CA2362233A1 - Process for cross-linking hyaluronic acid to polymers - Google Patents

Process for cross-linking hyaluronic acid to polymers Download PDF

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Publication number
CA2362233A1
CA2362233A1 CA002362233A CA2362233A CA2362233A1 CA 2362233 A1 CA2362233 A1 CA 2362233A1 CA 002362233 A CA002362233 A CA 002362233A CA 2362233 A CA2362233 A CA 2362233A CA 2362233 A1 CA2362233 A1 CA 2362233A1
Authority
CA
Canada
Prior art keywords
cross
hyaluronic acid
polymers
linked
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002362233A
Other languages
French (fr)
Other versions
CA2362233C (en
Inventor
Xiaobin Zhao
Catherine Alexander
Jane Elizabeth Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mentor Biopolymers Ltd
Original Assignee
Vitrolife Uk Limited
Xiaobin Zhao
Catherine Alexander
Jane Elizabeth Fraser
A-Life Limited
Mentor Biopolymers Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitrolife Uk Limited, Xiaobin Zhao, Catherine Alexander, Jane Elizabeth Fraser, A-Life Limited, Mentor Biopolymers Limited filed Critical Vitrolife Uk Limited
Publication of CA2362233A1 publication Critical patent/CA2362233A1/en
Application granted granted Critical
Publication of CA2362233C publication Critical patent/CA2362233C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/594—Mixtures of polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

The present invention provides a process for the production of hyaluronic acid (HA) derivatives cross-linked with another polymer, in particular multiple eg double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked derivatives, products containing them and their uses in cosmetic, medical and pharmaceutical applications.
CA002362233A 1999-02-05 2000-02-03 Process for cross-linking hyaluronic acid to polymers Expired - Fee Related CA2362233C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9902652.8A GB9902652D0 (en) 1999-02-05 1999-02-05 Process
GB9902652.8 1999-02-05
PCT/GB2000/000316 WO2000046252A1 (en) 1999-02-05 2000-02-03 Process for cross-linking hyaluronic acid to polymers

Publications (2)

Publication Number Publication Date
CA2362233A1 true CA2362233A1 (en) 2000-08-10
CA2362233C CA2362233C (en) 2006-11-14

Family

ID=10847228

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002362233A Expired - Fee Related CA2362233C (en) 1999-02-05 2000-02-03 Process for cross-linking hyaluronic acid to polymers

Country Status (16)

Country Link
US (2) US6703444B2 (en)
EP (1) EP1163274B9 (en)
JP (1) JP2002536465A (en)
CN (1) CN1243773C (en)
AT (1) ATE335011T1 (en)
AU (1) AU773628B2 (en)
BR (1) BR0007985B1 (en)
CA (1) CA2362233C (en)
DE (2) DE60029761T2 (en)
DK (1) DK1163274T3 (en)
ES (1) ES2181607T3 (en)
GB (1) GB9902652D0 (en)
MX (1) MXPA01007877A (en)
NZ (1) NZ512994A (en)
PT (1) PT1163274E (en)
WO (1) WO2000046252A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008060603A1 (en) 2008-12-06 2010-06-10 Meier, Bernd, Dr. Binding product comprises a polysaccharide which is bonded with medically active residue by the formation of a linker, where in the polysaccharide, a transport mediator is bonded by the formation of another linker

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* Cited by examiner, † Cited by third party
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