CA2375315C - Ion mobility spectrometers - Google Patents
Ion mobility spectrometers Download PDFInfo
- Publication number
- CA2375315C CA2375315C CA002375315A CA2375315A CA2375315C CA 2375315 C CA2375315 C CA 2375315C CA 002375315 A CA002375315 A CA 002375315A CA 2375315 A CA2375315 A CA 2375315A CA 2375315 C CA2375315 C CA 2375315C
- Authority
- CA
- Canada
- Prior art keywords
- dopant
- ion mobility
- molecular sieve
- sieve material
- mobility spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/16—Alumino-silicates
- B01J20/18—Synthetic zeolitic molecular sieves
- B01J20/186—Chemical treatments in view of modifying the properties of the sieve, e.g. increasing the stability or the activity, also decreasing the activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
Abstract
An ion mobility spectrometer system comprising: an ion mobility detector; a gas/vapour circulating system for the ion mobility detector into which samples of gases and vapours of interest ma y be drawn for detection by the ion mobility spectrometer; the circulating system comprising an ion mobility cell (12), means for dryin g and/or cleaning (20, 22) the circulating gases/vapours in the circulating system, a dopant source (20, 22), and means for causing circulation (10) of the gases/vapours within the circulating system; in which the dopant source and the means for drying and/or cleaning the circulating gases/vapours are combined (20, 22), whereby the need for a physically separate dopant source for the system is obviated. The dopant source material may be combined with the material for drying and or cleaning the circulating gases/vapours.< /SDOAB>
Description
Ion Mobility Spectrometers Technical Field The present invention relates to ion mobility spectrometers used for gas and vapour detection, and more particularly to ion mobility spectrometer systems in which the system is "doped", or has added to it, a low concentration of a trace reagent vapour or vapours (the "dopant") e.g. to improve the sensitivity of the system to gases or vapours of interest, or to improve the rejection of interfacing materials (i.e. those which may otherwise give rise to a response interfering with detection of gases and vapours of interest).
Background The use of dopants in Ion Mobility Spectrometer (IMS) systems is well known and the principles involved have been described in the literature, for example, in the introduction to EP-A-219602.
Dopant sources commonly consist of a sealed container with a permeation capability containing the chosen dopant material, with the container incorporated in the circulating system of the IMS detector, comprising the ion mobility cell, means such as a sieve pack for drying and cleaning the recirculating gases in the system, the dopant source, and a pump, into which samples of gases or vapours of interest, usually air-borne, are drawn for analysis.
Summary of the Invention In accordance with one aspect, the present invention provides an ion mobility spectrometer system comprising: an ion mobility detector; a gas/vapour circulating system for the ion mobility detector into which samples of gases and vapours of interest may be drawn for detection; the circulating system comprising an ion mobility cell, means for drying, cleaning or drying and cleaning the circulating gases/vapours in the circulating system including a molecular sieve material for drying and cleaning the circulating gases/vapours, a dopant source including a dopant material, and means for causing circulation of the gases/vapours within the circulating system; wherein the dopant material is combined with the molecular sieve material in a mixed dopant sieve material, whereby the need for a separate dopant source for the system is obviated.
In accordance with another aspect, the invention provides a combined dopant source and molecular sieve pack for use in an ion mobility spectrometer system according to the first aspect of the invention described above comprising a combined sieve and dopant source in which a dopant source material and a molecular sieve material are combined in a mixed dopant sieve material.
In accordance with yet another aspect the invention provides a method of producing an ion mobility spectrometer combined sieve and dopant source comprising a molecular sieve material and a dopant material which includes combining the sieve material with the dopant material in a mixed dopant sieve material.
Embodiments of the invention potentially provide a number of advantages over current practice in which separate dopant sources and molecular sieve packs are employed.
For example, in hand-held or body-worn IMS
equipment, space within the equipment housing is at a premium, and use of a combined dopant source/molecular sieve reduces the space requirement of the circulating system.
Background The use of dopants in Ion Mobility Spectrometer (IMS) systems is well known and the principles involved have been described in the literature, for example, in the introduction to EP-A-219602.
Dopant sources commonly consist of a sealed container with a permeation capability containing the chosen dopant material, with the container incorporated in the circulating system of the IMS detector, comprising the ion mobility cell, means such as a sieve pack for drying and cleaning the recirculating gases in the system, the dopant source, and a pump, into which samples of gases or vapours of interest, usually air-borne, are drawn for analysis.
Summary of the Invention In accordance with one aspect, the present invention provides an ion mobility spectrometer system comprising: an ion mobility detector; a gas/vapour circulating system for the ion mobility detector into which samples of gases and vapours of interest may be drawn for detection; the circulating system comprising an ion mobility cell, means for drying, cleaning or drying and cleaning the circulating gases/vapours in the circulating system including a molecular sieve material for drying and cleaning the circulating gases/vapours, a dopant source including a dopant material, and means for causing circulation of the gases/vapours within the circulating system; wherein the dopant material is combined with the molecular sieve material in a mixed dopant sieve material, whereby the need for a separate dopant source for the system is obviated.
In accordance with another aspect, the invention provides a combined dopant source and molecular sieve pack for use in an ion mobility spectrometer system according to the first aspect of the invention described above comprising a combined sieve and dopant source in which a dopant source material and a molecular sieve material are combined in a mixed dopant sieve material.
In accordance with yet another aspect the invention provides a method of producing an ion mobility spectrometer combined sieve and dopant source comprising a molecular sieve material and a dopant material which includes combining the sieve material with the dopant material in a mixed dopant sieve material.
Embodiments of the invention potentially provide a number of advantages over current practice in which separate dopant sources and molecular sieve packs are employed.
For example, in hand-held or body-worn IMS
equipment, space within the equipment housing is at a premium, and use of a combined dopant source/molecular sieve reduces the space requirement of the circulating system.
Additionally, and especially in small instruments, there is a need to regularly change the molecular sieve.
By providing a combined sieve and dopant source in a single pack, a dopant change, desirable for maintaining a consistent level of dopant within the circulating system, is provided at the same time by a single action.
Current practice requires dopant sources associated with IMS circulating systems to be heated when the instrument is operated at low temperatures. With a combined sieve and dopant source it has unexpectedly been found possible to maintain dopant levels within the circulating system at low temperatures without the need for heating, thereby further simplifying and reducing the space and power requirements of the instrument.
It has been found that combination of the dopant and the sieve material provides the required level of sensitisation of the IMS instrument to samples of interest and/or rejection of interferents.
Use of the combined dopant and sieve material within the circulating system of an IMS instrument, has also been found to improve dopant capability over a range of ambient temperatures from -30 C to +501C, even without heating.
Although it might be expected that applying dopant to a sieve would increase water takeup, and hence reduce the useful life of the product, the applicants have found in practice that that is not in fact the case.
3a Brief Description of the Drawings Embodiments of the invention are now described by way of example with reference to the accompanying Figure 1 showing a prior art ion mobility spectrometer and Figure 2 showing an ion mobility spectrometer in accordance with an embodiment of the invention.
Detailed Description Figure 1 of the accompanying drawings shows a simplified block diagram of a conventional ion mobility spectrometer employing a closed-loop recirculatory system, comprising a pump 10, an IMS cell 12, a pair of molecular sieve packs 14, 16 for drying the carrier gas, most usually air, in the recirculatory system, and a dopant source 18, for providing the required level of dopant for sensitivity enhancement, and/or interferent rejection.
In operation ambient air, which may contain gas or vapour of interest, is drawn into the circulatory system, by way of an inlet system, not here shown, and passed through the IMS cell 12 which is able, in association with conventional electronic instrumentation not here shown, to provide an electrical output representative of the presence and/or the quantity of a gas or vapour of interest in the ambient air sampled.
Figure 2 shows the same instrument as is shown in Figure 1, only with the original pair of molecular sieve packs and the dopant source replaced with a pair of combined dopant molecular sieve packs 20, 22. The sieve may be of any standard material, such as an alumino silicate (Zeolite).
3b The required combination of mixed sieve and dopant material may be produced by placing the dried molecular sieve material in a sealed vessel with the correct mass of doping material, and agitating and preferably heating the mixture to 50 C for some twelve hours.
The combination of the materials may be achieved at higher or lower temperatures, given an appropriate modification of the time to permit combination. The mixture does not always have to be heated, although to get good distribution of the dopant it is preferably for it to be agitated.
The combined material may also be made by passing a dry inert gas stream containing the dopant material at a fixed level over the molecular sieve material and allowing the molecular sieve material to absorb the dopant material.
The mechanism by which dopant material is adsorbed on to the molecular sieve is a reversible physical adsorption, meaning that with a given mass of material adsorbed on to the sieve at a given temperature the partial pressure of the adsorbed dopant material over the sieve is constant.
In an IMS system where there is carrier gas flow over the combined dopant/sieve material, and leakage of the carrier from the system, the adsorbed dopant material will be removed from the sieve material.
In a closed recirculating system, adsorbed material will be released into the carrier gas, but subsequently replaced in the sieve material, thereby maintaining a continuing constant level of dopant within the system.
By way of example, a combination of ammonium carbamate dopant, and a 13X (l0A) pore size molecular sieve material, combined in the proportion of between 0.1% to 5% by weight of dopant to sieve material, was used with an ion mobility spectrometer such as shown in Figure 2 of the drawings. Other concentrations may be used, depending upon the dopant, for example up to about 10%. The most preferred range is normally about 2 to 5%. Other pore sizes could also be used, for example 3A, 4A or 5A.
The spectral response of the three target compounds chosen for study DMMP (0,0-Dimethyl Methane Phosphonate); TEP (Triethyl Phosphate); and DPM (Dipropylene Glycol Mono Methyl Ether); using the specified combined dopant/molecular sieve material, remained sensibly constant over a temperature range of -30 C to +50 C.
It will be apparent that other doping compounds may be employed, chosen to provide a dopant level in a required range. In one embodiment, the dopant is preferably ammonia, or ammonia with COZ.
Other absorbent materials may also be employed in the manufacture of combined dopant/sieve materials.
It has been found that the system described is longer lasting than a 5 comparable standard permeation source and sieve system, and has a greater shelf-life.
Although the described example employs a combined dopant/sieve as the only dopant source within the system, the combined dopant/sieve may be used in an instrument system in addition to a standard dopant source, in order to provide multiple doping of the system, or to provide additional doping, for instance to support the standard permeation dopant source at low temperatures.
For example, one may wish to use a very heavy molecular mass dopant in association with a very light one. The only way to achieve that, otherwise, would be by providing a very large and heavy dopant source.
By providing a combined sieve and dopant source in a single pack, a dopant change, desirable for maintaining a consistent level of dopant within the circulating system, is provided at the same time by a single action.
Current practice requires dopant sources associated with IMS circulating systems to be heated when the instrument is operated at low temperatures. With a combined sieve and dopant source it has unexpectedly been found possible to maintain dopant levels within the circulating system at low temperatures without the need for heating, thereby further simplifying and reducing the space and power requirements of the instrument.
It has been found that combination of the dopant and the sieve material provides the required level of sensitisation of the IMS instrument to samples of interest and/or rejection of interferents.
Use of the combined dopant and sieve material within the circulating system of an IMS instrument, has also been found to improve dopant capability over a range of ambient temperatures from -30 C to +501C, even without heating.
Although it might be expected that applying dopant to a sieve would increase water takeup, and hence reduce the useful life of the product, the applicants have found in practice that that is not in fact the case.
3a Brief Description of the Drawings Embodiments of the invention are now described by way of example with reference to the accompanying Figure 1 showing a prior art ion mobility spectrometer and Figure 2 showing an ion mobility spectrometer in accordance with an embodiment of the invention.
Detailed Description Figure 1 of the accompanying drawings shows a simplified block diagram of a conventional ion mobility spectrometer employing a closed-loop recirculatory system, comprising a pump 10, an IMS cell 12, a pair of molecular sieve packs 14, 16 for drying the carrier gas, most usually air, in the recirculatory system, and a dopant source 18, for providing the required level of dopant for sensitivity enhancement, and/or interferent rejection.
In operation ambient air, which may contain gas or vapour of interest, is drawn into the circulatory system, by way of an inlet system, not here shown, and passed through the IMS cell 12 which is able, in association with conventional electronic instrumentation not here shown, to provide an electrical output representative of the presence and/or the quantity of a gas or vapour of interest in the ambient air sampled.
Figure 2 shows the same instrument as is shown in Figure 1, only with the original pair of molecular sieve packs and the dopant source replaced with a pair of combined dopant molecular sieve packs 20, 22. The sieve may be of any standard material, such as an alumino silicate (Zeolite).
3b The required combination of mixed sieve and dopant material may be produced by placing the dried molecular sieve material in a sealed vessel with the correct mass of doping material, and agitating and preferably heating the mixture to 50 C for some twelve hours.
The combination of the materials may be achieved at higher or lower temperatures, given an appropriate modification of the time to permit combination. The mixture does not always have to be heated, although to get good distribution of the dopant it is preferably for it to be agitated.
The combined material may also be made by passing a dry inert gas stream containing the dopant material at a fixed level over the molecular sieve material and allowing the molecular sieve material to absorb the dopant material.
The mechanism by which dopant material is adsorbed on to the molecular sieve is a reversible physical adsorption, meaning that with a given mass of material adsorbed on to the sieve at a given temperature the partial pressure of the adsorbed dopant material over the sieve is constant.
In an IMS system where there is carrier gas flow over the combined dopant/sieve material, and leakage of the carrier from the system, the adsorbed dopant material will be removed from the sieve material.
In a closed recirculating system, adsorbed material will be released into the carrier gas, but subsequently replaced in the sieve material, thereby maintaining a continuing constant level of dopant within the system.
By way of example, a combination of ammonium carbamate dopant, and a 13X (l0A) pore size molecular sieve material, combined in the proportion of between 0.1% to 5% by weight of dopant to sieve material, was used with an ion mobility spectrometer such as shown in Figure 2 of the drawings. Other concentrations may be used, depending upon the dopant, for example up to about 10%. The most preferred range is normally about 2 to 5%. Other pore sizes could also be used, for example 3A, 4A or 5A.
The spectral response of the three target compounds chosen for study DMMP (0,0-Dimethyl Methane Phosphonate); TEP (Triethyl Phosphate); and DPM (Dipropylene Glycol Mono Methyl Ether); using the specified combined dopant/molecular sieve material, remained sensibly constant over a temperature range of -30 C to +50 C.
It will be apparent that other doping compounds may be employed, chosen to provide a dopant level in a required range. In one embodiment, the dopant is preferably ammonia, or ammonia with COZ.
Other absorbent materials may also be employed in the manufacture of combined dopant/sieve materials.
It has been found that the system described is longer lasting than a 5 comparable standard permeation source and sieve system, and has a greater shelf-life.
Although the described example employs a combined dopant/sieve as the only dopant source within the system, the combined dopant/sieve may be used in an instrument system in addition to a standard dopant source, in order to provide multiple doping of the system, or to provide additional doping, for instance to support the standard permeation dopant source at low temperatures.
For example, one may wish to use a very heavy molecular mass dopant in association with a very light one. The only way to achieve that, otherwise, would be by providing a very large and heavy dopant source.
Claims (17)
1. An ion mobility spectrometer system comprising:
an ion mobility detector;
a gas/vapour circulating system for the ion mobility detector into which samples of gases and vapours of interest may be drawn for detection;
the circulating system comprising an ion mobility cell, means for drying, cleaning or drying and cleaning the circulating gases/vapours in the circulating system including a molecular sieve material for drying and cleaning the circulating gases/vapours, a dopant source including a dopant material, and means for causing circulation of the gases/vapours within the circulating system;
wherein the dopant material is combined with the molecular sieve material in a mixed dopant sieve material, whereby the need for a separate dopant source for the system is obviated.
an ion mobility detector;
a gas/vapour circulating system for the ion mobility detector into which samples of gases and vapours of interest may be drawn for detection;
the circulating system comprising an ion mobility cell, means for drying, cleaning or drying and cleaning the circulating gases/vapours in the circulating system including a molecular sieve material for drying and cleaning the circulating gases/vapours, a dopant source including a dopant material, and means for causing circulation of the gases/vapours within the circulating system;
wherein the dopant material is combined with the molecular sieve material in a mixed dopant sieve material, whereby the need for a separate dopant source for the system is obviated.
2. An ion mobility spectrometer system in accordance with Claim 1 in which the mixed dopant sieve material is provided in a pack.
3. An ion mobility spectrometer system in accordance with Claim 1 or Claim 2 in which at least one further dopant source is used in addition to the mixed dopant sieve material.
4. An ion mobility spectrometer system in accordance with Claim 1 in which the dopant material is ammonium carbamate, and the molecular sieve material is 13X pore size material.
5. An ion mobility spectrometer system in accordance with Claim 4 in which the dopant material and the molecular sieve material are combined in the proportions of between 0.1% to 0.5% by weight of dopant material to molecular sieve material.
6. An ion mobility spectrometer system in accordance with Claim 1, Claim 4 or Claim 5 in which the mixed dopant sieve material is produced by heating the dopant material and the molecular sieve material together in a sealed vessel.
7. An ion mobility spectrometer system in accordance with Claim 1, Claim 4 or Claim 5 in which the mixed dopant sieve material is produced by passing a dry inert gas stream containing the dopant material at a fixed level over the molecular sieve material, whereby the molecular sieve material absorbs the dopant material.
8. An ion mobility spectrometer system in accordance with Claim 1 in which the mixed dopant sieve material is produced by agitating together the dopant material and the molecular sieve material.
9. An ion mobility spectrometer system in accordance with Claim 1 in which the molecular sieve material has a pore size of 13X, 3A, 4A or 5A.
10. An ion mobility spectrometer system in accordance with Claim 1 in which the dopant material is ammonia or ammonia in CO2.
11. An ion mobility spectrometer system in accordance with Claim 1 in which the dopant material and the molecular sieve material are combined in the proportions of between 2 and 5% by weight of dopant material to molecular sieve material.
12. An ion mobility spectrometer system in accordance with Claim 1 in which the dopant material and the molecular sieve material are combined in the proportions of between 0.1 and 10% by weight of dopant material to molecular sieve material.
13. A combined dopant source and molecular sieve pack for use in an ion mobility spectrometer system as claimed in any one of claims 1 to 12 comprising a combined sieve and dopant source in which a dopant source material and a molecular sieve material are combined in a mixed dopant sieve material.
14. A method of producing an ion mobility spectrometer combined sieve and dopant source comprising a molecular sieve material and a dopant material which includes combining the sieve material with the dopant material in a mixed dopant sieve material.
15. A method as claimed in Claim 14 including heating the dopant material and the molecular sieve material together in a sealed vessel.
16. A method as claimed in Claim 14 or 15 including passing a dry inert gas stream containing the dopant material at a fixed level over the molecular sieve material, whereby the molecular sieve material absorbs the dopant material.
17. A method as claimed in Claim 14 including agitating together the dopant material and the molecular sieve material.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9914552.6A GB9914552D0 (en) | 1999-06-23 | 1999-06-23 | Ion mobility spectrometers |
| GB9914552.6 | 1999-06-23 | ||
| PCT/GB2000/002390 WO2000079261A1 (en) | 1999-06-23 | 2000-06-21 | Ion mobility spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2375315A1 CA2375315A1 (en) | 2000-12-28 |
| CA2375315C true CA2375315C (en) | 2009-01-06 |
Family
ID=10855819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002375315A Expired - Lifetime CA2375315C (en) | 1999-06-23 | 2000-06-21 | Ion mobility spectrometers |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6825460B2 (en) |
| EP (1) | EP1200818B1 (en) |
| JP (1) | JP4668487B2 (en) |
| KR (1) | KR100772464B1 (en) |
| AT (1) | ATE381015T1 (en) |
| AU (1) | AU5549200A (en) |
| CA (1) | CA2375315C (en) |
| DE (1) | DE60037428T2 (en) |
| ES (1) | ES2293904T3 (en) |
| GB (1) | GB9914552D0 (en) |
| WO (1) | WO2000079261A1 (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0310943D0 (en) * | 2003-05-13 | 2003-06-18 | Smiths Group Plc | Ims systems |
| CA2550088A1 (en) * | 2003-12-18 | 2005-07-07 | Sionex Corporation | Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification |
| US7361206B1 (en) * | 2004-09-07 | 2008-04-22 | United States Of America As Represented By The Secretary Of The Navy | Apparatus and method for water vapor removal in an ion mobility spectrometer |
| GB0508239D0 (en) | 2005-04-23 | 2005-06-01 | Smiths Group Plc | Detection apparatus |
| GB0508636D0 (en) * | 2005-04-28 | 2005-06-08 | Smiths Group Plc | Molecular sieves |
| GB0509874D0 (en) * | 2005-05-14 | 2005-06-22 | Smiths Group Plc | Detection systems and dopants |
| GB0511224D0 (en) * | 2005-06-02 | 2005-07-06 | Smiths Group Plc | IMS systems |
| US7946150B2 (en) * | 2005-07-20 | 2011-05-24 | Smiths Detection-Watford Limited | Detection systems |
| GB0520397D0 (en) | 2005-10-07 | 2005-11-16 | Smiths Group Plc | Vapour generators |
| GB0524972D0 (en) * | 2005-12-07 | 2006-01-18 | Micromass Ltd | Mass spectrometer |
| GB0612047D0 (en) * | 2006-06-17 | 2006-07-26 | Smiths Group Plc | Dopant delivery and detection systems |
| GB0612271D0 (en) * | 2006-06-21 | 2006-08-02 | Smiths Group Plc | Detection arrangements |
| GB0618669D0 (en) * | 2006-09-22 | 2006-11-01 | Smiths Group Plc | Detection |
| GB0620748D0 (en) | 2006-10-19 | 2006-11-29 | Smiths Group Plc | Spectrometer apparatus |
| GB0621990D0 (en) * | 2006-11-04 | 2006-12-13 | Smiths Group Plc | Detection |
| GB0625480D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detector apparatus, pre-concentrators and methods |
| GB0625478D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detection apparatus |
| GB0625481D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detector apparatus and pre-concentrators |
| GB0625479D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detection apparatus |
| GB0704137D0 (en) | 2007-03-03 | 2007-04-11 | Smiths Detection Watford Ltd | Ion mobility spectrometers |
| GB0704547D0 (en) * | 2007-03-09 | 2007-04-18 | Smiths Detection Watford Ltd | Ion mobility spectrometers |
| CN102318035B (en) * | 2007-07-30 | 2015-03-11 | 粒子监测系统有限公司 | Detection of analytes using ion mobility spectrometry |
| US7663099B2 (en) * | 2007-12-31 | 2010-02-16 | Morpho Detection, Inc. | Apparatus and method for generating an ammonia gas |
| GB2461346B (en) | 2008-07-04 | 2013-02-13 | Smiths Group Plc | Electrical connectors |
| US8461517B2 (en) | 2008-10-27 | 2013-06-11 | Smiths Detection Montreal Inc. | Ammonium salts as IMS positive mode calibrants/reactants |
| CN102033100B (en) | 2009-09-25 | 2013-03-13 | 同方威视技术股份有限公司 | Detecting system of ion migration spectrometer (IMS) using doping agent and detecting method thereof |
| CN102074448B (en) | 2009-11-20 | 2014-09-24 | 同方威视技术股份有限公司 | Ion mobility spectrometer and method for improving detection sensitivity thereof |
| EP2796868B1 (en) | 2013-04-24 | 2015-09-09 | Bruker Daltonik GmbH | Ion mobility spectrometer with device for generating ammonia gas |
| KR101703063B1 (en) | 2015-10-07 | 2017-02-06 | 국방과학연구소 | High voltage Radio Frequency waveform generating Apparatus and Method to operate ion mobility device using linear amplifier |
| JP7471141B2 (en) | 2020-05-13 | 2024-04-19 | 理研計器株式会社 | Ionization promoter supply member, dehumidifier, and analyzer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2331791A1 (en) * | 1975-11-13 | 1977-06-10 | Veillard Camille | Appts. for detecting noxious gases in air - esp. minute traces of hydrazine |
| US4551624A (en) * | 1983-09-23 | 1985-11-05 | Allied Corporation | Ion mobility spectrometer system with improved specificity |
| EP0219602A3 (en) * | 1985-08-01 | 1987-08-19 | Allied Corporation | Ionization detector |
| GB9120192D0 (en) * | 1991-09-21 | 1991-11-20 | Graseby Ionics Ltd | Ion mobility spectrometry equipment |
| GB9510405D0 (en) * | 1995-05-23 | 1995-07-19 | Graseby Dynamics Ltd | Ion mobility spectrometers |
| US5587581A (en) * | 1995-07-31 | 1996-12-24 | Environmental Technologies Group, Inc. | Method and an apparatus for an air sample analysis |
| US5554846A (en) * | 1995-07-31 | 1996-09-10 | Environmental Technologies Group, Inc. | Apparatus and a method for detecting alarm molecules in an air sample |
| GB9602158D0 (en) * | 1996-02-02 | 1996-04-03 | Graseby Dynamics Ltd | Corona discharge ion sources for analytical instruments |
-
1999
- 1999-06-23 GB GBGB9914552.6A patent/GB9914552D0/en not_active Ceased
-
2000
- 2000-06-21 AT AT00940573T patent/ATE381015T1/en not_active IP Right Cessation
- 2000-06-21 AU AU55492/00A patent/AU5549200A/en not_active Abandoned
- 2000-06-21 CA CA002375315A patent/CA2375315C/en not_active Expired - Lifetime
- 2000-06-21 WO PCT/GB2000/002390 patent/WO2000079261A1/en active IP Right Grant
- 2000-06-21 ES ES00940573T patent/ES2293904T3/en not_active Expired - Lifetime
- 2000-06-21 EP EP00940573A patent/EP1200818B1/en not_active Expired - Lifetime
- 2000-06-21 KR KR1020017016350A patent/KR100772464B1/en active IP Right Grant
- 2000-06-21 JP JP2001505180A patent/JP4668487B2/en not_active Expired - Lifetime
- 2000-06-21 DE DE60037428T patent/DE60037428T2/en not_active Expired - Lifetime
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2001
- 2001-12-19 US US10/025,006 patent/US6825460B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2293904T3 (en) | 2008-04-01 |
| EP1200818A1 (en) | 2002-05-02 |
| US20020088936A1 (en) | 2002-07-11 |
| ATE381015T1 (en) | 2007-12-15 |
| KR100772464B1 (en) | 2007-11-02 |
| US6825460B2 (en) | 2004-11-30 |
| CA2375315A1 (en) | 2000-12-28 |
| EP1200818B1 (en) | 2007-12-12 |
| AU5549200A (en) | 2001-01-09 |
| KR20020035009A (en) | 2002-05-09 |
| GB9914552D0 (en) | 1999-08-25 |
| JP4668487B2 (en) | 2011-04-13 |
| JP2003502666A (en) | 2003-01-21 |
| WO2000079261A1 (en) | 2000-12-28 |
| DE60037428T2 (en) | 2008-04-17 |
| DE60037428D1 (en) | 2008-01-24 |
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