CA2362243A1 - Cartridge for a liquid - Google Patents

Cartridge for a liquid Download PDF

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Publication number
CA2362243A1
CA2362243A1 CA002362243A CA2362243A CA2362243A1 CA 2362243 A1 CA2362243 A1 CA 2362243A1 CA 002362243 A CA002362243 A CA 002362243A CA 2362243 A CA2362243 A CA 2362243A CA 2362243 A1 CA2362243 A1 CA 2362243A1
Authority
CA
Canada
Prior art keywords
cartridge
cartridge according
connection portion
stopper
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002362243A
Other languages
French (fr)
Other versions
CA2362243C (en
Inventor
Heinrich Kladders
Bernd Zierenberg
Dieter Hochrainer
Joachim Eicher
Matthias Hausmann
Gilbert Wuttke
Michael Schyra
Andreas Fiol
Johannes Geser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MYPI99000627A external-priority patent/MY128732A/en
Application filed by Individual filed Critical Individual
Publication of CA2362243A1 publication Critical patent/CA2362243A1/en
Application granted granted Critical
Publication of CA2362243C publication Critical patent/CA2362243C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0008—Sealing or attachment arrangements between sprayer and container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00446—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means the means being located at the bottom of the container or of an enclosure surrounding the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container

Abstract

A practically diffusion-tight container which is capable of being stored ove r long periods of time and with which the liquid does not come into contact wi th the ambient air is required for withdrawing a liquid in a dosed manner out o f the same over a duration of several months. The inventive cartridge is a container which is comprised of three shells and which can consist of a collapsible bag containing the liquid, of a dimensionally stabile container, and of a stiff metal shell. The cartridge can be detachably connected to a withdrawing device. The cartridge can be provided with a micro-opening with which the time for the pressure compensation between the cartridge and the surroundings can be adjusted. The cartridge is suited for aqueous and alcoholic liquids which contain a pharmacologically active ingredient. The liquid in the cartridge is protected against external influences. The cartridge can be used in an atomizer for generating an aerosol which can be inhaled and which is provided for treating illnesses.

Claims (31)

1. A cartridge for a liquid, which can be connected to a dispensing device which includes an upper portion for receiving the cartridge and a lower portion which can be pushed over the connected cartridge, and the upper portion of the device is provided with a connection portion for the cartridge and with a dispensing connection portion for drawing off the liquid, wherein - the cartridge (1) is a three-shell container and comprises an outer stiff casing (4), a container (5) which is stable in respect of shape and which is disposed in the casing, and a collapsible bag (6) which is arranged in the container that is stable in respect of shape and which contains the liquid, and - the stiff casing has a bottom provided with an opening (22), and - the container which is stable in respect of shape is provided with an opening (14) and closed by a stopper (7), and - the stopper is provided with an insertion connection portion (17) which forms a sealingly closing, centred guide means for the dispensing connection portion, and - the stopper is non-releasably connected by the casing (4) to the container which is stable in respect of shape.
2. A cartridge according to claim 1 wherein - the cartridge (1) is releasably connected to the connection portion (2) by means of a plug connection.
3. A cartridge according to claim 1 wherein the cartridge (1) is releasably connected to the connection portion (2) by means of a screw connection or a bayonet connection.
4. A cartridge according to claims 1 to 3 wherein - the stopper (7), preferably of a thermoplastic material, is connected to the container (5) which is stable in respect of shape, in force-locking and positively locking relationship, by means of a snap connection (8).
5. A cartridge according to claims 1 to 3 wherein - the stopper (7) comprising a thermoplastic material is non-releasably connected to the container (5) which is stable in respect of shape and which comprises a thermoplastic material by means of a welded join with merging of the materials.
6. A cartridge according to claim 1 to 5 wherein - the stopper (7) is provided in the insertion connection portion (17) with a funnel-shaped centred guide means which possibly includes guide ribs (7a).
7. A cartridge according to claims 1 to 6 wherein - the stopper (7) is provided with a press fit (17a) as sealingly closing guide means, for the dispensing connection portion.
8. A cartridge according to claims 1 to 7 wherein - the stopper (7) is provided at the end of the insertion connection portion with a diaphragm (18) which is preferably disposed inclinedly with respect to the axis of the insertion connection portion.
9. A cartridge according to claims 1 to 8 wherein - disposed between the upper edge of the container which is stable in respect of shape and the inside of the stopper is a sealing disc (9) which is possibly provided with sealing beads.
10. A cartridge according to claims 1 to 9 wherein - the inside of the stopper is provided with a sealing lip (10) or with a plurality of sealing lips.
11. A cartridge according to claims 1 to 10 wherein - the stiff casing (4) - apart from the opening thereof - is diffusion-tight.
12. A cartridge according to claims 1 to 11 wherein - the stiff casing (4) is provided with a plurality of inwardly projecting projections (4a).
13. A cartridge according to claims 1 to 12 wherein - the stiff casing (4) is in one piece.
14. A cartridge according to claims 1 to 12 wherein - the stiff casing is in two pieces.
15. A cartridge according to claims 1 to 14 wherein - the stiff casing (4) is a deep-drawn metal casing, preferably of aluminium.
16. A cartridge according to claims 1 to 14 wherein - the stiff casing (4) comprises a plastic material, preferably thermoplastic material.
17. A cartridge according to claims 1 to 16 wherein - the stiff casing (4) is provided at its bottom with a projecting bead (20).
18. A cartridge according to claims 1 to 17 wherein - the stiff casing (4) has a recess in its bottom.
19. A cartridge according to claims 1 to 18 wherein - the stiff casing (4) is provided within the recess with an opening (22) whose diameter in the case of a circular cross-section is between 0:1 millimeter and 5 millimeters.
20. A cartridge according to claims 1 to 18 wherein - the stiff casing (4) is provided within the recess with an insert (26) including an opening, preferably in the form of a micro-opening (27), which communicates with the opening (28) in the bottom of the stiff casing, and which in the case of a circular cross-section is of a diameter of between 10 um and 500 ,um and is of a length of between 100 µm and 5000 µm.
21. A cartridge according to claims 1 to 20 wherein - the insert (26) is provided with a filter (25) in front of the micro-opening (27).
22. A cartridge according to claims 1 to 21 wherein - the stiff casing (4) of metal is provided with at least one peripherally extending crease (12) which embraces the stopper (7) in force-locking and positively locking relationship.
23. A cartridge according to claims 1 to 21 wherein - the stiff casing (4) of thermoplastic material is connected to the stopper (7) by means of a welded join with merging of materials.
24. A cartridge according to claims 1 to 23 wherein - the stiff casing (4) is provided in its upper part with a peripherally extending groove (11) which embraces the lower edge of the stopper (7).
25. A cartridge according to claims 1 to 24 wherein - the stiff casing (4) is provided in its upper part with a flanged-over portion (13) which embraces the upper edge of the stopper (7).
26. A cartridge according to claims 1 to 25 wherein - the cartridge is sealed in the region of the stopper (7) by a - possibly diffusion-tight - seating foil (16).
27. A cartridge according to claims 1 to 26 wherein - the stiff casing (4) is sealed on the outside of its bottom by a - possibly diffusion-tight - sealing foil (23).
28. A cartridge according to claims 1 to 27 wherein - provided in the central region of the sealing foil (23) on the outside of the bottom of the stiff casing (4) is a free space (24) which is covered by the sealing foil.
29. A cartridge according to claims 1 to 28 - which can be pulled out of the dispensing device by means of a withdrawal aid (30) which can be fitted on behind the projecting bead (20).

32. A lower device portion which can be pushed on, according to claim 1, wherein
30. A releasable connection according to claim 1 between a cartridge and a connection portion of the dispensing device, wherein - the cartridge (1) is releasably connected to the connection portion (2) on the upper portion of the dispensing device and the connection portion (2) is provided with snap hooks (19) which engage into the peripherally extending groove (11) in the upper part of the stiff casing (4) after the cartridge has been pushed into the dispensing device.
31. A releasable connection between a cartridge and the connection portion of the dispensing device, wherein - the cartridge (1) is releasably connected to the connection portion (2) on the upper portion of the dispensing device and - the connection portion (2) is provided with snap hooks (19) which engage into a peripherally extending groove in the stopper (7) or in the container (5) which is stable in respect of shape, after the container which is stable in respect of shape has been pushed into the dispensing device.

- the inside of the bottom of the lower device portion (3) is provided with a piercing device for the sealing foil (23) which is disposed on the underside of the bottom of the casing.
33. A cartridge according to claim 1 for an aqueous liquid, comprising a container (5) which is stable in respect of shape and which comprises polypropylene, with a stopper (7) of polypropylene and a collapsible bag (6) of polyethylene disposed in the container (5), wherein - the stiff casing (4) comprises plastic material, preferably polypropylene, and - the opening (22) in the bottom of the stiff casing (4) is a bore, and - the stopper (7) for the container (5) which is stable in respect of shape is provided with an insertion connection portion (17) which is closed at its end by a diaphragm (18) inclined with respect to the axis of the insertion connection portion, and which forms a sealingly closing, centred guide means, in the form of a press fit, for the dispensing connection portion (15), and which is connected by a snap connection to the container which is stable in respect of shape, and - the releasable plug connection between the cartridge (1) and the connection portion (2) of the dispensing device is in the form of a snap connection in which there are provided in the connection portion (2) of the upper portion of the dispensing device snap hooks (19) which engage into the peripherally extending groove (11) in the upper region of the cartridge (1), and - the inside of the bottom of the push-on portion (3) of the dispensing device is provided with the resilient piercing device (25) for the sealing foil (23) on the underside of the bottom of the casing.
34. A cartridge according to claim 1 for an alcoholic liquid, comprising a container (5) of polypropylene, which is stable in respect of shape, with a stopper of polypropylene and a collapsible bag (6) of polyethylene, which is disposed in the container (5), wherein - the stiff casing (4) comprises metal, preferably aluminium, and - the stopper (7) which is provided with an insertion connection portion (17) for the container (5) which is stable in respect of shape is closed at its end by a diaphragm (18) which is inclined with respect to the axis of the insertion connection portion, and - the stopper (7) is provided with a sealingly closing, centred guide means, in the form of a press fit, for the dispensing connection portion (15), and - the stopper (7) is non-releasably connected by the casing (4) to the container (5) which is stable in respect of shape, and - the releasable plug connection between the cartridge (1) and the connection portion (2) of the dispensing device is in the form of a snap connection in which there are provided in the connection portion (2) of the dispensing device snap hooks (19) which engage into the peripherally extending groove (11) in the upper region of the cartridge, and - provided in the bottom of the stiff casing (4) is an inset (26) with a micro-opening (27) and the micro-opening communicates with a bore (28) in the stiff casing (4), and - the inside of the bottom of the push-on portion (3) of the dispensing device is provided with the resilient piercing device (25) for the sealing foil (23) on the underside of the bottom of the casing.
35. A cartridge according to claims 1, 33 and 34 wherein - the liquid contains a pharmacologically active substance.
36. A cartridge according to claims 1 and 33 to 35 for a medical liquid wherein - the medical liquid contains one or more of the active substances Berotec (Fenoterol hydrobromide); 1-(3,5-dihydroxy-phenyl)-2-[[1-(4-hydroxy-benzyl)-ethyl]-amino]-ethanol hydrobromide), Atrovent (Ipratropium bromide), Berodual (combination of Fenoterol hydrobromide and Ipratropium bromide), Salbutamol, Salbutamol sulphate, Combivent, Oxivent (Oxitropium bromide), Ba 679 (Tiotropium bromide), BEA 2108 (di-(2-thienyl)-glycolic acid tropenol ester), Flunisolid, Budesonid and Beclomethasone.
37. Use of the cartridge according to claims 1 to 36 containing a medical liquid for producing an aerosol by means of an atomiser.
38. Use of the cartridge according to claims 1 to 37 containing a medical liquid for producing an inhalable aerosol for the treatment of illnesses.
CA2362243A 1999-02-23 2000-02-16 Cartridge for a liquid Expired - Lifetime CA2362243C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
MYPI99000627A MY128732A (en) 1998-02-27 1999-02-23 Container for a medical liquid
MYPI9900627 1999-02-23
DE19940713.4 1999-08-26
DE19940713A DE19940713A1 (en) 1999-02-23 1999-08-26 Diffusion resistant cartridge for storing and dosing liquids, especially for producing drug-containing inhalable aerosols, has three-shell structure with collapsible bag, container and rigid housing
PCT/EP2000/001249 WO2000049988A2 (en) 1999-02-23 2000-02-16 Cartridge for a liquid

Publications (2)

Publication Number Publication Date
CA2362243A1 true CA2362243A1 (en) 2000-08-31
CA2362243C CA2362243C (en) 2010-05-11

Family

ID=47289724

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2362243A Expired - Lifetime CA2362243C (en) 1999-02-23 2000-02-16 Cartridge for a liquid

Country Status (40)

Country Link
US (2) US6988496B1 (en)
EP (1) EP1156769B1 (en)
JP (1) JP4317664B2 (en)
KR (1) KR100605240B1 (en)
CN (1) CN1299662C (en)
AR (1) AR022717A1 (en)
AT (1) ATE277582T1 (en)
AU (1) AU759881B2 (en)
BG (1) BG64454B1 (en)
BR (1) BR0008423B1 (en)
CA (1) CA2362243C (en)
CO (1) CO5231169A1 (en)
CZ (1) CZ300652B6 (en)
DE (2) DE19940713A1 (en)
DK (1) DK1156769T3 (en)
EA (1) EA002787B1 (en)
EE (1) EE04518B1 (en)
EG (1) EG22811A (en)
ES (1) ES2228479T3 (en)
HK (1) HK1041807B (en)
HR (1) HRP20010614B1 (en)
HU (1) HU224662B1 (en)
ID (1) ID30509A (en)
IL (2) IL144984A0 (en)
ME (1) ME01410B (en)
MY (1) MY128950A (en)
NO (1) NO323053B1 (en)
NZ (1) NZ513996A (en)
PE (1) PE20001157A1 (en)
PL (1) PL196860B1 (en)
PT (1) PT1156769E (en)
SA (1) SA00201008B1 (en)
SI (1) SI1156769T1 (en)
SK (1) SK286702B6 (en)
TR (1) TR200102440T2 (en)
TW (1) TW523482B (en)
UA (1) UA70994C2 (en)
UY (1) UY26021A1 (en)
WO (1) WO2000049988A2 (en)
YU (1) YU49409B (en)

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MKEX Expiry

Effective date: 20200217