CA2359318A1 - Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups - Google Patents

Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups Download PDF

Info

Publication number
CA2359318A1
CA2359318A1 CA002359318A CA2359318A CA2359318A1 CA 2359318 A1 CA2359318 A1 CA 2359318A1 CA 002359318 A CA002359318 A CA 002359318A CA 2359318 A CA2359318 A CA 2359318A CA 2359318 A1 CA2359318 A1 CA 2359318A1
Authority
CA
Canada
Prior art keywords
unsaturated groups
nucleophilic addition
addition reaction
conjugated unsaturated
biomaterials formed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002359318A
Other languages
French (fr)
Other versions
CA2359318C (en
Inventor
Donald Elbert
Matthias Lutolf
Alison Pratt
Ronald Schoenmakers
Nicola Tirelli
Brent Vernon
Jeffrey A. Hubbell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Zuerich
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2359318A1 publication Critical patent/CA2359318A1/en
Application granted granted Critical
Publication of CA2359318C publication Critical patent/CA2359318C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions

Abstract

The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
CA002359318A 1999-02-01 2000-02-01 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups Expired - Lifetime CA2359318C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11809399P 1999-02-01 1999-02-01
US60/118,093 1999-02-01
PCT/US2000/002608 WO2000044808A1 (en) 1999-02-01 2000-02-01 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups

Publications (2)

Publication Number Publication Date
CA2359318A1 true CA2359318A1 (en) 2000-08-03
CA2359318C CA2359318C (en) 2009-06-30

Family

ID=22376466

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002359318A Expired - Lifetime CA2359318C (en) 1999-02-01 2000-02-01 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups

Country Status (10)

Country Link
US (1) US7744912B1 (en)
EP (2) EP1181323B1 (en)
JP (2) JP4954370B2 (en)
AT (1) ATE514729T1 (en)
AU (1) AU773914B2 (en)
CA (1) CA2359318C (en)
DK (1) DK1181323T3 (en)
ES (2) ES2632564T3 (en)
MX (1) MXPA01007777A (en)
WO (1) WO2000044808A1 (en)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
PT876165E (en) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp COMPOSITIONS OF RETICULATED POLYMERS AND PROCESSES FOR THEIR USE
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
MXPA01007777A (en) 1999-02-01 2003-10-06 Eidgenoess Tech Hochschule Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups.
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
KR20020000143A (en) 1999-02-23 2002-01-04 페어슨 메디칼 인크. Treatment of Trauma
AUPP939299A0 (en) * 1999-03-23 1999-04-15 University Of Melbourne, The Polymer gels and methods for their preparation
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
EP1292709B1 (en) * 2000-06-02 2012-01-18 Eidgenössische Technische Hochschule Zürich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
EP1355965B1 (en) * 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method of synthesizing block copolymers for multifunctional self-assembled systems
EP1245272A1 (en) * 2001-03-30 2002-10-02 Ucb S.A. Substrates, preparation and use
DE60230873D1 (en) * 2001-04-25 2009-03-05 Eidgenoess Tech Hochschule MEDICAMENT RELEASING MATRICES FOR THE PROMOTION OF WOUND HEALING
WO2002088331A1 (en) * 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
US7034037B2 (en) 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7030127B2 (en) 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
WO2003031483A1 (en) 2001-10-10 2003-04-17 The Regents Of The University Of Colorado Degradable thiol-ene polymers
US20070264227A1 (en) * 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
AU2002363343B2 (en) * 2001-11-07 2008-07-24 Eidgenossische Technische Hochschule Zurich Synthetic matrix for controlled cell ingrowth and tissue regeneration
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2002358272B2 (en) * 2001-12-18 2009-01-22 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
CA2468951A1 (en) 2001-12-20 2003-07-03 Trivascular, Inc. Advanced endovascular graft
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003226688B2 (en) * 2002-03-22 2009-08-13 Kuros Biosurgery Ag Composition for hard tissue augmentation
US8282912B2 (en) 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004046167A2 (en) 2002-11-14 2004-06-03 Northwestern University Synthesis and self-assembly of abc triblock bola peptide
WO2004046200A1 (en) 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
CN1744918A (en) 2002-12-31 2006-03-08 尼克塔治疗亚拉巴马公司 Polymeric reagents comprising a ketone or a related functional group
WO2004072104A2 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7632291B2 (en) 2003-06-13 2009-12-15 Trivascular2, Inc. Inflatable implant
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
JP4742491B2 (en) * 2003-09-30 2011-08-10 株式会社豊田中央研究所 Cell implantation method and cell tissue preparation method
WO2005037252A1 (en) * 2003-10-14 2005-04-28 Wockhardt Limited Sterile gelling agents
US20050090804A1 (en) * 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
EP1691854B1 (en) 2003-11-03 2011-09-14 Medtronic, Inc. Hydrogel providing cell-specific ingrowth
US8575332B2 (en) 2003-11-14 2013-11-05 Chugai Seiyaku Kabushiki Kaisha Crosslinked polysaccharide microparticles and method for their preparation
KR20070004560A (en) 2003-12-05 2007-01-09 노오쓰웨스턴 유니버시티 Self-assembling peptide amphiphiles and related methods for growth factor delivery
JP4741510B2 (en) 2003-12-05 2011-08-03 ノースウエスタン ユニバーシティ Branched peptide amphiphiles, related epitope compounds and their self-assembled structures
US20080026444A1 (en) * 2003-12-24 2008-01-31 Shionogi & Co., Ltd. Process For Producing Protein-Polymer Complex
US20050158272A1 (en) * 2004-01-07 2005-07-21 Trivascular, Inc. Methods, compositions and devices for embolizing body lumens
US7803178B2 (en) 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
NZ550964A (en) 2004-04-28 2011-05-27 Angiodevice Internat Gmbh Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US8377118B2 (en) * 2004-05-05 2013-02-19 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
EP1609491B1 (en) 2004-06-16 2008-02-06 Straumann Holding AG Barrier membrane
US7282584B2 (en) 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
EP1625856A1 (en) * 2004-08-13 2006-02-15 Complex Biosystems GmbH Hydrogel polymeric conjugates of a prodrug
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
EP2594291A1 (en) * 2004-07-05 2013-05-22 Ascendis Pharma GmbH Hydrogel
WO2006026731A1 (en) 2004-08-30 2006-03-09 Spineovations, Inc. Method of treating spinal internal disk derangement
WO2006026554A1 (en) 2004-08-30 2006-03-09 Neville Alleyne Method of using an implant for treatment of ligaments and tendons
WO2006034128A2 (en) 2004-09-17 2006-03-30 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
SE0403014D0 (en) 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
EP1862170B1 (en) 2004-12-10 2012-03-14 Straumann Holding AG Enamel formulation with amelogenin
JP5069125B2 (en) 2004-12-10 2012-11-07 シュトラウマン・ホールディング・アクチェンゲゼルシャフト Novel protein formulations
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
US7851445B2 (en) 2005-03-04 2010-12-14 Northwestern University Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
EP1891141B1 (en) 2005-05-31 2016-11-16 Ecole Polytechnique Fédérale de Lausanne (EPFL) Triblock copolymers for cytoplasmic delivery of gene-based drugs
JP5119148B2 (en) 2005-06-07 2013-01-16 ダイレクト フロウ メディカル、 インク． Stentless aortic valve replacement with high radial strength
EP2053066A1 (en) 2005-09-16 2009-04-29 Straumann Holding AG Use of methylene blue as polymerization inhibitor
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
ES2385895T3 (en) * 2006-02-20 2012-08-02 Straumann Holding Ag Material in granules and matrix
US20100111917A1 (en) * 2006-03-21 2010-05-06 Ying Jackie Y Cell-adhesive polyelectrolyte material for use as membrane and coating
AU2007247763B2 (en) * 2006-05-05 2013-06-06 The University Of Sydney Bis-pyridinium compounds
US8133213B2 (en) 2006-10-19 2012-03-13 Direct Flow Medical, Inc. Catheter guidance through a calcified aortic valve
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
WO2008051864A2 (en) * 2006-10-24 2008-05-02 Neville Alleyne Method of treating spinal internal disk derangement
AR064286A1 (en) * 2006-12-13 2009-03-25 Quiceno Gomez Alexandra Lorena PRODUCTION OF OPHTHALMIC DEVICES BASED ON POLYMERIZATION BY PHOTOINDUCIDED SCALE GROWTH
AU2008224435B2 (en) 2007-03-15 2014-01-09 Ortho-Space Ltd. Prosthetic devices and methods for using same
ES2381639T3 (en) 2007-04-13 2012-05-30 Kuros Biosurgery Ag Polymeric fabric sealant
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
EP2143446B1 (en) 2007-05-01 2019-07-24 National University Corporation Tokyo Medical and Dental University Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same
EP2014256A1 (en) 2007-07-12 2009-01-14 Straumann Holding AG Composite bone repair material
AU2008288796B2 (en) 2007-08-23 2014-03-20 Dfm, Llc Cardiovascular prosthetic valve
CN101917929A (en) 2007-10-04 2010-12-15 特里瓦斯库拉尔公司 Modular vascular graft for low profile percutaneous delivery
EP2227263A2 (en) 2007-12-28 2010-09-15 Kuros Biosurgery AG Pdgf fusion proteins incorporated into fibrin foams
US8469961B2 (en) 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
DE202008005131U1 (en) 2008-04-14 2008-08-28 Eidgenössische Technische Hochschule Zürich Synthetic matrix for the controlled ingrowth of cells and tissue regeneration
EP2341953B1 (en) 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US9271929B2 (en) 2008-11-25 2016-03-01 École Polytechnique Fédérale De Lausanne (Epfl) Block copolymers and uses thereof
WO2010120830A1 (en) 2009-04-13 2010-10-21 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
ES2636741T3 (en) 2009-07-31 2017-10-09 Sanofi-Aventis Deutschland Gmbh Long-acting insulin composition
WO2011012718A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Prodrugs comprising an insulin linker conjugate
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia Systems, methods, and devices for production of gas-filled microbubbles
CA2787138C (en) * 2010-01-13 2019-06-25 Georg Bischof Composition for producing a temporary intestinal occlusion
WO2011090428A1 (en) 2010-01-19 2011-07-28 Organoclick Ab Heterogeneous thiol-ene click modifications of solid polysaccharide-based materials
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
EP2380920A1 (en) 2010-04-22 2011-10-26 QGel SA Hydrogel precursor formulation and production process thereof
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
CN102375065A (en) * 2010-05-27 2012-03-14 杭州景杰生物科技有限公司 Identifying Method For Acylation Of Lysine Butane In Protein And Preparation Of Affine Reagent Thereof
US20130224880A1 (en) 2011-05-27 2013-08-29 Ptm Biolabs, Inc. Reagents and methods for detecting protein crotonylation
JP5848345B2 (en) 2010-07-09 2016-01-27 ハイライフ エスエーエス Transcatheter atrioventricular valve prosthesis
DE102010034331A1 (en) * 2010-08-14 2012-02-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Polymer-supported culture systems
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
US8518440B2 (en) * 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
WO2012103445A2 (en) 2011-01-28 2012-08-02 The Regents Of The University Of Colorado, A Body Corporate Convalently cross linked hydrogels and methods of making and using same
EP2686027B1 (en) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmaceutical formulation for use in spinal fusion
EP2720722A4 (en) 2011-06-16 2014-12-03 Univ Hong Kong Science & Techn Multi-vinylsulfone containing molecule
WO2013057566A2 (en) 2011-10-18 2013-04-25 Ortho-Space Ltd. Prosthetic devices and methods for using same
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
EP2822533B1 (en) 2012-02-02 2021-01-20 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
US9993328B2 (en) 2012-04-03 2018-06-12 Trivascular, Inc. Advanced kink resistant stent graft
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9879062B2 (en) 2012-07-03 2018-01-30 Ecole Polytechnique Federale De Lausanne Protein-binding peptide isolated from placenta growth factor
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014059114A2 (en) 2012-10-10 2014-04-17 Trivascular, Inc. Endovascular graft for aneurysms involving major branch vessels
WO2014070973A1 (en) * 2012-11-02 2014-05-08 Board Of Supervisors Of Louisiana State University And Agricural And Mechanical College Thiol acrylate nanocomposite foams
WO2014190317A2 (en) 2013-05-24 2014-11-27 Cedars-Sinai Medical Center Left atrial appendage occlusion devices and methods
ES2746804T3 (en) * 2013-05-31 2020-03-06 Xeltis Bv Compositions for the repair of tissues of blood vessels
WO2015013510A1 (en) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl High aspect ratio nanofibril materials
US11123205B2 (en) 2013-09-24 2021-09-21 Trivascular, Inc. Tandem modular endograft
WO2015073758A1 (en) 2013-11-15 2015-05-21 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
US9873769B2 (en) * 2014-07-10 2018-01-23 Cambridge Polymer Group, Inc. Thiolated PEG-PVA hydrogels
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3229851A4 (en) 2014-12-09 2018-08-01 Tangible Science LLC Medical device coating with a biocompatible layer
MX2017009241A (en) 2015-01-16 2018-03-23 Spineovations Inc Method of treating spinal disk.
BR112017017029A2 (en) 2015-02-09 2018-04-10 Mosaic Biosciences Inc degradable thiolene polymers and methods for their manufacture
WO2017046647A1 (en) 2015-09-18 2017-03-23 Ortho-Space Ltd. Intramedullary fixated subacromial spacers
CN109563353B (en) 2016-07-27 2022-01-14 东丽株式会社 Resin composition
EP3573806A4 (en) 2017-01-30 2019-12-11 Ortho-Space Ltd. Processing machine and methods for processing dip-molded articles
US20220075098A1 (en) * 2018-12-19 2022-03-10 Tangible Science, Inc. Systems and methods of treating a hydrogel-coated medical device
EP3918324A2 (en) 2019-01-30 2021-12-08 Ventana Medical Systems, Inc. Calibration slides for digital pathology
US20220389158A1 (en) * 2019-09-21 2022-12-08 Ixaka France DMSO-Free Synthesis of Oligopeptide-Modified Poly(Beta-Amino Ester)s and Their Use in Nanoparticle Delivery Systems

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA992105A (en) 1970-03-26 1976-06-29 Exxon Research And Engineering Company Polythioethers formed by anionic ring opening of episulfides
JPS6198734A (en) * 1984-10-19 1986-05-17 Showa Denko Kk Curable composition
US4618400A (en) 1984-12-28 1986-10-21 Shell Oil Company Wastepaper deinking process
US4711903A (en) * 1986-01-31 1987-12-08 G. D. Searle & Co. Phenolic thioethers as inhibitors of 5-lipoxygenase
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5247041A (en) * 1989-02-22 1993-09-21 Toray Industries, Inc. Thiol methacrylate or acrylate resin obtained by polymerizing a thiol methacrylate or acrylate compound
US5268305A (en) * 1989-06-15 1993-12-07 Biocircuits Corporation Multi-optical detection system
US5330911A (en) 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5852182A (en) 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5292514A (en) * 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
DE69316223T2 (en) 1992-08-25 1998-05-28 Searle & Co SULFONYLALKANOYLAMINOHYDROXYETHYLAMINOSULFONAMIDES USED AS RETROVIRAL PROTEASE INHIBITORS
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
DE69433723T3 (en) * 1993-02-22 2008-10-30 Abraxis Bioscience, Inc., Los Angeles PROCESS FOR IN VIVO ADMINISTRATION OF BIOLOGICAL SUBSTANCES AND COMPOSITIONS USED THEREFROM
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
JPH0848770A (en) * 1994-06-03 1996-02-20 Toyo Ink Mfg Co Ltd Liquid resin composition, its production and curing resin composition
JPH0892369A (en) * 1994-07-29 1996-04-09 Toyo Ink Mfg Co Ltd Curable liquid resin composition and production of cured product therefrom
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US6136564A (en) 1995-11-16 2000-10-24 Roche Diagnostics Gmbh Process for the production of peptides by way of streptavidin fusion proteins
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
PT876165E (en) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp COMPOSITIONS OF RETICULATED POLYMERS AND PROCESSES FOR THEIR USE
US5914182A (en) 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
JP2001508783A (en) 1997-01-29 2001-07-03 ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー PEGylation method
DE19705963A1 (en) 1997-02-17 1998-08-20 Hoechst Ag Crosslinked vinyl polymers with bile acid adsorber effect
DK1053019T3 (en) 1998-01-07 2004-04-13 Debio Rech Pharma Sa Degradable heterobifunctional polyethylene glycol acrylates and gels and conjugates derived therefrom
US5958874A (en) 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
MXPA01007777A (en) 1999-02-01 2003-10-06 Eidgenoess Tech Hochschule Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups.
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
EP1355965B1 (en) 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method of synthesizing block copolymers for multifunctional self-assembled systems
US20030044468A1 (en) 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
AU2002363343B2 (en) 2001-11-07 2008-07-24 Eidgenossische Technische Hochschule Zurich Synthetic matrix for controlled cell ingrowth and tissue regeneration

Also Published As

Publication number Publication date
EP2311895B1 (en) 2017-04-12
ES2368988T3 (en) 2011-11-24
EP1181323B1 (en) 2011-06-29
JP2012101095A (en) 2012-05-31
AU3220400A (en) 2000-08-18
ES2632564T3 (en) 2017-09-14
JP4954370B2 (en) 2012-06-13
EP1181323A4 (en) 2005-04-20
EP1181323A1 (en) 2002-02-27
US7744912B1 (en) 2010-06-29
CA2359318C (en) 2009-06-30
EP2311895A1 (en) 2011-04-20
AU773914B2 (en) 2004-06-10
JP2002535108A (en) 2002-10-22
ATE514729T1 (en) 2011-07-15
MXPA01007777A (en) 2003-10-06
WO2000044808A1 (en) 2000-08-03
DK1181323T3 (en) 2011-10-17

Similar Documents

Publication Publication Date Title
CA2359318A1 (en) Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
AU7522601A (en) Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
HK1041011A1 (en) Cross-linked hyaluronic acids and medical uses thereof
ZA983109B (en) Polymer compositions having improved elongation.
WO2002100244A3 (en) Microfabricated surgical device
AU5143000A (en) Implantable medical device such as an anastomosis device
HK1030425A1 (en) Photoresist compositions comprising polycyclic polymers with acid labile pendant groups.
AU7855800A (en) Unsaturated nitrogenous compounds as electron donors for use with ziegler-natta catalysts
ZA200001591B (en) Polymer compositions.
AU3016401A (en) Process for the preparation of ethylene polymers
EP1978031A3 (en) Tropoelastin derivatives
EP0976766A4 (en) Polymers, processes for producing the same, and curable compositions produced therefrom
GB0130651D0 (en) Aqueous compositions containing polyurethane-acrylic hybrid polymer dispersions
WO2003102185A3 (en) Methods and compositions for treating neoplasia relating to hnrnp a1 and a2 nucleic acid molecules
AU7028300A (en) Polymerisation catalyst
AU7014000A (en) Complexes based on dendritic polymers, their use as bioactive agents
AU2002317259A1 (en) Pharmaceutical composition for diagnosis, prevention or treatment of a tumorous state, comprising a modulator of the actin polymerisation state
AUPQ197799A0 (en) Hydrophilic biomedical compositions
WO2001041709A3 (en) Methods for treating cell death diseases and inflammation
AU5234100A (en) Isobutene polymerisation process
AU6005000A (en) Polymerisation process
WO2000048584A3 (en) Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain
HK1050533A1 (en) Substituted pyrroles as antiproliferative agents for the treatment of cancer.
AU6304400A (en) Polymerisation catalysts
WO2001021211A3 (en) Process for lessening polymorphic conversion of a drug

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200203