CA2373889A1 - Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall - Google Patents
Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall Download PDFInfo
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- CA2373889A1 CA2373889A1 CA002373889A CA2373889A CA2373889A1 CA 2373889 A1 CA2373889 A1 CA 2373889A1 CA 002373889 A CA002373889 A CA 002373889A CA 2373889 A CA2373889 A CA 2373889A CA 2373889 A1 CA2373889 A1 CA 2373889A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
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- A—HUMAN NECESSITIES
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- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
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- A—HUMAN NECESSITIES
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- A61B2018/00065—Material properties porous
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- A—HUMAN NECESSITIES
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- A61B2018/00089—Thermal conductivity
- A61B2018/00101—Thermal conductivity low, i.e. thermally insulating
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- A61B2018/00148—Coatings on the energy applicator with metal
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- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
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- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
Abstract
This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a locati on where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
Claims (72)
1. A tissue ablation system for treating atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium, comprising:
a circumferential ablation member with a circumferential support member that is adjustable between a first position which is adapted to be delivered through a delivery sheath into the atrium and a second position having a substantially circumferentially looped shape, an ablation element located substantially along the circumferential support member and that is adapted to ablatively couple to a circumferential area adjacent to the support member in the second position, and a positioning assembly coupled to the circumferential support member to adjust the circumferential support member between the first and second positions when the circumferential support member is substantially unconfined within the atrium; and a delivery assembly cooperating with the circumferential ablation member and which is adapted to at least in-part deliver the circumferential ablation member to the location, wherein the ablation element and the circumferential support member are configured such that the circumferential area coincides with the circumferential region of tissue when the circumferential support member is adjusted to the second position at the location.
a circumferential ablation member with a circumferential support member that is adjustable between a first position which is adapted to be delivered through a delivery sheath into the atrium and a second position having a substantially circumferentially looped shape, an ablation element located substantially along the circumferential support member and that is adapted to ablatively couple to a circumferential area adjacent to the support member in the second position, and a positioning assembly coupled to the circumferential support member to adjust the circumferential support member between the first and second positions when the circumferential support member is substantially unconfined within the atrium; and a delivery assembly cooperating with the circumferential ablation member and which is adapted to at least in-part deliver the circumferential ablation member to the location, wherein the ablation element and the circumferential support member are configured such that the circumferential area coincides with the circumferential region of tissue when the circumferential support member is adjusted to the second position at the location.
2. The system of claim 1, wherein the delivery assembly comprises a delivery member with a proximal end portion and a distal end portion with a longitudinal axis and a radial axis; and the circumferential support member comprises an elongate body which in the first position has a substantially straight shape relative to the longitudinal axis with a proximal end secured to the distal end portion, a distal end extending away from the distal end portion substantially along the longitudinal axis, and an intermediate region extending between the proximal and distal ends, wherein in the second position the elongate body is adjusted to the substantially circumferentially looped shape.
3. The system of claim 2, wherein the delivery member has a passageway extending between a distal port adjacent the proximal end of the elongate body and a proximal port located along the proximal end portion of the delivery member;
the positioning assembly comprises a pull-wire with a proximal end portion and a distal end portion;
the pull-wire is moveably engaged within the passageway such that the proximal end portion of the pull-wire extending proximally through the proximal port, the distal end portion of the pull-wire extends distally through the distal port;
the distal end portion of the pull-wire is secured to the distal end of the elongate body;
in the first position the first and second ends of the elongate body are spaced along the pull-wire with the intermediate region of the elongate body extending along the longitudinal axis adjacent to the pull-wire; and the circumferential support member is adjustable to the second position at least in part by adjusting the relative position of the pull-wire with respect to its moveable engagement within the passageway of the delivery member such that the proximal and distal ends of the elongate body are longitudinally collapsed toward each other and the intermediate region is radially deflected to form at least in part the substantially looped shape between the longitudinally collapsed ends.
the positioning assembly comprises a pull-wire with a proximal end portion and a distal end portion;
the pull-wire is moveably engaged within the passageway such that the proximal end portion of the pull-wire extending proximally through the proximal port, the distal end portion of the pull-wire extends distally through the distal port;
the distal end portion of the pull-wire is secured to the distal end of the elongate body;
in the first position the first and second ends of the elongate body are spaced along the pull-wire with the intermediate region of the elongate body extending along the longitudinal axis adjacent to the pull-wire; and the circumferential support member is adjustable to the second position at least in part by adjusting the relative position of the pull-wire with respect to its moveable engagement within the passageway of the delivery member such that the proximal and distal ends of the elongate body are longitudinally collapsed toward each other and the intermediate region is radially deflected to form at least in part the substantially looped shape between the longitudinally collapsed ends.
4. The system of claim 3, wherein the intermediate region is constructed with a predisposed bias toward the substantially looped geometry.
5. The system of claim 3, further comprising at least one indicator which indicates when the circumferential ablation member is in the second position.
6. The system of claim 5, wherein said at least one indicator comprises a first radiopaque marker at a first location corresponding to the proximal end of the elongate body and a second radiopaque marker at a second location corresponding to the distal end of the elongate body, wherein the relative locations of the first and second radiopaque markers indicate the relative location of the proximal and distal end portions of the elongate body.
7. The system of claim 5, wherein said at least one indicator comprises a first visible indicator located along the proximal end portion of the delivery member and a second visible indicator coupled to the proximal end portion of the pull-wire.
8. The system of claim 1, wherein the delivery assembly comprises first and second delivery members each having a proximal end portion and a distal end portion;
the circumferential support member comprises an elongate body with a distal end secured to the distal end portion of the first delivery member and a proximal end secured to the distal end portion of the second delivery member;
the positioning assembly comprises an outer member with a proximal end portion and a distal end portion that surrounds the distal end portions of the first and second delivery members and that has a longitudinal axis, wherein the distal end portion of at least one of the delivery members is longitudinally moveable within the outer member such that in the first position the distal end portions of the first and second delivery members are positioned relative to each other such that the elongate body extends distally from the first delivery member substantially along the longitudinal axis, and wherein in the second position the distal end portions of the first and second delivery members are longitudinally adjusted relative to each other and also relative to the outer member such that the elongate body is positioned externally of the distal end portion of the outer member with the proximal end of the elongate body adjacent to the distal end of the elongate body, such that the elongate body between the proximal and distal ends is adjusted into the substantially circumferentially looped shape.
the circumferential support member comprises an elongate body with a distal end secured to the distal end portion of the first delivery member and a proximal end secured to the distal end portion of the second delivery member;
the positioning assembly comprises an outer member with a proximal end portion and a distal end portion that surrounds the distal end portions of the first and second delivery members and that has a longitudinal axis, wherein the distal end portion of at least one of the delivery members is longitudinally moveable within the outer member such that in the first position the distal end portions of the first and second delivery members are positioned relative to each other such that the elongate body extends distally from the first delivery member substantially along the longitudinal axis, and wherein in the second position the distal end portions of the first and second delivery members are longitudinally adjusted relative to each other and also relative to the outer member such that the elongate body is positioned externally of the distal end portion of the outer member with the proximal end of the elongate body adjacent to the distal end of the elongate body, such that the elongate body between the proximal and distal ends is adjusted into the substantially circumferentially looped shape.
9. The system of claim 8, wherein the first delivery member is adapted to be positioned within the pulmonary vein, and further comprising an anchor along the distal end portion of the first delivery member and which is adapted to secure the first delivery member within the pulmonary vein.
10. The system of claim 9, wherein the anchor comprises an expandable member which is adapted to expand to radially engage the pulmonary vein in order to secure the first delivery member.
11. The system of claim 1, wherein the delivery assembly comprises a delivery member with a proximal end portion and a distal end portion with a longitudinal axis and a radial axis; and the positioning assembly comprises an array of circumferentially spaced splines that are positioned around the longitudinal axis, each spline having proximal end portion coupled to the distal end portion of the delivery member and a distal end portion coupled to the circumferential support member, and each spline being adjustable between a first configuration wherein the distal end portion of the spline extends substantially along the longitudinal axis and a second configuration wherein the distal end portion of the spline extends radially away from the longitudinal axis, such that the first position for the circumferential support member is characterized at least in part by each of the splines being adjusted to the first configuration, and the second position for the circumferential support member is characterized at least in part by each spline being adjusted to the second configuration.
12. The system of claim 11, wherein each spline comprises a single elongate member that terminates along the distal end portion of the spline at the coupling to the circumferential support member.
13. The system of claim 11, wherein each spline comprises a looped member having an apex along the distal end portion of the spline and two legs extending proximally from the apex along the proximal end portion of the spline.
14. The system of claim 13, wherein the circumferential support member is threaded through the apices of the circumferentially spaced splines.
15. The system of claim 11, wherein the system is adapted to cooperate with an ablation actuator, and:
at least one spline is adapted to couple at least in part the ablation element to the ablation actuator.
at least one spline is adapted to couple at least in part the ablation element to the ablation actuator.
16. The system of claim 15, further comprising:
a proximal coupler located along the proximal end portion of the delivery member and which is adapted to couple to the ablation actuator; and an ablation actuating member which extends between the proximal coupler and the ablation element along the at least one spline.
a proximal coupler located along the proximal end portion of the delivery member and which is adapted to couple to the ablation actuator; and an ablation actuating member which extends between the proximal coupler and the ablation element along the at least one spline.
17. The system of claim 16, wherein the ablation element comprises a fluid ablation element;
the proximal coupler comprises a fluid coupler that is adapted to couple to a fluid source; and the ablation actuating member comprises a tubular member with a passageway that fluidly couples the ablation element with a fluid source coupled to the proximal coupler.
the proximal coupler comprises a fluid coupler that is adapted to couple to a fluid source; and the ablation actuating member comprises a tubular member with a passageway that fluidly couples the ablation element with a fluid source coupled to the proximal coupler.
18. The system of claim 16, wherein the ablation element comprises an electrical current ablation element;
the proximal coupler is adapted to couple to an electrical current source; and the ablation actuating member comprises an electrical conductor lead that electrically couples the electrical current ablation element with a electrical current source coupled to the proximal coupler.
the proximal coupler is adapted to couple to an electrical current source; and the ablation actuating member comprises an electrical conductor lead that electrically couples the electrical current ablation element with a electrical current source coupled to the proximal coupler.
19. The system of claim 11, wherein the ablation element comprises a plurality of individual ablation elements, wherein each individual ablation element extends along the circumferential support member between two adjacent splines.
20. The system of claim 11, wherein each of the splines comprises a material having a memory to the second configuration.
21. The system of claim 1, wherein the ablation element comprises a fluid ablation element.
22. The system of claim 1, wherein the ablation element comprises an electrical current ablation element.
23. The system of claim 22, wherein the electrical current ablation element comprises:
at least one electrode along the circumferential support member which is adapted to be coupled to an electrical current source; and a porous wall that substantially surrounds the electrode within an enclosed fluid chamber which and is adapted to be fluidly coupled to a source of electrically conductive fluid, wherein the porous wall is adapted to electrically couple an ablative electrical current between the circumferential region of tissue positioned coincident to the circumferential area and the electrode via the electrically conductive fluid.
at least one electrode along the circumferential support member which is adapted to be coupled to an electrical current source; and a porous wall that substantially surrounds the electrode within an enclosed fluid chamber which and is adapted to be fluidly coupled to a source of electrically conductive fluid, wherein the porous wall is adapted to electrically couple an ablative electrical current between the circumferential region of tissue positioned coincident to the circumferential area and the electrode via the electrically conductive fluid.
24. The system of claim 1, wherein the ablation element comprises a microwave ablation element.
25. The system of claim 1, wherein the ablation element comprises a cryogenic ablation element.
26. The system of claim 1, wherein the ablation element comprises a thermal ablation element.
27. The system of claim 1, wherein the ablation element comprises a light emitting ablation element.
28. A tissue ablation system for treating atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium, comprising:
a delivery member having a proximal end portion and a distal end portion with a longitudinal axis and a radial axis;
a housing with a distal wall, that is located at least in part along the distal end portion, and that is mechanically adjustable between a first condition and a second condition, wherein the first condition the distal wall is substantially radially collapsed such that the housing is adapted to be delivered through a delivery sheath into the atrium, and wherein the second condition the distal wall is radially extended at least in part from the longitudinal axis with a distal orientation and a distal facing surface located along a circumferential region that surrounds the longitudinal axis;
a mechanical positioning assembly coupled to the housing to mechanically adjust the housing between the first and second conditions; and an ablation element cooperating with the housing and which is adapted to ablatively couple to a circumferential area normal to the distal facing surface along the circumferential region when the housing is in the second position, wherein the ablation element and distal facing surface are configured such that the circumferential area coincides with the circumferential region of tissue when the housing is adjusted to the second condition at the location.
a delivery member having a proximal end portion and a distal end portion with a longitudinal axis and a radial axis;
a housing with a distal wall, that is located at least in part along the distal end portion, and that is mechanically adjustable between a first condition and a second condition, wherein the first condition the distal wall is substantially radially collapsed such that the housing is adapted to be delivered through a delivery sheath into the atrium, and wherein the second condition the distal wall is radially extended at least in part from the longitudinal axis with a distal orientation and a distal facing surface located along a circumferential region that surrounds the longitudinal axis;
a mechanical positioning assembly coupled to the housing to mechanically adjust the housing between the first and second conditions; and an ablation element cooperating with the housing and which is adapted to ablatively couple to a circumferential area normal to the distal facing surface along the circumferential region when the housing is in the second position, wherein the ablation element and distal facing surface are configured such that the circumferential area coincides with the circumferential region of tissue when the housing is adjusted to the second condition at the location.
29. The system of claim 28, wherein in the second condition the distal wall along the circumferential region comprises a porous membrane that encloses at least in part a fluid chamber within the housing;
the distal facing surface is located along the porous membrane; and the porous membrane is adapted to ablatively couple a volume of ablative fluid within the fluid chamber to the circumferential area.
the distal facing surface is located along the porous membrane; and the porous membrane is adapted to ablatively couple a volume of ablative fluid within the fluid chamber to the circumferential area.
30. The system of claim 29, wherein the porous membrane is adapted to allow the volume of ablative fluid to flow from within the fluid chamber and into the circumferential area.
31. The system of claim 29, wherein the ablation element comprises a volume of ablative fluid medium within the fluid chamber and that ablatively couples with the circumferential area across the porous membrane.
32. The system of claim 29, wherein the porous membrane comprises a porous tetrafluoropolymer.
33. The system of claim 29, wherein the ablation element comprises an ablative energy source located within the fluid chamber.
34. The system of claim 28, wherein the housing comprises an outer jacket with a distal end portion and a proximal end portion, the distal wall is located along the distal end portion, and a proximal wall is located along the proximal end portion;
the mechanical positioning assembly comprises an array of longitudinal splines that are circumferentially spaced around the longitudinal axis, each of the longitudinal splines having a distal end portion and a proximal end portion and an intermediate region therebetween; and the distal and proximal end portions of the outer jacket are positioned to surround at least a part of the proximal and distal end portions of the splines, respectively, wherein in the first condition the proximal and distal end portions of each spline are respectively spaced along the longitudinal axis with the intermediate region being substantially radially collapsed within the outer jacket, and wherein the housing is adjusted to the second condition by longitudinally collapsing the relative position of the proximal and distal end portions of each spline such that the intermediate region of each spline deflects radially outwardly from the longitudinal axis and further such that the outer jacket around the intermediate regions of the splines is forced radially outwardly to thereby provide distal and proximal orientations, respectively, to the distal and proximal walls.
the mechanical positioning assembly comprises an array of longitudinal splines that are circumferentially spaced around the longitudinal axis, each of the longitudinal splines having a distal end portion and a proximal end portion and an intermediate region therebetween; and the distal and proximal end portions of the outer jacket are positioned to surround at least a part of the proximal and distal end portions of the splines, respectively, wherein in the first condition the proximal and distal end portions of each spline are respectively spaced along the longitudinal axis with the intermediate region being substantially radially collapsed within the outer jacket, and wherein the housing is adjusted to the second condition by longitudinally collapsing the relative position of the proximal and distal end portions of each spline such that the intermediate region of each spline deflects radially outwardly from the longitudinal axis and further such that the outer jacket around the intermediate regions of the splines is forced radially outwardly to thereby provide distal and proximal orientations, respectively, to the distal and proximal walls.
35. The system of claim 34, wherein the outer jacket comprises an elastomeric material.
36. The system of claim 28, wherein the housing further comprises a proximal wall which in the second condition has a proximally facing surface, and the proximal wall is connected to the distal wall.
37. The system of claim 36, wherein the distal and proximal walls are formed from an integral member.
38. The system of claim 36, wherein the distal wall in the second position further comprises an outer circumferential region that circumscribes the circumferential region that includes the distal facing surface, and also an inner circumferential region that is circumscribed by the circumferential region that includes the distal facing surface; and the distal and proximal walls are connected along at least one of the outer and inner circumferential regions.
39. The system of claim 36, wherein the distal wall in the second position further comprises an inner circumferential region that is circumscribed by the circumferential region that includes the distal facing surface; and the mechanical positioning assembly comprises at least one support member extending between the distal and proximal walls at least across the inner circumferential region and the circumferential region that includes the distal facing surface.
40. The system of claim 28, wherein the mechanical positioning assembly is coupled to the delivery member.
41. The system of claim 28, wherein the mechanical positioning assembly comprises an array of splines that are circumferentially spaced around the longitudinal axis, each spline having a distal end portion coupled to the distally oriented wall and a proximal end portion coupled to the distal end portion, and wherein each of the array of splines is adjustable between a first position which is substantially radially collapsed and extending along the longitudinal axis and a second position wherein the distal end portion of the spline extends radially outwardly from the longitudinal axis, such that the first and second positions for the splines characterize at least in part the first and second conditions for the housing.
42. The system of claim 41, wherein the ablation element comprises an energy source that is located along a spline at a position corresponding to the circumferential region.
43. A tissue ablation system for treating atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium, comprising:
a delivery member with a proximal end portion and a distal end portion having a longitudinal axis and a radial axis; and a circumferential ablation member coupled to the distal end portion and having an array of splines each with a proximal end portion and a distal end portion, and also having an array of individual ablation elements each supported along a support region of one of the splines, wherein the array of splines are circumferentially spaced around the longitudinal axis, each of the array of splines being adjustable between a first condition and a second condition wherein the respectively supported individual ablation element is adjustable between a first radial position and a second radial position, wherein each spline in the first condition is substantially radially collapsed and extends substantially along the longitudinal axis such that the circumferential ablation member is adapted to be delivered through a delivery sheath into the atrium, and in the second condition the support region of each spline extends at least in part radially away from the longitudinal axis such that each of the individual ablation elements is held by the supporting spline in the second radial position with the array of individual ablation elements being spaced along a circumferential pattern that surrounds the longitudinal axis, said circumferential pattern being configured such that the array of individual ablation elements is adapted to engage and ablate the circumferential region of tissue when the splines are adjusted to the second condition at the location.
a delivery member with a proximal end portion and a distal end portion having a longitudinal axis and a radial axis; and a circumferential ablation member coupled to the distal end portion and having an array of splines each with a proximal end portion and a distal end portion, and also having an array of individual ablation elements each supported along a support region of one of the splines, wherein the array of splines are circumferentially spaced around the longitudinal axis, each of the array of splines being adjustable between a first condition and a second condition wherein the respectively supported individual ablation element is adjustable between a first radial position and a second radial position, wherein each spline in the first condition is substantially radially collapsed and extends substantially along the longitudinal axis such that the circumferential ablation member is adapted to be delivered through a delivery sheath into the atrium, and in the second condition the support region of each spline extends at least in part radially away from the longitudinal axis such that each of the individual ablation elements is held by the supporting spline in the second radial position with the array of individual ablation elements being spaced along a circumferential pattern that surrounds the longitudinal axis, said circumferential pattern being configured such that the array of individual ablation elements is adapted to engage and ablate the circumferential region of tissue when the splines are adjusted to the second condition at the location.
44. The system of claim 43, wherein each of the splines has a memory to the second condition.
45. The system of claim 44, wherein each of the splines comprises a shape-memory material.
46. The system of claim 45, wherein each of the splines comprises a nickel-titanium alloy.
47. The system of claim 43, further comprising an outer member with a proximal end portion and a distal end portion which surrounds the distal end portion of the delivery member, wherein the splines are adapted to be withdrawn into the outer member in the first position.
48. The system of claim 43, wherein the distal end portion of each of the splines in the second position has a radius of curvature away from the longitudinal axis.
49. The system of claim 43, wherein the distal end portion of each of the splines in the second position has a radius of curvature toward the longitudinal axis.
50. The system of claim 43, wherein the ablation element comprises an electrical current ablation element.
51. The system of claim 43, wherein the ablation element comprises a thermal ablation element.
52. The system of claim 43, wherein the ablation element comprises an ultrasound ablation element.
53. The system of claim 43, wherein the ablation element comprises a microwave ablation element
54. The system of claim 43, wherein the ablation element comprises a thermal ablation element.
55. The system of claim 43, wherein the ablation element comprises a cryoablation element.
56. The system of claim 43, wherein the ablation element comprises a fluid ablation element.
57. The system of claim 43, wherein the ablation element comprises a light emitting ablation element.
58. A tissue ablation system for treating atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium, comprising:
a delivery member with a proximal end portion and a distal end portion having a longitudinal axis and a radial axis; and a contact member located along the distal end portion and which is adjustable between a first condition and a second condition, wherein in the first condition the contact member is adapted to be delivered through a delivery sheath into the atrium, and wherein in the second condition the contact member comprises a circumferential wall that surrounds the longitudinal axis; and an ablation element having an ablative energy source that is located along the distal end portion, wherein the ablation element cooperates with the contact member such that the ablative energy source emits a circumferential pattern of energy having a distal orientation through the circumferential wall and into a circumferential area normal to the circumferential wall without coupling an electrical current between the ablative energy source and the circumferential area, wherein the ablation element and contact member are configured such that the circumferential area coincides with the circumferential region of tissue when the contact member is adjusted to the second condition at the location.
a delivery member with a proximal end portion and a distal end portion having a longitudinal axis and a radial axis; and a contact member located along the distal end portion and which is adjustable between a first condition and a second condition, wherein in the first condition the contact member is adapted to be delivered through a delivery sheath into the atrium, and wherein in the second condition the contact member comprises a circumferential wall that surrounds the longitudinal axis; and an ablation element having an ablative energy source that is located along the distal end portion, wherein the ablation element cooperates with the contact member such that the ablative energy source emits a circumferential pattern of energy having a distal orientation through the circumferential wall and into a circumferential area normal to the circumferential wall without coupling an electrical current between the ablative energy source and the circumferential area, wherein the ablation element and contact member are configured such that the circumferential area coincides with the circumferential region of tissue when the contact member is adjusted to the second condition at the location.
59. The system of claim 58, wherein the contact member comprises an inflatable balloon, the circumferential wall comprises an outer skin of the balloon, and the ablative energy source is adapted to emit the circumferential pattern of energy through the outer skin of the balloon and into the circumferential region of tissue.
60. The system of claim 58, wherein the ablation element comprises a thermal ablation element.
61. The system of claim 58, wherein the ablation element comprises an ultrasound ablation element.
62. The system of claim 61, wherein the ultrasound ablation element comprises an ultrasound transducer assembly mounted onto the distal end portion with a distally oriented face which is adapted to emit an ultrasonic energy signal distally at an angle relative to the longitudinal axis and through the circumferential wall of the contact member.
63. The system of claim 62, wherein the ultrasound transducer assembly comprises a conically shaped transducer with an outer conical surface having a distal orientation.
64. The system of claim 62, wherein the ultrasound transducer assembly comprises a curved distal face.
65. The system of claim 62, wherein the ultrasound transducer assembly comprises at least one ultrasound transducer panel that is adjustable from a radially collapsed position to a radially extended position having a distally oriented face that is adapted to emit the circumferential pattern of energy with the distal orientation.
66. The system of claim 65, wherein the transducer panel is adjustable with an expandable member located between the panel and the distal end portion of the delivery member.
67. The system of claim 66, wherein the expandable member comprises a balloon.
68. The system of claim 66, wherein the expandable member comprises a cage.
69. The system of claim 58, wherein the ablation element comprises a microwave ablation element
70. The system of claim 58, wherein the ablation element comprises a cryoablation element.
71. The system of claim 58, wherein the ablation element comprises a fluid ablation element.
72. The system of claim 58, wherein the ablation element comprises a light emitting ablation element.
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US09/435,281 US6652515B1 (en) | 1997-07-08 | 1999-11-05 | Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall |
US09/435,281 | 1999-11-05 | ||
PCT/US2000/013204 WO2000067656A1 (en) | 1999-05-11 | 2000-05-11 | Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall |
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CA2373889A1 true CA2373889A1 (en) | 2000-11-16 |
CA2373889C CA2373889C (en) | 2010-01-19 |
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CA002373889A Expired - Lifetime CA2373889C (en) | 1999-05-11 | 2000-05-11 | Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall |
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US (3) | US6652515B1 (en) |
EP (1) | EP1182980B1 (en) |
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CA (1) | CA2373889C (en) |
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DK (1) | DK1182980T3 (en) |
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1999
- 1999-11-05 US US09/435,281 patent/US6652515B1/en not_active Expired - Lifetime
-
2000
- 2000-05-11 WO PCT/US2000/013204 patent/WO2000067656A1/en active IP Right Grant
- 2000-05-11 DE DE60029100T patent/DE60029100T2/en not_active Expired - Lifetime
- 2000-05-11 AU AU48483/00A patent/AU770220B2/en not_active Expired
- 2000-05-11 CA CA002373889A patent/CA2373889C/en not_active Expired - Lifetime
- 2000-05-11 AT AT00930709T patent/ATE331479T1/en not_active IP Right Cessation
- 2000-05-11 DK DK00930709T patent/DK1182980T3/en active
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- 2000-05-11 ES ES00930709T patent/ES2267537T3/en not_active Expired - Lifetime
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2002
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2004
- 2004-11-24 US US10/996,523 patent/US7340307B2/en not_active Expired - Fee Related
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EP1182980B1 (en) | 2006-06-28 |
AU770220B2 (en) | 2004-02-19 |
ES2267537T3 (en) | 2007-03-16 |
WO2000067656A1 (en) | 2000-11-16 |
CA2373889C (en) | 2010-01-19 |
US7340307B2 (en) | 2008-03-04 |
AU4848300A (en) | 2000-11-21 |
US20060084966A1 (en) | 2006-04-20 |
US20030125726A1 (en) | 2003-07-03 |
US6652515B1 (en) | 2003-11-25 |
US6964660B2 (en) | 2005-11-15 |
DK1182980T3 (en) | 2006-10-30 |
DE60029100T2 (en) | 2007-06-14 |
ATE331479T1 (en) | 2006-07-15 |
DE60029100D1 (en) | 2006-08-10 |
EP1182980A1 (en) | 2002-03-06 |
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