion 14 to urge movement between the respective portions to manipulate the device into the expanded spacing to configuration shown in FIG. 3. Expansion of the device creates an implant having greater stability to the intervertebral space via a broader support area and less tendency to topple over in the disc space. Further cavity 33 between portions and 14 provides an area to receive material to promote bony incorporation and fusion. Once implant 10 has been properly positioned, bone grovvh promoting 15 material 32 may be positioned between first portion 12 and second portion 14 to encourage bone growth into and through implant 10. Although not illustrated, it will be understood that typically a second implant will be placed in disc space D to provide further stability.
As shown more clearly in FIG. 4, implant 10 has a height H which is 2o substantially equal to the height of disc space D formed between vertebra 36 and vertebra 38. It will understood by those skilled in the art that in the preferred embodiment illustrated herein, the height H is substantially constant from the insertion shown in FIG. 3 to the expanded configuration shown in FIG. 4.
Furthermore, while a uniform height implant is shown in FIG. 2, it will be 25 understood that implant 10 may have a tapering height such that the implant could be utilized for establishing or maintaining the proper lordotic curvature in the spine. With reference to rigid bone portion 14, upper bearing surface 25 engages and supports upper vertebral body 38 while lower bearing surface 27 engages and supports the implant on lower vertebral body 36. Rigids 18 and 19 engage the surface of vertebral bodies 38 and 36, respectively, to resist expulsion.
Rigid bone portion 14, in conjunction with rigid bone portion 12 having similar engagement with the vertebrae, has sufficient rigid and structural integrity to substantially maintain height H and to withstand normal forces applied to the spinal column.
Flexible area 16 need not have such structural requirements, although, preferably, it assists in the implant stability by maintaining the connection between the two support walls.
Flexible bone implant 10 provides the desirable features of being formed of a highly successful bone fusion material, i.e. natural bone, with the advantages of Io having a reduced size insertion configuration and an expanded spacing configuration. Thus, while the implant maintains the desired height of disc space distraction, the width of the implant opposite central portion 16 is readily expandable from the insertion configuration of FIG. 2 to the expanded configuration of FIG. 3. This feature permits insertion through a smaller access 15 site and increases implant stability in the disc space.
Referring now to FIGS. 5 through 7, there is shown a further embodiment of an implant according to the present invention. FIG. 5 shows a threaded cortical bone dowel 50 modified in accordance with the present invention. Bone dowel 50 includes a thread 58 for engaging adjacent vertebra to advance the implant in a 2o controlled manner and to resist expulsion. Implant 50 has a recessed slot 64 for engaging a driving tool adapted to rotate the device. In accordance with the invention, threaded bone dowel 50 is divided into a first side wall 52 and second side wall 54 separated by flexible area 56 and slot 62. As described further herein, flexible area 56 is created by at least partial demineralization of the bone in this 25 area of the implant. Each of the first and second side walls 52 and 54 include upper and lower bearing surfaces. Threaded dowel 50 further includes a central opening 60. This opening may be created by the natural medullary canal of a diaphyseal bone or by removal of a cancellous portion of a donor bone, although this depends on the configuration of the donor bone.
In the configuration of FIG. 5, the device may be inserted through an insertion tube or other device into a disc space as previously described. Once positioned with opening 60 adjacent the upper and lower vertebral bodies, first side wall 52 and second side wall 54 are urged away from each other with the implant flexing at flexible portion 56. The implant 50 is shown in its expanded condition in FIG. 7. Once the desired expansion has been created, bone growth promoting material 64 may be inserted into the interior area 60 between first side wall 52 and second side wall 54. The side walls provide structured support to maintain the disc space height. As shown in FIGS. 5 through 7, bone implant SO has a reduced-size 1 o insertion configuration and an expanded spacing configuration.
Referring to FIG.B, in still a further embodiment of the present invention, a threaded, cylindrical bone dowel has been modified in accordance with the present invention. Specifically, bone implant 80 has been modified to include at least two areas 86 and 88 of reduced mineral content, providing a degree of flexibility in the implant. Demineralized sections 86 and 88 are disposed between rigid portions and 84. Thus, sudden changes in forces applied to rigid portions 82 or 84 may be dampened by the intervening flexible areas. Referring to FIG. 8, such a device is implanted in disc space 94 between vertebral body V 1 and vertebral body V2 with rigid portions 92 and 94 positioned adjacent vertebral bodies V 1 and V2, respectively. It will be understood that as force is applied to vertebral bodies V 1 and V2, there will be a tendency for the implant to flex at demineralized areas 86 and 88 to provide a degree of flexibility in the implant and to provide physiologic loading environment. Specifically, compressive forces represented by arrows 102, 103, 104 and 105 may be more normally transferred by flexing of flexible portions 86 and 88 to positions 110 and 112, respectively. Such devices may have application in both fusion (normal loading) and arthroplasty (normal motion).
Refernng to FIG. 9, there is shown yet a further aspect of the present invention. Donor bone 120 is a substantially ring-shaped bone segment having an internal cavity 30, such as a femoral ring. A slot 128 is formed in ring 120.
Opposite slot 128, portion 126 is treated to remove at least a portion of the bone minerals. This creates an area of flexibility at portion 126. Thus, the bone is divided into side walls 122 and 124, separated by slot 128 and flexible portion 126.
As previously described, the bone graft may be expanded after insertion by movement of side wall 124 away from side wall 122.
Referring now to FIG. 10(a), there is shown an alternative embodiment according to the present invention. Spacer 180 is a Smith-Robinson type bone graft that is typically used in the cervical region of the spine. Spacer 180 includes an internal cavity 188 defined by walls 182, 183, 184 and 191. Cavity 188 is to suitable for receiving bone graft material to promote fusion between adjacent vertebrae. To provide for expansion, an opening 186 in wall 183 is created and an opposing flexible hinge area 190 is created in wall 191 by at least partial demineralization. In this manner, walls 182 and 184 may be moved in the direction of arrows 192 and 194, respectively, to expand the implant after insertion between adjacent vertebrae. It will be understood that wall 191 will be at least partially deformed during the expansion process.
FIG. 10(b) shows a modified embodiment of the implant of FIG. 10(a). In FIG. 10(b), spacer 195 has an internal chamber 208 defined by walls 199, 200, 201, and 202. Wall 201 includes an opening 196 formed there through. Flexible areas of bone are created by at least partial demineralization at hinge areas 197 and 198 on walls 200 and 202, respectively, adjacent the connection to wall 199. Walls 200 and 202 may be moved in the direction of arrows 204 and 206 to permit expansion of spacer 195. The use of dual hinge areas on the implant permits precise placement of wall 199 in the disc space and permits the expansion to take place laterally without the location of a portion of wall 199 being altered during expansion.
In addition to the above described embodiments, the present invention may have further uses. Specifically, but without limitation, one such may be to reform donor bone segments to conform more closely to spaces needing implants. In some cases, donor bone segments may have shapes incompatible with the shape of the implantation site. These bone segments may have flexible areas to reform the bone graft to more closely match its intended use. Such segments may have one or more flexible areas such that the overall shape of the donor bone segment may be modified by flexing at the flexible segments. This may preserve much of the load bearing strength of the implants. This use of the present invention may increase the potentially useable portions of the limited supply of donor bone. Full utilization of donor bone and alternative graft shapes is more fully disclosed in U.
S. Patent Application No. 09/181,353 filed October 29, 1998, entitled IMPACTED
1 o BONE IMPLANTS AND INSTRUMENTATION, incorporated herein by reference.
Creation of the demineralized portion of the bone will now be described.
The processing involves the use of donor bone with processing in a clean room environment within a bone processing facility. Such donor bone may include 15 allograft from human sources or xenograft from animal sources. Further, it is contemplated that as technology advances in the area of bone processing, the donor bone may be generated in the manufacturing process, either by bone growth or by a processing of constituent components of bone to create artificial materials having properties very similar to bone. More specifically, while any available allogenic or 2o xenogenic bone stock may be utilized for the procedure, cortical bone is conventionally preferred for spinal fusion for its structural properties, although cortical cancellous or cancellous bone may be used depending upon the particular requirements for the implantable device.
In further processing, the connective tissues are removed and the bone is 25 cleaned, rinsed, and defatted using a solvent such as ethanol or hydrogen peroxide.
The bone is then machined or otherwise shaped using conventional techniques to create its final shape, such as a wedge, dowel, or other shape. An intermediate portion of the bone is delineated as needing an increased degree of flexibility.
Demineralization takes place solely at the location requiring the flexible capability.
Penetration of the demineralization fluid into the bone adjacent the desired area of flexibility may be controlled by hydrostatic pressure thereby limiting the area of demineralization. The amount of mineral removed from the bone may be adjusted to create the desired amount of flexibility. This demineralization conventionally uses an organic acid such as hydrochloric, nitric, or citric acid. Preferably, the demineralization solution comprises 0.1 to 1.0 N HCI, most preferably 0.3 N
HCI.
If a xenograft is used, known techniques on the utilization of organic solvents to inactivate bone proteins and reduce antigenecity may be applied at this point.
Additionally, the use of glutaraldehyde may take place in order to further cross-line 1 o the collagen structure following removal of the mineral portion. Once the device has been machined and partially demineralized, it may be stored prior to insertion.
Although the above-described processing is disclosed herein as a preferred embodiment, it is contemplated that other suitable processes may be used.
While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiments have been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected.
Claims (20)
1. An implant for promoting fusion between adjacent upper and lower vertebral bodies, comprising:
a first bone portion made of bone;
a second bone portion made of bone;
a flexible portion joining said first bone portion and said second bone portion, said flexible portion permitting movement of said first bone portion in relation to said second bone portion; and an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a first height, and said second bone portion included an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a second height, said first and second heights adapted to maintain spacing between adjacent upper and lower vertebral bodies.
a first bone portion made of bone;
a second bone portion made of bone;
a flexible portion joining said first bone portion and said second bone portion, said flexible portion permitting movement of said first bone portion in relation to said second bone portion; and an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a first height, and said second bone portion included an upper bearing surface for engaging said upper vertebra and a lower bearing surface for engaging said lower vertebra separated by a second height, said first and second heights adapted to maintain spacing between adjacent upper and lower vertebral bodies.
2. The implant of claim 1, wherein said flexible portion is at least partially demineralized bone.
3. The implant of claim 2, wherein said flexible portion includes an area of completely demineralized bone.
4. The implant of claim 1, wherein said first height and said second height are substantially equal.
5. The implant of claim 1, wherein each of said upper and lower bearing surfaces includes a bone engaging surface to inhibit expulsion from a disc space between two adjacent vertebra.
6. The implant of claim 1, wherein said first and second bone portions have corresponding tapered bearing surfaces to provide an implant having a spacing height gradually increasing from a first end to an opposite second end, wherein said implant is adapted for use in maintaining lordosis.
7. The implant of claim 1, wherein said first bone portion, said second bone portion, and said flexible portion are formed of a single bone segment.
8. The implant of claim 1, wherein the implant is substantially ring shaped
9. A spinal fusion implant adapted for insertion into the space between adjacent first and second vertebral bodies, comprising:
a first bone portion having a first bearing surface for engaging a first vertebral body, wherein said first bone portion is made of bone;
a second bone portion having a second bearing surface for engaging a second vertebral body, wherein said second bone portion is made of bone;
a proximal end and an opposite distal end;
a first flexible portion disposed adjacent said proximal end and a second flexible portion, spaced from said first flexible portion, disposed adjacent to said distal end; and said flexible portions permitting movement between said first bone portion and said second bone portion.
a first bone portion having a first bearing surface for engaging a first vertebral body, wherein said first bone portion is made of bone;
a second bone portion having a second bearing surface for engaging a second vertebral body, wherein said second bone portion is made of bone;
a proximal end and an opposite distal end;
a first flexible portion disposed adjacent said proximal end and a second flexible portion, spaced from said first flexible portion, disposed adjacent to said distal end; and said flexible portions permitting movement between said first bone portion and said second bone portion.
10. The implant of claim 9, wherein said first bearing surface and said second bearing surface including cooperating thread patterns permitting threaded insertion of the implant into the space between the first and second vertebral bodies.
11. The implant of claim 9, wherein said implant is formed of a single segment of bone.
12. A method of preparing a flexible bone implant, comprising:
providing a rigid bone segment;
delineating an intermediate portion of the bone segment;
exposing said intermediate portion to a demineralizing fluid; and limiting contact of bone adjacent the intermediate portion with the demineralizing fluid by utilizing hydrostatic pressure to limit the movement of the demineralizing fluid into the bone adjacent the intermediate portion to create a flexible segment between adjacent sections of rigid bone.
providing a rigid bone segment;
delineating an intermediate portion of the bone segment;
exposing said intermediate portion to a demineralizing fluid; and limiting contact of bone adjacent the intermediate portion with the demineralizing fluid by utilizing hydrostatic pressure to limit the movement of the demineralizing fluid into the bone adjacent the intermediate portion to create a flexible segment between adjacent sections of rigid bone.
13. The method of claim 12, further including forming a bone-engaging surface on the implant.
14. The method of claim 13, wherein said bone engaging surface includes raised bone structures.
15. The method of claim 13, wherein said bone engaging surface is a tread pattern.
16. The method of claim 13, wherein said one engaging surface is configured to prevent movement of the implant.
17. A method of inserting an interbody fusion implant made of bone, comprising:
providing an insertion tube and an implant formed of bone and having a first portion, a second portion and a central flexible portion joining the first and second portions;
positioning the insertion tube adjacent a disc space between two vertebra;
inserting the implant into the insertion tube;
advancing the implant through the insertion tube and into the disc space;
moving the first portion with respect to the second portion.
providing an insertion tube and an implant formed of bone and having a first portion, a second portion and a central flexible portion joining the first and second portions;
positioning the insertion tube adjacent a disc space between two vertebra;
inserting the implant into the insertion tube;
advancing the implant through the insertion tube and into the disc space;
moving the first portion with respect to the second portion.
18. A method of implanting a bone implant for spinal spacing, comprising:
providing a bone implant with at least a portion thereof moveable from a reduced insertion configuration to an expanded spacing configuration;
delivering the implant to the disc space in the reduced insertion configuration; and positioning the implant in the expanded spacing configuration.
providing a bone implant with at least a portion thereof moveable from a reduced insertion configuration to an expanded spacing configuration;
delivering the implant to the disc space in the reduced insertion configuration; and positioning the implant in the expanded spacing configuration.
19. The method of claim 18, wherein said implant is at least partially resilient.
20. The method of claim 19, wherein said delivering is accomplished by a tube having an internal passageway configured to receive said implant in the reduced insertion configuration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/227,976 US6206923B1 (en) | 1999-01-08 | 1999-01-08 | Flexible implant using partially demineralized bone |
US09/227,976 | 1999-01-08 | ||
PCT/US2000/000154 WO2000040179A1 (en) | 1999-01-08 | 2000-01-05 | Flexible implant using partially demineralized bone |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2358455A1 true CA2358455A1 (en) | 2000-07-13 |
Family
ID=22855238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002358455A Abandoned CA2358455A1 (en) | 1999-01-08 | 2000-01-05 | Flexible implant using partially demineralized bone |
Country Status (9)
Country | Link |
---|---|
US (3) | US6206923B1 (en) |
EP (1) | EP1139929B1 (en) |
JP (1) | JP4282239B2 (en) |
AT (1) | ATE262866T1 (en) |
AU (1) | AU747356B2 (en) |
CA (1) | CA2358455A1 (en) |
DE (1) | DE60009446T2 (en) |
ES (1) | ES2215606T3 (en) |
WO (1) | WO2000040179A1 (en) |
Families Citing this family (270)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2753368B1 (en) * | 1996-09-13 | 1999-01-08 | Chauvin Jean Luc | EXPANSIONAL OSTEOSYNTHESIS CAGE |
ATE220564T1 (en) * | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | COMPOSITION AND DEVICE FOR REPAIRING CARTILAGE TISSUE IN VIVO CONSISTING OF NANOCAPSULES WITH OSTEOINDUCTIVE AND/OR CHONDROINDUCTIVE FACTORS |
US6652592B1 (en) | 1997-10-27 | 2003-11-25 | Regeneration Technologies, Inc. | Segmentally demineralized bone implant |
US6090998A (en) * | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
US6986788B2 (en) * | 1998-01-30 | 2006-01-17 | Synthes (U.S.A.) | Intervertebral allograft spacer |
USRE38614E1 (en) | 1998-01-30 | 2004-10-05 | Synthes (U.S.A.) | Intervertebral allograft spacer |
US7087082B2 (en) * | 1998-08-03 | 2006-08-08 | Synthes (Usa) | Bone implants with central chambers |
DE69916280T2 (en) | 1998-08-03 | 2005-05-25 | Synthes Ag Chur, Chur | INTERVERTEBRAL allograft DISTANZSTÜCK |
US20060241763A1 (en) * | 1998-08-03 | 2006-10-26 | Synthes (Usa) | Multipiece bone implant |
US6193757B1 (en) * | 1998-10-29 | 2001-02-27 | Sdgi Holdings, Inc. | Expandable intervertebral spacers |
US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
US7094239B1 (en) | 1999-05-05 | 2006-08-22 | Sdgi Holdings, Inc. | Screws of cortical bone and method of manufacture thereof |
EP1198208B1 (en) * | 1999-05-05 | 2013-07-10 | Warsaw Orthopedic, Inc. | Nested interbody spinal fusion implants |
WO2001087369A2 (en) * | 2000-05-12 | 2001-11-22 | Osteotech, Inc. | Osteoimplant and method for making same |
US6277149B1 (en) * | 1999-06-08 | 2001-08-21 | Osteotech, Inc. | Ramp-shaped intervertebral implant |
FR2897259B1 (en) * | 2006-02-15 | 2008-05-09 | Ldr Medical Soc Par Actions Si | INTERSOMATIC TRANSFORAMINAL CAGE WITH INTERBREBAL FUSION GRAFT AND CAGE IMPLANTATION INSTRUMENT |
US8679180B2 (en) * | 1999-10-08 | 2014-03-25 | Anova Corporation | Devices used to treat disc herniation and attachment mechanisms therefore |
US20030040796A1 (en) * | 1999-10-08 | 2003-02-27 | Ferree Bret A. | Devices used to treat disc herniation and attachment mechanisms therefore |
US20030004574A1 (en) * | 1999-10-08 | 2003-01-02 | Ferree Bret A. | Disc and annulus augmentation using biologic tissue |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
US6830570B1 (en) * | 1999-10-21 | 2004-12-14 | Sdgi Holdings, Inc. | Devices and techniques for a posterior lateral disc space approach |
DE19952939A1 (en) | 1999-11-03 | 2001-05-10 | Tutogen Medical Gmbh | Bone material implant |
AU2624801A (en) * | 1999-12-30 | 2001-07-16 | Osteotech, Inc. | Intervertebral implants |
US6458144B1 (en) * | 1999-12-30 | 2002-10-01 | Osteotech, Inc. | Methods for manufacturing skeletal implants |
AR027685A1 (en) * | 2000-03-22 | 2003-04-09 | Synthes Ag | METHOD AND METHOD FOR CARRYING OUT |
US6350283B1 (en) * | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
US7462195B1 (en) | 2000-04-19 | 2008-12-09 | Warsaw Orthopedic, Inc. | Artificial lumbar interbody spinal implant having an asymmetrical leading end |
EP1278487B1 (en) * | 2000-04-28 | 2006-09-13 | Perumala Corporation | Rotating, locking intervertebral disk stabilizer |
FR2808995B1 (en) * | 2000-05-18 | 2003-02-21 | Aesculap Sa | INTERSOMATIC CAGE WITH UNIFIED GRAFT |
DE10026306A1 (en) * | 2000-05-26 | 2001-11-29 | Tutogen Medical Gmbh | Jawbone transplant is domed and can be bent to U-shapes and is made of spongiose, cortical or compact bone material of human or animal origin |
EP1284707A4 (en) * | 2000-05-30 | 2003-06-25 | Paul S Lin | Implant for placement between cervical vertebrae |
AU8047601A (en) * | 2000-06-30 | 2002-01-14 | Stephen Ritland | Polyaxial connection device and method |
US7018416B2 (en) * | 2000-07-06 | 2006-03-28 | Zimmer Spine, Inc. | Bone implants and methods |
US9387094B2 (en) * | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
US6638310B2 (en) | 2000-07-26 | 2003-10-28 | Osteotech, Inc. | Intervertebral spacer and implant insertion instrumentation |
EP1315470B1 (en) * | 2000-08-28 | 2009-07-15 | Disc Dynamics, Inc. | System for mammalian joint resurfacing |
US7204851B2 (en) * | 2000-08-30 | 2007-04-17 | Sdgi Holdings, Inc. | Method and apparatus for delivering an intervertebral disc implant |
US20020026244A1 (en) * | 2000-08-30 | 2002-02-28 | Trieu Hai H. | Intervertebral disc nucleus implants and methods |
EP1563808B1 (en) * | 2000-08-30 | 2008-04-02 | Warsaw Orthopedic, Inc. | Intervertebral disc nucleus implants |
US6620196B1 (en) * | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
US7503936B2 (en) * | 2000-08-30 | 2009-03-17 | Warsaw Orthopedic, Inc. | Methods for forming and retaining intervertebral disc implants |
US6443987B1 (en) * | 2000-09-15 | 2002-09-03 | Donald W. Bryan | Spinal vertebral implant |
US6500206B1 (en) | 2000-09-15 | 2002-12-31 | Donald W. Bryan | Instruments for inserting spinal vertebral implant |
US6761738B1 (en) * | 2000-09-19 | 2004-07-13 | Sdgi Holdings, Inc. | Reinforced molded implant formed of cortical bone |
US7166073B2 (en) * | 2000-09-29 | 2007-01-23 | Stephen Ritland | Method and device for microsurgical intermuscular spinal surgery |
US20030120274A1 (en) * | 2000-10-20 | 2003-06-26 | Morris John W. | Implant retaining device |
US6613089B1 (en) * | 2000-10-25 | 2003-09-02 | Sdgi Holdings, Inc. | Laterally expanding intervertebral fusion device |
MXPA03004180A (en) * | 2000-11-13 | 2004-12-02 | Boehm Frank H Jr | Device and method for lumbar interbody fusion. |
WO2002045623A1 (en) * | 2000-12-08 | 2002-06-13 | Osteotech, Inc. | Segmentally demineralized bone implant and method for its manufacture |
US6890343B2 (en) * | 2000-12-14 | 2005-05-10 | Ensure Medical, Inc. | Plug with detachable guidewire element and methods for use |
US6846319B2 (en) * | 2000-12-14 | 2005-01-25 | Core Medical, Inc. | Devices for sealing openings through tissue and apparatus and methods for delivering them |
US6623509B2 (en) | 2000-12-14 | 2003-09-23 | Core Medical, Inc. | Apparatus and methods for sealing vascular punctures |
US6896692B2 (en) | 2000-12-14 | 2005-05-24 | Ensure Medical, Inc. | Plug with collet and apparatus and method for delivering such plugs |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
US8083768B2 (en) | 2000-12-14 | 2011-12-27 | Ensure Medical, Inc. | Vascular plug having composite construction |
US6468311B2 (en) * | 2001-01-22 | 2002-10-22 | Sdgi Holdings, Inc. | Modular interbody fusion implant |
US6562073B2 (en) * | 2001-02-06 | 2003-05-13 | Sdgi Holding, Inc. | Spinal bone implant |
US6576017B2 (en) | 2001-02-06 | 2003-06-10 | Sdgi Holdings, Inc. | Spinal implant with attached ligament and methods |
US7931692B2 (en) | 2001-02-14 | 2011-04-26 | Osteotech, Inc. | Implant derived from bone |
AU2002244116A1 (en) * | 2001-02-16 | 2002-09-04 | Sulzer Spine-Tech Inc. | Bone implants and methods |
US6855169B2 (en) * | 2001-02-28 | 2005-02-15 | Synthes (Usa) | Demineralized bone-derived implants |
US20030045935A1 (en) * | 2001-02-28 | 2003-03-06 | Angelucci Christopher M. | Laminoplasty implants and methods of use |
US6595998B2 (en) | 2001-03-08 | 2003-07-22 | Spinewave, Inc. | Tissue distraction device |
US6890355B2 (en) | 2001-04-02 | 2005-05-10 | Gary K. Michelson | Artificial contoured spinal fusion implants made of a material other than bone |
US6989031B2 (en) * | 2001-04-02 | 2006-01-24 | Sdgi Holdings, Inc. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
US6749636B2 (en) * | 2001-04-02 | 2004-06-15 | Gary K. Michelson | Contoured spinal fusion implants made of bone or a bone composite material |
US20040083002A1 (en) * | 2001-04-06 | 2004-04-29 | Belef William Martin | Methods for treating spinal discs |
EP1408884A1 (en) | 2001-07-12 | 2004-04-21 | Osteotech, Inc. | Intervertebral impant with movement resistant structure |
FR2827156B1 (en) | 2001-07-13 | 2003-11-14 | Ldr Medical | VERTEBRAL CAGE DEVICE WITH MODULAR FASTENING |
US20050107795A1 (en) * | 2001-08-10 | 2005-05-19 | John Morris | Bone plating system and method of use |
US7018412B2 (en) | 2001-08-20 | 2006-03-28 | Ebi, L.P. | Allograft spinal implant |
US6635087B2 (en) | 2001-08-29 | 2003-10-21 | Christopher M. Angelucci | Laminoplasty implants and methods of use |
US6736815B2 (en) | 2001-09-06 | 2004-05-18 | Core Medical, Inc. | Apparatus and methods for treating spinal discs |
US6991632B2 (en) | 2001-09-28 | 2006-01-31 | Stephen Ritland | Adjustable rod and connector device and method of use |
AU2002330146B2 (en) | 2001-09-28 | 2007-10-18 | Zimmer Spine, Inc. | Skeletal stabilization implant |
JP4249021B2 (en) | 2001-09-28 | 2009-04-02 | リットランド、ステファン | Connecting rod for screw or hook multi-axis system and method of use |
JP4394441B2 (en) * | 2001-10-02 | 2010-01-06 | レックス メディカル リミテッド パートナーシップ | Spinal implant |
KR20040047746A (en) * | 2001-10-12 | 2004-06-05 | 오스테오테크, 인코포레이티드 | Improved bone graft |
DE20117773U1 (en) * | 2001-10-31 | 2003-03-20 | Koenigsee Implantate & Instr | Implant to stabilize the vertebrae cervicales |
US6855167B2 (en) * | 2001-12-05 | 2005-02-15 | Osteotech, Inc. | Spinal intervertebral implant, interconnections for such implant and processes for making |
AU2002366381A1 (en) * | 2001-12-18 | 2003-06-30 | Ebi, L.P. | Spinal implants |
SE0104323D0 (en) * | 2001-12-20 | 2001-12-20 | Matts Andersson | Method and arrangement of implants for preferably human intermediate disc and such implant |
US7241813B2 (en) * | 2001-12-21 | 2007-07-10 | Isotis Orthobiologics, Inc. | End-capped polymers and compositions containing such compounds |
US7205337B2 (en) * | 2001-12-21 | 2007-04-17 | Isotis Orthobiologics, Inc. | End-capped polymers and compositions containing such compounds |
AR038680A1 (en) * | 2002-02-19 | 2005-01-26 | Synthes Ag | INTERVERTEBRAL IMPLANT |
AU2003239118B2 (en) | 2002-02-20 | 2007-09-20 | Stephen Ritland | Pedicle screw connector apparatus and method |
US20040010315A1 (en) * | 2002-03-29 | 2004-01-15 | Song John K. | Self-expanding intervertebral device |
US6966910B2 (en) * | 2002-04-05 | 2005-11-22 | Stephen Ritland | Dynamic fixation device and method of use |
DE10220139A1 (en) * | 2002-05-06 | 2003-11-20 | Tutogen Medical Gmbh | Bone material implant |
EP2457529A1 (en) * | 2002-05-08 | 2012-05-30 | Stephen Ritland | Dynamic fixation device and method of use |
US8388684B2 (en) | 2002-05-23 | 2013-03-05 | Pioneer Signal Technology, Inc. | Artificial disc device |
US7001433B2 (en) * | 2002-05-23 | 2006-02-21 | Pioneer Laboratories, Inc. | Artificial intervertebral disc device |
US7622562B2 (en) * | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
EP1698308A3 (en) * | 2002-09-13 | 2007-06-27 | Replication Medical, INC. | Surgical instrument for driving a folded intervertebral implant |
ATE385755T1 (en) * | 2002-09-13 | 2008-03-15 | Replication Medical Inc | TOOLS FOR HANDLING AND RECEIVING AN IMPLANT |
US6723126B1 (en) | 2002-11-01 | 2004-04-20 | Sdgi Holdings, Inc. | Laterally expandable cage |
US20050124993A1 (en) * | 2002-12-02 | 2005-06-09 | Chappuis James L. | Facet fusion system |
AU2003201614B2 (en) | 2003-02-06 | 2008-02-14 | Synthes Gmbh | Intervertebral implant |
WO2004082526A2 (en) * | 2003-03-14 | 2004-09-30 | Schneiderman Gary A | Intervertebral disk nuclear augmentation system |
US7819903B2 (en) | 2003-03-31 | 2010-10-26 | Depuy Spine, Inc. | Spinal fixation plate |
US7771478B2 (en) | 2003-04-04 | 2010-08-10 | Theken Spine, Llc | Artificial disc prosthesis |
US20050143824A1 (en) * | 2003-05-06 | 2005-06-30 | Marc Richelsoph | Artificial intervertebral disc |
US7105024B2 (en) * | 2003-05-06 | 2006-09-12 | Aesculap Ii, Inc. | Artificial intervertebral disc |
US7291173B2 (en) | 2003-05-06 | 2007-11-06 | Aesculap Ii, Inc. | Artificial intervertebral disc |
DE20308171U1 (en) * | 2003-05-21 | 2003-07-31 | Aesculap Ag & Co Kg | Vertebral body replacement implant |
US8262571B2 (en) * | 2003-05-22 | 2012-09-11 | Stephen Ritland | Intermuscular guide for retractor insertion and method of use |
JP2007503292A (en) | 2003-06-11 | 2007-02-22 | オステオテック インコーポレーテッド | Bone implant and manufacturing method thereof |
US7226482B2 (en) * | 2003-09-02 | 2007-06-05 | Synthes (U.S.A.) | Multipiece allograft implant |
DE10347175B4 (en) * | 2003-10-08 | 2005-10-20 | Aesculap Ag & Co Kg | Intervertebral implant |
DE10347172B4 (en) * | 2003-10-08 | 2005-09-29 | Aesculap Ag & Co. Kg | Intervertebral implant |
US8852229B2 (en) * | 2003-10-17 | 2014-10-07 | Cordis Corporation | Locator and closure device and method of use |
US7361183B2 (en) | 2003-10-17 | 2008-04-22 | Ensure Medical, Inc. | Locator and delivery device and method of use |
US7381180B2 (en) * | 2003-10-31 | 2008-06-03 | Medtronic, Inc. | Implantable devices and methods for treating fecal incontinence |
US7585271B2 (en) * | 2003-11-01 | 2009-09-08 | Thd Spa | Implantable devices and methods for treating urinary incontinence |
EP1691760B1 (en) * | 2003-11-20 | 2012-06-27 | Koninklijke Philips Electronics N.V. | Devices to fixate tissue within the pharyngeal conduit |
US7771479B2 (en) | 2004-01-09 | 2010-08-10 | Warsaw Orthopedic, Inc. | Dual articulating spinal device and method |
US20050171608A1 (en) * | 2004-01-09 | 2005-08-04 | Sdgi Holdings, Inc. | Centrally articulating spinal device and method |
US20050154467A1 (en) * | 2004-01-09 | 2005-07-14 | Sdgi Holdings, Inc. | Interconnected spinal device and method |
CA2554571A1 (en) | 2004-01-27 | 2005-08-11 | Osteotech, Inc. | Stabilized bone graft |
JP2007519492A (en) * | 2004-01-30 | 2007-07-19 | オステオテック,インコーポレイテッド | Stacked implant for spinal fusion |
US7585316B2 (en) | 2004-05-21 | 2009-09-08 | Warsaw Orthopedic, Inc. | Interspinous spacer |
DE202004009542U1 (en) * | 2004-06-16 | 2004-08-12 | Aesculap Ag & Co. Kg | Artificial intervertebral disk, comprising core with intensely curved upper and less curved lower surface |
US20060058881A1 (en) * | 2004-09-16 | 2006-03-16 | Trieu Hai H | Intervertebral disc nucleus implants and methods |
US7455639B2 (en) * | 2004-09-20 | 2008-11-25 | Stephen Ritland | Opposing parallel bladed retractor and method of use |
WO2006034436A2 (en) | 2004-09-21 | 2006-03-30 | Stout Medical Group, L.P. | Expandable support device and method of use |
WO2006042334A2 (en) * | 2004-10-12 | 2006-04-20 | Stout Medical Group, L.P. | Expandable support device and method of use |
US20060089719A1 (en) * | 2004-10-21 | 2006-04-27 | Trieu Hai H | In situ formation of intervertebral disc implants |
CA2509253A1 (en) * | 2004-10-27 | 2006-04-27 | Brent A. Felix | Surgical implant |
ATE524121T1 (en) | 2004-11-24 | 2011-09-15 | Abdou Samy | DEVICES FOR PLACING AN ORTHOPEDIC INTERVERTEBRAL IMPLANT |
KR20070101239A (en) * | 2005-01-08 | 2007-10-16 | 알파스파인, 아이엔씨. | Modular disk device |
CN101141934B (en) * | 2005-01-14 | 2010-11-24 | 骨骼技术股份有限公司 | Expandable osteoimplant |
US7267690B2 (en) * | 2005-03-09 | 2007-09-11 | Vertebral Technologies, Inc. | Interlocked modular disc nucleus prosthesis |
US7674296B2 (en) * | 2005-04-21 | 2010-03-09 | Globus Medical, Inc. | Expandable vertebral prosthesis |
WO2006116761A2 (en) * | 2005-04-27 | 2006-11-02 | Stout Medical Group, L.P. | Expandable support device and methods of use |
US7608108B2 (en) * | 2005-04-29 | 2009-10-27 | Jmea Corporation | Tissue repair system |
US20060247781A1 (en) * | 2005-04-29 | 2006-11-02 | Sdgi Holdings, Inc. | Implant |
US7632313B2 (en) | 2005-04-29 | 2009-12-15 | Jmea Corporation | Disc repair system |
US8702718B2 (en) | 2005-04-29 | 2014-04-22 | Jmea Corporation | Implantation system for tissue repair |
US8088144B2 (en) * | 2005-05-04 | 2012-01-03 | Ensure Medical, Inc. | Locator and closure device and method of use |
US8926654B2 (en) | 2005-05-04 | 2015-01-06 | Cordis Corporation | Locator and closure device and method of use |
WO2006134813A1 (en) * | 2005-06-14 | 2006-12-21 | Olympus Biomaterial Corp. | Bone supplementing material introducing device, method of operating the device, and bone supplementing material |
DE202005009755U1 (en) * | 2005-06-21 | 2005-09-08 | Cervitech, Inc. | Device for temporary accommodation of implant replacing intervertebral disk, comprising stepped holding area |
EP1736120A1 (en) | 2005-06-22 | 2006-12-27 | Cervitech, Inc. | Intervertebral prosthesis with self-cutting fixation protrusions |
US20070010889A1 (en) * | 2005-07-06 | 2007-01-11 | Sdgi Holdings, Inc. | Foldable nucleus replacement device |
JP5081822B2 (en) * | 2005-07-14 | 2012-11-28 | スタウト メディカル グループ,エル.ピー. | Expandable support device and system |
AU2006269900A1 (en) | 2005-07-19 | 2007-01-25 | Stephen Ritland | Rod extension for extending fusion construct |
ITPD20050231A1 (en) * | 2005-07-28 | 2007-01-29 | 2B1 Srl | APPARATUS FOR THE NEUROCURGURGICAL-ORTHOPEDIC TREATMENT OF PATHOLOGIES OF THE HUMAN VERTEBRAL COLUMN |
FR2891135B1 (en) | 2005-09-23 | 2008-09-12 | Ldr Medical Sarl | INTERVERTEBRAL DISC PROSTHESIS |
WO2007056671A1 (en) * | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
EP1959870B1 (en) | 2005-12-08 | 2009-07-08 | FBCdevice ApS | Disc implant |
US7988695B2 (en) * | 2005-12-21 | 2011-08-02 | Theken Spine, Llc | Articulated delivery instrument |
US20070162132A1 (en) | 2005-12-23 | 2007-07-12 | Dominique Messerli | Flexible elongated chain implant and method of supporting body tissue with same |
US7811326B2 (en) | 2006-01-30 | 2010-10-12 | Warsaw Orthopedic Inc. | Posterior joint replacement device |
US7635389B2 (en) * | 2006-01-30 | 2009-12-22 | Warsaw Orthopedic, Inc. | Posterior joint replacement device |
US20100305704A1 (en) * | 2006-02-27 | 2010-12-02 | Synthes Gmbh | Intervertebral implant with fixation geometry |
US7976549B2 (en) * | 2006-03-23 | 2011-07-12 | Theken Spine, Llc | Instruments for delivering spinal implants |
WO2007131002A2 (en) | 2006-05-01 | 2007-11-15 | Stout Medical Group, L.P. | Expandable support device and method of use |
US20070260314A1 (en) * | 2006-05-02 | 2007-11-08 | Ashok Biyani | Transforaminal lumbar interbody fusion cage |
US20080071379A1 (en) * | 2006-05-10 | 2008-03-20 | Mark Rydell | Intervertebral disc replacement |
US7959564B2 (en) | 2006-07-08 | 2011-06-14 | Stephen Ritland | Pedicle seeker and retractor, and methods of use |
US8034110B2 (en) | 2006-07-31 | 2011-10-11 | Depuy Spine, Inc. | Spinal fusion implant |
US8043377B2 (en) * | 2006-09-02 | 2011-10-25 | Osprey Biomedical, Inc. | Implantable intervertebral fusion device |
US8506636B2 (en) * | 2006-09-08 | 2013-08-13 | Theken Spine, Llc | Offset radius lordosis |
US8715350B2 (en) | 2006-09-15 | 2014-05-06 | Pioneer Surgical Technology, Inc. | Systems and methods for securing an implant in intervertebral space |
EP2063817A4 (en) | 2006-09-15 | 2012-04-18 | Pioneer Surgical Technology Inc | Joint arthroplasty devices having articulating members |
US20080077241A1 (en) * | 2006-09-22 | 2008-03-27 | Linh Nguyen | Removable rasp/trial member insert, kit and method of use |
US8066750B2 (en) | 2006-10-06 | 2011-11-29 | Warsaw Orthopedic, Inc | Port structures for non-rigid bone plates |
US8142507B2 (en) * | 2006-11-16 | 2012-03-27 | Rex Medical, L.P. | Spinal implant and method of use |
US9737414B2 (en) | 2006-11-21 | 2017-08-22 | Vertebral Technologies, Inc. | Methods and apparatus for minimally invasive modular interbody fusion devices |
US7824427B2 (en) * | 2007-01-16 | 2010-11-02 | Perez-Cruet Miquelangelo J | Minimally invasive interbody device |
CA2677903A1 (en) * | 2007-02-12 | 2008-08-21 | Osteotech, Inc. | Joint revision implant |
US8021429B2 (en) * | 2007-03-08 | 2011-09-20 | Zimmer Spine, Inc. | Deployable segmented TLIF device |
US20080234825A1 (en) * | 2007-03-16 | 2008-09-25 | Chappuis James L | Modular Lumbar Interbody Fixation Systems and Methods |
US8992616B2 (en) * | 2007-03-19 | 2015-03-31 | James L. Chappuis | Modular lumbar interbody fixation systems and methods with reconstruction endplates |
US8864832B2 (en) * | 2007-06-20 | 2014-10-21 | Hh Spinal Llc | Posterior total joint replacement |
FR2916956B1 (en) | 2007-06-08 | 2012-12-14 | Ldr Medical | INTERSOMATIC CAGE, INTERVERTEBRAL PROSTHESIS, ANCHORING DEVICE AND IMPLANTATION INSTRUMENTATION |
US10821003B2 (en) | 2007-06-20 | 2020-11-03 | 3Spline Sezc | Spinal osteotomy |
WO2009006432A2 (en) | 2007-06-29 | 2009-01-08 | Synthes (U.S.A.) | Flexible chain implants and instrumentation |
US20090012620A1 (en) * | 2007-07-06 | 2009-01-08 | Jim Youssef | Implantable Cervical Fusion Device |
CN101808596B (en) * | 2007-09-14 | 2014-06-11 | 普渡研究基金会 | Demineralized cancellous bone scaffolds |
CN101854872B (en) * | 2007-09-14 | 2014-04-30 | 新特斯有限责任公司 | Interspinous spacer |
BRPI0820172A2 (en) | 2007-11-16 | 2015-06-16 | Synthes Gmbh | Low Profile Intervertebral Implant |
US8486148B2 (en) * | 2008-01-16 | 2013-07-16 | Life Spine, Inc. | Hinged spinal fusion cages |
US8267939B2 (en) | 2008-02-28 | 2012-09-18 | Stryker Spine | Tool for implanting expandable intervertebral implant |
WO2009155577A2 (en) * | 2008-06-19 | 2009-12-23 | Synthes Usa, Llc | Bone screw purchase augmentation implants, systems and techniques |
EP2358352B1 (en) * | 2008-10-24 | 2018-08-29 | Warsaw Orthopedic, Inc. | Compositions and methods for promoting bone formation |
CA2743247A1 (en) | 2008-11-07 | 2010-05-14 | Synthes Usa, Llc | Vertebral interbody spacer and coupled plate assembly |
WO2010056895A1 (en) | 2008-11-12 | 2010-05-20 | Stout Medical Group, L.P. | Fixation device and method |
US20100211176A1 (en) | 2008-11-12 | 2010-08-19 | Stout Medical Group, L.P. | Fixation device and method |
US8721723B2 (en) * | 2009-01-12 | 2014-05-13 | Globus Medical, Inc. | Expandable vertebral prosthesis |
FR2946525B1 (en) * | 2009-06-10 | 2012-06-15 | Creaspine | INTERVERTEBRAL IMPLANT AND ITS IMPLEMENTATION TOOL |
KR20120047231A (en) * | 2009-06-17 | 2012-05-11 | 트리니티 올쏘피딕스, 엘엘씨 | Expanding intervertebral device and methods of use |
EP2451404B1 (en) | 2009-07-09 | 2015-12-16 | R Tree Innovations, LLC | Flexible inter-body implant |
US20110029085A1 (en) * | 2009-07-31 | 2011-02-03 | Warsaw Orthopedic, Inc. | Flexible spinal implant |
US20110029083A1 (en) * | 2009-07-31 | 2011-02-03 | Warsaw Orthopedic, Inc. | Flexible Spinal Implant |
US8617245B2 (en) | 2009-09-17 | 2013-12-31 | DePuy Synthes Products, LLC | Intervertebral implant having extendable bone fixation members |
US8211126B2 (en) * | 2009-09-22 | 2012-07-03 | Jmea Corporation | Tissue repair system |
US8979748B2 (en) * | 2009-10-23 | 2015-03-17 | James L. Chappuis | Devices and methods for temporarily retaining spinal rootlets within dural sac |
US9801732B2 (en) * | 2009-10-30 | 2017-10-31 | Spinefrontier, Inc | System and method for an intervertebral implant assembly |
US8764806B2 (en) * | 2009-12-07 | 2014-07-01 | Samy Abdou | Devices and methods for minimally invasive spinal stabilization and instrumentation |
CN102781487B (en) | 2009-12-13 | 2016-11-16 | 阿米特·普拉卡什·戈维 | Biological activity graft and complex |
US9833331B2 (en) | 2009-12-31 | 2017-12-05 | Ldr Medical | Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument |
US8834568B2 (en) | 2010-02-04 | 2014-09-16 | Paul S. Shapiro | Surgical technique using a contoured allograft cartilage as a spacer of the carpo-metacarpal joint of the thumb or tarso-metatarsal joint of the toe |
US8282683B2 (en) | 2010-04-12 | 2012-10-09 | Globus Medical, Inc. | Expandable vertebral implant |
US9301850B2 (en) | 2010-04-12 | 2016-04-05 | Globus Medical, Inc. | Expandable vertebral implant |
US8870880B2 (en) | 2010-04-12 | 2014-10-28 | Globus Medical, Inc. | Angling inserter tool for expandable vertebral implant |
US8591585B2 (en) | 2010-04-12 | 2013-11-26 | Globus Medical, Inc. | Expandable vertebral implant |
US8535380B2 (en) | 2010-05-13 | 2013-09-17 | Stout Medical Group, L.P. | Fixation device and method |
EP3017793A3 (en) | 2010-07-15 | 2016-08-17 | Spine Wave, Inc. | A plastically deformable inter-osseous device |
US8343229B2 (en) | 2010-07-16 | 2013-01-01 | Ebi, Llc | Textured bone block implants |
EP2608747A4 (en) | 2010-08-24 | 2015-02-11 | Flexmedex Llc | Support device and method for use |
EP2446860B1 (en) * | 2010-10-26 | 2015-12-02 | Christian Röbling | Spinal disc prosthesis |
US9220535B2 (en) | 2010-10-26 | 2015-12-29 | Christian Röbling | Process for introducing a stabilizing element into a vertebral column |
GB2545819B (en) | 2010-11-10 | 2018-01-10 | Mitsubishi Materials Corp | Vertebral body spacer |
JP5942076B2 (en) * | 2010-11-10 | 2016-06-29 | 三菱マテリアル株式会社 | Vertebral spacer |
JP5942075B2 (en) | 2010-11-10 | 2016-06-29 | 三菱マテリアル株式会社 | Vertebral spacer |
US9149286B1 (en) | 2010-11-12 | 2015-10-06 | Flexmedex, LLC | Guidance tool and method for use |
US8512408B2 (en) | 2010-12-17 | 2013-08-20 | Warsaw Orthopedic, Inc. | Flexiable spinal implant |
WO2012088238A2 (en) | 2010-12-21 | 2012-06-28 | Synthes Usa, Llc | Intervertebral implants, systems, and methods of use |
US9241809B2 (en) | 2010-12-21 | 2016-01-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US8486149B2 (en) | 2011-02-23 | 2013-07-16 | DePuy Synthes Products, LLC | Expandable interbody fusion implant |
JP5784757B2 (en) * | 2011-02-23 | 2015-09-24 | シンセス・ゲーエムベーハーSynthes GmbH | Deployable interbody fusion graft |
US9579214B1 (en) | 2011-03-01 | 2017-02-28 | John W. McClellan | Peripheral vertebral body spacer implant and insertion tool |
EP3123982B1 (en) | 2011-08-16 | 2018-05-23 | Stryker European Holdings I, LLC | Expandable implant |
EP2747682A4 (en) | 2011-08-23 | 2015-01-21 | Flexmedex Llc | Tissue removal device and method |
US9668783B2 (en) | 2011-09-06 | 2017-06-06 | Atul Goel | Devices and method for treatment of spondylotic disease |
US10881526B2 (en) | 2011-09-16 | 2021-01-05 | Globus Medical, Inc. | Low profile plate |
US9204975B2 (en) | 2011-09-16 | 2015-12-08 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US9770340B2 (en) | 2011-09-16 | 2017-09-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US9149365B2 (en) | 2013-03-05 | 2015-10-06 | Globus Medical, Inc. | Low profile plate |
US9237957B2 (en) | 2011-09-16 | 2016-01-19 | Globus Medical, Inc. | Low profile plate |
US9398960B2 (en) | 2011-09-16 | 2016-07-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US9848994B2 (en) | 2011-09-16 | 2017-12-26 | Globus Medical, Inc. | Low profile plate |
US9681959B2 (en) | 2011-09-16 | 2017-06-20 | Globus Medical, Inc. | Low profile plate |
US8961606B2 (en) | 2011-09-16 | 2015-02-24 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US10245155B2 (en) | 2011-09-16 | 2019-04-02 | Globus Medical, Inc. | Low profile plate |
US9539109B2 (en) | 2011-09-16 | 2017-01-10 | Globus Medical, Inc. | Low profile plate |
US8845728B1 (en) | 2011-09-23 | 2014-09-30 | Samy Abdou | Spinal fixation devices and methods of use |
US9198765B1 (en) | 2011-10-31 | 2015-12-01 | Nuvasive, Inc. | Expandable spinal fusion implants and related methods |
US9198769B2 (en) | 2011-12-23 | 2015-12-01 | Pioneer Surgical Technology, Inc. | Bone anchor assembly, bone plate system, and method |
US20130226240A1 (en) | 2012-02-22 | 2013-08-29 | Samy Abdou | Spinous process fixation devices and methods of use |
FR2987256B1 (en) | 2012-02-24 | 2014-08-08 | Ldr Medical | ANCHORING DEVICE FOR INTERVERTEBRAL IMPLANT, INTERVERTEBRAL IMPLANT AND IMPLANTATION INSTRUMENTATION |
US9510953B2 (en) | 2012-03-16 | 2016-12-06 | Vertebral Technologies, Inc. | Modular segmented disc nucleus implant |
US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
US9248026B2 (en) | 2012-08-23 | 2016-02-02 | DePuy Synthes Products, Inc. | Surface expanding spacer |
US9198767B2 (en) | 2012-08-28 | 2015-12-01 | Samy Abdou | Devices and methods for spinal stabilization and instrumentation |
US9445918B1 (en) | 2012-10-22 | 2016-09-20 | Nuvasive, Inc. | Expandable spinal fusion implants and related instruments and methods |
US9320617B2 (en) | 2012-10-22 | 2016-04-26 | Cogent Spine, LLC | Devices and methods for spinal stabilization and instrumentation |
US10172651B2 (en) | 2012-10-25 | 2019-01-08 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US9265609B2 (en) | 2013-01-08 | 2016-02-23 | Warsaw Orthopedic, Inc. | Osteograft implant |
FR3001381A1 (en) * | 2013-01-31 | 2014-08-01 | Spineart Sa | DEFORMABLE INTERSOMATIC DEVICE |
US10342675B2 (en) | 2013-03-11 | 2019-07-09 | Stryker European Holdings I, Llc | Expandable implant |
FR3005569B1 (en) | 2013-05-16 | 2021-09-03 | Ldr Medical | VERTEBRAL IMPLANT, VERTEBRAL IMPLANT FIXATION DEVICE AND IMPLANTATION INSTRUMENTATION |
FR3016793B1 (en) | 2014-01-30 | 2021-05-07 | Ldr Medical | ANCHORING DEVICE FOR SPINAL IMPLANT, SPINAL IMPLANT AND IMPLANTATION INSTRUMENTATION |
US9980715B2 (en) | 2014-02-05 | 2018-05-29 | Trinity Orthopedics, Llc | Anchor devices and methods of use |
FR3020756B1 (en) | 2014-05-06 | 2022-03-11 | Ldr Medical | VERTEBRAL IMPLANT, VERTEBRAL IMPLANT FIXATION DEVICE AND IMPLANT INSTRUMENTATION |
JP6263314B2 (en) | 2014-06-04 | 2018-01-17 | ヴェンツェル スパイン,インコーポレイテッド | Interbody fusion device that expands bilaterally |
US9867718B2 (en) | 2014-10-22 | 2018-01-16 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
WO2016172026A1 (en) | 2015-04-20 | 2016-10-27 | The Board Of Regents Of The University Of Texas System | Clec11a is a bone growth agent |
US10857003B1 (en) | 2015-10-14 | 2020-12-08 | Samy Abdou | Devices and methods for vertebral stabilization |
US10973648B1 (en) | 2016-10-25 | 2021-04-13 | Samy Abdou | Devices and methods for vertebral bone realignment |
US10744000B1 (en) | 2016-10-25 | 2020-08-18 | Samy Abdou | Devices and methods for vertebral bone realignment |
US10376385B2 (en) | 2017-04-05 | 2019-08-13 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
US11452608B2 (en) | 2017-04-05 | 2022-09-27 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
JP2020533070A (en) | 2017-09-08 | 2020-11-19 | パイオニア サージカル テクノロジー インコーポレイテッド | Intervertebral implants, instruments, and methods |
USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
US11179248B2 (en) | 2018-10-02 | 2021-11-23 | Samy Abdou | Devices and methods for spinal implantation |
US11219531B2 (en) | 2019-04-10 | 2022-01-11 | Wenzel Spine, Inc. | Rotatable intervertebral spacing implant |
US11707361B2 (en) | 2020-02-05 | 2023-07-25 | K2M, Inc. | Flexible interbody implant |
DE102020133356A1 (en) | 2020-12-14 | 2022-06-15 | Gottfried Wilhelm Leibniz Universität Hannover, Körperschaft des öffentlichen Rechts | Bone dowel and method of making same |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932973A (en) | 1983-09-30 | 1990-06-12 | El Gendler | Cartilage and bone induction by artificially perforated organic bone matrix |
US4887020A (en) * | 1984-07-23 | 1989-12-12 | U.S. Philips Corporation | Self-compensating brushless alternator |
US4877020A (en) * | 1984-11-30 | 1989-10-31 | Vich Jose M O | Apparatus for bone graft |
US5053049A (en) | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
US4627853A (en) | 1985-05-29 | 1986-12-09 | American Hospital Supply Corporation | Method of producing prostheses for replacement of articular cartilage and prostheses so produced |
US4678470A (en) | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
US4743259A (en) | 1986-10-29 | 1988-05-10 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
US5108438A (en) | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
US5735902A (en) | 1987-07-20 | 1998-04-07 | Regen Biologics, Inc. | Hand implant device |
DE3741487A1 (en) * | 1987-12-08 | 1989-06-22 | Roland Man Druckmasch | Supporting element which can be inserted between two bones |
GB8813033D0 (en) | 1988-06-02 | 1988-07-06 | Geistlich Soehne Ag | Chemical compound |
IT216721Z2 (en) | 1989-06-30 | 1991-09-19 | Euroresearch S R L Milano | TUTOR CONSTITUTED BY A HETEROLOGICAL COLLAGEN TUBULAR, SUITABLE FOR USE IN THE SUTURE OF CABLE ORGANS. |
US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5112354A (en) | 1989-11-16 | 1992-05-12 | Northwestern University | Bone allograft material and method |
FR2654625B1 (en) | 1989-11-22 | 1992-02-21 | Transphyto Sa | PROCESS FOR MANUFACTURING A MATERIAL FOR OSTEOPLASTY FROM A NATURAL BONE TISSUE AND MATERIAL OBTAINED BY THIS PROCESS. |
US5425769A (en) | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
US5231169A (en) | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
ES2076467T3 (en) | 1990-10-31 | 1995-11-01 | El Gendler | FLEXIBLE MEMBRANES PRODUCED WITH ORGANIC BONE MATTER FOR THE REPAIR AND RECONSTRUCTION OF PARTS OF THE SKELETON. |
US5147402A (en) | 1990-12-05 | 1992-09-15 | Sulzer Brothers Limited | Implant for ingrowth of osseous tissue |
JP3007903B2 (en) * | 1991-03-29 | 2000-02-14 | 京セラ株式会社 | Artificial disc |
US5314476A (en) | 1992-02-04 | 1994-05-24 | Osteotech, Inc. | Demineralized bone particles and flowable osteogenic composition containing same |
US5507813A (en) | 1993-12-09 | 1996-04-16 | Osteotech, Inc. | Shaped materials derived from elongate bone particles |
JPH0810275A (en) * | 1994-06-28 | 1996-01-16 | Nippon Electric Glass Co Ltd | Intervertebral spacer |
US5562736A (en) * | 1994-10-17 | 1996-10-08 | Raymedica, Inc. | Method for surgical implantation of a prosthetic spinal disc nucleus |
US5968098A (en) * | 1996-10-22 | 1999-10-19 | Surgical Dynamics, Inc. | Apparatus for fusing adjacent bone structures |
US6190414B1 (en) * | 1996-10-31 | 2001-02-20 | Surgical Dynamics Inc. | Apparatus for fusion of adjacent bone structures |
US5749916A (en) * | 1997-01-21 | 1998-05-12 | Spinal Innovations | Fusion implant |
US6039761A (en) | 1997-02-12 | 2000-03-21 | Li Medical Technologies, Inc. | Intervertebral spacer and tool and method for emplacement thereof |
US6641614B1 (en) | 1997-05-01 | 2003-11-04 | Spinal Concepts, Inc. | Multi-variable-height fusion device |
US6033438A (en) * | 1997-06-03 | 2000-03-07 | Sdgi Holdings, Inc. | Open intervertebral spacer |
WO1999009914A1 (en) | 1997-08-27 | 1999-03-04 | University Of Florida Tissue Bank, Inc. | Cortical bone cervical smith-robinson fusion implant |
US6090998A (en) | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6290718B1 (en) | 1998-02-02 | 2001-09-18 | Regeneration Technologies, Inc. | Luminal graft, stent or conduit made of cortical bone |
DE19807236C2 (en) | 1998-02-20 | 2000-06-21 | Biedermann Motech Gmbh | Intervertebral implant |
US6193757B1 (en) | 1998-10-29 | 2001-02-27 | Sdgi Holdings, Inc. | Expandable intervertebral spacers |
-
1999
- 1999-01-08 US US09/227,976 patent/US6206923B1/en not_active Expired - Fee Related
-
2000
- 2000-01-05 ES ES00902318T patent/ES2215606T3/en not_active Expired - Lifetime
- 2000-01-05 DE DE60009446T patent/DE60009446T2/en not_active Expired - Fee Related
- 2000-01-05 WO PCT/US2000/000154 patent/WO2000040179A1/en active IP Right Grant
- 2000-01-05 CA CA002358455A patent/CA2358455A1/en not_active Abandoned
- 2000-01-05 JP JP2000591938A patent/JP4282239B2/en not_active Expired - Fee Related
- 2000-01-05 AU AU24054/00A patent/AU747356B2/en not_active Ceased
- 2000-01-05 AT AT00902318T patent/ATE262866T1/en not_active IP Right Cessation
- 2000-01-05 EP EP00902318A patent/EP1139929B1/en not_active Expired - Lifetime
-
2001
- 2001-02-02 US US09/776,590 patent/US20010010021A1/en not_active Abandoned
-
2003
- 2003-06-30 US US10/609,857 patent/US6913621B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60009446T2 (en) | 2005-01-27 |
EP1139929A1 (en) | 2001-10-10 |
US20010010021A1 (en) | 2001-07-26 |
JP2002534156A (en) | 2002-10-15 |
DE60009446D1 (en) | 2004-05-06 |
ES2215606T3 (en) | 2004-10-16 |
WO2000040179A1 (en) | 2000-07-13 |
WO2000040179B1 (en) | 2000-10-12 |
US6913621B2 (en) | 2005-07-05 |
AU747356B2 (en) | 2002-05-16 |
ATE262866T1 (en) | 2004-04-15 |
AU2405400A (en) | 2000-07-24 |
US6206923B1 (en) | 2001-03-27 |
EP1139929B1 (en) | 2004-03-31 |
JP4282239B2 (en) | 2009-06-17 |
US20040002760A1 (en) | 2004-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6206923B1 (en) | Flexible implant using partially demineralized bone | |
US11759331B2 (en) | Stabilized expandable intervertebral spacer | |
US6562073B2 (en) | Spinal bone implant | |
EP1124512B1 (en) | Expandable intervertebral spacers | |
US6447547B1 (en) | Artificial spinal fusion implants | |
US8425608B2 (en) | Lordotic expanding vertebral body spacer | |
AU2002240168A1 (en) | Spinal bone implant | |
US20040010315A1 (en) | Self-expanding intervertebral device | |
WO2001095838A1 (en) | Intervertebral spacer | |
WO2008112607A2 (en) | Spinal implant | |
US20220125596A1 (en) | Expandable interbody spacer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |